Minoru Ikeda

• Nihon University

Objectives We aimed to elucidate the prognostic factors of the patients with taste disorders who were treated with popular and common medication in Japan. Materials and methods A retrospective study on the medical charts of a total of 255 patients with taste disorders who were treated primarily with oral medication including a zinc agent. Results...

Conclusions: The feelings of dizziness and unsteadiness of the patients with fibromyalgia supposed specifically amplified by the hypersensitivity mechanism of CSS (central sensitivity syndrome) of them. The severity of subjective pain and physical distress according to the questionnaires were not correlated with the objective body sway on the stab...

In a taste disorder, an agreement between patients' complaints and gustatory function test results is not necessarily found both at the initial hospital visit and during the course of treatment; therefore, it is difficult to assess treatment responses and review treatment strategies based on the assessed treatment responses. The present study inves...

Conclusion: We found a difference in expression sites between TAS2Rs and ENaC (epithelial sodium channels). The number of TAS2R-positive cells and ENaC-positive cells were decreased in zinc-deficient diet rats. These findings suggest that decreased expression of taste receptor genes may play an important role in the onset of zinc deficiency-associ...

While fibromyalgia is frequently associated with ear-related symptoms such as feeling of ear fullness, earache, and tinnitus, the pathogenesis of these ear-related symptoms in fibromyalgia patients is unknown. Here, we focused on clarifying the pathogenesis of ear fullness, a particularly common symptom observed in fibromyalgia patients. Twenty pat...

Patients with peripheral facial palsy frequently complain of fluid leakage and food retention during meals. We investigated oral function during eating in adults with peripheral facial palsy. A prospective two-phase controlled observational study. Data were collected at the ENT clinic in Nihon University Itabashi Hospital (patients) and Nihon Unive...

With vertigo patients, it is important that we pay attention to vertigo caused by central lesions as there are different diagnoses. Vertigo caused by central lesions such as brain tumors and cerebellar infarction sometimes appear as if the lesions were peripheral ones. The patient in the present study was a 50 y.o. female, with cerebellar metastasi...

味覚障害は, その評価において患者の自覚的な訴えに頼らざるを得ず, 現在もさらなるエビデンスの集積が求められている診断・治療の難しい疾患である. 今回われわれは亜鉛欠乏性または特発性に分類される味覚障害患者219例を対象に, ポラプレジンクを用いた亜鉛補充治療の効果をプラセボコントロールの無作為化二重盲検法により検討し, さらに背景データ等による詳細な検討を加えた. その結果, 亜鉛群は投与8週時から濾紙ディスク味覚検査法の認知域値でプラセボ群に対して有意に改善し, その差は投与終了の4週間後でも持続した. ただし, 事前に定めた「有効」の判定基準に従った有効率では統計学的な差が認められなかった. 性別または抑うつ性の程度により治療効果の違いを認め, 男性およびSDS (Self-ratin...

Conclusion: Superselective intra-arterial chemotherapy is a safe and useful treatment that preserves the vocal, swallowing, and feeding functions of the larynx in T3 cancer supplied by the superior laryngeal artery and T4a cancer not extending beyond the thyroid cartilage. Objective: To evaluate the outcomes of superselective intra-arterial chem...

Unlabelled: Abstract Conclusion: P-glycoprotein is abundantly expressed in certain parotid mucoepidermoid carcinoma tissues, known historically to be multidrug resistant. This discovery may be important in incrementally advancing our ability to develop alternative pharmacologic strategies to improve multi-modality tumor control. Objective: P-gly...

Objectives: Human papilloma virus (HPV) infection is involved in both juvenile and adult laryngeal papilloma. We wished to determine which types of adult laryngeal papilloma were clinically related to HPV infection. We hypothesized that multiple-site and recurrent papillomas would have a strong relationship to HPV and conducted the present study t...

Recently there have been cases of vertigo patients with Superior Semicircular Canal Dehiscence Syndrome. In this present report, we describe a 40 y.o. female patient with vertigo after nose-blowing. Although a vertigo patient with nose-blowing is often diagnosed as having a perilymph fistula, our patient was diagnosed as having left Superior Semici...

