Mina Kelleni

Mina Kelleni
Minia University · Department of Medical Pharmacology

Doctor of Medicine

About

131
Publications
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461
Citations

Publications

Publications (131)
Preprint
A young Egyptian mother suffering from iritis has recently passed away by anaphylaxis after an ophthalmologist asked for a fluorescein angiography and only administered hydrocortisone to manage her and unfortunately top academic Egyptian ophthalmology professors and association defended this malpractice. I started a public advocacy campaign in Egyp...
Preprint
A female in her late seventh decade with a history of chronic hepatitis B viral infection and moderately reduced kidney function suffered a syndrome of severe headache, abdominal pain, nausea, vomiting, confusion, and insomnia that could have been attributed to pancreatitis. However, her CT chest and laboratory investigations showed evidence of COV...
Preprint
Do you wonder why almost 1/6 of all COVID-19 deaths worldwide occurred in USA? I'm trying to answer you in this Afro-Egyptian critical analysis of USA FDA most recent approvals which are also adopted in most western and developed countries for COVID pharmacotherapy. I suggest the compass has been lost since day one and until today, innocent deaths...
Preprint
A first global family report, how a physician & scientist safely and effectively repurposed the very safe, very old, very economic live attenuated BCG vaccine to protect against COVID-19 complications for immunocompetent children, adults and geriatric participants.
Preprint
I wish to recommend not to approve either Paxlovid or molnupiravir in those countries that are still considering their license, to revoke the emergency use authorization in those countries that issued it, and it is very unfortunate for humanity that safe, generic and highly effective Kelleni’s African protocol used to manage pediatric, adult and pr...
Preprint
Most children and healthy young adults should have never received SARS CoV-2 Vaccines. Inactivated SARS CoV-2 vaccines are safer than nucleic acid-based ones.0-14 days regimen is probably better than 0-21 days regimen for inactivated SARS CoV-2 vaccines. Post vaccination syndrome is analogous to post or para COVID-19 syndrome (long haulers). Nuclei...
Article
Full-text available
We have previously published several papers illustrating numerous immunomodulatory and anti-inflammatory potential benefits when we repurposed safe, generic non-steroidal anti-inflammatory drugs (NSAIDs)/nitazoxanide/azithromycin (Kelleni’s protocol), to early manage our COVID-19 pediatric, adult, and pregnant patients. In this manuscript, we discu...
Article
Full-text available
In this manuscript, COVID-19, Ebola virus disease, Nipah virus infection, SARS, and MERS are suggested to be considered for a novel immunological reclassification as acute onset immune dysrhythmia syndrome (n-AIDS) due to altered monocytic, Th1/Th2, as well as cytokines and chemokines balances. n-AIDs is postulated to be the cause of the acute resp...
Preprint
This reply has recently received, some editors do not read, understand or perhaps they don't care that lives are wasted because of their careless attitude. I have received tons of similar rejection letters during my COVID journey, but fortunately, I have encountered so many honorable editors and for each and every one of them I'm much indebted.Re:...
Preprint
A recent meta-analysis has suggested that angiotensin converting enzyme inhibitors might possess more benefit over angiotensin receptor blockers regarding the likelihood of COVID-19 infection and non-COVID pneumonia induced mortality. We present a clinical and pharmacological COVID-19 contradictory point of view, and we also recommend extreme cauti...
Preprint
I began my quest for a safe COVID-19 pharmacotherapy in March 2020 while refuting a claim that non-steroidal anti-inflammatory drugs (NSAIDs) are hazardous to be used in COVID-19, I have first called this claim a scam in a correspondence sent to NEJM (20-06753) and it took me almost six months to lower the tone of my criticism as well as to be join...
Preprint
A science editor has advocated vaccine mandates to college students and in this reply I am refuting all his mentioned claims while illustrating a scientific point of view of those who refuse to receive mRNA and adenovector based SARS CoV-2 vaccines or allow the governments to mandate them for their children. Meanwhile, these arguments also apply to...
Preprint
mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmun...
