Miquel Serra-Burriel

Miquel Serra-Burriel
University of Zurich | UZH · Epidemiology, Biostatistics and Prevention Institute

PhD

About

65
Publications
7,079
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
1,002
Citations

Publications

Publications (65)
Article
Full-text available
Background The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especiall...
Article
Full-text available
BACKGROUND: The development of liver cirrhosis is usually an asymptomatic process until late stages when complications occur. The potential reversibility of the disease is dependent on early diagnosis of liver fibrosis and timely targeted treatment. Recently, the use of non-invasive tools has been suggested for screening of liver fibrosis, especial...
Article
Study design: Post-hoc analysis. Objective: Advances in machine learning have led to tools offering individualized outcome predictions for adult spinal deformity (ASD). Our objective is to examine the properties of these ASD models in a cohort of adult symptomatic lumbar scoliosis (ASLS) patients. Summary of background data: Machine-learning a...
Preprint
Aims Evidence on long-term costs of atrial fibrillation (AF) and associated factors is scarce. As part of the Swiss-AF prospective cohort study we aimed to characterise AF costs and their development over time, and to assess specific patient clusters and their cost trajectories. Methods Swiss-AF enrolled 2,415 patients with variable duration of AF...
Article
Full-text available
Background Surgeons often rely on their intuition, experience and published data for surgical decision making and informed consent. Literature provides average values that do not allow for individualized assessments. Accurate validated machine learning (ML) risk calculators for adult spinal deformity (ASD) patients, based on 10 year multicentric pr...
Article
Full-text available
Background Patients with atrial fibrillation (AF) face an increased risk of adverse cardiovascular events. Evidence suggests that early rhythm control including AF ablation may reduce this risk. Methods To compare the risks for cardiovascular events in AF patients with and without pulmonary vein isolation (PVI), we analysed data from two prospecti...
Article
Full-text available
Introduction Many countries have implemented indoor smoking bans over the past two decades. Although smoking bans have been shown to reduce cardiovascular outcomes, little is known about their impact on respiratory health. This study investigated the impact of a nationwide indoor smoking ban on smoking behaviour and lung function. Methods We used...
Chapter
Unsupervised learning, the task of clustering observations in such a way that observations within cluster are more similar than those assigned to other clusters is one the central tasks of data science. Its exploratory and descriptive nature make it one of the most underused and underappreciated methods. In the present chapter we describe its core...
Article
Full-text available
Patients with decompensated cirrhosis, particularly those with acute‐on‐chronic liver failure (ACLF), show profound alterations in plasma metabolomics. The aim of this study was to investigate the effect of treatment with simvastatin and rifaximin on plasma metabolites of patients with decompensated cirrhosis, specifically on compounds characterist...
Article
Key messages • Liver disease is now the second leading cause of years of working life lost in Europe, after only ischaemic heart disease • The clinical focus in patients with liver disease is oriented towards cirrhosis and its complications, whereas early and reversible disease stages are frequently disregarded and overlooked • The dissociation be...
Article
Background & Aims Fibrosis-4 (FIB-4) and the NAFLD fibrosis score (NFS) are the two most popular non-invasive blood-based serum tests proposed for widespread fibrosis screening. We therefore aimed to describe the accuracy of FIB-4 and NFS to detect elevated liver stiffness as an indicator of hepatic fibrosis in low-prevalence populations. Approach...
Article
Full-text available
Background: The major limitation of piecemeal endoscopic mucosal resection (EMR) is the inaccurate histological assessment of the resected specimen, especially in cases of submucosal invasion. Objective: To classify non-pedunculated lesions ≥20 mm based on endoscopic morphological features, in order to identify those that present intramucosal ne...
Article
Background Intensive care unit (ICU)–acquired infections with antibiotic-resistant bacteria have been associated with substantial health and economic costs. Moreover, southern Europe has historically reported high levels of antimicrobial resistance. Objectives We estimated the attributable economic burden of ICU-acquired infections due to resistan...
Article
Objective: The reported rate of complications and cost of adult spinal deformity (ASD) surgery, associated with an exponential increase in the number of surgeries, cause alarm among healthcare payers and providers worldwide. The authors conjointly analyzed the largest prospective available ASD data sets to define trends in quality-of-care indicato...
Article
Background & Aims Portal hypertension (PH) is the strongest predictor of hepatic decompensation and death in patients with cirrhosis. However, its discriminatory accuracy in patients with non-alcoholic fatty liver disease (NAFLD) has been challenged as hepatic vein catheterization may not reflect the real portal vein pressure as accurately as in pa...
Article
Full-text available
Cirrhosis, highly prevalent worldwide, develops after years of hepatic inflammation triggering progressive fibrosis. Currently, the main etiologies of cirrhosis are non‐alcoholic fatty liver disease (NAFLD) and alcohol‐related liver disease (ALD), although chronic hepatitis B and C infections are still major etiological factors in some areas of the...
Article
Full-text available