Conclusion: Superselective intra-arterial chemotherapy, which enables local control and laryngeal preservation, is a safe and useful therapy for preservation of nutrition, speech, and swallowing functions. Objective: To improve the laryngeal preservation rate in patients with hypopharyngeal piriform sinus squamous cell carcinoma by superselectiv...

We examined the effect of zinc deficiency and supplementation on the expression of bitter taste receptor (TAS2R) and epithelial sodium ion channel (ENaC) genes on the tongue in rats. Prospective animal study. A total of 36 male Sprague-Dawley rats (3 weeks old) were used. Twelve rats were fed a normal diet for 28 (n = 6) or 56 (n = 6) days, another...

Conclusion: Patients who received concurrent chemoradiation therapy or radiation therapy alone were followed over a long term. The complete response (CR), 10-year survival, and 10-year larynx preservation rates were 87.5%, 95.3%, and 75.1%, respectively. Statistically, concurrent chemoradiation therapy contributes to laryngeal preservation but not...

Conclusion: Concurrent chemoradiation therapy with docetaxel (DOC) at a dose of 10 mg/m(2) twice a week contributed to laryngeal preservation. Objective: To determine laryngeal preservation following concurrent chemoradiation therapy with DOC. Methods: A total of 141 patients with untreated T2N0M0 squamous cell carcinoma of the glottic larynx...

Conclusion: Superselective intra-arterial chemotherapy, which can provide local control and laryngeal preservation, is safe and useful for preserving pharyngeal and laryngeal functions. Objective: To evaluate superselective intra-arterial chemotherapy in terms of the contribution to survival and laryngeal preservation in squamous cell carcinoma...

Conclusion: Patients who received concurrent chemoradiation therapy with carboplatin were followed up on a long-term basis. In 25 patients treated with carboplatin at an AUC of 2.0 mg/ml, the complete response (CR), 10-year survival, and 10-year larynx preservation rates were 96.0%, 91.1%, and 75.2%, respectively, and the safety margin for partial...

Conclusion: This therapy produced better results than intravenous multidrug chemotherapy (CF therapy, CPF therapy, etc.) or superselective intra-arterial chemotherapy (SIC) alone with cisplatin (CDDP) and 5-fluorouracil (5-FU). Primary tumor may be controlled by SIC alone in cases of T2 and many cases of T3 tumors, and by the combination of SIC an...

Selective graphene growth on copper twin crystals by chemical vapor deposition has been achieved. Graphene ribbons can be formed only on narrow twin crystal regions with a (001) or high-index surface sandwiched between Cu crystals having (111) surfaces by tuning the growth conditions, especially by controlling the partial pressure of CH(4) in Ar/H(...

Von Hippel-Lindau disease (VHL) is a dominantly inherited familial cancer syndrome predisposing the patient to a variety of malignant and benign neoplasms, most frequently hemangioblastoma, renal cell carcinoma, pheochromocytoma, and pancreatic tumors. VHL is caused by mutations of the VHL tumor suppressor gene on the short arm of chromosome 3, and...

Objectives The taste receptor gene family T2R has been implicated in the sensation of bitter taste. Phantogeusia is a spontaneous abnormal taste with no external stimulus. We analyzed the expression of T2R taste receptor genes in the tongues of patients with phantogeusia to assess their role in the pathogenesis of phantogeusia. Methods We obtained...

A long-term study was carried out on 57 patients treated with radiation alone who had T2N0M0 squamous cell carcinoma of the glottic larynx. The response and survival rates were satisfactory, but the complete response (CR) and the larynx preservation rates showed a need for improvement. Thirty-four patients underwent salvage operations and a safe ma...

A number of reports have investigated the relationship between laryngeal papilloma and human papilloma virus (HPV) infection. On the other hand, it is unclear whether the HPV infection is involved in the occurrence of pharyngeal papilloma. We hypothesized that HPV infection was involved in the occurrence of pharyngeal papilloma similarly to larynge...

