Ming Zhou

North China Electric Power University | NCEPU · Key Laboratory of Power Systems Protection & Dynamic Security Monitoring & Control

■As a bridge connecting data and characteristics of complex nonlinear systems, Koopman Operator enables analysis of complex features of large power grids based on measured data, and provides a new research paradigm for the data-driven stability control. Koopman Operator aims to map nonlinear dynamics to global linear representation. ■A data-driven...

N ⁶ -Methyladenosine (m ⁶ A) is an evolutionarily highly conserved epigenetic modification that affects eukaryotic RNAs, especially mRNAs, and m ⁶ A modification is commonly linked to tumor proliferation, progression, and therapeutic resistance by participating in RNA metabolism. Autophagy is an intracellular degradation and recycling biological pr...

Immune evasion represents a crucial milestone in the progression of cancer and serves as the theoretical foundation for tumor immunotherapy. In this study, we reveal a negative association between Human Papillomavirus (HPV)-encoded circular RNA, circE7, and the infiltration of CD8⁺ T cells in head and neck squamous cell carcinoma (HNSCC). Both in v...

Bromodomain-containing protein 7 (BRD7) is downregulated and functions as a tumor suppressor in many types of cancers including breast cancer, and the dysregulation of BRD7 expression is closely related to the development and progression of breast cancer. Whereas little attention has been focused on the regulation of BRD7 protein levels in breast c...

Purpose Cinobufotalin injection has obvious curative effects on liver cancer patients with less toxicity and fewer side effects than other therapeutic approaches. However, the core ingredients and mechanism underlying these anti-liver cancer effects have not been fully clarified due to its complex composition. Methods Multidimensional network anal...

Background Radiation therapy stands to be one of the primary approaches in the clinical treatment of malignant tumors. Nasopharyngeal Carcinoma, a malignancy predominantly treated with radiation therapy, provides an invaluable model for investigating the mechanisms underlying radiation therapy resistance in cancer. While some reports have suggested...

Purpose: BRD7 is downregulated and functions as a tumor suppressor in many types of cancers including breast cancer, and the dysregulation of BRD7 expression is closely related to the development and progression of breast cancer. Whereas little attention has been focused on the regulation of BRD7 protein levels in breast cancer, which needs to be f...

Ferroptosis is an iron-dependent regulatory cell necrosis induced by iron overload and lipid peroxidation. It occurs when multiple redox-active enzymes are ectopically expressed or show abnormal function. Hence, the precise regulation of ferroptosis-related molecules is mediated across multiple levels, including transcriptional, posttranscriptional...

Our research addresses the critical intersection of communication and power systems in the era of advanced information technologies. We highlight the strategic importance of communication base station placement, as its optimization is vital for minimizing operational disruptions in energy systems. Our study introduces a communications and power coo...

Ras-GTPase-activating protein (GAP)-binding protein 1 (G3BP1) is an RNA-binding protein implicated in various malignancies. However, its role in nasopharyngeal carcinoma (NPC) remains elusive. This study elucidates the potential regulation mechanisms of G3BP1 and its significance in NPC advancement. Through knockdown and overexpression approaches,...

Immune evasion represents a crucial milestone in the progression of cancer and serves as the theoretical foundation for tumor immunotherapy. Currently, immune checkpoint inhibitors such as anti-PD-1/PD-L1 have shown promising therapeutic efficacy in clinical settings for various tumors. However, a significant proportion of tumor patients fail to be...

BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNAs (CircRNAs) are involved in the occurrence and development of NPC as oncogenes or tumor suppressors. However, the function and mechanism of the circular RNA forms derived from BRD7 in NPC are not well understood. In this study, we first identified that circBRD...

Background NOP2/Sun RNA methyltransferase 2 (NSUN2), an important methyltransferase of m5C, has been poorly studied in cancers, and the relationship between NSUN2 and immunity remains largely unclear. Therefore, the purpose of this study was to explore the expression and prognostic value of NSUN2 and the role of NSUN2 in immunity in cancers. Metho...

Tumor metastasis is a leading cause of death in nasopharyngeal carcinoma (NPC) patients. Previous research has identified that transcription factor Yin Yang 1 (YY1) acts as a tumor suppressor that inhibits cell proliferation and tumor growth in NPC; however, the role and the molecular mechanisms of YY1 in NPC invasion and metastasis remain unclear....

With the increasing scale of the inter-provincial transmission, the number of the inter-provincial and inter-regional transmission channels gradually increases and couples closely, and the traditional Available Transmission Capacity (ATC) cannot reflect the influence of the intra-provincial security constraints on the inter-regional transmission po...

Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), which have not been thoroughly elucidated. In this study, we revealed for the first time that circRILPL1 was upregulated in NPC, weakened adhesion and decreased stiffness of NPC cells, and promoted NPC proliferation and...

Due to the low computational efficiency and high communication pressure caused by centralized control, decentralized coordination of electric vehicles (EVs) has become a research hotspot in recent years. However, the integration of numerous EVs with homogeneous parameters brings unprecedented challenges for the optimal scheduling of the power syste...

Currently, more than 170 modifications have been identified on RNA. Among these RNA modifications, various methylations account for two-thirds of total cases and exist on almost all RNAs. Roles of RNA modifications in cancer are garnering increasing interest. The research on m6A RNA methylation in cancer is in full swing at present. However, there...

Circular RNAs (circRNAs) are a novel type of endogenous non-coding RNAs, which are covalently closed loop structures formed by precursor mRNAs (pre-mRNAs) through back-splicing. CircRNAs are abnormally expressed in many tumors, and play critical roles in a variety of tumors as oncogenes or tumor suppressor genes by sponging miRNAs, regulating alter...

Yin-Yang 1 (YY1) is a member of the GLI-Kruppel family of zinc finger proteins and plays a vital dual biological role in cancer as an oncogene or a tumor suppressor during tumorigenesis and tumor progression. The tumor microenvironment (TME) is identified as the "soil" of tumor that has a critical role in both tumor growth and metastasis. Many stud...

Reasonable scheduling flexible resources play an important role in the reliable operation of high proportion renewables energy power systems. However, how to determine the system operation decision respecting the system security constraints and flexibility demand is still an open problem. In this chapter, the concept of wind power accommodation dom...

This chapter takes balancing market mechanism design as an example, to studies the possible impact of balancing market mechanism design on improving power system flexibility. With the increasing proportion of renewable energy in the power system, it is necessary to improve it from the aspect of power market. Due to its short-term trading characteri...

With the continuous development of the types, functions, and controllability, demand-side resources begin to respond actively according to the operation state of power systems. The power demand side contains abundant adjustable resources, and have great potential in improving the flexibility of power systems. This chapter investigates the demand si...

The increasing integration of volatile renewables energy (VRE) has highlighted the importance of flexibility in power system operation. Due to the imbalance in development between large-scale VRE and electricity load centers, the transmission of large amounts of VRE has drawn substantial attention. Given that HVDC offers a unique capability in term...

This chapter studies the aggregation of large-scale distributed flexibility resources, and aggregates a large number of flexible loads into a small number of aggregation load models. This chapter mainly considers large scale demand response aggregation and distributed energy storage aggregation. From the study of large-scale demand response and dis...

With the ever-increasing integration of renewable energy sources represented by wind and solar energy into power grids, its strong uncertainty and fluctuation present great challenges to the flexible operation of power grids. The traditional power regulation means of “generation-side” and “demand-side” are limited. With the rapid development of pow...

The power system flexibility refers to the adaptability of the system to internal and external uncertain factors, that is, the response capability of the system when internal or external variables change. Flexible resources come from all regulation means that can deal with the system volatility and uncertainty. Flexible resources in power systems c...

BRD7 functions as a crucial tumor suppressor in numerous malignancies including nasopharyngeal carcinoma (NPC). However, its function and exact mechanisms involved in tumor progression are not well understood. Here, we found that the B7BS was a potential enhancer region of BIRC2, and BRD7 negatively regulated the transcriptional activity and expres...

As data centers emerge as the information backbone of an increasingly digital world, the associated service demand has been rising rapidly. The operational nature of the data center brings great flexibility potential for energy systems. However, there remains an open question as to how to capture the flexibility potentials of geographically dispers...

CircHIPK3 is a type of endogenous circular RNA, which contains a covalently closed circular structure and cannot encode protein or polypeptide. CircHIPK3 is unusually expressed in varieties of tumors and plays dual roles of tumor promotion or tumor inhibition in tumorigenesis and development of tumors by serving as the sponge for miRNA in multiple...

As a most promising alternative carrier of energy in the future low-carbon energy system, the possibility of power-to-hydrogen (P2H) generally proton exchange membrane (PEM)-based water electrolyzers, has been explored for frequency response provision. However, there remains an open question as to how to capture the interaction of P2H operation and...

With an increase in the electrification of end-use sectors, various resources on the demand side provide great flexibility potential for system operations, which also leads to problems such as the strong randomness of power consumption behavior, the low utilization rate of flexible resources, and difficulties in cost recovery. With the core idea of...

