Mir-Shahram Safari

Mir-Shahram Safari
Shahid Beheshti University of Medical Sciences · Neuroscience Research Center

PhD

About

67
Publications
6,947
Reads
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307
Citations
Citations since 2017
14 Research Items
209 Citations
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
201720182019202020212022202301020304050
Additional affiliations
January 2012 - present
RIKEN
Position
  • Researcher
March 2003 - October 2011
Shahid Beheshti University of Medical Sciences
Position
  • Researcher

Publications

Publications (67)
Article
Introduction: Sensory processing is profoundly regulated by brain neuromodulatory systems. One of the main neuromodulators is serotonin which influences higher cognitive functions such as different aspects of perceptual processing. So, malfunction in the serotonergic system may lead to visual illusion in psychiatric disorders such as autism and sch...
Preprint
It has been hypothesized that Gamma cortical oscillations play important roles in numerous cognitive processes and may involve psychiatric conditions including anxiety, schizophrenia, and autism. Gamma rhythms are commonly observed in many brain regions during both waking and sleep states, yet their functions and mechanisms remain a matter of debat...
Article
Cholinergic inputs from the basal forebrain modulate various visual cortex functions, including visual discrimination, contrast response function, orientation tuning, signal to noise ratio (SNR), and plasticity. Acetylcholine (ACh) has been known to exert its modulatory action via two distinct acetylcholine receptors (AChR), namely nicotinic ACh re...
Conference Paper
Full-text available
Cholinergic inputs from the basal forebrain modulate various visual cortex functions, including visual discrimination, contrast response function, orientation tuning, signal to noise ratio (SNR), and plasticity. Acetylcholine (ACh) has been known to exert its modulatory action via two distinct acetylcholine receptors (AChR), namely nicotinic ACh re...
Article
Full-text available
A lot of efforts have been made to understand the structure and function of neocortical circuits. In fact, a promising way to understand the functions of cortical circuits is the classification of the neural types, based on their different properties. Recent studies focused on applying modern computational methods to classify neurons based on molec...
Article
Full-text available
Neural circuits in the cerebral cortex consist primarily of excitatory pyramidal (Pyr) cells and inhibitory interneurons. Interneurons are divided into several subtypes, in which the two major groups are those expressing parvalbumin (PV) or somatostatin (SOM). These subtypes of interneurons are reported to play distinct roles in tuning and/or gain...
Conference Paper
The neuronal cell-type classification has been much debated since the inception of modern neuroscience. An automatic classification and labeling of neural types on the base of electrophysiological properties would be one of the important solutions to understanding differential functions of specific cell-types. Although this kind of approach is one...
Article
Full-text available
Visual responsiveness of cortical neurons changes depending on the brain state. Neural circuit mechanism underlying this change is unclear. By applying the method of in vivo two-photon functional calcium imaging to transgenic rats in which GABAergic neurons express fluorescent protein, we analyzed changes in visual response properties of cortical n...
Article
Full-text available
Properties and plasticity of inhibitory synapses on fast-spiking (FS) GABAergic (FS-GABA) interneurons in layer II/III of the mouse visual cortex were examined in cortical slices by whole-cell recordings of IPSCs or IPSPs evoked by activation of presynaptic FS or non-FS GABAergic interneurons. Unitary IPSCs (uIPSCs) evoked by action potentials of F...
Article
Full-text available
Impaired memory performance in offspring is one of the long-lasting neurobehavioral consequences of prenatal opiate exposure. Here, we studied the effects of prenatal morphine exposure on inhibitory avoidance memory performance in male and female offspring and also investigated whether these deficits are reversible during the postnatal development....
Article
Full-text available
Introduction: Previous studies have shown that stimulation of lateral hypothalamus (LH) produces antinociception. Orexin-A (OXA) receptor is strongly expressed in the nucleus locus coeruleus (LC) and orexinergic fibers densely project from LH to LC. In this study, we assessed the role of LC and its OXA receptors in antinociceptive response induced...
Article
The Hosoya index of a graph C is defined as the total number of independent edge subsets of the graph. A connected tricyclic graph is a connected simple graph with n vertices and n+2 edges. We characterize the (n,n+2)-graphs with the smallest Hosoya index. We show that the lower bound of the Hosoya index of the (n,n+2)-graphs, is 4n-6.
Article
Orexinergic projection originated from the lateral hypothalamus (LH) to the ventral tegmental area (VTA) has an important role in the acquisition of morphine conditioned place preference (CPP). However, little if any is known about the function and/or effect of orexin on CPP in rats. In the present study, we investigated the direct effect of orexin...
Conference Paper
Full-text available
Article
Several lines of evidence have shown that stimulation or inactivation of lateral hypothalamus (LH) produces antinociception. In this study, we assessed the role of nucleus locus coeruleus (LC) in antinociceptive response induced by LH stimulation or inactivation in the rat. The cholinergic agonist carbachol (125 nmol/0.5 microl saline) or lidocaine...

Questions

Questions (6)
Question
Scientists trying to elucidate structural and functional organization of cognition in world brain initiatives. But question is studying detailed structure and functional connectom is the appropriate strategy to decoding of cognition or not. Specially about consciousness this is a big issue because most of the reductionistic studies have not been promising. 
Question
I never seen any comparison between IPSC recorded in "in vivo" condition with "in vitro" in same neuron. I think main reason is technical challenges. But I think it would be possible to answer this question by recording IPSC in a population of defined cell-type in vivo and in vitro and comparing properties of IPSC in this two condition. I would like to know your opinion about this issue.
Question
Some epistemological beliefs are barrier for scientific thinking and some of them are helpful. I am interested specially to know about the epistemological barriers in different cultures and languages.

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Projects

Project (1)
Project
The cholinergic system is a potent neuromodulatory system that plays critical roles in cortical plasticity, attention and learning.In this project, we are examining how the cholinergic system modulate the activity of neurons of V1 in response to stimulus contrast.