Miloš Pjanić

Miloš Pjanić
University of Novi Sad

About

148
Publications
17,969
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1,085
Citations
Citations since 2016
125 Research Items
1046 Citations
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250
2016201720182019202020212022050100150200250

Publications

Publications (148)
Chapter
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Editors Srdjan Redžepagić Antonio Portugal Duarte Marianna Siničáková Duško Bodroža
Chapter
This research analyses the results of the Belt and Road Initiative in 17 Central, Eastern, and Southeastern European countries that signed the China-Central and Eastern European Countries Initiative. The subject of the research is the extent to which the initiative would provide benefits for the growth and development of these countries. Special at...
Article
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The paper analyses the neutrality of taxation of investment projects on the example of Serbia. The aim of the research is to confirm/reject the existence of uniformity of the tax burden on investment projects that differ regarding the asset type, industry and the source of finance. The uniformity of tax burden, that is, the absence of discriminatio...
Cover Page
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Economic Annals is an international professional journal published quarterly by the Faculty of Economics, University of Belgrade. It publishes research in all areas of economics and business administration, particularly for transition and emerging economies. The journal encourages the submission of original unpublished works, not under consideratio...
Article
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In the process of globalization, the importance of foreign direct investment has changed significantly, because today they represent one of the most important factors of competitiveness, development and application of new technology, education, innovation and economic development. As a significant form of financing national economies, foreign direc...
Chapter
The research presented in this paper aims to examine the shortterm and long-term effects of international tourism on the economic growth of 17 Mediterranean countries in the period 2000 to 2019. The impact of tourism is not analysed separately. Actually, the indicators of the countries’ labour potential, annual investments, openness to total foreig...
Chapter
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Tourism represents one of the most important economic activities for the global economy. Over the last several decades, the tourism industry has been achieving substantial growth and development in the global market, as well as a positive direct and indirect impact on other economic activities. The paper aims to examine the connection between five...
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Background: To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we create a catalog of genetic variants associated with three stages of transcriptional cis-regulation in primary human coronary artery vascular smooth muscle cell...
Article
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Background: Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated in coronary artery disease risk. We hypothesized that AHR can affect atherosclerosis by regulating phenotypic modulation...
Preprint
Introduction Smooth muscle cells (SMC) play a critical role in atherosclerosis. The Aryl hydrocarbon receptor (AHR) is an environment-sensing transcription factor that contributes to vascular development, and has been implicated in coronary artery disease (CAD) risk. We hypothesized that AHR can affect atherosclerosis by regulating phenotypic modul...
Preprint
Background To investigate the epigenetic and transcriptional mechanisms of coronary artery disease (CAD) risk, as well as the functional regulation of chromatin structure and function, we have created a catalog of genetic variants associated with three stages of transcriptional cis -regulation in primary human coronary artery vascular smooth muscle...
Article
Full-text available
Genome-wide association studies have identified multiple novel genomic loci associated with vascular diseases. Many of these loci are common non-coding variants that affect the expression of disease-relevant genes within coronary vascular cells. To identify such genes on a genome-wide level, we performed deep transcriptomic analysis of genotyped pr...
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The global economic crisis destabilised the public debt of many countries. The purpose of this paper is to investigate the predictors of public debt in European Union countries divided into non-member countries and members of the European Monetary Union in the period from 2001 to 2018. The aim is to discover their relationship with public debt and...
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Rationale: The gene encoding TCF21 (transcription factor 21) has been linked to coronary artery disease risk by human genome-wide association studies in multiple racial ethnic groups. In murine models, Tcf21 is required for phenotypic modulation of smooth muscle cells (SMCs) in atherosclerotic tissues and promotes a fibroblast phenotype in these c...
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Background The prevalence of obesity and its comorbidities, including type 2 diabetes mellitus (T2DM), is dramatically increasing throughout the world; however, the underlying aetiology is incompletely understood. Genome-wide association studies (GWAS) have identified hundreds of genec susceptibility loci for obesity and T2DM, although the causal g...