Preprint
An updated preprint https://www.authorea.com/users/318758/articles/522091-autoimmunity-and-antibody-dependent-covid-19-enhancement-of-sars-cov-2-vaccination-a-global-human-right-to-know-then-decide
Preprint
In the initial draft, I have made a mistake SARS COV-2 Vaccines have not shared in development of the original SARS CoV-2 B.1.617 variants in India (yet they might have shared in the evolution of the more virulent delta plus variant). I have updated the manuscript, thanks to Authorea, and in the updated versions Remdesivir, Favipiravir and Dexameth...
Preprint
Introduction: COVID-19 management still lacks a protocol of proven efficacy and we present a novel COVID-19 immunomodulatory protocol basing on our early pioneering article that justified repurposing nitazoxanide/azithromycin combination for early COVID-19 which was followed by two articles to justify addition of non-steroidal anti-inflammatory dru...
Preprint
We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered to manage COVID-19 and in this commentary, we add other potential benefits related to SARS CoV-2 ORF proteins dependent activation of caspases with subsequent mitochondrial dysfunction, endoplasmic reticulum stress and necroptosis that...
Preprint
Aspirin has been recently suggested to be independently associated with reduced risk of mechanical ventilation, ICU admission and in-hospital mortality of COVID-19. However, we claim that the molecular interpretation of these important results was not scientifically valid, and we provide our academic interpretation that is also basing on our real-l...
Article
Full-text available
In this manuscript we provide the scientific basis to adopt a novel combination of two widely available nutraceuticals; resveratrol and zinc in management of COVID-19 recommending their administration using a nano-carrier based drug-delivery system. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red...
Preprint
ACE2 polymorphisms have been previously linked to increased susceptibility to multiple diseases and are currently linked to SARS CoV-2 susceptibility and complications. Notably, ACE2 transcribed or regulated proteins include the activity of metaloproteinsase-2 and apelin-13 and 36, might be linked to abnormal immune responses and complications. Pot...
Preprint
Introduction: No treatment protocol of proven efficacy was approved to manage COVID-19 and we present a novel COVID-19 immunomodulatory protocol basing on our early pioneering article that justified repurposing nitazoxanide/azithromycin combination for early cases of COVID-19 which was followed by two articles to justify addition of non-steroidal a...
Preprint
mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmun...
Preprint
mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmun...
Preprint
In the initial draft, I have made a mistake SARS COV-2 Vaccines have not shared in development of SARS CoV-2 B.1.617 variants in India. I have updated the manuscript, thanks to Authorea, and in the updated versions Remdesivir, Favipiravir and Dexamethasone are suggested as potential crucial causes that led to B.1.617 variants in India and elsewhere...
Preprint
No treatment protocol of proven efficacy was approved to manage COVID-19 and we present a novel COVID-19 immunomodulatory protocol basing on our early pioneering article that justified repurposing nitazoxanide/azithromycin combination for early cases of COVID-19 which was followed by two articles to justify addition of non-steroidal anti-inflammato...
Preprint
mRNA based and adenovirus vectored vaccines, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g., thrombocytopenia and some of these complications might also reason for some of the post vaccination sudden death reports e.g., autoimmun...
Article
Full-text available
Introduction: Mediators of immunity and inflammation are playing a crucial role in COVID-19 pathogenesis and complications as demonstrated by several genetic and clinical studies. Thus, repurposing of drugs that possess anti-inflammatory and/or immune-modulatory effects for COVID-19 is considered a rational approach. Areas covered: We analyze selec...
Preprint
SARS CoV-2 vaccines are being advertised as a tool to beat COVID-19, yet with the emergence of different variants that are suggested to be vaccine-resistant, and the emergence of SARS CoV-2 vaccine induced serious adverse effects a personalized risk benefit ratio should be carefully assessed. mRNA based and adenovirus vectored vaccines, types of nu...
Preprint
To date no treatment protocol of proven efficacy was approved to manage COVID-19. We have developed a novel COVID-19 immunomodulatory protocol basing on our early pioneering article that justified repurposing of nitazoxanide/azithromycin combination for early cases of COVID-19 which was followed by two articles to justify addition of non-steroidal...
