Ming-Tzer Lin

National Taiwan University Hospital · Department of Internal Medicine

Introduction The mechanism of weight gain after continuous positive airway pressure (CPAP) treatment for treating obstructive sleep apnea (OSA) has not been fully elucidated. We hypothesized that CPAP treatment could result in positive energy expenditure through lowering basal metabolic rate (BMR) and increasing nutrition intake which the later ass...

Objective Adenotonsillectomy is one of the most common surgical procedures performed on children. Caregivers are often concerned about voice change after the procedure, and such concerns remain unsettled. This meta‐analysis analyzed voice change in children after adenotonsillectomy. Data Sources The PubMed, Medline, EMBASE, and Cochrane databases....

Introduction A couple of studies investigated the energy balance in patients with obstructive sleep apnea (OSA) but the results were inconclusive. Moreover, OSA have been associated with visceral adiposity but the mechanism has not been fully elucidated. We hypothesized that OSA was associated with lower basal metabolic rate (BMR) and increased nut...

Purpose The effects of sleep surgery on the lipid profile of adults diagnosed as having obstructive sleep apnea (OSA) remain unclear. This meta-analysis aimed to clarify whether sleep surgeries improve patients’ lipid profile. Methods The study protocol was registered on PROSPERO (CRD42020154425). Two authors independently searched the PubMed, MED...

Until now, no study has directly network meta‐analysed the impact of nasal masks, nasal pillows and oronasal masks on continuous positive airway pressure therapy in patients with obstructive sleep apnea. This study aimed to meta‐analyse the impact of three kinds of nasal interfaces with both network meta‐analysis and pairwise comparison. PubMed, EM...

Objective: To evaluate whether sleep surgery is associated with inflammatory cytokine changes. This study hypothesizes cytokines may change after surgery in adult obstructive sleep apnea (OSA). Study design: Systematic review and meta-analysis. Methods: The study protocol was registered on PROSPERO (CRD42020154425). Two authors independently s...

Background: The reported prevalence of sleep disorders in children with chronic kidney disease (CKD) varies greatly. A quantitative meta-analysis to estimate the prevalence of sleep disorders among pediatric CKD patients may provide further information. Objectives: The objective of this study is to estimate the prevalence of sleep disorders in c...

This meta-analysis evaluates the effect of sleep surgery on blood pressure (BP) in adults with OSA. The study protocol was registered on PROSPERO (CRD42020154425). The PubMed, MEDLINE, EMBASE, and Cochrane databases were independently searched by 2 authors up to March 2020. The keywords used were sleep apnea, OSA, sleep apnea syndromes, surgery, an...

Background While adenotonsillectomy (T&A) is widely recognized as the first-line therapy for pediatric obstructive sleep apnea (OSA), effects of T&A on blood pressure (BP) remain unclear. This meta-analysis evaluates the associations between T&A and BP in children with OSA. Methods The study protocol was registered on PROSPERO (CRD42020154425). Tw...

Introduction Mandibular advancement device (MAD) responder phenotype are not well understood in patients with obstructive sleep apnea (OSA). Recent studies have reported the association between MAD treatment response and polysomnographic phenotypes using positional and sleep stage dependency, but with inconsistent findings. Thus, the study aims to...

Objectives/Hypothesis To evaluate associations between sleep surgery and CRP (C‐reactive protein) levels in adults with obstructive sleep apnea (OSA). Study Design Meta‐analysis. Methods Two authors independently searched PubMed, Medline, EMBASE, and Cochrane review databases until July 2019. The keywords used were sleep apnea, OSA, sleep apnea s...

Objective Adenotonsillectomy outcomes in obstructive sleep apnea (OSA) treatment among children with Prader-Willi syndrome (PWS) remain unclear. This study aimed to elucidate the effectiveness of adenotonsillectomy in OSA treatment among children with PWS. Data Source PubMed, MEDLINE, Embase, and Cochrane Review up to February 2019. Review Method...

Introduction The effect of continuous positive airway pressure (CPAP) on abdominal adiposity in severe obstructive sleep apnea (OSA) was inconclusive. The effect may be affected by confounders derived from subjects and study design. The present study aimed to test that if the effects of CPAP treatments on visceral adiposity in patients with severe...

Background The present study aimed to test if the temporal sequence between sleep apnea (SA) diagnosis and incident myocardial infarction (MI) was associated with the long-term mortality and cardiovascular event in a community-based cohort. Methods We retrieved data from 9,453 incident MI patients between Jan. 1st 2000 and Dec. 31st 2012 from the...

Studies investigating impact of sleep apnea (SA) on cardiovascular prognosis after acute myocardial infarction (AMI) or acute coronary syndrome (ACS). (DOCX)

The interactions between sleep apnea (SA) diagnosis after incident MI and major adverse cardiac and cerebrovascular events (MACCEs) were analyzed by Cox proportional hazards regression models using cubic spline functions. Dash line: 95% confidence intervals. SA-pMI: SA diagnosed post incident myocardial infarction; Analysis included 96 SA-pMI and 9...

The trend of polysomnography (PSG) prescription and diagnosis of sleep apnea (SA) in total populations (black line) and patients with myocardial infarction (MI) (red line) from 2000 to 2012. A. Prevalence of MI and SA in MI patients and the general population. B. PSG prescription rate in MI patients and the general population. C. The ratio of PSG p...

Diagnosis and corresponding International Classification of Diseases, Ninth Revision, Clinical Modification (ICD-9-CM) codes. (DOCX)

Study objectives: To estimate the prevalence of obstructive sleep apnea (OSA) in children with Down syndrome. Methods: Two authors independently searched databases, namely PubMed, MEDLINE, EMBASE, and the Cochrane Review database. The keywords used were "Down syndrome," "Trisomy 21," "OSA," "sleep apnea syndromes," "polysomnography" and "polygra...