Background: There are major shortfalls in the identification and screening of at-risk migrant groups. This study aims to evaluate the effectiveness of a new digital tool (IS-MiHealth) integrated into the electronic patient record system of primary care centres in detecting prevalent migrant infections. IS-MiHealth provides targeted recommendations...
Article
Full-text available
Objective We examined real-world effects of cantonal legislations to direct surgery patients from the inpatient to the outpatient setting in Switzerland. Methods Analyses were based on claims data of the Helsana Group, a leading Swiss health insurance. The study population consisted of 13’145 (in 2014), 12’455 (in 2016), and 12’875 (in 2018) insur...
Article
Full-text available
Background: Lynch syndrome is the most common genetic predisposition for hereditary cancer. Carriers of pathogenic changes in mismatch repair (MMR) genes have an increased risk of developing colorectal (CRC), endometrial, ovarian, urinary tract, prostate, and other cancers, depending on which gene is malfunctioning. In Lynch syndrome, differences...
Article
Full-text available
Adult spinal deformity (ASD) is a complex and heterogeneous disease that can severely impact patients’ lives. While it is clear that surgical correction can achieve significant improvement of spinopelvic parameters and quality of life measures in adults with spinal deformity, there remains a high risk of complication associated with surgical approa...
Article
Full-text available
Increases in medication cost‐sharing rates remain a controversial system‐wide cost‐containment measure for chronic mental health patients. The objective was to investigate the effects of cost‐sharing increases on adherence to prescribed antipsychotic medication and psychiatric hospitalizations among schizophrenia patients. In July 2012, a Spanish N...
Article
Full-text available
Purpose For adult spinal deformity (ASD) patients receiving operative (op) and non-operative (non-op) treatment, the relationship between HRQoL measures, complications and self-reported satisfaction remains unclear. The objective of this analysis is to study nonlinear association dynamics between ASD patient satisfaction, HRQoL, and complications o...
Article
Full-text available
In recruitment processes, candidates are often judged one after another. This sequential procedure affects the outcome of the process. Here, we introduce the generosity-erosion effect, which states that evaluators might be harsher in their assessment of candidates after grading previous candidates generously. Generosity is defined as giving a candi...
Article
Full-text available
Background Digital proximity tracing apps have been released to mitigate the transmission of SARS-CoV-2, the virus known to cause COVID-19. However, it remains unclear how the acceptance and uptake of these apps can be improved. Objective This study aimed to investigate the coverage of the SwissCovid app and the reasons for its nonuse in Switzerlan...
Article
Full-text available
Background Population-based organized screening programmes for colorectal cancer (CRC) are underway worldwide, with many based on the faecal immunochemical test (FIT). No clinical trials assessing FIT compared with no screening are planned, and few studies have assessed the population impact of such programmes. Methods Before 2010, 11 out of 50 Sp...
Preprint
BACKGROUND Digital proximity tracing (DPT) apps have been released to mitigate SARS-CoV-2 transmission. But it remains unclear how their acceptance and uptake can be improved. OBJECTIVE This study aimed to investigate SwissCovid app coverage and reasons for not using the app in Switzerland during a time of increasing SARS-CoV-2 incidence. METHODS...
Article
Background and aims Colonoscopy reduces colorectal (CRC) incidence and mortality in Lynch syndrome (LS) carriers. However, a high incidence of post-colonoscopy CRC (PCCRC) has been reported. Colonoscopy is highly dependent on operator skill and subject to quality variability. We aimed to evaluate the impact of key colonoscopy quality indicators on...
Article
Full-text available
Background: Colon capsule endoscopy (CCE) and CT colonography (CTC) are minimally invasive techniques for colorectal cancer (CRC) screening. Our objective is to compare CCE and CTC for the identification of patients with colorectal neoplasia among participants in a CRC screening programme with positive faecal immunochemical test (FIT). Primary out...
Preprint
Digital proximity tracing (DPT) apps have been released to mitigate SARS-CoV-2 transmission, but it remains unclear how their effectiveness should be monitored. The aim of this study was to formalize indicators for measuring the fulfillment of assumptions for appropriate proximity tracing app functioning. Six indicators were developed to monitor th...
Article
BACKGROUND CONTEXT Health care costs in first-world economies are continuing to accelerate at an unsustainable rate and present significant economic burden, especially for management of complex disease. Machine learning models have the ability to preoperatively predict which patients will benefit most from surgery prior to incurring the expense of...
Article
Full-text available
Management of decompensated cirrhosis is currently geared towards the treatment of complications once they occur. To date there is no established disease-modifying therapy aimed at halting progression of the disease and preventing the development of complications that can be used for patients with decompensated cirrhosis. The design of clinical tri...
Article
Full-text available
Background & Aims An algorithm based on fecal levels of 2 microRNAs (miR-421 and miR-27a-3p), fecal hemoglobin concentration, and patient age and sex can identify patients with advanced colorectal neoplasia. We investigated whether this algorithm, called miRFec, could increase effectiveness and efficiency of fecal immunochemical test (FIT)-based co...
Article
Full-text available
Background Infections with multidrug resistant (MDR) bacteria in hospital settings have substantial implications in terms of clinical and economic outcomes. However, due to clinical and methodological heterogeneity, estimates about the attributable economic and clinical effects of healthcare-associated infections (HAI) due to MDR microorganisms (MD...