Taste receptor genes associated with bitterness belong to the T2R gene family. In this study, we compared the expression of genes of the T2R family in the tongues of patients with hypogeusia to those in healthy subjects and examined the possibility that T2R genes are involved in the pathogenesis of hypogeusia. Prospective clinical and basic study....

The aim of this work is to examine the clinical findings of patients with taste disorders due to central lesions and also to study the central gustatory pathway in humans. We conducted a retrospective review of 13 patients with central taste disorders that visited Nihon University Itabashi Hospital. An additional 25 cases with central taste disorde...

Consecutive daily low-dose S-1 therapy was less toxic and its efficacy was not inferior to the conventional administration schedule. Consecutive daily low-dose S-1 chemotherapy appears to be a treatment option for patients in whom it is difficult to continue the conventional administration schedule of S-1 due to adverse events. To evaluate the safe...

To predict the efficacy of cisplatin and radiation therapy for maxillary squamous cell carcinoma, we examined the mRNA expression of 14 cisplatin-resistant genes and p53 mutation in specimens biopsied from patients prior to initiation of therapy. Five of 10 patients had mutations in the p53 gene, of whom four had residual tumors pathologically foll...

Facial nerve paralysis associated with middle ear cholesteatoma, although well known, is only occasionally encountered and its clinical features and management have been evaluated in only a few studies. We studied its clinical features associated with facial paralysis. Subjects numbered 20 [15 males and 5 females] from 3-82 years old (mean: 42. 6 y...

We report a rare pediatric case of congenital cholesteatoma initially manifesting as facial paralysis. A 3-year-old boy seen for acute facial palsy had developed left facial paralysis on January 4, 2008, undergoing predonisolone therapy by a local pediatrician from January 10. Upon referred on March 5, facial palsy was a severe Grade V in House-Bra...

We report a case of hemorrhage from brainstem cavernous angioma that caused various symptoms including neurootological, gustatory and facial sensory disturbances. A man experienced nausea and numbness of his right ear. It was confirmed that the symptom were derived not from a peripheral lesion but from retrocochlear and brainstem impairment based u...

Intractable oropharyngeal mucosa disease is common and its diagnosis may be delayed if the mucosal lesion is simply a symptom of systemic disease. We report two cases of pemphigus vulgaris localized in the oropharyngeal mucosa. Case 1: A 50-year-old man showed multiple oropharyngeal erosiones and was biopsied at his first visit. The histopathologic...

Multiple sclerosis patients sometimes complain of vertigo as one of their symptoms. We experienced a case in which vertigo was seen as the chief complaint. MRI and neurootological examinations led to the diagnosis that the vertigo was caused by recurrent multiple sclerosis lesions of the posterior cranial fossa. We then considered five earlier mult...

The effect of a zinc-containing compound, Polaprezinc, was shown to clinically improve the disease conditions of idiopathic taste disorders with no serious side effects in a well controlled double-blinded clinical study. The purpose of the present study was to evaluate the efficacy and safety of a zinc-containing compound in the treatment of patien...

A lengthy alteration of gravity direction produced different effects on the intrinsic horizontal and vertical optokinetic oculomotor systems. To examine both optokinetic nystagmus (OKN) and optokinetic after-nystagmus (OKAN) in a 6 h 6 degrees head-down bedrest study, in which the subjects were kept lying under simulated micro-gravity conditions. I...

Brainstem disorders are often characterized by abnormal eye movements, however, the type of abnormal movements vary depending on the localization and severity of the damage. Here, we report a case of pontine hemorrhage who exhibited horizontal conjugate gaze palsy and disorder of speech discrimination. The 34-year-old man presented with eye pain an...

Although genetic abnormalities on 3p have been suggested to be linked to the development of squamous cell carcinoma of the head and neck, to the authors' knowledge no study to date has examined such genetic abnormalities in patients with squamous cell carcinoma of the tongue. In the current study, loss of heterozygosity (LOH) was evaluated at sever...

