Mira Karrasch

Mira Karrasch
Åbo Akademi University · Department of Psychology

PhD, Clinical Neuropsychologist
Currently teaching, supervising, conducting research and doing some clinical work on the side.

About

84
Publications
18,586
Reads
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1,730
Citations
Citations since 2017
37 Research Items
804 Citations
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2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
2017201820192020202120222023020406080100120140
Additional affiliations
January 2015 - December 2015
Åbo Akademi University
Position
  • Head of Department
September 2009 - December 2009
Turku University Hospital
Position
  • Clinical Neuropsychologist
January 2008 - present
Medishare
Position
  • Clinical Neuropsychologist
Description
  • Private practice
Education
January 2003 - January 2010
Department of Psychology and Logopedics, Abo Akademi University
Field of study
January 2000 - May 2005
Department of Psychology and Logopedics, Abo Akademi University
Field of study
  • Neuropsychology, Neuroscience

Publications

Publications (84)
Article
Full-text available
Objectives: Little is known about the very long-term cognitive outcome in patients with childhood-onset epilepsy. The aim of this unique prospective population-based cohort study was to examine cognitive outcomes in aging participants with childhood-onset epilepsy (mean onset age=5.3 years) five decades later (mean age at follow-up=56.5 years). M...
Article
Full-text available
Background: Free recall memory deficits are common in Parkinson's disease (PD), even at early stages before mild cognitive impairment or dementia. Their association with brain structural changes has not been established. Objective: We studied local gray matter volumes in relation to different memory tasks in early stage PD. Methods: Magnetic r...
Article
Full-text available
The aim of this study was to evaluate the longitudinal changes in [(11)C]PIB uptake in mild cognitive impairment (MCI) and Alzheimer's disease (AD) over a long-term follow-up. Six AD patients, ten MCI patients and eight healthy subjects underwent a [(11)C]PIB PET scan at baseline and at 2 and 5 years. The clinical status of the MCI patients was eva...
Article
Background: Frontostriatal and cognitive dysfunctions in Parkinson's disease (PD) are hypothesized to be linked predominately to dopaminergic dysfunction within neural networks linking dorsal striatum to dorsolateral prefrontal cortex. Methods: The authors evaluated the relationship between frontostriatal dopaminergic function and cognitive perf...
Article
Full-text available
The aim of the study was to examine the Consortium to Establish a Registry for Alzheimer's Disease (CERAD) test performances cross-sectionally in patients suffering from amnestic mild cognitive impairment (MCI) and mild Alzheimer's disease (AD). Moreover, we wanted to determine the sensitivity to amnestic MCI and mild AD, as well as the specificity...
Article
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Background Our aim was to investigate the discriminative value of ¹⁸ F-Flutemetamol PET in longitudinal assessment of amyloid beta accumulation in amnestic mild cognitive impairment (aMCI) patients, in relation to longitudinal cognitive changes. Methods We investigated the change in ¹⁸ F-Flutemetamol uptake and cognitive impairment in aMCI patient...
Article
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We aimed to evaluate the feasibility of using real-world register data for identifying persons with mild Alzheimer’s disease (AD) and to describe their cognitive performance at the time of diagnosis. Patients diagnosed with AD during 2010–2013 (aged 60–81 years) were identified from the Finnish national health registers and enlarged with a smaller...
Article
Introduction: The educational background and size of the elderly population are undergoing significant changes in Finland during the 2020s. A similar process is likely to occur also in several European countries. For cognitive screening of early Alzheimer's disease (AD), using outdated norms and cutoff scores may negatively affect clinical accurac...
Article
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Background Detailed characterization of early pathophysiological changes in preclinical Alzheimer's disease (AD) is necessary to enable development of correctly targeted and timed disease-modifying treatments. ASIC-E4 study (“Beta-Amyloid, Synaptic loss, Inflammation and Cognition in healthy APOE ε4 carriers”) combines state-of-the-art neuroimaging...
Article
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Purpose To determine the impact of childhood-onset uncomplicated epilepsy (COE) on brain aging over 50-year prospective follow-up. Methods A population-based cohort of 41 aging subjects with COE and their 46 matched controls participated in a detailed in-person prospective assessment in 2012 and 2017 to characterize ongoing changes in the aging br...
Article
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Semantic tasks are frequently used when examining language functions in patients with acquired disorders such as Alzheimer’s disease (AD) and aphasia. Little is known about the possible covariation between different types of tasks or their factor structure in healthy adults. Additionally, few studies have examined semantic task performances in diff...