Article
Full-text available
Background & aims: Screening for colorectal cancer (CRC) is effective in average-risk population. The most extended strategy in organized programs involves the fecal immunochemical test, which is limited by low sensitivity for detection of advanced adenomas (AAs). We aimed to identify microRNA (miRNA) signatures in fecal samples that identify pati...
Article
Full-text available
Purpose Health-related quality of life (HRQL) instruments are essential in value-driven health care, but patients often have more specific, personal priorities when seeking surgical care. The Scoliosis Research Society-22R (SRS-22R), an HRQL instrument for spinal deformity, provides summary scores spanning several health domains, but these may be d...
Article
Study design: Retrospective review of prospectively-collected, multicenter adult spinal deformity (ASD) database. Objective: To evaluate the rate of patients who accrue catastrophic cost (CC) with ASD surgery utilizing direct, actual costs and determine the feasibility of predicting these outliers. Summary of background data: Cost outliers or...
Article
Background & aims: Non-alcoholic fatty liver disease and alcohol-related liver disease pose an important challenge to current clinical healthcare pathways because of the large number of at-risk patients. Therefore, we aimed to explore the cost-effectiveness of transient elastography (TE) as a screening method to detect liver fibrosis in a primary...
Article
Full-text available
Purpose: Pathogenic variants affecting MLH1, MSH2, MSH6, and PMS2 cause Lynch syndrome and result in different but imprecisely known cancer risks. This study aimed to provide age and organ-specific cancer risks according to gene and gender and to determine survival after cancer. Methods: We conducted an international, multicenter prospective obs...
Article
Objective: Adult spinal deformity (ASD) surgery has a high rate of major complications (MCs). Public information about adverse outcomes is currently limited to registry average estimates. The object of this study was to assess the incidence of adverse events after ASD surgery, and to develop and validate a prognostic tool for the time-to-event ris...
Article
STUDY DESIGN: Retrospective review of prospectively-collected, multicenter adult spinal deformity (ASD) databases. OBJECTIVE: To apply artificial intelligence (AI)-based hierarchical clustering as a step toward a classification scheme that optimizes overall quality, value, and safety for ASD surgery. SUMMARY OF BACKGROUND DATA: Prior ASD classifi...
Article
Full-text available
Purpose The aim of this study was to evaluate factors that distinguish between patients with adult spinal deformity (ASD) with and without an indication for surgery, irrespective of their final treatment. Methods Baseline variables (demographics, medical history, outcome measures, coronal, sagittal and neurologic parameters) were evaluated in a mu...
Preprint
Statistical methods for the identification of subgroup effects in causal inference have exponentially grown in the last decade. This growth in statistical tools and guidelines has not permeated applied research in medicine, social or behavioural sciences. We apply a recursive partitioning algorithm into the first International Stroke Trial to ident...
Article
BACKGROUND CONTEXT Adult spinal deformity (ASD) surgery is responsible for 6% of all United States (US) healthcare costs. There has been increasing interest in cost prediction for bundled payment models and risk sharing initiatives. Catastrophic cost (CC) outliers are typically excluded in bundled payment settings making their preoperative identifi...
Article
BACKGROUND CONTEXT Adult spinal deformity (ASD) surgery is costly with variable outcomes; in some series only 50% of patients achieve clinically important (MCID) improvements. Predictive modeling with machine learning is a relatively unexplored area of patient-reported outcomes research. These methods may be useful in shared-decision making, surgic...
Article
Study design: Retrospective analysis of data collected prospectively in an adult spine deformity multicenter database. Objective: To determine the impact of adult scoliosis (AS) on the type of Roussouly's sagittal shape in terms of classification applicability, scoliosis modification of a patient theoretical sagittal shape, and coronal-sagittal...
Article
Full-text available
Cesarean sections have been associated in the literature with poorer newborn health, particularly with a higher incidence of respiratory morbidity. Most studies suffer, however, from potential omitted variable bias, as they are based on simple comparisons of mothers who give birth vaginally and those who give birth by cesarean section. We try to ov...
Article
Full-text available
Background and aims: Liver fibrosis is the main determinant of long-term outcome in chronic liver diseases. Little is known about prevalence of liver fibrosis in general population. Aim of the study was to investigate the prevalence of liver fibrosis in general adult population with unknown liver disease. Methods: Population-based, cross-section...
Article
Full-text available
Objective To increase discriminatory accuracy (DA) for emergency cesarean sections (ECSs). Study design We prospectively collected data on and studied all 6,157 births occurring in 2014 at four public hospitals located in three different autonomous communities of Spain. To identify risk factors (RFs) for ECS, we used likelihood ratios and logistic...
Presentation
Full-text available
Machine Learning and Causality
Article
Full-text available
Objective This NMA compared the efficacy and safety between IV antibiotics that are used in the current standard of care for managing adult patients (≥18 years of age) with ABSSSI. Methods Comparators were chosen on the basis that both direct and indirect comparisons between the interventions of interest could be performed. Outcomes of the analysi...