The deterioration in the circumstances of the economy and human resources for hospitals and medical industry is now broadly recognized. We succeeded in reducing the assessed loss of the Otolaryngology Department Outpatient Clinic, which resulted in a gain of over 75% profit through the cooperation of the doctors and office staff. It was assumed tha...

According to a survey, 240,000 patients with taste disorders in Japan visited otolaryngologists in 2003. This represents an approximate 1.8-fold increase from the number of patients reported in 1990. Taste, as well as smell, responds to chemical substances ; thus they are called chemical senses. Taste dysfunction can be attributed to various causes...

A 3 M NaCl solution does not stimulate the trigeminal nerve in the human tongue. Objectives. In rats, the trigeminal nerve has been reported to respond when the tongue is stimulated by a solution with an NaCl concentration of 0.4 M or greater. We have attempted to clarify whether or not relatively high concentrations of NaCl stimulate the trigemina...

In most cases, pendular tonsils are benign. We report a 75-year-old man who presented with a pendular tonsil which was finally diagnosed as a squamous cell carcinoma of the tonsil. The patient was seen with the chief complaint of a foreign body in his throat. On his first visit, a smooth-surfaced pedunculated mass protruding from the lower pole of...

We report a case of Hunt syndrome with the primary complaint of lower cranial nerve paralysis. The patient experienced not only lower cranial nerve paralysis, but also, finally, paralysis of the facial nerve. The patient was a 68-year-old woman. She came to the hospital complaining of herpetic vesicles around the right ear and pain, vertigo, and ho...

The clinical and surgical findings of this study indicated advanced cholesteatoma in many patients with facial paralysis. The outcome of facial paralysis was good. Poor outcomes were observed in cases with petrosal cholesteatoma and in those who underwent surgery > or = 2 months after the onset of paralysis. To investigate clinical features of chol...

In Japan, the number of patients seeking treatment for taste disorders from otolaryngologists is approximately 240 000/year, and this number has almost doubled in the last 13 years. Taste examinations are routinely conducted in almost all university hospitals; testing is not as common in private clinics. Administration of zinc is the main treatment...

We examined the laterality of the human gustatory neural pathway by measuring gustatory-evoked magnetic fields (GEMfs) and demonstrating the activation of the human primary gustatory cortex (PGC). In patients whose chorda tympani nerve had been severed unilaterally on the right side, we stimulated the normal side (i.e., left side) of the chorda tym...

To show the significance of various factors when predicting the outcome of facial nerve paralysis. Retrospective chart review. Nihon University Itabashi Hospital in Tokyo. Four hundred sixty-seven patients with facial paralysis who visited the hospital within 14 days of disease onset. The failure rate of complete recovery was studied for each of th...

We have measured and compared several metallic elements and matrix metalloproteinases (MMPs) in saliva from patients with taste disorder and healthy subjects. Stimulated whole saliva was collected from 20 patients and 35 healthy subjects. Inductively coupled plasma mass spectrometry (ICP-MS) was used for the determination of metallic elements in sa...

The etiology of sudden sensorineural hearing loss is unknown, but viral infection is suspected as one possible cause. We retrospectively studied 102 sudden sensorineural hearing loss patients to evaluate the efficacy of acyclovir therapy. Acyclovir had been administered to 25 patients as single therapy or in combination with corticosteroid or batro...

Tezon® is a supplement containing trace elements (iron, zinc, copper, selenium, and other minerals). We presented this supplement for 10 taste disorder patients (32 to 72 years old, mean 56.3 years old, four males and six females). Serum copper/zinc ratios were improved and selenium levels were raised in all cases. The overall rate of improvement i...

Facial palsy may cause excessive stress due to the obviousness of its manifestations. We evaluated psychological stress in patients with facial palsy. Subjects were 57 patients with Bell's palsy, 12 with Ramsay Hunt syndrome, and 11 with zoster sine herpete. Eighteen of 50 questions from the Psychological Stress Response Scale (PSRS) were selected...

The post-operative outcome of hearing, the reconstructed external auditory canal, and the state of the reconstructed middle-ear cavity after canal wall down tympanoplasty with canal and attico-antrum reconstruction was studied in 103 ears with middle-ear cholesteatoma. The reconstructed mastoid cavity was re-aerated in 36.5 per cent of the cases, w...

