About
55
Publications
36,503
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
647
Citations
Introduction
Skills and Expertise
Publications
Publications (55)
The leading cause of increased mortality rates is infections from implanted medical devices, with catheters accounting for more than 80% of these infections. Polypropylene (PP) composites with antimicrobial properties were developed by adding binary mixed oxide (CuO-TiO2). The outcomes demonstrated that the spreading and encapsulation of CuO-TiO2 p...
Polymer-based appliances are vulnerable to bacterial infections and pose a significant concern in biomedical field. Potential sources of infections have been found to be two categories of strain, namely Staphylococcus aureus (S. aureus) and Escherichia coli (E. coli), necessitating a comprehensive exploration of innovative materials and strategies...
The leading cause of increased mortality rates is infections from implanted medical devices, with catheters accounting for more than 80% of these infections. Polypropylene (PP) composites with antimicrobial properties were developed by adding binary mixed oxide (CuO-TiO 2). The outcomes demonstrated that the spreading and encapsulation of CuO-TiO 2...
Polymer-based appliances are vulnerable to bacterial infections and poses a significant concern in biomedical field. Both Gram-positive and Gram-negative bacteria have been identified as potential sources of infectious diseases, necessitating a comprehensive exploration of innovative materials and strategies to mitigate this issue. Accordingly, thi...
Momordica cochinchinensis (Gac fruit) is a perennial tropical fruit which nutritional benefits have drawn significant attention in Southeast Asian countries but are not completely explored in this region. In addition to aril extracts, pulp and seed extracts were the focus of this study in terms of their phytochemical composition, antioxidant, antim...
Dialysed C-serum precipitate (DCP), a sub-fraction of latex C-serum originating from Hevea brasiliensis, has shown specific in vitro antiproliferative properties towards cancer-origin cell lines. As a potential agent to be used in cancer treatment, preclinical safety assessment tests are crucial. This study focused on investigating the mutagenicity...
Plants contain bioactive compounds and are constantly explored as safer alternatives to conventional insecticides. Despite numerous studies on many plants, information on the insecticidal potential of underutilised plants like tiger nut, Cyperus esculentus L., are scant, although their pharmacological potentials are well known. Hence, this study in...
Exploration of the constituents of rubber for medicinal application is very limited due to the concern of allergenicity. However, the recent discovery of the ability of latex sera to exert specific antiproliferative activity against cancer-origin cell lines has paved a light of utilising rubber latex as therapeutics. Rubber latex and its seed oil s...
Aims: This study aimed to evaluate the cellular activities of a subfraction (F1) of red onion peel crude ethanolic extract in MDA-MB-231. Materials and Methods: The cell cycle profile and apoptosis induction in F1-treated MDA-MB-231 were measured using flow cytometry, and the migratory activity was measured using wound healing assay, Boyden chamber...
The fabrication of affordable biodegradable plastics remains a challenging issue for both the scientific community and industries as mechanical properties and biodegradability improve at the expense of the high cost of the material. Hence, the present work deals with fabrication and characterization of biodegradable polymer with 40% rice husk waste...
Gac fruit (Momordica cochinchinensis Spreng) is an exploitable perennial dioecious fruit found commonly in Southeast Asian countries (SA). Gac fruit has been traditionally used in folk medicine due to its high medicinal and nutritive value. Generally, the aril of the fruit is used as a red colourant for cuisines and supplement for healthier vision....
Dialysed latex C-serum supernatant (DCS) sub-fraction from the rubber tree (Hevea brasiliensis) was reported to exert significant anti-proliferative effect on specific cancer cell lines, especially in human triple negative breast cancer (MDA-MB-231) and human liver carcinoma (HepG2) cells. In the present study, two human non-cancer origin cell line...
LED red light has been reported to have many health benefits. The present study was conducted to characterise anti-proliferation properties of four LED red light wavelengths (615, 630, 660 and 730 nm) against non-triple negative (MCF-7) and triple negative (MDA-MB-231) breast cancer-origin cell lines. It has been shown by MTT assay that at 24 h pos...
The antibacterial performance of hybrid ZnO particles coupled with a narrow bandgap semiconductor is a research field worthy to explore. WO3/ZnO hybrid particles were prepared by depositing WO3 on pre-synthesized ZnO particles via liquid impregnation method. The hybrid particles were mainly wurtzite ZnO. FESEM showed that the ZnO particles have rod...
Spider lily (Hymenocallis littoralis) belongs to Amaryllidaceae family is a well-known plant species for its
medicinal properties. The inhibitory effects of H. littoralis methanol sonication extracts were evaluated for wound
healing activity. This is the first report on the wound healing activity of Malaysian origin H. littoralis. The bulb, flower,...
Semiconductor-based photocatalyst is an alternative approach for wastewater treatment. The effectiveness of semiconductor nanoparticles to eliminate textile dye substances in the contaminant water has been widely studied in the last decade. This work discusses the photocatalytic activities of ZnO nanodisks by using different dye substance (rhodamin...
