Ming-Ting Wu

Ming-Ting Wu
National Yang Ming University | NYMU · Faculty of Medicine

MD

About

161
Publications
14,517
Reads
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4,726
Citations
Citations since 2017
36 Research Items
1651 Citations
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Additional affiliations
August 2002 - present
National Yang Ming University
Position
  • Professor (Full)
August 2000 - present
VGHKS Kaohsiung Veterans General Hospital
Position
  • Section Chief
August 1995 - July 1996
Massachusetts General Hospital
Position
  • Research Associate

Publications

Publications (161)
Preprint
Full-text available
Background Coronary artery calcification (CAC) burden assessed by Agatston score (AS) is currently recommended to stratify patients at risk for future acute coronary syndrome (ACS). Besides the CAC burden, the biostructure of CAC may also play a vital role in the vulnerability of CAC, which CT radiomics could reveal. Propensity-score matching of th...
Article
Background: The myocardial kinetic energy (KE) and its association with pulmonary regurgitation (PR) have yet to be investigated in repaired tetralogy of Fallot (rTOF) patients. Purpose: To evaluate the adaptation of myocardial KE in rTOF patients by tissue phase mapping (TPM). Study type: Prospective. Population: A total of 49 rTOF patients...
Article
Background: The latest European System for Cardiac Operative Risk Evaluation (EuroSCORE) II is a well-accepted risk evaluation system for mortality in cardiac surgery in Europe. Objectives: To determine the performance of this new model in Taiwanese patients. Methods: Between January 2012 and December 2014, 657 patients underwent cardiac surge...
Article
Full-text available
Purpose: Violent subjects were demonstrated to exhibit abnormal brain structures; however, the brain changes may be different between criminals committing affective (VA), predatory violence (VP), and non-violence (NV). Therefore, the purpose of this study was to compare the differences in brain structures and psychological characteristics between...
Article
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Learning a skill has been demonstrated to relate to neural plasticity in both animal and human brains. Performing diabolo consists of different tricks and may cause brain structural changes associated with psychophysical functions. Therefore, the purpose of this study was to investigate gray matter (GM) and white matter (WM) changes associated with...
Article
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The objective of this study was to determine how coronary computed tomography angiography (CCTA) can be employed to detect coronary artery disease in hospital employees, enabling early treatment and minimizing damage. All employees of our hospital were assessed using the Framingham Risk Score. Those with a 10-year risk of myocardial infarction or d...
Article
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Background This study is aimed at developing a prediction nomogram for subclinical coronary atherosclerosis in an Asian population with baseline zero score, and to compare its discriminatory ability with Framingham risk score (FRS) and atherosclerotic cardiovascular disease (ASCVD) models. Methods Clinical characteristics, physical examination, a...
Article
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Background: The myocardial adaptive mechanism in patients with repaired tetralogy of Fallot (rTOF) is less understood. We aimed to investigate biventricular myocardial adaptive remodeling in rTOF patients. Methods: We recruited 32 rTOF patients and 38 age- and sex-matched normal controls. The pulmonary stenosis of rTOF patients was measured usin...
Article
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Background: We aimed to investigate the natural course of coronary artery calcium progression in an Asian population with a baseline coronary artery calcium (CAC) score of zero, and to determine subclinical coronary atherosclerosis. Methods: Four hundred fifty-nine subjects with at least two CAC scans with an initial score of zero were included....
Article
The COVID-19 global pandemic has emerged as an unprecedented health care crisis. To reduce risks of severe acute respiratory syndrome coronavirus 2 transmission in the Radiology Department, this article describes measures to increase the preparedness of Radiology Department, such as careful screening of staff and patients, thorough disinfection of...
Article
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Low-dose computed tomography lung cancer screening aims to detect early-stage lung cancers in order to decrease the incidence of advanced-stage lung cancers and to reduce lung cancer mortality. We analyzed the time trends of lung cancer stage distribution and mortality rates after the gradual implementation of the low-dose computed tomography lung...
Article
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Screening programs for lung cancer aim to allow diagnosis at the early stage, and therefore the decline in mortality rates. Thus, the aim of this retrospective cohort study was to the comparison of screened and non-screened lung cancer in terms of lung cancer characteristics, overdiagnosis and survival rate. A retrospective study in which 2883 pati...
