Min Jae Kim

Min Jae Kim
University of Pennsylvania | UP

Bachelor of Science

About

24
Publications
1,848
Reads
How we measure 'reads'
A 'read' is counted each time someone views a publication summary (such as the title, abstract, and list of authors), clicks on a figure, or views or downloads the full-text. Learn more
105
Citations
Additional affiliations
June 2022 - present
Brigham and Women's Hospital
Position
  • Research Assistant
April 2019 - January 2020
Massachusetts General Hospital
Position
  • Research Intern
Education
May 2023 - May 2027
University of Pennsylvania
Field of study
  • MD/PhD (Medical Scientist Training Program)
August 2018 - May 2022
Johns Hopkins University
Field of study
  • Biomedical Engineering, Neuroscience

Publications

Publications (24)
Article
Full-text available
Background Deep Brain Stimulation (DBS) of the subthalamic nucleus or globus pallidus internus is used to treat the motor symptoms of Parkinson's disease. The former can worsen impulsive and compulsive behaviors after controlling for the reduction of dopaminergic medications. However, the effect of pallidal DBS on such behaviors in PD patients is l...
Article
Background: Growing evidence suggests that piriform cortex resection during anterior temporal lobectomy is important for achieving good seizure outcome in mesial temporal lobe epilepsy (mTLE). However, the relationship between seizure outcome and piriform cortex ablation during MR-guided laser interstitial thermal therapy (MRgLITT) remains unclear...
Article
Objective: Laser Interstitial Thermal Therapy (LiTT) is a minimally invasive surgical procedure for intractable mesial temporal epilepsy (mTLE). LiTT is safe and effective, but seizure outcomes are highly variable due to patient variability, suboptimal targeting, and incomplete ablation of the epileptogenic zone. Apparent Diffusion Coefficient (AD...
Preprint
Full-text available
Background Parkinsonian bradykinesia is rated using a composite scale incorporating slowed frequency of repetitive movements, decrement amplitude, and arrhythmicity. Differential localization of these movement components within basal ganglia would drive the development of more personalized network-targeted symptomatic therapies. Methods Using an o...
Article
Objective Olfactory dysfunction is well-documented in epilepsy. We recently found that olfactory assessment may have clinical utility in identifying surgical candidates with intractable epilepsy who benefit from magnetic resonance–guided laser interstitial thermal therapy (MRgLiTT). However, the demographic, clinical, and cognitive correlates of ol...
Preprint
Full-text available
Objective MR-guided Laser Interstitial Thermal Therapy (LiTT) is a minimally invasive surgical procedure for intractable mesial temporal epilepsy (mTLE). LiTT is safe and effective but seizure outcomes are highly variable due to patient variability, suboptimal targeting, and incomplete ablation of epileptogenic zone. Apparent Diffusion Coefficient...
Article
OBJECTIVE Piriform cortex (PC) is one of the critical structures in the epileptogenesis of mesial temporal lobe epilepsy (mTLE), but its role is poorly understood. The authors examined the utility of apparent diffusion coefficient (ADC; an MR-based marker of tissue pathology) of the PC as a predictor of seizure outcome in patients with mTLE undergo...
Article
Full-text available
Memories encoded in the dentate gyrus (DG) - CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1 parvalbumin inhibitory neurons (PV INs) orchestrate hippocampal-cortical communication, we know less about CA3 PV INs or DG - CA3 principal neuron - IN circuit mechanisms that contribute...
Conference Paper
Full-text available
Rationale: MR-guided Laser Interstitial Thermal Therapy (MRgLiTT) is a minimally invasive surgical procedure that is rapidly becoming an alternate first-line surgical option in intractable mesial temporal epilepsy (mTLE). Though safe and effective, seizure outcomes following MRgLiTT are highly variable partly because of patient variability as well...
Article
OBJECTIVE Maximal safe ablation of target structures during magnetic resonance–guided laser interstitial thermal therapy (MRgLiTT) is critical to achieving good seizure outcome in patients with mesial temporal lobe epilepsy (mTLE). The authors sought to determine whether intraoperative physiological variables are associated with ablation volume dur...
Article
Background Magnetic resonance-guided laser interstitial thermal therapy (MRgLiTT) is becoming a first-line surgical therapy for mesial temporal lobe epilepsy (mTLE) due to good seizure control and low complication risk. However, seizure outcomes after MRgLiTT remain highly variable and there is a need to improve patient selection and post-operative...
Preprint
Full-text available
Memories encoded in the dentate gyrus (DG)-CA3 circuit of the hippocampus are routed from CA1 to anterior cingulate cortex (ACC) for consolidation. Although CA1 parvalbumin inhibitory neurons (PV INs) orchestrate hippocampal-cortical communication, we know less about CA3 PV INs or DG-CA3 principal neuron-IN circuit mechanisms that contribute to evo...
Conference Paper
Full-text available
COVID-19 is a deadly respiratory disease that has caused a worldwide pandemic. Currently, there is no approved vaccine, and few therapeutic options are available. One treatment involves the invasive process of intubating a patient and placing them on a ventilator. Due to a shortage of ventilators, intensive care unit beds, and complications associa...
Article
Background Deep brain stimulation (DBS) lead revision due to suboptimal therapy is common but there is no standardised protocol. We describe a novel technique using iMRI to perform concurrent new Globus Pallidus Internus (GPi) DBS lead implantation and old lead removal in a dystonia patient. Case-description: A 60-year-old woman with medication and...
Conference Paper
Parkinson's Disease (PD) is a neurodegenerative disease characterized by its hallmark motor symptoms of bradykinesia and tremor. Numerous studies have suggested novel quantification methods of its symptoms. However, there lacks the means to accurately assess improvements in an intraoperative setting during deep brain stimulation (DBS) electrode imp...
Conference Paper
Phase-amplitude coupling (PAC), in which the amplitude of a faster neural oscillation couples to the phase of a slower rhythm, is one of the most common representations of complex neuronal rhythmic activities. In a healthy brain, PAC accompanies cognitive function, and abnormal patterns of PAC have been linked to several neurological disorders. Amo...
Conference Paper
Full-text available
Approximately 500,000 dialysis patients in America are at a high risk of hyperkalemia, a condition where blood potassium becomes elevated above normal levels. Hyperkalemia is extremely dangerous, as it can result in severe cardiac complications if untreated. Hyperkalemia may be silent or present vague symptoms until those complications develop, at...
Article
A rapid aptasensor capable of early diagnosing prostate cancer was developed using a dual aptamer, which is composed of a prostate specific antigen (PSA) aptamer and hemin aptamer connected by a linker composed of 5 adenines. The dual aptamers immobilized on the surface of paramagnetic beads were able to competitively bind with PSA or hemin in huma...
Article
A biosensor capable of rapidly quantifying trace levels of CA 19-9 using an enzyme-free immunoassay with 1,1’oxalayldiimidazole chemiluminescent (ODI-CL) detection was developed. The highly sensitive enzymefree immunoassay with ODI-CL detection can rapidly quantify CA 19-9 in human serum. This research demonstrates how the biosensor can be applied...
Article
Acacetin (5,7-dihydroxy-4'-methoxyflavone), a flavonoid compound isolated from Flos Chrysanthemi Indici, chrysanthemum, safflower, and Calamintha and Linaria species has been shown to have anti-cancer activity, indicating its potential clinical value in cancer treatment. In this study, we sought to study the potentials of acacetin in preventing hum...

Network

Cited By