[This corrects the article DOI: 10.1371/journal.pone.0187032.].

Introduction This study aimed to determine the effect of combining positive airway pressure (PAP) therapy and mandibular advancement device (MAD) in patients with severe obstructive sleep apnea (OSA) who were pressure intolerant for PAP and were unresponsive to MAD. Methods This retrospective study reviewed the medical records of severe OSA patien...

Pretreatment demographics and PPAP of 14 patients who underwent CT. (PDF)

Oxygen desaturation index (ODI) before and under treatment for the 14 patients who underwent CT. (PDF)

Comparison of pretreatment and PPAP of patients with MAD responder and non-responder. (PDF)

Apnea-hypopnea index (AHI) before and under treatment for the 14 patients who underwent CT. (PDF)

% total sleep time (TST) of SpO2 <90% before and under treatment for the 14 patients who underwent CT. (PDF)

Importance: Evidence indicates correlations between lingual tonsil hypertrophy and pediatric obstructive sleep apnea (OSA). However, to our knowledge, a meta-analysis of surgical outcomes for lingual tonsillectomy in children with OSA has not been conducted. Objective: To evaluate the therapeutic outcomes of lingual tonsillectomy for treatment o...

Background: OSA is frequently coexistent with AMI. However, the impact of OSA in AMI patients was not clear so far. Also, if the impact changed with time after AMI has never been studied. This study aimed to clarify the impact of OSA on AMI with a population-based cohort study. Methods: Totally 9,453 adult patients newly diagnosed of AMI between 2...

Objective: To comprehensively review changes in sleep parameters and the success rate of supraglottoplasty for treating obstructive sleep apnea (OSA) in children. In particular, to elucidate treatment modalities and factors affecting treatment outcomes in children with both laryngomalacia and OSA. Methods: The study protocol was registered on PR...

Background Use of polysomnography (PSG) is the gold standard of diagnosis and measurement of treatment effectiveness for pediatric obstructive sleep apnea (OSA). Although adenotonsillectomy (T&A) is effective in diminishing the apnea-hypopnea index (AHI), a meta-analysis of post-operative changes for all other PSG parameters, and outcome comparison...

Dyslipidemia is considered as one mechanism causing cardiovascular sequelae in obstructive sleep apnea (OSA). Continuous positive airway pressure (CPAP) can reduce cardiovascular morbidities but its effect on lipid profiles is inconclusive. This study aimed to investigate the effects of CPAP on lipid profiles by a meta-analysis of the existing rand...

We report a patient with non-small cell lung cancer (NSCLC) developed leptomeningeal carcinomatosis (LMC) after 4 years of multiple treatments. High-dose tyrosine kinase inhibitor (TKI) was given for LMC at first but was not effective. She then received dual therapy combining of afatinib and cetuximab. Brain magnetic resonance imaging (MRI) showed...

To assess the value of soluble triggering receptor expressed on myeloid cells-1 as a biomarker of infection in patients with neutropenic fever comparing with procalcitonin and C-reactive protein. Prospective, comparative, single-center study. Hematology ward at a university hospital. Seventy-five patients with neutropenic fever after chemotherapy f...

Serum soluble triggering receptor expressed on myeloid cells-1 (sTREM-1), a detector of acute inflammatory response to microbial products and a good marker for diagnosing sepsis and pneumonia, has not yet been described as a predictor for infection or a prognostic factor in patients with acute respiratory distress syndrome (ARDS). This prospective...

Transcatheter arterial chemoembolization (TACE) has become an effective alternative treatment strategy for patients with inoperable hepatocellular carcinoma (HCC). Although TACE is relatively safe, pulmonary lipiodol embolism is a rare and potentially fatal complication which is often not anticipated by physicians.1 About 14 patients with pulmonary...

Acute respiratory distress syndrome (ARDS), a serious inflammatory reaction to acute lung injury, is associated with high mortality rates. Decoy receptor (DcR) 3 is a soluble protein with immunomodulatory effects. Biomarkers that reliably predict outcomes in ARDS are not currently available. Comparing DcR3 with the Acute Physiology and Chronic Heal...

Delayed diagnosis and treatment of a polymorphonuclear cell (PMN)-predominant pleural effusion due to Mycobacterium tuberculosis (MTB) are associated with poor outcome and the risk of tuberculosis transmission. We investigated the clinical differences of PMN-predominant pleural effusion due to MTB or other microorganisms. From January 2000 to April...

Pleurocutaneous fistula is defined as a pathologic communication between the pleural space and the subcutaneous tissues. It can occur as a complication of an infectious process, neoplasm, foreign body aspiration, or iatrogenic procedures. Diagnosis is usually made on imaging studies, such as CT. We describe a 72-year-old woman with esophageal cance...

Recombinant factor VIIa (rFVIIa) was developed for the treatment of bleeding in hemophilic patients with inhibitors. It has also been used to stop bleeding in nonhemophilic patients who fail to respond to conventional treatment. We report a case of catastrophic hemothorax in which bleeding was stopped by administration of rFVIIa. A 68-year-old woma...

Myopericarditis is not uncommon, but often under-diagnosed. In fulminant cases, it may lead rapidly to circulatory failure or malignant arrhythmia, causing mortality. In this report, we describe a 41-year-old man who had episodes of convulsion one week after an upper respiratory tract infection. His electrocardiograms (ECGs) recorded during attack...