Miloud Slimani

Taher Moulay University of Saida · Department of Biology

Green anis is a plant known since antiquity with its different therapeutic effects such as; antifungal, antimicrobial, antiviral, analgesic, antioxidant and hepatoprotective effects. However, mercury is a trace element metal that is very common in the environment and has adverse effects on human health. The liver is considered to be the seat of met...

This study aims to examine the effects induced by lead acetate (Pb) using different experimental approaches, such as neurobehavioral, biochemical, and histological in young Wistar rats during gestation and lactation, and to test the probiotic effect of Lactobacillus rhamnosus (Prob) throughout correcting or not the harmful effects of the studied me...

The objective of this study, on the one hand, is to evaluate the impact of aluminium intoxication, on the biochemical and hematological approaches of adult Wistar rats, on the other hand, to test the efficacy of Syzygium aromaticum essential oil (CEO) in restoring or not the harmful effects of the studied metal with a daily intraperitoneal injectio...

The present study aimed to evaluate the protective effect of Cinnamomum cassia essential oil on nephrotoxicity induced by manganese chloride (4.79mg/ml) in young Wistar rats during the development period. Wistar rat animals were exposed to manganese through maternal watering on a postnatal day (PND) 1 to (PND) 21. After weaning, the rats exposed to...

Purpose: Aluminum (Al) and its various forms are environmental xenobiotics that pose great threats to public health. The probiotic strain has been reported to have important protective effects against aluminum cytotoxicity. Therefore, the current study was designed to assess the disruption of neurobehavioral and hematobiochemical parameters caused...

Purpose: Mercury is one of the metallic trace elements. This metal is harmful to health. However, Green anis is a plant widely used in the medical field for its various therapeutic virtues. The aim of this study is to evaluate the effect of subchonic exposure to mercury chloride (HgCl2) on the neurobehavioral status of young wistar rats as well as...

Coronavirus (SARS-COV2) caused several deaths worldwide. This virus infects the target cell by binding to angiotensin-converting enzymes 2 (ACE2) receptor through its receptor-binding domain (RBD) and replicates. Thus, a high level of ACE2 expression is detected in the testicular cells so that the testis is believed to count as a potential target f...

This work is a review of the results of some studies conducted around the world on the essential oil of Mentha spicata . Thus, chemical analysis by gas chromatography-mass spectrometry (GC-MS) have identified several compounds in the oil. Among the main ones, we cited carvone, limonene, germacrene D, β-caryophyllene, menthone and 1,8-cineole. Indee...

The present study was carried out in order to evaluate, on the one hand, the modifications induced by manganese chloride according to a neurobehavioral, biochemical and histological approach in developing Wistar rats and, on the other hand, to test the effectiveness of Foeniculum vulgare (fennel) essential oil (FEO) in restoring or not the harmful...

Background: Is a pleasant-smelling perennial shrub that grows in many parts of the world, Rosmarinus officinalis a well known valuable herbal medicine which is widely used in pharmaceuticals and traditional medicine as a digestive, tonic, astringent, diuretic, diaphoretic and useful for urinary ailments. Objective: The objective of this study has,...

The principle aim of this work is to evaluate the antimicrobial and antiochratoxic power of the essential oil of Mentha spicata (EOM). This oil was obtained by hydrodistillation with a yield of 0.3%. EOM was screened for its possible antibacterial activity in vitro against five strains of pathogenic bacteria, using the solid disc diffusion method a...

The objective of this study, on the one hand, is to evaluate the impact of Candida Albicans infection (10 6 CFU per 0.2 ml of intravenous inoculum) on the biochemical and hematological approaches of adult Wistar rats, on the other hand, to test the efficacy of Syzygium aromaticum essential oil (CEO) in restoring or not the harmful effects of the st...

Our work focused on the impact of chronic lead acetate and manganese chloride poisoning on renal function in Wistar rats. It also tested the efficacy of the essential oil extracted from (Mentha spicata) spearmint in reversing these effects by treating previously poisoned rats with a daily intraperitoneal injection of 0.1 ml HEM/kg over a 21-days pe...

Nickel compounds are environmental hazards, capable of inducing severe health problems and carcinogenic effects, which can be mitigated by numer-ous antioxidants. Therefore, the aim of this study was to determine the pro-tective effect of Haloxylon articulatum essential oil (HAOA) by intraperitone-al injection of 0.1 ml/kg/day for a period of 21 da...