Article
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Executive functioning (EF) is one of the building blocks in parental caregiving behavior, and contextual variables have been reported to moderate the link between EF and caregiving behavior. Although psychological distress due to various factors is prevalent during early parenthood and is negatively associated with adult EF, it is not known whether...
Article
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https://www.frontiersin.org/articles/10.3389/fpsyg.2021.719996/abstract Parental executive functioning (EF) and parenting behaviors can be affected by the multiple stressors that are often present during early parenthood. However, little is known about how commonly experienced psychological distress during early parenthood is associated with paren...
Article
We studied the association between episodic memory and cortical fibrillar β-amyloid pathology within twin pairs. Using telephone-administered cognitive screening of 1415 twin pairs in a population-based older Finnish Twin Cohort study, we identified 45 (mean [SD] age 72.9 [4.0] years, 40% women) cognitively discordant same-sex twin pairs (24 dizygo...
Article
https://lehti.yliopistopedagogiikka.fi/2021/05/28/monialaisen-koulutuksen-hyodyt-monin-verroin-panoksia-suuremmat/
Article
Full-text available
Background: White matter hyperintensities (WMHs) are markers for cerebrovascular pathology, which are frequently seen in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Verbal fluency is often impaired especially in AD, but little research has been conducted concerning the specific effects of WMH on verbal fluency in MCI...
Article
β‐amyloid pathology (Aβ) and episodic memory (EM) impairment are biological and cognitive hallmarks of Alzheimer’s disease (AD). However, most studies on the Aβ–EM association have been conducted in unrelated individuals and cannot tell if this relationship is confounded by shared genetic and/or environmental effects. We investigated if cortical am...
Poster
Epsilon 4 allele (E4) of APOE gene is an important genetic risk factor for late onset Alzheimer’s disease (AD). We investigated differences in regional neuroinflammation and beta‐amyloid (Aβ) deposition in vivo in cognitively normal homozygotic (Group 1: E4/E4) or heterozygotic (Group 2: E4/E3) carriers of the APOE*E4 allele in comparison to non‐ca...
Article
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This study tested whether executive functioning (EF)/learning tasks from the CogState computerized test battery show a unitary latent structure. This information is important for the construction of composite measures on these tasks for applied research purposes. Based on earlier factor analytic research, we identified five CogState tasks that have...
Article
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Polypharmacy is common in patients with a diagnosis of bipolar disorder. Although polypharmacy is known to increase the risk of iatrogenic neurological conditions, the recovery of cognitive function after drug withdrawal has been rarely documented in psychiatric patients using standardized neuropsychological methods. We present a neuropsychological...
Article
Background: Brain changes involving the white matter (WM), often an indication of cerebrovascular pathology, are frequently seen in patients with mild cognitive impairment (MCI) and Alzheimer's disease (AD). Few studies have examined possible cognitive domain- or group-specific cognitive effects of WM pathology in old age, MCI, and AD. Objective:...
Article
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Alzheimer’s disease is associated with chronic response of innate immune system, referred as neuroinflammation. PET radioligands binding to the 18 kilodalton translocator protein are potential biomarkers of neuroinflammation. Translocator protein PET studies in mild cognitive impairment and Alzheimeŕs disease have indicated controversial results, p...
Article
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Some studies have linked bilingualism with a later onset of dementia, Alzheimer’s disease (AD), and mild cognitive impairment (MCI). Not all studies have observed such relationships, however. Differences in study outcomes may be due to methodological limitations and the presence of confounding factors within studies such as immigration status and l...
Article
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Background: Type 2 diabetes (T2DM) increases the risk for Alzheimer's disease (AD) but not for AD neuropathology. The association between T2DM and AD is assumed to be mediated through vascular mechanisms. However, insulin resistance (IR), the hallmark of T2DM, has been shown to associate with AD neuropathology and cognitive decline. Objective: T...
Poster
Targets: Antidepressant medication has been implicated as a possible factor impairing working memory function in depression (Snyder, 2013), but many studies have included patients with older antidepressants (AD) with known cognitive side effects. The aim of the present study was to examine working memory performance in newer generation AD users. Ma...
Article
Background: Atrophy of the deep gray matter (DGM) has been associated with a risk of conversion from mild cognitive impairment (MCI) to Alzheimer's disease (AD) and the degree of cognitive impairment. However, specific knowledge of the associations between degenerative DGM changes and neurocognitive functions remains limited. Objective: To exami...