Article
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Objective: We evaluated the diagnostic accuracy of myocardial blood flow (MBF) and perfusion reserve (MPR) measured from low-dose dynamic contrast-enhanced (DCE) imaging with a whole-heart coverage CT scanner for detecting functionally significant coronary artery disease (CAD). Methods: Twenty one patients with suspected or known CAD had rest an...
Article
Aim: To test the diagnostic performance of a deep learning-based system for the detection of clinically significant pulmonary nodules/masses on chest radiographs. Materials and methods: Using a retrospective study of 100 patients (47 with clinically significant pulmonary nodules/masses and 53 control subjects without pulmonary nodules), two radi...
Article
Background: Hepatic dysfunction is an important long-term complication in Fontan patients. The purpose of this study was to evaluate the hepatic computed tomography (CT) findings after Fontan surgery and identify their association with clinical parameters. Methods: This study recruited 43 patients (20 female patients aged 15.3±6.8 years) who und...
Article
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Resting-state functional magnetic resonance imaging (MRI) has been used to investigate the brain activity related to autism spectrum disorder (ASD). In this study, we applied information from a large-scale dataset, the Autism Brain Imaging Data Exchange (ABIDE), to clinical applications. We recruited 21 patients with ASD and 23 individuals with neu...
Article
There are physiological consequences of overeating that can lead to increased morbidity and mortality. The purpose of this review article is to acquaint the reader with the current state of the art in the non-cardiac-gated, noncontrast chest computed tomographic (NCCT) imaging biomarkers of the metabolic syndrome and their prognostic significance f...
Article
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Background: The long-term natural course and outcomes of subsolid nodules (SSNs) in terms of true growth, substantial growth, and stage shift need to be clarified. Methods: Between 2002 and 2016, 128 subjects with persistent SSNs of 3cm or smaller were enrolled. The baseline and interval changes in the series computed tomography (CT) findings du...
Article
Background: To evaluate the frequency of renal artery dissection (RAD) and renal hypoperfusion in aortic dissection (AD) and its effect on subsequent renal atrophy in patients who did not undergo therapeutic intervention. Methods: Initial CT data of 155 patients with acute AD (Stanford type A = 88, B = 67) were retrospectively analyzed. The fals...
Article
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Objectives: We proposed a modification of the ACR Lung Imaging Reporting and Data System (Lung-RADS) to clarify the characteristics of subsolid nodules with categories 1-11, and to compare the diagnostic accuracy with Lung-RADS and National Lung Screening Trial criteria in an Asian population with high prevalence of adenocarcinoma. Methods: We a...
Article
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Rationale and objectives: The main aim of this study was to evaluate the clinical validity and correlation with pathologic invasiveness in the pulmonary adenocarcinoma spectrum based on the novel qualitative computed tomography criterion for subsolid nodule (SSN) classification, which classified SSN into pure ground-glass nodule, heterogeneous gro...
Article
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We aimed to analyze CT features of persistent subsolid nodules (SSN) ≦3 cm diagnosed pathologically as adenocarcinoma spectrum to investigate whether parameters enable distinction between invasive pulmonary adenocarcinomas (IPAs) and pre-invasive lesions. A total of 129 patients with 141 SSNs confirmed with surgically pathologic proof were retrospe...
Article
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Background: The aim of this prospective study was to assess biventricular performance in asymptomatic adolescents with repaired tetralogy of Fallot (TOF) using 2D speckle tracking and real time 3D echocardiography simultaneously. Methods: We studied 31 patients with repaired TOF (M/F: 22/9, age: 16.1 ± 6.1 yrs) who had history of cardiac surgery wi...
Article
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Background Lung cancer has been the leading cause of cancer-related mortality worldwide among both men and women in recent years. There is an increase in the incidence of nonsmoking-related lung cancer in recent years. The purpose of the present study was to investigate multiple potential risk factors for nonsmoking-related lung cancer among Asian...
Article
Objectives: We aimed to characterise regional myocardial motion and twist function in the left ventricles (LV) in patients with repaired tetralogy of Fallot (rTOF) and preserved LV global function. Methods: We recruited 47 rTOF patients and 38 age-matched normal volunteers. Tissue phase mapping (TPM) was performed for evaluating the LV myocardia...
Article
Full-text available
A 77-year-old man with a progressively dry cough (two months duration) was admitted with hemoptysis. Chest computed tomography (CT) revealed left lingular lobe consolidation and one thick-walled cavity lesion over the left lower lobe, which was accompanied by satellite micro-nodules in a tree-in-bud pattern. CT-guided biopsy confirmed mycobacterial...