The efficient integration of renewable energy with hydrogen storage is an important means for China to achieve carbon neutrality. Concentrated solar power (CSP) is an emerging technology for solar energy utilization that combines the advantages of power generation and energy storage. However, CSP has not been fully exploited because of the high gen...

Circular RNAs (circRNAs) are a type of endogenous non-coding RNA and a critical epigenetic regulation way that have a closed-loop structure and are highly stable, conserved, and tissue-specific, and they play an important role in the development of many diseases, including tumors, neurological diseases, and cardiovascular diseases. CircSMARCA5 is a...

Background: BRD7 was identified as a tumor suppressor in nasopharyngeal carcinoma (NPC). Circular RNA (CircRNAs) are involved in the occurrence and development of NPC as oncogenes or tumor suppressors. However, the function and mechanism of the circRNAs derived from BRD7 in NPC are not well understood. Methods: Bioinformatics analysis, agarose gel...

BRD7 functions as a crucial tumor suppressor in numerous malignancies including nasopharyngeal carcinoma (NPC). However, its function and exact mechanisms involved in tumor progression are not well understood. Here, we found that the B7BS is a potential enhancer region of BIRC2, and BRD7 negatively regulates the transcriptional activity and express...

Recently, the turnover of energy services between transmission-distribution grids has continued to increase, arousing widespread attention to the efficient coordination between transmission system operator (TSO) and distribution system operator (DSO). The existing literature has characterized the feasible region of distribution networks via equival...

Background Circular RNAs (circRNAs) play an important regulatory role in the pathogenesis and progression of nasopharyngeal carcinoma (NPC), but they have not been sufficiently studied. Methods The high expression of circRILPL1 in NPC tissues was confirmed by quantitative real-time polymerase chain reaction (qRT-PCR) and in situ hybridization (ISH...

Recent years have witnessed an increasing proliferation of biomass technologies since biomass is recognized as a natural carbon-neutral fuel. Existing studies have paid extensive attention to the concept and modeling of zero-carbon energy systems or buildings. However, few studies have explored the multi-energy coupling method and techno-economic e...

Ferroptosis is a type of cell death that depends on iron and reactive oxygen species (ROS). The accumulation of iron and lipid peroxidation primarily initiates oxidative membrane damage during ferroptosis. The core molecular mechanism of ferroptosis includes the regulation of oxidation and the balance between damage and antioxidant defense. Tumor c...

The integration of a large number of distributed renewable energy has brought new challenges to the flexible and efficient operation of urban energy system. Demand side flexible resources with rapid response capability, such as distributed energy storage, have attracted extensive attention. However, the imperfection of the current auxiliary service...

With an increasing penetration of distributed energy resources (DERs), it has become a public interest regarding how to efficiently manage large-scale DERs into wholesale markets. The existing literature has focused on various coordination methods including iteration-based (e.g., Lagrangian relaxation) and projection-based (e.g., vertex enumeration...

Introduction: Mutations in the promoter region and exons of ABO gene may cause changes in the expression of blood group antigens, often showing a weak ABO phenotype. Here, we identified a novel weak ABO subgroup allele that caused Bel phenotype and explored its mechanisms. Methods: The ABO phenotype of subjects (Chinese Han nationality) was clas...

The rapid development of the Internet of Things (IoT) has given rise to a novel business model, i.e., Internet of Storage (IoS), in which distributed in-home storage systems can be shared and equivalently aggregated as a utility-scale storage. While the existing literature has focused on the scheduling of distributed storage, few studies have quant...

With the development of internet technology, information has become an increasingly important asset for the operation and planning of power systems. However, the existing studies and practices pay little attention to information value evaluation, i.e., the potential for information to be converted into actual economic benefits. To this end, this pa...

Genomic instability and amplification are intrinsically important traits determining the development and heterogeneity of tumors. The role of extrachromosomal circular DNA (eccDNA) in tumors has recently been highlighted. EccDNAs are unique genetic materials located off the chromosomal DNA. They have been detected in a variety of tumors. This revie...

The proposal of the “carbon neutrality” target promotes the rapid development of variable renewable energy, which leads to the reduction of inertia and the deficiency of flexible reserve in power systems. Wind turbines (WTs) now are asked for providing frequency support and reserve through proper control strategy. This proposes a new issue on how t...

The coordination between local and wholesale markets has been widely regarded as an effective means to improve the utilization of demand side resources. Existing literature has begun to explore the feasible region for incorporating local electricity markets into the wholesale level via projection algorithms. However, it remains challenging to deal...