Article
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Concomitant white matter (WM) brain pathology is often present in patients with mild cognitive impairment (MCI) and Alzheimer’s disease (AD). Cognitive effects of WM pathology on cognition in normal and pathological aging have been studied, but very little is known about possible group-specific effects in old age, MCI and AD. The purpose of the cur...
Article
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Aging is often associated with changes in brain structures as well as in cognitive functions. Structural changes can be visualized with Magnetic Resonance Imaging (MRI) using voxel-based grey matter morphometry (VBM) and visual rating scales to assess atrophy level. Several MRI studies have shown that possible neural correlates of cognitive changes...
Article
Objective To study associations of the severity of impairment in childhood neurocognition (NC) with long‐term mortality and complete seizure remission. Methods A population‐based cohort of 245 subjects with childhood onset epilepsy was followed up for 50 years (median = 45, range = 2‐50). Childhood NC before age 18 years was assessed as a combinat...
Article
Full-text available
We examined whether cerebrovascular white matter pathology is related to cognition as measured by the compound score of CERAD neuropsychological battery in cognitively normal older adults, patients with mild cognitive impairment, and patients with Alzheimer’s disease (total n = 149), controlling for age and education. Trend-level effects of white m...
Article
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A large body of epidemiological and experimental data exploring the relationship between physical activity (PA) and Alzheimer’s disease (AD) are now available. Despite observational evidence supporting a role for PA in delaying the onset of AD, randomised controlled trials have reported mixed findings, likely due to the heterogeneity in study cohor...
Article
Background Brain atrophy is associated with mild cognitive impairment (MCI), and by using volumetric and visual analyzing methods, it is possible to differentiate between individuals with progressive MCI (MCIp) and stable MCI (MCIs). Automated analysis methods detect degenerative changes in the brain earlier and more reliably than visual methods....
Article
Uncomplicated childhood-onset epilepsy is associated with increased brain amyloid load at late middle age, but its possible association with Alzheimer-type neurodegenerative processes is unclear. After 50-year follow-up, 42 childhood onset epilepsy subjects and 45 matched controls were investigated with [(18)F]fluorodeoxyglucose PET. There were no...
Article
Full-text available
Emotional content is known to enhance memory in a content-dependent manner in healthy populations. In middle-aged and older adults, a reduced preference for negative material, or even an enhanced preference for positive material has been observed. This preference seems to be modulated by the emotional arousal that the material evokes. The neuroanat...
Data
Demographic, behavioral and ROI volumetric data. (SAV)
Article
Full-text available
Importance: The effect of childhood epilepsy on later-life cognitive and brain health is an unclear and little-explored issue. Objective: To determine whether adults with a history of childhood-onset epilepsy exhibit increased brain amyloid accumulation, possibly predisposing to accelerated cognitive impairment or even frank cognitive disorders...
Article
Full-text available
The purpose of this project was to characterize brain structure and organization in persons with active and remitted childhood onset epilepsy 50 years after diagnosis compared with healthy controls. Participants from a population-based investigation of uncomplicated childhood onset epilepsy were followed up 5 decades later. Forty-one participants h...
Article
Full-text available
Functional neuroimaging studies have shown age-related differences in brain activation and connectivity patterns for emotional memory. Previous studies with middle-aged and older adults have reported associations between episodic memory and white matter (WM) microstructure obtained from diffusion tensor imaging, but such studies on emotional memory...
Article
Full-text available
Objective: To study the impact of childhood-onset epilepsy on a variety of outcomes across the life span. Methods: A population-based cohort of 245 subjects with childhood-onset epilepsy was assessed for outcomes at 45 years. In addition, 51 of 78 surviving subjects with uncomplicated epilepsy and 52 of 99 originally matched controls participate...
Article
Atrophy of the medial temporal lobe (MTL) is the main structural magnetic resonance imaging (MRI) finding in the brain of patients with Alzheimer's disease (AD). However, evaluating the degree of atrophy is still demanding. The visual rating method (VRM) was compared with multi-template tensor-based morphometry (TBM), in terms of its efficacy in di...
Article
Full-text available
Objectives This study examined whether controlling for educational background in the CERAD cognitive screening battery would affect the likelihood of patients with Parkinson's disease to fulfill criteria for mild cognitive impairment (PD-MCI) and dementia (PDD).Materials & Methods One-hundred seventeen patients with PD were studied. Cognitive impai...
Article
Full-text available
Language-and culture-specific norms are needed for research on emotion-laden stimuli. We present valence and arousal ratings for 420 Finnish nouns for a sample of 996 Finnish speakers. Ratings are provided both for the whole sample and for subgroups divided by age and gender in light of previous research suggesting age- and gender-specific reactivi...
