Mingze He

• Doctor of Philosophy
• Bioinformatician at SRI International

Despite dedicated research in precision medicine, identification of therapeutic strategies for oncogenic drivers remains a major challenge as many mutations are difficult to target directly. Synthetic lethality-based target prediction becomes a powerful approach for drug discovery. We previously developed a computational platform, Mining Synthetic...

The unfolded protein response (UPR) is a highly conserved response that protects plants from adverse environmental conditions. The UPR is elicited by endoplasmic reticulum (ER) stress, in which unfolded and misfolded proteins accumulate within the ER. Here, we induced the UPR in maize (Zea mays) seedlings to characterize the molecular events that o...

Genome-wide molecular gene expression studies generally compare expression values for each gene across multiple conditions followed by cluster and gene set enrichment analysis to determine whether differentially expressed genes are enriched in specific biochemical pathways, cellular components, biological processes, and/or molecular functions, etc....

Genome-wide molecular gene expression studies generally compare expression values for each gene across multiple conditions followed by cluster and gene set enrichment analysis to determine whether differentially expressed genes are enriched in specific biochemical pathways, cellular components, biological processes, and/or molecular functions, etc....

Plant phenotype datasets include many different types of data, formats, and terms from specialized vocabularies. Because these datasets were designed for different audiences, they frequently contain language and details tailored to investigators with different research objectives and backgrounds. Although phenotype comparisons across datasets have...

As modern humans migrated out of Africa, they encountered many new environmental conditions, including greater temperature extremes, different pathogens and higher altitudes. These diverse environments are likely to have acted as agents of natural selection and to have led to local adaptations. One of the most celebrated examples in humans is the a...

Autism Spectrum Disorder (ASD) demonstrates high heritability and familial clustering, yet the genetic causes remain only partially understood as a result of extensive clinical and genomic heterogeneity. Whole-genome sequencing (WGS) shows promise as a tool for identifying ASD risk genes as well as unreported mutations in known loci, but an assessm...

Background Autism spectrum disorders (ASDs) represent a group of childhood neurodevelopmental disorders that affect 1 in 88 children in the US. Previous exome sequencing studies on family trios have implicated a role for rare, de-novo mutations in the pathogenesis of autism. Methods To examine the utility of whole-genome sequencing to identify inh...

Non-human primates have emerged as an important resource for the study of human disease and evolution. The characterization of genomic variation between and within non-human primate species could advance the development of genetically defined non-human primate disease models. However, non-human primate specific reagents that would expedite such res...

Coverage of targeted orthologous genes. Coverage of 18,594 gene coding regions of human CCDS by theoretical target region, target orthologous region and sequencing data from 3 species. (RAR)

Sanger sequencing validation result of SNP and Indels. (XLS)

Data production. Summary of captured target sequence coverage for each non-human primate exome and two human exomes. (XLSX)

Indels. Indels of 21 individuals identified through aligning the exomes to the human reference genome. (XLSX)