Preprint
We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered to manage COVID-19 and in this commentary, we add other potential benefits related to SARS CoV-2 ORF proteins dependent activation of caspases with subsequent mitochondrial dysfunction, endoplasmic reticulum stress and necroptosis that...
Preprint
We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered to manage COVID-19 and in this commentary, we add other potential benefits related to SARS CoV-2 ORF proteins dependent activation of caspases with subsequent mitochondrial dysfunction, endoplasmic reticulum stress and necroptosis that...
Preprint
Introduction Mediators of immunity and inflammation are playing a crucial role in COVID-19 pathogenesis and complications as demonstrated by several genetic and clinical studies. Moreover, a weak, irregular, or inhibited early interferon response to SARS CoV-2 infection was shown to trigger an exaggerated inflammatory response leading to the COVID-...
Preprint
ACE2 polymorphisms have been previously linked to increased susceptibility to multiple diseases and are currently linked to SARS CoV-2 susceptibility and complications. Notably, ACE2 transcribed or regulated proteins include the activity of metaloproteinsase-2 and apelin-13 and 36, might be linked to abnormal immune responses and complications. Pot...
Preprint
India is known to be one of the biggest countries all over the world which manufacture and distribute SARS CoV-2 vaccines and it is also known with its abundant use of the very notorious antiviral drugs remdesivir and favipiravir. We claim that this unholy trinity is the cause of the current man-made hades that is being encountered through evolutio...
Preprint
Full-text available
mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases e.g. thrombocytopenia and some of these complications might also reason for some of the post vaccinat...
Preprint
To date no treatment protocol of proven efficacy was approved to manage COVID-19. We have developed a novel COVID-19 protocol basing on our early pioneering article that justified repurposing of nitazoxanide/azithromycin combination for early cases of COVID-19 which was followed by two articles to justify addition of non-steroidal anti-inflammatory...
Preprint
We have previously suggested numerous immunomodulatory and anti-inflammatory benefits when NSAIDs are administered as first choice therapy early in management of COVID-19 and in this manuscript we add several additional clues and it is really unfortunate that for more than one year of relentless struggle, this call is not yet adopted to save precio...
Article
Full-text available
In this manuscript, we discuss the expectations versus the real-world results of four repurposed COVID-19 drugs: tocilizumab, remdesivir, favipiravir, and dexamethasone from a clinical and pharmacovigilant point of view. We suggest that though the results of two-phase III double-blind clinical trials have been less than expected, tocilizumab has a...
Preprint
Updated, peer reviewed and published https://link.springer.com/article/10.1007/s10787-021-00896-7#Sec7 In this manuscript we further build on our previous suggested potential beneficial effects of using NSAIDs as first choice drugs in COVID-19 management while discussing the role that SARS CoV-2 ORF proteins induced caspases play in the pathophysio...
Preprint
In this manuscript, we combine our insights towards COVID-19 to present a hypothesis that might explain its pathogenesis and complications while presenting an interesting case report of post COVID-19 allergic cell mediated (dysregulated) delayed type hypersensitivity. Moreover, we confirm our call to reclassify it as novel acute immune dysrhythmic...
Preprint
Guanylate kinase 1 (GK1) was suggested to play a crucial role in SARS CoV-2 replication and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of this hypothesis while discussing guanylate kinase physiological function, pharmacolo...
Article
In order to assess the possible protective potential of BCG vaccination as regards to COVID-19, we have analyzed BCG vaccination status and SARS CoV-2 morbidity and mortality in China and we have also examined other studies performed in other countries to assess the potential of booster doses of BCG vaccination for adults. We have concluded that BC...
Preprint
SARS CoV-2, SARS, and MERS, the three highly contagious and relatively fatal coronaviruses which have evolved in only two decades and are anticipated to be joined by others, as well as the highly fatal Ebola virus disease have both similarities and differences to human immune deficiency virus (HIV) and its acquired immune deficiency syndrome (AIDS)...