N6‐methyladenosine (m6A) is an extremely common and conservative posttranscriptional modification, that can specifically target and regulate the expression or stability of a series of tumor‐related genes, thus playing critical roles in the occurrence and development of tumors. c‐Myc is an important tumorigenic transcription factor that promotes tum...

With the core idea of "access over ownership", the concept of sharing economy has gained substantial popularity in the energy sector in recent years. To date, most existing review articles focus on sharing distributed energy resources on the demand side. Therefore, a systematic review of the sharing economy in energy markets is provided in this pap...

Nasopharyngeal carcinoma (NPC) is the malignant tumor arising from the nasopharynx epithelium with ethnic and geographical distribution preference. Y-box binding protein-1 (YB1) is the highly expressed DNA/RNA-binding protein with cold shock domain, and enhanced YB1 expression was proved to be associated with many kinds of malignant tumors. There i...

To simultaneously improve economic efficiency and resilience of distribution networks, this paper proposes a three-stage robust planning model for siting and sizing distributed wind turbines, battery storages and dispatchable generators (e.g., diesel generators) in distribution systems. In the first stage, these distributed energy resources (DERs)...

With the rapid development of re-electrification, traditional load forecasting faces a significant increase of influencing factors. Existing literature focuses on examining the influencing factors related to load profiles in order to improve the prediction accuracy. However, a large number of redundant features may lead to the overfitting of the fo...

With the development of information and communication technology (ICT), massive distributed energy resources (DERs) are aggregated to share the surplus energy across a community. Contingencies on the communication side may lead to incorrect control commands, which could influence the physical operation of power systems. This chapter introduces clou...

Due to the significance of renewable energy toward low-carbon energy transition, it has been advocated as promising pathway to aggregate various forms of renewables for uncertainty mitigation. This chapter proposes a profit-sharing mechanism for aggregating renewable energy resources as a cooperative game. On the one hand, the proposed mechanism ai...

In this chapter, the mechanism designs for sharing economy in wholesale and retail markets are investigated. In wholesale markets, according to generation adequacy, we firstly categorize electricity markets into three stages: the market tends to be perfectly competitive; the generation tends to be inadequate but the N − 1 capacity is still sufficie...

This chapter presents the formulation and critical evaluation of an aggregate bidding based on sharing economy. Sharing economy realizes the aggregation and utilization of idle resources and have won huge success in different fields. The aggregate bidding based on sharing economy enables market participation of different trading varieties to increa...

This chapter investigates the sharing economy in energy systems integration. An integrated energy sharing market realizes the coupling among single energy-carrier markets including electricity, heat and natural gas through integrated energy service providers, covering energy, transportation and other physical systems. Since the existing single ener...

A well-designed market mechanism can reveal each participant’s externality, thus inducing effective price signals for fair profit sharing. In this chapter, we propose a novel concept, termed as overall nodal pricing (ONP), which incorporates transmission cost allocation (TCA) into traditional locational marginal pricing (LMP). Due to the essence of...

The increasing integration of renewable energy has highlighted the importance of sharing economy in multi-area electricity markets. In some existing multi-area electricity markets, the marginal-pricing (MP) mechanism is adopted. However, this mechanism is known to lose market efficiency when profit-maximizing units strategically bid to manipulate e...

Marginal pricing (MP) mechanism has been widely used in many electricity markets across the world. However, both theory and practice have proved that MP mechanism may not well reveal truthfulness when generation adequacy tends to be insufficient. The previous chapter has proposed a general formulation of profit sharing mechanism based on VCG theory...

Bromodomain-containing protein 7 (BRD7) was found to be down-expressed in nasopharyngeal carcinoma as well as breast cancer and to function as a potential tumor suppressor. BRD7 interacts with p53 and is required for p53-dependent oncogene-induced senescence. However, the mechanism how BRD7 functions as tumor suppressor roles in breast cancer remai...

Epstein-Barr virus (EBV) is reportedly the first identified human tumor virus, and is closely related to the occurrence and development of nasopharyngeal carcinoma (NPC), gastric carcinoma (GC), and several lymphomas. PD-L1 expression is elevated in EBV-positive NPC and GC tissues; however, the specific mechanisms underlying the EBV-dependent promo...

With the proposal of carbon neutrality goals and hydrogen energy development strategies in various countries, the development and construction of hydrogen supply chains have been widely concerned. However, the existing research has paid little attention to the hydrogen market and pricing. Therefore, a hydrogen pricing method based on marginal prici...