To understand to what extent evaluations of facial paralysis by physicians coincide with self-evaluations by patients. Prospective clinical study. One hundred thirty-one patients (68 male patients and 63 female patients) with facial paralysis were included in the study. The relationship between the evaluation of facial paralysis using the Yanagihar...

For clarification of the direct relationship between the reactivation of herpes simplex virus and the development of Bell's Palsy, a detection of the virus genome by deoxyribonucleic acid diagnostics and a quantitative analysis of its time-course change are both needed. The authors detected the HSV genome in specimens from patients with Bell's Pals...

To clarify the dynamics of the reactivation of the varicella zoster virus in Ramsay Hunt syndrome. Varicella zoster virus DNA in the tear fluid, submandibular gland saliva, and parotid gland saliva of 15 patients with Ramsay Hunt syndrome was studied. The presence of varicella zoster virus DNA was detected quantitatively by the use of polymerase ch...

In 96 patients who visited our hospital with glossodynia, we conducted gustatory tests, measured serum zinc and copper levels, examined lingual papillae using biomicroscopy, conducted psychological tests and investigated the effectiveness of treatments directed at the cause of dysgeusia. Gustatory test results showed that 43 (44.8%) of the patients...

Changes in gustatory sense were investigated in 97 pregnant women and in 30 healthy, non-pregnant women who served as controls. All 97 pregnant women completed a questionnaire regarding taste changes and 32 of them underwent serial tests of gustatory function, including electrogustometry and testing with filter paper disks placed over the areas of...

We treated five patients with Hunter's glossitis following total gastrectomy. The major complaints of the patients were taste disorder and abnormal glossal sensation. In all five cases, the patient's tongue was red and smooth, and laboratory testing showed the presence of macrocytic anemia and decreased serum concentration of vitamin B12 (cyanocoba...

A 14-year-old female developed gustatory disorder due to an orthodontic wire having pierced the right trigonal retromolar. The patient's complaints included traction pain on the right lower jaw, numbness on the right front half of the tongue and hypogeusia with the exception of sweet tastes. Possible causes of dysgeusia in this case were: (i) direc...

Electrogustometry (EGM) has a number of strengths and a few limitations in clinical use. The strengths of EGM are: (i) the range of measurements can be kept constant; (ii) quantitative control of the intensity of the stimulation is possible; (iii) only a short period of time is required for testing; (iv) it is possible to detect even slight taste d...

Several characteristics of the gustatory function of the soft palate principally elucidated by our own recent investigations, as well of those of others, are described. The soft palate has a gustatory function which is independent of the tongue and is innervated by the greater petrosal nerve. Taste papillae of the soft palate are morphologically si...

The course of recovery from taste receptor disturbance was studied in 119 patients with moderate-to-severe taste receptor disturbance that was cured or improved with zinc therapy. Taste receptor disturbance was idiopathic in 45 patients, drug-induced in 38 and due to zinc deficiency in 36. Recovery of taste, evaluated by filter paper disk testing a...

We tested sensory and secretomotor function of the greater petrosal nerve (GPN) by means of electrogustometry (EGM) of the soft palate and Schirmer's tear test in 115 patients (59 males, 56 females) with acute peripheral facial paralysis. Facial paralysis was caused by Bell's palsy in 78 cases, Ramsay Hunt syndrome in 27 cases and zoster sine herpe...

Ramsay Hunt症候群は,水痘•帯状疱疹ウイルス(VZV)の再活性化により発症することが明らかにされている.今回Ramsay Hunt症候群15症例の涙液,顎下腺唾液および耳下腺唾液におけるVZVの分泌動態をPCR法とマイクロプレート•ハイブリダイゼーション法を併用し検討した.ハイブリダイゼーション信号の検出は,ストレプトアビジン標識βーガラクトシダーゼの系を用いて酵素反応産物の蛍光強度をfluoroscanで測定し,数値化することによりウイルスのDNAコピー数を概算し定量化した.涙液,顎下腺唾液および耳下腺唾液それぞれよりVZVが検出された.顎下腺唾液からの検出率は72%,耳下腺唾液からは57%と高率にVZVが検出され,涙液からの検出率27%との間に有意差がみられた.また,顎下腺唾液...