Article
Purpose Regurgitant fraction (RF) measured from 2D phase-contrast MRI has been used as a standard to quantitate the degree of pulmonary regurgitation and serves as a determinant indicator of prognosis for tetralogy of Fallot after surgical repair. This study demonstrated the potential underestimate of RF using the conventional definition and its im...
Article
Full-text available
Background: The National Lung Screening Trial (NLST) showed low-dose screening chest computed tomography (CT) reduced the lung cancer mortality rate up to 20% in high-risk patients in the United States. We aimed to investigate the impact of applying the NLST eligibility criteria to the population in Taiwan, and to identify additional risk factors...
Article
Full-text available
The aim of the present study was to compare differential impacts of bariatric surgery and exercise-induced weight loss on excessive abdominal and cardiac fat deposition. Excessive fat accumulation around the heart may play an important role in the pathogenesis of cardiovascular disease. Recent evidences have suggested that bariatric surgery results...
Article
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Background: Previous studies have shown that excessive abdominal visceral adipose tissue (AVAT) and epicardial adipose tissue (EAT) are risk factors of cardiometabolic disease; we hypothesized there is differential contribution of abdominal and cardiac fat deposits to the cardiometabolic profiles. Methods: Two hundred eight consecutive subjects...
Article
We applied voxelwise diffusion tensor magnetic imaging studying in a group of early adolescents born with very low birth weight (VLBW) who were currently without cognitive and neuromotor deficits. Our goal was to globally detect white matter alterations and explore their relationships with emotional-behavioral symptoms in this subgroup of VLBW adol...
Article
The conventional method of bone mineral density (BMD) report production by dictation and transcription is time consuming and prone to error. We developed an automated BMD reporting system based on the raw data from a dual energy X-ray absorptiometry (DXA) scanner for facilitating the report generation. The automated BMD reporting system, a web appl...
Article
Full-text available
Increased myocardial triglyceride (TG) content has been recognized as a risk factor for cardiovascular disease. However, its relation with cardiac function in patients on recovery from acute heart failure (HF) remains unclear. In this cross-sectional study, we sought to investigate the association between myocardial TG content measured on magnetic...
Article
Purpose: The aim of this study was to compare the usefulness of lung perfusion scintigraphy and echocardiogram in the evaluation of the branch pulmonary arteries stenosis in children with tetralogy of Fallot (TOF). Materials and methods: From February 2006 to November 2008, 74 children (mean age 7.8 years, range 1-18 years) who underwent repair...
Article
Full-text available
Background: Coronary artery calcium (CAC) assessed by non-contrast cardiac CT has been shown to be an independent factor from the Framingham risk factors in predicting cardiovascular events. However, many patients with acute coronary syndrome (ACS) have low CAC score. A recent study that re-analyzed the previous CAC CT scan of MESA cohort showed t...
Article
The noninvasive assessment of coronary stents by coronary CT angiography (CCTA) is an attractive method. However, the radiation dose associated with CCTA remains a concern for patients. The purpose of this study is to compare the radiation doses and image qualities of CCTA performed using tube voltages of 100 or 120 kVp for the evaluation of corona...
Article
Eddy current distortion is an important issue that may influence the quantitative measurements of diffusion tensor imaging (DTI). The corrections of eddy current artifacts could be performed using bipolar diffusion gradients or unipolar gradients with affine registration. Whether the diffusion pulse sequence affects the quantification of DTI indice...
Article
Full-text available
Results As compared to Group 1, MPA of Group 2 and 3 showed larger cross-sectional area (P<0.001), decreased distensibility (P=0.001), slower flow velocity (P<0.001), faster PWV (p=0.005), with more (P<0.001) and longer duration (P=0.030) of vortex and higher PVR (P<0.001). (Table). Compared to Group 2, Group 3 had lower flow rate (P=0.002), shorte...
Article
Objective: The objective of this study was to use high-resolution computed tomography (HRCT) imaging to predict the presence of smear-positive active pulmonary tuberculosis (PTB) in elderly (at least 65 years of age) and non-elderly patients (18-65 years of age). Methods: Patients with active pulmonary infections seen from November 2010 through...
Article
A 7-year-old girl was brought to the pediatric outpatient clinic because of exertional dyspnea for 2 years and chest pain for 2 months. Physical examination showed grade 2/6 s ystolic murmur at left lower sternal border. Electrocardiogram (ECG) revealed left ventricular hypertrophy with left axis deviation. Transthoracic echocardiogram showed enlar...