Data
Affective ratings and psycholinguistic measures for 420 Finnish nouns. The database includes valence and arousal ratings separately for the whole sample (All) and for the demographic groups divided by gender and age, as well as psycholinguistic measures obtained by the WordMill Lexical Search Program [42] from an unpublished extensive database of w...
Article
Full-text available
Verbal fluency impairments are frequent in Parkinson's disease (PD) and they may be present already at early stages. Semantic fluency impairment is associated with Parkinson's disease dementia and temporal, frontal and cerebellar cortical changes. Few studies have addres-sed cerebral structural correlates of different verbal fluency tasks in early...
Article
Many patients with Parkinson's disease (PD) develop mild cognitive impairment (PD-MCI) and dementia (PDD). The Consortium to Establish a Registry for Alzheimer's Disease (CERAD) neurocognitive test battery was originally developed to identify early Alzheimer's disease, but it has become a widely used screening instrument also for other types of dem...
Article
Full-text available
Background: Neuropsychiatric symptoms and impairment in performing activities of daily living (ADL) in patients with Parkinson's disease (PD) are strong predictors of the overall caregiver burden and they increase the risk for nursing home admission of the patients. The purpose of the present study was to assess the association of neuropsychiatric...
Article
Full-text available
Purpose Amyloid PET tracers have been developed for in vivo detection of brain fibrillar amyloid deposition in Alzheimer’s disease (AD). To serve as an early biomarker in AD the amyloid PET tracers need to be analysed in multicentre clinical studies. Methods In this study 238 [11C]Pittsburgh compound-B (PIB) datasets from five different European ce...
Data
MMSE, ApoE genotype and neuropsychological test performance from each centre
Conference Paper
Full-text available
RATIONALE: The implications of childhood onset epilepsy for later life cognition and brain structure remain uncertain. Here we present preliminary findings from the very long-term follow-up of a population-based cohort of persons with childhood onset (<age 16) epilepsy and non-affected population-based controls. Participants underwent neuropsycholo...
Article
Full-text available
Aim: To compare the diagnostic accuracy of a computerized test, the CANTAB paired associate learning (PAL) to that of an established and validated noncomputerized test, the CERAD Wordlist Learning task in differentiating between normal aging, aMCI and AD in a cross-sectional design. Methods: 58 participants were assessed (19 with mild probable A...
Article
Full-text available
Background/aims: The relationship between baseline (11)C-Pittsburgh compound B ((11)C-PIB) uptake and cognitive decline during a 2-year follow-up was studied in 9 patients with mild cognitive impairment (MCI) who converted to Alzheimer's disease (AD) and 7 who remained with MCI. Methods: (11)C-PIB PET scan was conducted at baseline and cognitive...
Article
Full-text available
Free recall memory deficits are common at early stages of Parkinson's disease (PD). As most studies have used intentional memory tasks, there is little information on how non-intentional, incidental encoding conditions affect memory performance in PD. We studied possible differences between PD patients and controls on free recall using incidental a...
Article
Full-text available
Etenevien muistisairauksien tutkimuksessa ja diagnostiikassa korostetaan oireiden mahdolli-simman varhaisen toteamisen tärkeyttä. Perus-terveydenhuollossa käytetään muistipotilaiden ensivaiheen tutkimuksina potilaalle ja läheiselle suunnattuja muistikyselyitä sekä CERAD:n kognitiivista tehtäväsarjaa arvioitaessa tarkem-piin tutkimuksiin lähettämise...
Article
Full-text available
Early Alzheimer's disease (AD) is associated with deficits in episodic memory. Semantic memory and naming have also been found to be affected, although to a lesser degree than episodic memory. Most episodic memory tests used in clinical settings assess intentional memory. The aim of the present paper was to present an incidental memory modification...
Article
Objective: In Alzheimer disease (AD), the accumulation pattern of beta-amyloid over time and its relationship with dementia severity are unclear. We investigated the brain uptake of the amyloid ligand (11)C-labeled Pittsburgh compound B ([(11)C]PIB) and volumetric brain changes over a 2-year follow-up in patients with AD and in aged healthy contro...
Article
Full-text available
Sporadic Alzheimer disease (AD) is a multifactorial disease to which both genetic and environmental factors contribute. Therefore, twin pairs are useful in studying its pathogenesis and aetiology. Cerebral glucose metabolism has been found to be reduced in AD patients. Cerebral glucose metabolism was studied in seven monozygotic (MZ) and nine same-...