DOI: 10.15835/nsb13110878 The purpose of this study was to evaluate the prophylactic effect of Pimpinella anisum (green anis) on neurobehavioral status following mercury chloride intoxication during the developmental period. For this purpose, rats exposed to 100 mg/L of HgCl2 during the gestation and lactation period. A group of rats was treated w...

In view of the global rise of antimicrobial resistance, the discovery of new antimicrobial agents of plant origin has become essential. In this study, the therapeutic capacity of different extracts of Salvia argentea was evaluated in vitro by testing the antimicrobial activity on 16 bacterial strains and 4 yeast strains. Aqueous, ethanolic, and met...

Our work focused on the impact of chronic lead acetate and manganese chloride poisoning on renal function in Wistar rats. It also tested the efficacy of the essential oil extracted from (Mentha spicata) spearmint in reversing these effects by treating previously poisoned rats with a daily intraperitoneal injection of 0.1 ml HEM/kg over a 21-days pe...

The present study was designed to evaluate the protective effect of Cinnamomum cassia essential oil (CCEO) on hepatotoxicity induced by co-exposure to lead acetate (Pb) (2.84mg/ml) and manganese chloride (Mn) (4.79mg/ml) in developing Wistar rats. After we aning, rats exposed to Pb-Mn received injections of Cinnamomum cassia essential oil (0.1 ml/k...

Aluminum is present in medicines and food. Its toxicity induces deleterious effects in various living organisms. At the same time, Hordeum vulgare a cereal known as an important nutritional source and also endowed with bioactive molecules. The ob- jective of this study was to evaluate, on the one hand, the modifications induced by aluminum chloride...

The mechanisms that cause nickel (Ni) toxicity are multiple and potentially affect all cells in the body. For this purpose, we were interested in the oxidative stress induced by the Ni at the erythrocyte level at a dose of 2 g/l during the gestation and lactation period in the Wistar rats and the capacity of the clove essential oil, Syzygium aromat...

The present study was undertaken to determine the effectiveness of the extract of Hordeum vulgare L to restore the adverse effects induced by the aluminum chloride (AlCl 3) in Wistar rats, and this is through gavage with a dose of 13 ml/kg/d during a period of 21 days. H.vulgare L extraction by mac-eration allowed us to obtain an aqueous extract wi...

The persistent nature of heavy metals makes them hazardous in long term. The use of natural chelation by tolerant plants remains a more rational and promising way for the environment compared to the use of chemical chela-tors. Barley has already been used as a model plant in the case of heavy met-als pollution.The present study focuses on the effec...

The present study was undertaken to determine the effectiveness of the extract of Hordeum vulgare L to restore the adverse effects induced by the aluminum chloride (AlCl3) in Wistar rats, and this is through gavage with a dose of 13 ml/kg/d during a period of 21 days. H.vulgare L extraction by mac-eration allowed us to obtain an aqueous extract wit...

This study evaluated the antioxidant activity of Mentha Spicata essential oil against to lead and manganese-induced brain oxidative damage in Wistar rats. Chronic oral co-exposure to lead (0.2%) and manganese (4.79 mg/ml) during periods of gestation and lactation resulted in a significant reduction in both body and brain weight. produced significan...

La présente étude a été réalisée afin d’évaluer le pouvoir thérapeutique de l’extrait aqueux de la Pimpinella anisum L. suite à une exposition à l’imidaclopride (IMD) durant 28 jours chez les rats Wistar. Les résultats relatifs au test d’ open field représentent une réduction significative ( p < 0,001) du nombre de carreaux traversés chez le lot in...

The exposure to toxic levels of lead and manganese during developmental period can impair growth with potential adverse effects on biological tissues. In the current study, we examined the toxicity effects of lead and manganese maternal ingestion in drinking water during gestation and lactation on blood and bone marrow changes. Wistar rat pups via...

The objective of this study is to evaluate, on the one hand, the changes in hepatotoxicity induced by lead and manganese according to a biochemical and histological experimental approach in developing Wistar rats and, on the other hand, to test the effectiveness of mint essential oil (Mentha spicata) in restoring or not the harmful effects of the m...

Triazole and its derivatives possess a great importance in medicinal chemis-try with different biological effects; antiviral, antifungical, antibacterial and analgesic. The purpose of the present work is to assess the effects of 5 phe-nyl 1,2,4 Traizole 3 thiol (5 PTT) through a neurobehavioral exploration in Wistar rats. 5 PTT exposured rats showe...

Phytic acid (Inositol hexaphosphate; IP6) is a natural plant antioxidant, it is found in most grain and legumes. Although much attention has been focused on the preventive effect during critical periods of development in lead poi-soned rats. Phytic acid (1%) was administered to Wistar rats during the ges-tation period and then exposed them to lead...