Preprint
Low dose aspirin use was recently shown to be associated with significantly lower rate of mechanical ventilation, intensive care unit (ICU) admission, and in-hospital mortality after controlling for confounding variables. However, the interpretation of the published studies included some important flaws and the author provides a rapid response to p...
Preprint
In this manuscript, I have presented my idea that led to this development of a new drug by combining two generic anticonvulsant drugs into one novel compound. This new drug possess a great neurological medical potentials that might benefit millions of patients suffering from epilepsy and other diseases as discussed. My colleagues and I are wishing...
Preprint
Premature ejaculation and erectile dysfunction are affecting millions of patients all over the world and the quest for novel and safe drugs to manage either or both diseases is considered of great importance. Topical use of the herbal extract berberine might provide potential cure through restoration of endothelial homeostasis that is disturbed in...
Preprint
In this manuscript we provide the scientific basis to adopt a novel combination of resveratrol and zinc in management of COVID-19. Resveratrol, a well-known antioxidant and anti-inflammatory triphenolic stilbene, is abundant in red grapes, red wine, dark chocolate, and peanut butter. Furthermore, we recommend performing of clinical trials to assess...
Preprint
A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of th...
Preprint
Some notable scientists have adopted a physics theory developed by Professor Stephen Hawking to prove that something or even a universe might arise out of nothing and denied the existence of God. A Christian physician can never be convinced by such theories which are being scientifically argued against by other scientific research and theories. In...
Preprint
A recent study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments and previous studies have suggested a role in the pathogenesis of some neoplasms. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis of th...
Preprint
mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases that might also reason for some of the post vaccination sudden death reports. On the other hand, all...
Preprint
In this manuscript, a suggested reclassification of COVID-19, Ebola virus disease, Nipah virus infection, SARS, and MERS to be considered as a novel acute onset immune dysrhythmia syndrome (n-AIDS) due to altered monocytic, Th1/Th2 as well as cytokines and chemokines balances is provided. n-AIDs is postulated to be the cause of the acute respirator...
Article
Cisplatin is an important antineoplastic drug used in multiple chemotherapeutic regimens but unfortunately causes serious toxic effects as ovarian and uterine toxicity. This study aimed to investigate the potential protective effect of resveratrol (RSV) against cisplatin-induced ovarian and uterine toxicity in female rats. Thirty-two female Wistar...
Preprint
mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these new types possess a potential risk to induce auto-immune diseases more possibly in the short yet potentially the long term as well. On the other hand, all SARS CoV-2 t...
Preprint
mRNA based and adenovirus vectored vaccines, types of nucleic acid-based vaccination, were first ever or first commercially ever approved for the public, respectively. However, these types possess a potential risk to induce auto-immune diseases and a strict system for post marketing surveillance must be secured to report any encountered serious adv...
Preprint
The public has a moral and legal right to know the potential hazards of COVID-19 newly approved vaccines to freely decide whether to receive any, after an informed personalized risk benefit ratio is provided. Since most of the serious adverse effects and fatalities are reported with the Pfizer-BioNTech SARS CoV-2 mRNA vaccine and a faulty design ha...
Preprint
Pairo-Castineira et al. have recently demonstrated that altered expression of certain genes related to the immune and inflammatory systems reduced the odds of severe COVID-19 and protected against it; we agree with their results from a clinical perspective. However, they have suggested some drugs, including barictinib, to be of priority to be teste...
Preprint
Background: The current pandemic of coronavirus disease 2019 has necessitated trial of several drugs searching for a potential cure. We developed a novel protocol basing on our early pioneering article that recommended and justified adoption of nitazoxanide/azithromycin for early cases of COVID-19 which was followed by two published articles to jus...
Preprint
A recent interesting study has suggested that guanylate kinase 1 (GK1) plays a crucial role in SARS CoV-2 replication and recommended to test GK 1 inhibitors for invitro experiments. We are providing a concise strengths, weaknesses, opportunities, and threats (SWOT) analysis while discussing guanylate kinase physiological function, pharmacological...
