Mira Ali Bosso

Faculty of Medicine (Kuwait University) · Pathology

Whole genome amplification systems were developed to meet the increasing research demands on DNA resources and to avoid DNA shortage. The technology enables amplification of nanogram amounts of DNA into microgram quantities and is increasingly used in the amplification of DNA from multiple origins such as blood, fresh frozen tissue, formalin-fixed...

The growing interest in the Raf kinase inhibitory protein (RKIP) is leading investigators to expand their purview to include its dynamic role in inflammation. While much of the current research on RKIP has been focused on cancer, parallel progress is being attained in relation to its impact on inflammation. Inflammation is a pathological process th...

The mechanism for the Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) infection requires the binding of the virus to the angiotensin-converting enzyme 2 (ACE2) receptor, well-known for its role in counteracting ACE. ACE2 is involved in modulating blood pressure and establishing blood pressure homeostasis. Recently, a critical debatable...

Oxazolidinone hydroxamic acid derivatives were synthesised and evaluated for inhibitory activity against leukotriene (LT) biosynthesis in three in vitro cell-based test systems and on direct inhibition of recombinant human 5-lipoxygenase (5-LO). Thirteen of the 19 compounds synthesised were considered active ((50% inhibitory concentration (IC50) ≤...

Objectives Bariatric surgery is well established as a treatment for obesity and associated complications. This procedure improves metabolic homeostasis through changes in energy expenditure. We hypothesized that sleeve gastrectomy (SG) improves metabolic homeostasis by modulating energy expenditure and enhancing thermogenesis through increasing the...

Background / Purpose: The availability of sufficient quantity and quality of DNA is crucial to any genetic analysis, especially with current analytical tools that require high DNA input such as Single Nucleotide Polymorphism (SNP) analysis and microarray technology. Whole Genome Amplification (WGA) methods were developed in an attempt to immortal...