Article
Purpose: To achieve better spatial and temporal resolution of dynamic contrast-enhanced MR imaging, the concept of k-space data sharing, or view sharing, can be implemented for PROPELLER acquisition. As found in other view-sharing methods, the loss of high-resolution dynamics is possible for view-sharing PROPELLER (VS-Prop) due to the temporal smo...
Article
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Background There is growing evidence about the importance of epicardial adiposity on cardiometabolic risk. However, the relation of location-specific epicardial adipose tissue (EAT) thickness to coronary atherosclerotic burden is still unclear. Methods This meta-analysis was used to study the relations between location-specific EAT thickness and o...
Article
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This study evaluated the use of high-resolution computed tomography (HRCT) to predict the presence of culture-positive pulmonary tuberculosis (PTB) in adult patients with pulmonary lesions in the emergency department (ED). The study included a derivation phase and validation phase with a total of 8,245 patients with pulmonary disease. There were 13...
Article
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Background/Purpose The 64-slice multidetector CT (64-MDCT) has bolstered the sensitivity and specificity of coronary CT angiography (CCTA) for detecting coronary artery disease. We performed this study to understand the current status of CCTA using 64-MDCT, so as to determine further promotion and optimal regulation schemes of CCTA in Taiwan. Meth...
Article
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A 67-year-old woman presented with progressive dyspnea and both legs swelling for recent two months. She denied any known history of systemic illness. Physical examination shows clear lungs, normal heart sounds without murmurs, and pitting edema of his lower extremities bilaterally. The laboratory investigation data were as follows: leukocyte 6110...
Article
A 75-year-old man presented to the ED with a 5-day history of back pain and intermittent fever. He had undergone endovascular aortic repair of a thoracic aortic aneurysm 7 years previously.
Article
A diffusion tensor imaging (DTI) study was conducted in 12 adolescents with attention deficit/hyperactivity disorder and 14 age- and IQ-matched healthy controls. Inter-subject comparison of fractional anisotropy (FA) of the whole brain between the groups was obtained using the tract-based spatial statistics method. Results revealed significantly lo...
Article
Full-text available
Background Due to the different properties of the contrast agents, the lung perfusion maps as measured by 99mTc-labeled macroaggregated albumin perfusion scintigraphy (PS) are not uncommonly discrepant from those measured by dynamic contrast-enhanced MRI (DCE-MRI) using indicator-dilution analysis in complex pulmonary circulation. Since PS offers t...
Article
Full-text available
Pulmonary regurgitation (PR) is a common phenomenon in pulmonary arteries in patients after repair of tetralogy of Fallot (TOF). The regurgitation fraction of left pulmonary artery (LPA) is usually greater than right pulmonary artery (RPA) according to clinic data. It may be related to blood flow in pulmonary arteries. Therefore, understanding hemo...
Article
Objectives: To validate the reliability of the visual coronary artery calcification score (VCACS) on low-dose CT (LDCT) for concurrent screening of CAC and lung cancer. Methods: We enrolled 401 subjects receiving LDCT for lung cancer screening and ECG-gated CT for the Agatston score (AS). LDCT was reconstructed with 3- and 5-mm slice thickness (...
Conference Paper
PURPOSE To evaluate the characteristics of MDCT measurements of main pulmonary artery (MPA) and right ventricular outflow tract (RVOT) in high-resistance versus high-flow subtype of pulmonary arterial hypertension (PAH) METHOD AND MATERIALS Sixty-one patients receiving ECG-gated, dose-optimized MDCT were enrolled: group-1, healthy control (N=14);...
Article
The purpose of the study was to investigate dual-phase MDCT for assessing obstructive lesions and the extent and severity of the subtending myocardium at risk in patients presenting with chest pain syndromes 9 or more months after having undergone revascularization for the treatment of ST-segment elevation myocardial infarction (STEMI). Dual-phase...
Conference Paper
Full-text available
The purpose of this project was to develop a software tool for studying the dynamic changes of the cross-sections of the pulmonary arteries from computer-tomography (CT) scans. The software for analyzing CT images in the DICOM format was developed using Cocoa, the Apple's object-oriented C++ application programming interface (API) for the Mac OS X...
Article
Dynamic contrast-enhanced MR imaging has long been an attractive alternative to measure pulmonary perfusion as it offers simultaneous acquisition of high-resolution anatomical images and various functional information without exposing to ionizing radiation. As higher temporal resolution in addition to simultaneous acquisition of more slices from di...