The mechanisms in the origin of lead and manganese poisoning (Pb-Mn) are multiple, and potentially touch all the body cells. For this purpose, we are interested in oxidative stress induced by Pb-Mn at the erythrocytic level at a dose of 0.2% (Pb) and 4.79 mg/ml (Mn) during the period of gestation and lactation in wistars rats and the ability of min...

The essential oil of Pimpinella anisum has been widely used in traditional medicine to treat a variety of diseases. This study was aimed to test, in vivo, effect of exposition to mercury chloride (100mg/L) in wistar rats during the gestation and lactation period. On the other hand, treatment of pups with essential oil of P. anisum (0.25 ml/kg) for...

The present study was aimed to investigate the protective effect of essential oil of Syzygium aromaticum,on Lead acetate (0.2%) induced nephrotoxicity, in wistar rats pups during the gestation and lactation period. The animals wistar rat pups were exposed to Lead acetate via their dams’ drinking water from postnatal day (PND) 1 to (PND) 21. After w...

The aim of this study was to determine and to compare the presence of oxytetracycline (OTC) residues in raw and cooked (boiled) meat before and after withdrawal period with the Maximum Residue Limits (MRL) using biological and physicochemical techniques. In animal building of 2000 broiler chickens (Gallus domesticus, breed ISA F15) and under the sa...

This ethnopharmacological survey is a first study to assess the traditional uses of Salvia argentea by the local people of Saida, located in the north- western region of Algeria. This plant belonging to the Lamiaceae family, orig- inating from North Africa, is still relatively little studied in Algeria and has no application in conventional medicin...

An ethnobotanical study was carried out in the Saïda region among herbalists to evaluate the use of Salvia argentea (L.), a plant species native from North Africa belonging to the Lamiaceae family. Forty-two herbalists were interviewed individually, aged between 30 and 70 years, all males, 52.38% of them having received a secondary education level...

L’objectif de cette étude est d’évaluer les modifications du statut oxydatif au niveau cérébral, induites par la coexposition au plomb (0,2 %) et au manganèse (4,79 g/l) chez des jeunes rats wistar durant la période de gestation et de lactation, et de tester l’efficacité de l’huile essentielle de clou de girofle (HEC), Syzygium aromaticum , pour ré...

We have simulated different physical properties of Pb1−xSrxTe semiconductors, using the Ab-initio full potential augmented plane wave (FP-LAPW) method. The two commonly used exchange potentials viz., PBE-GGA and WC-GGA are used along with the most recently developed modified Becke and Johnson (mBJ) potential to study the electronic and optical prop...

The objective of this study is, on the one hand, to evaluate the changes in the oxidative state at the brain level induced by co-exposure to lead (0.2%) and manganese (4.79 g/l) in young wistar rats during the gestation and lactation period, and on the other hand, to test the effectiveness of clove essential oil Syzygium aromaticum (HEC) in relievi...

In this work, the full-potential linearized augmented plane wave (FP-LAPW) method was used to calculate the structural, electronic, thermal and thermodynamic properties of BaS and CaS compounds and their ternary mixtures, Ba1-xCaxS. The local-density approximation (LDA), the Wu-Cohen generalized gradient approximation (WC-GGA) and the Perdew-Burke-...

First-principles calculations have been used to study the electronic and optical properties of calcium chalcogenides compounds CaS, CaSe and CaTe using a full potential linearized augmented plane-wave method (FP-LAPW) within density functional theory (DFT). The Perdew, Burke and Ernzerhof (PBE-GGA) as well as the Engel-Vosko (EV-GGA) generalized gr...

Objective: Lead poisoning induced severe behavioral abnormalities and impaired cognitive functions in experimental animals. The aim of the present study is to investigate the detrimental effects of lead exposure on the behavior of rats and its association with altered neurochemistry. Methods: Twenty-four young male Wistar rats were divided into 4 g...

The plant of Ramnus alaternus L. (Rhamnaceae) has been object of many therapeutic indications for traditional medicine. Many studies have showed a hepatoprotective activity of R. alaternus L. The objective of this study was to compare the hepatoprotective activities of decoction and macerated R. Alaternus L. leaves extracts on rats initially expose...

The present work deals with the extraction of the essential oil of the Chinese cinnamon Cinnamomum cassia CEO that takes part on the investigation dealing with erythrocyte antioxidant power of Ni SO 4 exposed wistar rats during gestation and lactation periods. The extraction by hydrodistillation allowed obtaining an essential oil with a yield of 1%...