Preprint
Full-text available
Long noncoding RNAs (lncRNA) comprise an underlying regulatory network in the human genome that remains largely unexplored and could represent a molecular mechanism connecting GWAS risk variants with the disease causal genes. Human coronary artery smooth muscle cells (HCASMC) are one of the most important cells in the regulation of atherosclerotic...
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We combined CAGE sequencing in human adipocytes during differentiation with data from genome-wide association studies to identify an enhancer in the SNX10 locus on chromosome 7, presumably involved in body fat distribution. Using reporter assays and CRISPR-Cas9 gene editing in human cell lines, we characterized the role of the enhancer in adipogene...
Article
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In response to various stimuli, vascular smooth muscle cells (SMCs) can de-differentiate, proliferate and migrate in a process known as phenotypic modulation. However, the phenotype of modulated SMCs in vivo during atherosclerosis and the influence of this process on coronary artery disease (CAD) risk have not been clearly established. Using single...
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Background: Genome-wide association studies have identified over 160 loci that are associated with coronary artery disease. As with other complex human diseases, risk in coronary disease loci is determined primarily by altered expression of the causal gene, due to variation in binding of transcription factors and chromatin-modifying proteins that...
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The research paper provides an empirical evaluation of the tax effects on economic growth in 35 OECD countries from 1996 to 2016. The objective of this paper is to find how taxes effect on the economy, where analysis involves gross domestic product as a proxy for economic growth. Ensuring fundamental econometric procedures, the research paper refle...
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Recent genome-wide association studies (GWAS) have identified multiple new loci which appear to alter coronary artery disease (CAD) risk via arterial wall-specific mechanisms. One of the annotated genes encodes LMOD1 (Leiomodin 1), a member of the actin filament nucleator family that is highly enriched in smooth muscle-containing tissues such as th...
Article
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Although numerous genetic loci have been associated with coronary artery disease (CAD) with genome wide association studies, efforts are needed to identify the causal genes in these loci and link them into fundamental signaling pathways. Recent studies have investigated the disease mechanism of CAD associated gene SMAD3, a central transcription fac...
Data
IPA analysis of genes identified in siTCF21 knockdown and RNA-Seq studies of differentially expressed genes shows enrichment in Cardiovascular Disease phenotype genes. (XLSX)
Data
Comparison of siSMAD3 RNAseq top processes in IPA (Physiologic System Dvlp and Fxn), compared to recent CAD GWAS IPA analysis of predicted CAD GWAS causal genes. (XLSX)
Data
IPA analysis of genes identified in siTCF21 knockdown-RNA-Seq studies, identified CV System Development and Function terms. (XLSX)
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Regulation of matrix protein gene expression by SMAD3. A) Expression levels of TIMP1, TIMP2, TIMP3, MMP1, and MMP10 were measured in HCASMC transfected with either specific siRNA (S3 KD) or scrambled RNA (SCR), and expression levels measured with qRT-PCR. B) Similar experiments were performed with SMAD3 over-expression (SMAD3) and control transfect...
Data
SMAD3 promotes expression of differentiation markers, migration, and inhibits proliferation of HCASMC. A) HCASMC were treated with SMAD3-specific (S3 KD) or scrambled sequence (SCR) siRNA, and evaluated by western blot analysis for expression of lineage markers ACTA2 and TAGLN and control protein GAPDH. Identical cultures of HCASMC were transfected...
Data
SMAD3 has an opposing effect on expression of many of the genes in the previously described TCF21 “vascular disease” transcriptional network. A) RNAseq data of HCASMC studied under control and siTCF21 knockdown conditions was analyzed with DEseq to identify differentially regulated genes. Analysis of these identified genes with the Ingenuity analys...
Data
IPA analysis of DE genes identified in siTCF21 knockdown—RNA-Seq studies, molecular and cellular function pathways. (XLSX)
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IPA analysis of DE genes identified in siSMAD3 knockdown—RNA-Seq studies identified a Vascular Development regulatory network. (XLSX)
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SMAD3 ChIPseq analyses. A) ChIP-PCR confirmation of SMAD3 binding sites at TAGLN, CNN1, COL1A1, and SERPINE1 loci identified by ChIPseq studies. B) DAVID Gene Ontology molecular function analysis of all SMAD3 target genes identified by GREAT with basal plus extension mode. C) GO analysis of target genes (GREAT output) of all SMAD3 peaks that coloca...
Article
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWASs) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret these loci, we generated transcriptome and whole-genome datasets using human coronary artery smoot...
Article
Atherosclerotic coronary artery disease (CAD) continues to be the leading cause of mortality and morbidity worldwide, with an estimated 40% of one’s lifetime risk attributed to genetic factors. Meta-analysis of genome-wide association studies implemented to identify this risk in human populations, has now identified rs2820315 (P=7.7E-10; OR=1.05),...
