Milindmitra Lonare

• Ph.D.
• Professor (Assistant) at Guru Angad Dev Veterinary and Animal Sciences University

This review explores Ethnoveterinary Medicinal (EVM) plants employed in the treatment of various parasitic diseases in livestock, highlighting their associated phytochemicals and antiparasitic properties. Our objective is to offer a structured overview of the herbs, including their botanical identification, phytochemical profiles and ethnomedicinal...

In present study in-vitro and in silico analysis of hydroethanolic bark extract of Melia azedarach was carried out for development of new remediation against E. coli and S. aureus. The MIC of the bark extract against E. coli and S. aureus was found to be 8 mg/ml and 1 mg/ml, respectively. Furthermore, binding interactions were explored through mole...

Background: Mesenchymal stem cells are a potential candidate for regenerative medicine. Many factors may influence the physiological characteristics of stem cells that may lead to the alteration in their potential. Methods: The impact of age on mesenchymal stem cell characteristics was investigated in older buffaloes (aged over 10 years) and compar...

Exposure to two or more compounds in a living system may result in unexpected outcomes. The present study was planned to investigate the effect of two pesticides, Imidacloprid (IMI) and Carbendazim (CBZ), when exposed alone and in combination, on hematological indicators. All mice were equally divided into six different groups consisting of normal...

The ancient Indian medical system, or Ayurveda, is based on a "natural" and holistic physical and mental health approach. Ethno- veterinary Medicine is an alternative treatment option using medicinal plants and locally available herbs. It is a cost-effective, efficacious, and farmer-friendly option to manage common ailments of bovines and other spe...

The present study was conducted on adipose tissue-derived mesenchymal stem cells (MSCs) from 5 young (<2 years) and 5 adult (>10 years) buffaloes to evaluate the effect of age on growth pattern, differentiation potential, cellular senescence and apoptosis in MSCs. Stem cells were isolated by enzymatic digestion and cultured in DMEM with 12.5% FB...

The presence of one or more pesticides in a variety of mediums is responsible for their indirect toxicological events leading to cell senescence. In the present investigation, the endeavor was made to see the effect of pesticides Car- Benda-Zim (CBZ) and IMIdacloprid (IMI) alone and in combination with bone marrow-derived Mesenchymal Stem Cells (bM...

The effect of a combination of two pesticides, carbendazim (CBZ) and imidacloprid (IMI), was investigated on mesenchymal stem cells derived from the bone marrow of buffalo (bMSCs). The bMSCs were exposed to the CBZ (2.25 µM, 4.49 µM, and 8.98 µM) and IMI (0.81 mM, 1.61 mM, and 3.22 mM) alone as well as in combinations. The bMSCs were found to be po...

Background: The antipyretic, analgesic and anti-inflammatory activities of two concentrations (100 and 200 mg/kg) of ethanolic extract of leaf, bark, flower and fruit pulp of C. fistula were determined in male wistar albino rats. Methods: Antipyretic activity was assessed by E. coli endotoxin induced pyrexia. Analgesic activity was assessed by hot...

Estrogen and progesterone congeners as found in various oral contraceptive formulations have been implicated as the cause of cancer in sex and tissue-specific targets. The mechanism of carcinogenesis by sex steroids is still debatable. In this study, we evaluated the genotoxicity induced by two components of one of the commonly used oral contracept...

Bloat tympany is an overdistention of the rumen reticulum full of gas because of excessive fermentation. Gas in the form of persistent foam mixed with the food particles primary or frothy bloat) or in the form of free gas separated from the ingested food materials (secondary bloat). It is a predominant disorder of cattle but some time may see in sh...

Man has been attracted to animals since time immemorial and animals such as cow, buffalo, goat, etc. were means of livelihood to him, whereas flesh and other by-products of a few of them were utilized as food. Moreover, animals like horses, elephants, camels, etc. were used in warfare affairs and also as a means of transportation. However, the soci...

The present study was aimed to evaluate the toxic effects of quinestrol (a synthetic estradiol) in male lesser bandicoot rat, Bandicota bengalensis. Effect was studied on body weight, weight of vital organs, changes in level of biochemical parameters and genotoxicity. Feeding of bait containing 0.01% quinestrol in bi-choice and 0.02 and 0.03% quine...

Cardiovascular disorders constitute the principal cause of deaths worldwide and will continue as the major disease-burden by the year 2060. A significant proportion of heart failures occur because of use and misuse of drugs and most of the investigational agents fail to achieve any clinical relevance. Here, we investigated rosuvastatin and retinoic...