The present work deals with the extraction of the essential oil of the Chinese cinnamon Cinnamomum cassia CEO that takes part on the investigation dealing with erythrocyte antioxidant power of Ni SO4 exposed wistar rats during gestation and lactation periods. The extraction by hydrodistillation allowed obtaining an essential oil with a yield of 1%....

Le sulfate de Cadmium (CdSO4) et le chlorure de Zinc (ZnCl2) ont des effets antagonistes. Le Cd est connu pour son effet nécrotique et le Zn pour son rôle protecteur. L’objectif de cette étude est d’évaluer les effets de l’exposition au Cd sur l’histologie du foie et des reins chez des rats Wistar en présence du Zn. L’étude a porté sur 16 rats, âgé...

The full potential-linearized augmented plane wave (FP-LAPW) method within density functional theory (DFT) was applied to study the structural, electronic, optic and thermodynamic properties of CaS1-xSe x temary alloys. The local density approximation was used with generalized gradient correction (GGA) as well as the Engel-Vosko GGA formalism to ca...

The ab initio full potential linearized augmented plane wave (FP-LAPW) method within density functional theory was applied to study the effect of composition on the structural and electronic properties Pb l-x Ca x S temary alloys. The effect of composition on lattice parameter, bulk modulus, band gap was investigate. Deviations of the lattice const...

The present study examines the impact of nickel poisoning sulphate at a dose of 0.2 % on neurobehavioral functions in Wistar rats during gestation and lactation. nickel exposure during the development period, has allowed to register, through the forced swimming test, a significant increase (P < 0.001) in the immobility time compared to the control...

The essential oil of Syzygium aromaticum has been widely used in traditional medicine to treat a variety of diseases, including some neurological disorders. This study aims at testing, in vivo, the possible anxiolytic and antidepressant effects, of the Syzygium aromaticum essential oil against chronic manganese chloride (4.79 mg/l) intoxication dur...

The essential oil of Syzygium aromaticum has been widely used in traditional medicine to treat a variety of diseases, including some neurological disorders. This study aims at testing, in vivo, the possible anxiolytic and antidepressant effects, of the Syzygium aromaticum essential oil against chronic manganese chloride (4.79 mg/l) intoxication dur...

Green tea, consumed worldwide since ancient times, is considered beneficial to human health. The present study aimed to evaluate the effect of green tea extract (GTE) on liver damage in male rats treated with lead acetate. Three groups of rats were used in the study. Lead and GTE was given orally to the rats with drinking water for 4 weeks. Lead co...

Lead is an industrial pollutant that may exert specific toxic effects on male mammals. The aim of this study was to investigate further the protective effects of vitamin E on lead acetate (Pb)-induced reproductive toxicities and genotoxic effects on male rats. Sexually mature male Wistar rats (weighing 120-160 g) were given Pb (20 mg/Kg) and vitami...

Lead is industrial pollutant that may have toxic effects on the male. The aim of this study was to further investigate the protective effects of vitamin E on lead acetate (Pb) induced reproductive toxicities and genotoxicity effects in male rat. Sexually mature male Wistar rats (weighing 120-160 g) were given Pb (20 mg/Kg) and vitamin E (600 mg/kg/...

Lead is industrial pollutant that may have toxic effects on the male. The aim of this study was to further investigate the protective effects of vitamin E on lead acetate (Pb) induced reproductive toxicities and genotoxicity effects in male rat. Sexually mature male Wistar rats (weighing 120-160 g) were given Pb (20 mg/Kg) and vitamin E (600 mg/kg/...

Density functional theory calculations have been performed to study the structural, electronic and optical properties of CaLiF3 cubic fluoroperovskite. Our calculations were carried out by means of the full-potential linearized augmented plane-wave method. The exchange–correlation potential is treated by the local density approximation and the gene...

Background: The essential oil of Pimpinella anisum has been widely used in traditional medicine to treat a variety of diseases, including some neurological disorders. Aims: This study was aimed to test, in vivo, the possible anxiolytic and antidepressant effects, of the essential oil of Pimpinella anisum against chronic lead acetate (0.2%) intoxica...

Previous human and experimental studies have demonstrated that lead exposure may modify the metabolism of lipid. Oxidative stress with subsequent lipid peroxidation has been postulated as one mechanism for lead toxicity. The protective action of vitamins C against lead affects lipid hydroperoxide level and liver functions in male rats has been stud...