Visible-light-driven wide bandgap semiconductor photocatalysts were commonly developed via doping or coupling with another narrow bandgap metal oxide. However, these approaches required extra processing. The aim of study was to evaluate the photocatalytic performance of narrow bandgap WOx nanoparticles. A mixture of WO2 and WO3 nanoparticles were s...
Background/Aims
Breast cancer is the most common female cancer worldwide. The high mortality of breast cancer patients is increasing over the years due to the late stage discovery of the cancer when the cancer cells may have already metastasized. In many developing and underdeveloped countries such as Ghana, the delay in cancer detection is partly...
Photocatalytically active tungsten oxide (WOx) layer were deposited on polyethylene terephthalate (PET) fibers using sol gel method in order to minimize the lost of WOx into flowing water during photocatalysis process. This helped to reduce the deterioration of photocatalytic performance of WOx over time as well as the formation of secondary pollut...
This work studied the photocatalytic performance of ZnO nanorods and WO3/ZnO nanorods in bromocresol green (BCG). The ZnO nanorods were pre-synthesized via solution precipitation method. Subsequently, the nanorods were kept in sodium tungstate solution for the deposition of WO3. The present of WO3 was confirmed by XRD and EDX analysis. ZnO nanorods...
Most of the studies on the use of semiconductor photocatalyst for decomposition of organic compounds involve colloidal particles. However, there is a need for the removal of particles from the slurry in the later stage, which is time consuming and costly. In order to rectify this problem, WO3 layer was deposited onto the PET fiber by sol-gel method...
In some parts of the world, Cyperus esculentus L. is widely used as a healthy food for both humans and animals due to their nutritional and functional properties. Current research and reviews on this plant have focused mainly on organoleptic properties, phytochemical compositions, oil content, biochemical activities, and nutritional values. The med...
Dialysed latex C-serum fractions have been investigated for anti-proliferative activity against human cancer origin cell lines. The present report describes further fractionation of dialysed C-serum supernatant (DCS) and analysis of the sub-fractions that elicit anti-proliferative activity on HepG2 and MDA-MB231, the test cancer origin cell lines....
WO 3 particles were synthesized using sol-gel method. The WO 3 particles was prepared using 0.4 M of sodium tungstate dehydrate for 21 h at 90 °C. The photocatalytic activity of WO 3 particles in removal of RhB dye followed first order kinetics in both visible light and UV light irradiation. The investigation showed that WO 3 particles degraded RhB...
This study evaluated phytochemical composition, antifungal, antibacterial and preliminary cytotoxic activities of red onion peel extracts. The dried red onion peel extracts were prepared with different solvents and different drying methods. The phytochemical composition of the extracts was analyzed using standard phytochemical test procedures, the...
The study of the proximate analysis on the leaves of Vitex negundo L. (VN) was done to gain the preliminary data of the anti-proliferative properties on cancer cell lines. Aqueous and organic extracts of the leaves of VN were used to identify its cytotoxic effect on six types of cancer-origin and normal cells, namely hormone-dependent breast cancer...
Ocmium tenuiflorum L. known as “ruku” in Malaysia is traditionally used as herbal medicine in West Asia. The effect of solvent type in antimicrobial extraction from Ocimum tenuiflorum L. against seven types of bacteria, two fungi and two yeast strains isolates by the disc diffusion and broth dilution methods was studied. Amoxicillin was used as pos...
INTRODUCTION: Medicinal plants form a rich source of novel drugs that forms the ingredients in traditional systems of medicine, modern medicines, nutraceuticals, food supplements, folk medicines, pharmaceutical intermediates, bioactive principles and lead compounds in synthetic drugs
Natural rubber latex sera have been investigated for anti-proliferative property on cancer cell lines. The present report describes fractionation of latex B- and C-serum using cell viability assay (anti-proliferative activity) as a guide to narrow down on the active constituents. Dialysis of B- and C-serum against distilled water caused some of its...
All protein-protein interaction is a well-known phenomenon in cancer cell signaling pathway. To study the potential docking between WIF-1 and EGFR molecules, initial protein-protein docking was performed using CAPRI-listed online servers, namely ZDOCK, GRAMM-X, HEX and PatchDock. The predicted docking conformation issued from various servers sugges...
Latex from the natural rubber tree known as Hevea brasiliensis has always been considered as an economic commodity and never been thought as a medicinal alternative until recently. Our recent findings have indicated that latex C-serum possessed antiproliferation properties against specific cancer-origin cell line. The present study has further conf...
Bacterial are highly transmitted in our environment and have been identified as a primary contributor to the problem of indoor air quality and consequently lead to the illness of the occupants. Recently, nanotechnology represents an innovative approach to develop new formulations based on metallic nanoparticles with antimicrobial properties. TiO2 h...
Methanol, ethanol, Tween 20 and dimethyl sulfoxide (DMSO) are widely used as dissolving agents in Artemia salina lethality test (aka brine shrimp lethality test [BSLT]) to screen the pharmaceutical properties of natural products. Nevertheless, there is lack of toxicity level of these solvents against brine shrimp. High concentration of these organi...