Fifty five cases with middle ear cholesteatoma which were performed second look and revision surgery were studied. In those cases, at the first operation, the posterior wall of the external auditory canal was reconstructed after canal down mastoidectomy. At the second operation, in 27 cases, the reconstructed posterior wall was totally removed, aga...

Polaprezinc is an anti-ulcerative drug that contains zinc. We used this drug for the treatment of 41 taste disorder patients (21 to 76 years). The rates of improvement were 80.0% in drug-induced, 100.0% in zinc deficient, and 62.5% in idiopathic taste disorder. The overall rate of improvement in all patients was 73.2% (30 cases). These results reve...

抄録 A case report of unilateral paralysis of the X, X and XI cranial nerves without skin lesions is reported. The patient was a 22-year-old male who complained of hoarseness and dysphasia. Physical examination revealed paralysis of the left soft palate, left laryngial paralysis and left sternocleidomastoideus and trapezius muscle impairment. There w...

Thirty cases of press-through package (PTP) as esophageal foreign bodies were analyzed. The patients were 8 males and 22 females. Patient ages were between 14 and 89 y/o, the average age was 64.2 y/o. Esophagogram or endoscopic examination were performed following plain X-ray exam to confirm the presence of the forein body. The foreign bodies inclu...

This is a case report of a 14-year-old female who developed gustatory disorder due to an orthodontic wire. Because the wire deviated from the regular fixed position and pierced the right trigonum retromolar, the patient complained of traction pain on the right lower jaw, numbness on the right front half of the tongue, and hypogeusia except for swee...

In three cases of Heerfordt syndrome, we evaluated the severity of facial paralysis and topographically diagnosed the site of damage to the facial nerve. One patient with severe facial nerve paralysis showed lacrimal dysfunction, absence of stapedial reflex and taste dysfunction on the same side as facial paralysis, and the site of damage to the fa...

We coducted electrogustometry (EGM) of the soft palate as a functional test of the greater petrosal nerve (GPN) in patients with acute peripheral facial paralysis and compared these findings with results of the Schirmer's test. One hundred fifteen cases,59 males and 56 females were examined. Seventy-eight cases had Bell's palsy,27 cases Ramsay Hunt...

We investigated the efficacy of large-dose steroid therapy in 28 patients with Ramsay Hunt syndrome, within 2 weeks after disease onset. Facial paralysis were evaluated as severe in all cases. In one group, large dose steroid (starting with 500 mg of methylprednisolone) and an anti-viral agent (Acyclovir) were prescribed for 12 patients. As a resul...

Substantiated treatment methods for sudden deafness have not been established. We administered a batroxobin preparation (DefibraseR) with a steroid to 17 patients with sudden deafness, most of whom were resistant to a steroid therapy regimen in previous treatment, and observed symptom improvements in 17 respective ears. Results showed 76.5% mild or...

Deep cervical abscess is an infection which develops widely in the interfascial gaps of the cervical area, and it sometimes causes serious problems. This is a report of 4 patients with gas-for ming deep cervical abscess, whose ages ranged from 29-59 years old. One of them was a diabetic. Causes of infection were dental caries in 3 and a fish bone s...

This is a case report of a massive mastoid cyst that developed in the middle cranial fossa. The patient was a 69-year-old female, who visited the Dept. of Neurology because of a headache that persisted for several months. At the initial examination, a perforation of the right tympanic membrane and mixed hearing loss were observed, but no other neur...

Gustatory test results from patients whose chief complaint is glossodynia often show dysgeusia, although these patients may not be aware of it. In this study, we conducted gustatory tests on patents who visited our hospital with glossodynia, and examined (1) the rate of dysgeusia complications in these patients as well as (2) the effectiveness of t...