The single dose pharmacokinetics (PK) of marbofloxacin was compared with repeated intravenous (IV) administrations in six healthy goats at the dose rate of 2 mg/kg body weight at 24 h interval for 5 days. Blood samples were collected at times: 5, 15, 30 min and 1, 2, 4, 6, 9, 12, 24, 36, 48 and 72 h post drug administration. Plasma drug concentrati...

The main objective of study was to investigate the effect of Carbendazim (CBZ) a most popular agriculture fungicide on hemato-biochemical alterations in male rats and possible ameliorative effect of quercetin. Sprague Dawley male rats were administered CBZ @100, 200 and 400 mg/kg body weight, PO and quercetin (25mg/kg body weight, PO) alone and con...

Present study was undertaken to evaluate the acetamiprid-mediated toxicity and possible protective effect of curcumin in rats. Rats were divided into seven different groups. They received curcumin (100 mg/kg, b.wt. p.o.) and acetamiprid (26.25 and 105 mg/kg b.wt., p.o.) alone and in their combinations for period of 28 days. Lipid peroxidation and a...

The intensive use of pesticides in agro-vet practices resulted in their persistence in environmental medium responsible for adverse effect on living system. The present study was planned to evaluate the cytotoxicity and oxidative stress potential of aldrin on BALB/c 3T3 mouse fibroblast cells. Short exposure of 3 h was given to the BALB/c 3T3 fibro...

A safety evaluation of lincomycin was carried out to assess clinical impact of intramuscular administration of lincomycin on various haematological and biochemical parameters in goats to establish safety profile of lincomycin. Six healthy female goats were treated with single intramuscular dose of lincomycin @10.0 mg/kg body weight. The blood sampl...

The present study was carried out to evaluate the aldrin-induced oxidative stress and apoptosis in murine macrophage (J774A.1) cells. Acute exposure of aldrin for 2 hrs was given to the J774A.1 cells cultured in DMEM with 10% FBS at 37oC and 5% CO2 in air with 95% relative humidity under in vitro system. Lethal concentration-50 (LC50) was calculate...

This study was undertaken to investigate the toxic effects of imidacloprid (IM) on male reproductive system and ameliorative effect of curcumin (CMN) in male Wistar rats. For this purpose, IM (45 and 90 mg/kg, body weight) and CMN (100 mg/kg, body weight) were administered orally to the rats either alone or in combinations for a period of 28 days....

The present study was carried out to evaluate the neurotoxic effect and biochemical alteration as a result of imidacloprid (IMI) exposure and potential protective role of curcumin (Cur) against it in rats. Rats were administered with IMI (45 and 90 mg/kg body weight; orally) and Cur (100 mg/kg body weight; orally) alone and in combinations for the...

Nitric oxide synthesized from inducible nitric oxide synthase (iNOS) plays role in acetaminophen (APAP)-induced liver damage. The present study was undertaken to evaluate the effect of iNOS inhibitor S-methylisothiourea (SMT) in APAP-induced hepatotoxicity in rats (1 g/kg, i.p.). SMT was (10, 30, and 100 mg/kg; i.p.) given 30 min before and 3 h aft...

Nitric oxide synthesized from inducible nitric oxide synthase (iNOS) plays role in acetaminophen (APAP)-induced liver damage. The present study was undertaken to evaluate the effect of iNOS inhibitor S-methylisothiourea (SMT) in APAP-induced hepatotoxicity in rats (1 g/kg, i.p.). SMT was (10, 30, and 100 mg/kg; i.p.) given 30 min before and 3 h aft...

Lantana camara is more popular as toxic weed rather than medicinal plant in most of the countries responsible for infesting pastures, grazing lands, orchards and crops like, tea, coffee, oil palm, coconut and cotton, and reduces the economic viability of the crops. This plant can grow even in extreme harsh climatic conditions of tropical and sub-tr...

The present study undertaken to study the cellular immune response in seabuckihorn fed White Leghorn broiler chickens which was evaluated by OTH reaction. Both the SBT fed groups showed higher DTH reaction recorded at 24 hr post challenge as compared to control group. Histopathological investigation revealed higher degree of lymphofollicular reacti...

The literature on Indian Medicinal plants describes the anthelmintic value of many plants (Nadkarni, 1954, Kirtikar and Basu, 1975). Some of the common plants are Azadirachta indica (kadunimba), Butea frondosa (palash), Nigella sativa (Krishnajira) and Piperlongum (pimpli). Most of the earlier research on these plants was pertaining to study of ant...