Preprint
Full-text available
Coronary artery disease (CAD) is the leading cause of death globally. Genome-wide association studies (GWAS) have identified more than 95 independent loci that influence CAD risk, most of which reside in non-coding regions of the genome. To interpret these loci, we generated transcriptome and whole-genome datasets using human coronary artery smooth...
Article
Whole-genome transcriptional profiling has become a standard genomic approach to investigate biological processes. RNA sequencing (RNAseq) in particular has witnessed myriad applications in genetics and various biomedical fields. RNAseq involves a relatively simple experimental protocol of RNA extraction and cDNA library preparation and, because of...
Article
Full-text available
Modern business conditions are characterized by corporate governance that imposes the need for constant growth and development of the company. In such circumstances, it is necessary to measure the achievements of the company in the realization of the set of goals, among which is highlighted the effective financial performance and maximization of re...
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Increased concentration on the market often leads to a limitation of the market share of other market participants, with the increase in market share being mostly accompanied by growth in market power. The increase in market power and the dominant position of individual market participants do not always create adverse effects for other market parti...
Article
Coronary artery disease (CAD) remains the leading cause of mortality and morbidity worldwide and has an estimated heritability of 40%. Meta-analyses of genome-wide association studies have now identified 73 genome-wide significant loci and the most recent multi-ethnic meta-analysis identified a number of arterial wall-specific loci. One of these lo...
Conference Paper
Coronary artery disease (CAD) is the leading cause of death globally. Its complex etiology is influenced by both genetic and environment risk factors. Large-scale population association studies have identified over 150 risk loci, explaining ~10% of the disease heritability. Functional interpretation of the risk-associated variants has been challeng...
Conference Paper
RNA-Seq gene expression analysis comprises multiple steps, including quality control, mapping, read counting and differential expression (DE) analysis. Here we present a pipeline for automated RNA-Seq DE analysis based on top isoform selection. RNASeqFPro is a combined bash/R pipeline that automates the process of RNA-Seq DE analysis. It is designe...
Article
Full-text available
Bisphenol A (BPA) is a synthetic unit of polycarbonate polymers and epoxy resins, the types of plastics that could be found in essentially every human population and incorporated into almost every aspect of the modern human society. BPA polymers appear in a wide range of products, from liquid storages (plastic bottles, can and glass linings, water...
Conference Paper
Background RNA-Seq gene expression analysis comprises multiple steps, including quality control, mapping, read counting and differential expression (DE) analysis. Here we present a pipeline for automated RNA-Seq DE analysis based on top isoform selection. Results RNASeqFPro is a combined bash/R pipeline that automates the process of RNA-Seq DE anal...
Article
Both environmental factors and genetic loci have been associated with coronary artery disease (CAD), however gene-gene and gene-environment interactions that might identify molecular mechanisms of risk are not easily studied by human genetic approaches. We have previously identified the transcription factor TCF21 as the causal CAD gene at 6q23.2 an...
Data
Gene ontology analysis of significant associations between TCF21 and AHR networks. (XLSX)
Data
Overlap of TCF21 and AHR-ARNT position weight matrices. (XLSX)
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GO terms identified with TCF21 overexpression in HCASMC. (PDF)
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AHR and ARNT are upregulated by TCF21 overexpression. (PDF)
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Oxidized LDL is an activator of the AHR pathway. (PDF)
Data
AHR-TCF21 ChIP-Seq co-occupied genes display clustering patterns in mass-spectrometry and high resolution isoelectric focusing proteomic data from human carotid artery plaques. (PDF)
Data
Analysis of differentially regulated genes in TCF21 overexpression with DAVID. (XLSX)
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TCF21 ChIP-Seq summits called with MACS. (XLSX)
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Separate GO enrichment analysis of genes near TCF21 and AHR-ARNT PWM overlap sites, where overlap is phased or un-phased. (XLSX)
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GO enrichment analysis of genes near TCF21, AHR and ARNT ChIP-Seq peaks. (XLSX)
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Active regulation of the AHR gene in aortic and coronary artery tissues. (PDF)
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TCF21, AHR, and ARNT co-expression modules build a strong interconnected network of genes. (PDF)
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TCF21 binds AHR dimerization partner ARNT gene upstream region in human coronary artery smooth muscle cells. (PDF)
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AHR-ARNT, AHR-TCF21 and AHR-ARNT-TCF21 overlapping ChIP-Seq sites enrich in coronary and inflammatory GWAS lead SNPs in window of +/-10kb and +/-5kb. (PDF)
Data
Increased expression of IL1A and MMP1 in human carotid artery plaques. (PDF)