Preprint
Pairo-Castineira et al. have recently demonstrated that altered expression of certain genes related to the immune and inflammatory systems reduced the odds of severe COVID-19 and protected against it; we agree with their results from a clinical perspective. However, they have suggested some drugs, including barictinib, to be of priority to be teste...
Preprint
In this manuscript, we discuss the expectations versus the real word results of four repurposed COVID-19 drugs; tocilizumab, remdesivir, favipiravir and dexamethasone from a pharmacovigilant point of view. We recommend considering a personalized risk benefit ratio before a decision is made using any of these drugs. We suggest that though the result...
Preprint
Aiming to decrease the unexplained COVID-19 mortality in some young and otherwise healthy patients, including health care professionals, we suggest that ACE2 polymorphisms might be reflected through under/overexpression of ACE2 transcribed or regulated proteins including the activity of metaloproteinsase-2 and apelin-13 and 36 cleavage, leading to...
Preprint
Nucleic acid-based vaccination, after its rapid approval, is considered first of its kind to be licensed for commercial use in humans. However, adenovirus vectored, and RNA based SARS CoV-2 vaccines possess a potential risk to induce auto-immune diseases and autoimmune myocarditis might be the reason for sudden death encountered in some cases. Thus...
Article
Full-text available
The pathogenesis of Coronavirus disease 2019 is still obscure and the need for exploration of possible mechanisms to suggest drugs based on knowledge should never be delayed. In this manuscript, we present a novel theory to explain the pathogenesis of COVID-19; lymphocyte distraction theory upon which the author has used, in a preprinted protocol,...
Preprint
Full-text available
Background: The current pandemic of coronavirus disease 2019 has necessitated trial of several drugs searching for a potential cure. We have published an article to justify adoption of nitazoxanide/azithromycin for early cases of COVID-19 followed by two other articles providing the theoretical basis to add non-steroidal anti-inflammatory drugs to...
Preprint
This manuscript has been published on the 29 th of May 2020 by the honorable BMJ as a rapid response to a related article. However since a DOI has not been assigned and two subsequent manuscripts have cited it, I’m preprinting a copy wishing it might reach all the interested colleagues and researchers in an easier way.
Preprint
On the same day the results of the RECOVERY study was published; July 17, 2020, we have submitted a letter to New England Journal of Medicine (NEJM, ID 20-25534) representing some concerns about this study and its status was with editor until November 29, 2020 on which a withdrawal request has been sent to NEJM and was promptly accepted on the foll...
Article
Full-text available
Background: Testicular toxicity is one of the serious side effects of cisplatin, which is used in chemotherapy. Objectives: This study aimed to investigate the protective effects of blackberry juice on cisplatin-induced testicular toxicity in rats. Materials and Methods: A total of 32 male Wistar Albino rats were used in this study. The rats were d...
Article
During the COVID-19 pandemic, a correspondence, published at the Lancet Respiratory Medicine, that linked angiotensin-converting enzyme inhibitors, angiotensin receptor blockers and ibuprofen to a higher risk of SARS CoV-2 infection and complications, has influenced, when adopted by official health authorities, the practical management of COVID-19...
Preprint
Full-text available
Azithromycin has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2 (SARS CoV-2); ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019 (COVID-19). Further, BCG vaccination is being considered for clinical trials aiming to test its pot...
Article
Azithromycin has been shown to have a clinical efficacy against severe acute respiratory syndrome coronavirus 2; ivermectin has also demonstrated a remarkable experimental efficacy with a potential to be used for Coronavirus disease 2019. Further, BCG vaccination is being considered for clinical trials aiming to test its potential for lowering COVI...
Article
Full-text available
The aim of this study was to investigate the possible protective effect of the antioxidant sodium selenite (0.1 mg/kg/day) via gavage once a day for 30 days for the first time in a model of malathion (27 mg/kg/day) via gavage once a day for 30 days induced testicular toxicity in mice. Results of this study revealed that concomitant administration o...

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