Plants, particularly fruits and vegetables, have many phytochemicals that possess various bioactivities, including antioxidant and anticancer properties. In this study, the aim was to investigate the antiproliferative properties of Syzygium fruits, namely water apple (Syzygium aqueum), milk apple (Syzygium malaccense), and malay apple (Syzygium mal...
Aqueous and methanol extracts of the flowers of Clitoria ternatea (CT), a popularly plant consumed for blue colour in Nasi Kerabu was selected to explore its cytotoxic effect on six types of normal and cancer-origin cell lines. These included the hormone-dependent breast cancer cell line (MCF-7), non-hormone-dependent breast cancer cell line (MDA-M...
The in vitro cell response was investigated on flat Ti surface vs nanostructured TiO2 nanotube surface. The titanium dioxide nanotube layers were prepared by electrochemical anodization of Ti in ethylene glycol, 5 wt% NH4F and 1ml H2O2. The nanotube layered structure and morphology were characterized using X-ray diffraction (XRD) and field emission...
Objectives:
Latex from Hevea brasiliensis (natural rubber tree primarily cultivated for its rubber particles) has no known primary metabolic function, although its biological role is as a plant defence system. The present study has evaluated specific anti-proliferative effects of latex whole C-serum and its subfractions, on human cancer cell lines...
Hevea brasiliensis latex sera are being investigated for anti-cancer property. In the present cell-based assay, whole latex B- and C-sera were shown to be largely ineffective against human B lymphocytes, of both cancer-origin (BDCM) and non-cancer-origin (Bristol 8); albeit slight dip in cell viability were discerned at high concentrations (> 100 μ...
The rubber tree (Hevea brasiliensis) extracts are becoming increasingly visible in pharmaceutical and therapeutical research. The present study is aimed at examining the specific anti-proliferation property of H. brasiliensis latex B-serum sub-fractions against human breast cancer epithelial cell lines MCF-7 and MDA-MB231. The results showed that t...
Latex from Hevea brasiliensis, the natural rubber tree, is primarily cultivated for its rubber particles. Latex has no known primary metabolic function but has strongly been implicated in plant defense against herbivorous insects. In the present study, sub-fractions of whole latex C-serum especially DCS and DCP, were shown to have specific anti-pro...
Human immunoglobulin G4 (hIgG4) is increasingly being used for the detection of various infectious diseases and in allergy-related immunoassays, thus, anti-hIgG4 antibody is of interest in the development of diagnostic tests. The present study was conducted to prepare the plasmid construct of pQE-2-IgG4 for peptide expression and pCDNA3-IgG4 for us...
The extracts of Hevea brasiliensis, the natural rubber tree, have never been noted for folk medicinal use though its latex is regarded as an economic importance. Easily cultivated and widely available in the Asian region, latex from Hevea brasiliensis plays a role in plant defense system with strong anti-fungal properties. The present study investi...
Lignosus rhinocerus (Cooke), commonly known as Tiger’s Milk Mushroom, has been used to treat asthma, fever, cough, cancer, food poisoning, wound healing as well as strengthening immune system by the local community. The present study was aimed at assessing the anti-proliferation property of the water extract of L. rhinocerus on six cancer-origin an...
Hevea brasiliensis extracts could potentially be employed as a relatively low cost resource for various anti-fungal activities due to the simplicity of the extract preparation and its abundance especially in the tropical region. Latex B-serum was reported to have anti-cancer property and its specificity in anti-fungal property has not been elucidat...
Hevea brasiliensis extract could potentially be employed as a relatively low cost resource for various anti-fungal activities due to the simplicity of latex preparation and the abundance of latex that can be obtained in rubber producing regions. The present study was aimed at examining the species specific anti-fungal property of H. brasilensis lat...
Human immunoglobulin G4 (hIgG4) is increasingly being used for the detection of various infectious diseases and in allergy-related immunoassays, thus, anti-hIgG4 antibody is of interest in the development of diagnostic tests. The present study was conducted to produce a recombinant peptide antigen that can be used to generate monoclonal antibodies...
An increasing amount of cancer research is being directed towards the investigation of plant-derived anticancer compounds, many of which have been used in traditional herbal treatments for centuries. Extracts of Hevea brasiliensis, the natural rubber tree, had been demonstrated previously to have anti-cancer properties. In the present study, latex...
Previous results suggested a potential role for T-cell protein tyrosine phosphatase (TC-PTP) in cell proliferation. However, no conclusive data has supported such a function in the modulation of this process. In order to clarify this issue, we isolated TC-PTP-/- murine embryonic fibroblasts (MEFs) as well as cell lines to characterize the role of T...
Genetic studies in Drosophila and in vertebrates have implicated basic helix-loop-helix (bHLH) transcription factors in neural determination and differentiation. In this report, we analyze the role that several bHLH proteins play in the transcriptional control of differentiation in chick retina. Our experimental system exploits the properties of th...
The promoters driving transcription of the neuronal nicotinic genes alpha 7 and beta 3 have been characterized in the chicken. Although their regulatory modalities are thoroughly different, they nevertheless lead to co-expression in the same neurons.
