Mingzhu Sun

Mingzhu Sun
Public Health England | HPA · Centre for Radiation, Chemical and Environmental Hazards (CRCE)

Doctor of Philosophy

About

27
Publications
2,006
Reads
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496
Citations
Additional affiliations
June 2010 - September 2012
University of Bristol
Position
  • Project Staff
October 2008 - June 2010
The University of Manchester
Position
  • PhD Student

Publications

Publications (27)
Article
Full-text available
The aim of this review is to investigate the literature pertaining to the potential risks of low-dose ionizing radiation to Lynch syndrome patients by use of computed tomography (CT), either diagnostic CT colonography (CTC), standard staging CT or CT surveillance. Furthermore, this review explores the potential risks of using radiotherapy for treat...
Article
Full-text available
Purpose The aim of this brief personal, high level review is to consider the state of the art for biological dosimetry for radiation routine and emergency response, and the potential future progress in this fascinating and active field. Four areas in which biomarkers may contribute to scientific advancement through improved dose and exposure charac...
Article
Dicentric analysis and the ring PCC assay as established biodosimetry methods both have limitations in the estimation of absorbed doses in suspected overexposure cases between 5 and 10 Gy. The proposed method based on calyculin A-induced PCC overcomes these limitations by scoring excess objects as the endpoint. This new scoring method can potential...
Article
Chemical-induced premature chromosome condensation (PCC) is an alternative biodosimetry method to the gold-standard dicentric analysis for ionizing radiation. However, existing literature shows great variations in the experimental protocols which, together with the different scoring criteria applied in individual studies, result in large discrepanc...
Article
Purpose: This study aimed to construct a calibration curve for high-dose exposure using cell fusion-induced premature chromosome condensation (PCC). Some of the associated practicalities and methodological details were also investigated. Materials and methods: Peripheral blood from two donors was used. PCC mediated by fusing mitotic CHO cells with...
Article
The RTGene study was focused on the development and validation of new transcriptional biomarkers for prediction of individual radiotherapy patient responses to ionizing radiation. In parallel, for validation purposes, this study incorporated conventional biomarkers of radiation exposure, including the dicentric assay. Peripheral blood samples were...
Article
Full-text available
Purpose: In the framework of RENEB, several biodosimetry exercises were conducted analyzing different endpoints. Among them, the analysis of translocations is considered the most useful method for retrospective biodosimetry due to the relative stability of their frequency with post irradiation time. The aim of this study was to harmonize the accura...
Article
Full-text available
Purpose: The RENEB accident exercise was carried out in order to train the RENEB participants in coordinating and managing potentially large data sets that would be generated in case of a major radiological event. Materials and methods: Each participant was offered the possibility to activate the network by sending an alerting email about a simu...
Technical Report
Full-text available
During the period between the start of 2006 and the end of 2015, 73 people suspected of being overexposed to ionising radiation were referred to Public Health England (and one of its predecessor organisations, the Health Protection Agency) for biological dosimetry. Of these, 45 were related to industrial uses of radiation, 27 were associated with r...
Article
Full-text available
During the period between the start of 2006 and the end of 2015, 73 people suspected of being overexposed to ionising radiation were referred to Public Health England (and one of its predecessor organisations, the Health Protection Agency) for biological dosimetry. Of these, 45 were related to industrial uses of radiation, 27 were associated with r...
Article
Full-text available
The gold standard in surgical management of a peripheral nerve gap is currently autologous nerve grafting. This confers patient morbidity and increases surgical time therefore innovative experimental strategies towards engineering a synthetic nerve conduit are welcome. We have developed a novel synthetic conduit made of poly ɛ-caprolactone (PCL) th...
Article
Given the significant socioeconomic impact of progressive multiple sclerosis (MS) and the paucity of treatment options, there is an urgent need to develop new and effective therapies for this disabling condition. The relatively recent appreciation that progressive disability is largely driven by neuronal loss has focused considerable research atten...
Article
Novel approaches are required in the clinical management of peripheral nerve injuries because current surgical techniques result in deficient sensory recovery. Microsurgery alone fails to address extensive cell death in the dorsal root ganglia (DRG), in addition to poor axonal regeneration. Incorporation of cultured cells into nerve conduits may of...
Article
In neurodegenerative disorders, including Parkinson's disease (PD), the potential of mesenchymal stem cells (MSCs) to produce neurorestoration via trans-differentiation has garnered much interest. We believe, however, that the paracrine effects of MSCs may have greater utility. MSCs release neurotrophic factors, including glial derived neurotrophic...
Article
To overcome the disadvantages of autografts for peripheral nerve repair, different methods such as artificial nerve conduits have been investigated for an alternative approach. This study demonstrated that solvent casting is a simple but efficient method to create thin polyester-based scaffolds for stem cell delivery. Using poly (ε-caprolactone) an...
Article
Randomly aligned nerve cells in vitro on conventional culture substrata do not represent the complex neuronal network in vivo and neurites growing in uncontrolled manner may form neuroma. It is of great importance to mimic the organised growth pattern of nerve cells in the study of peripheral nerve repair. The aim of this work was to modify and opt...
Article
Full-text available
In an attempt to obviate the drawbacks of nerve autograft, ultrathin microporous biodegradable PCL and PCL/PLA films were tested for their compatibility with motor neuron-like NG108-15 cells and primary Schwann cells. Data obtained from MTS colorimetric and DNA fluorimetric assays showed that both cell lines readily attached and proliferated on the...
Article
In this study, the physicochemical properties of microporous poly (epsilon-caprolactone) (PCL) films and a composite material made of PCL and polylactic acid (PLA) blend were tested. Fabricated by solvent casting using dichloromethane, these ultra-thin films (60 +/- 5 microm in thickness) have a novel double-sided surface topography, i.e. a porous...
Article
The reconstruction of peripheral nerve defects over a short distance (10-20mm) could benefit from the development of novel biomaterials. Bio-degradable and bio-compatible materials are being pursued to replace the currently used nerve autografts. We hypothesize that physical properties, particularly surface texture, could have substantial effects o...

Projects

Projects (5)
Project
The overall aim of this project is to develop existing knowledge on transcriptional responses to ionising radiation into a useable radiation specific biomarker of exposure and response.