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Introduction
Milena Korostenskaja (Dr. K) currently works at the Functional Brain Mapping and BCI Lab, AdventHealth Orlando. Milena does research in Biological Psychology, Cognitive Psychology, and Behavioural Science. Milena's current project is 'Brain-Computer Interfaces - Clinical Application.' Milena is also a Founder of The Institute of The Neuroapproaches, where she helps STEM professionals succeed in their careers by utilizing neuroscience-based coaching approaches: https://www.neuroapproaches.org/
Additional affiliations
June 2010 - July 2011
Publications
Publications (70)
Precise localization of eloquent cortex in children may provide much needed surgical
guidance and expand surgical epilepsy treatment options. It reduces the risk of
postsurgical functional deficits and benefits children’s quality of life, educational
capacity, and long-term employment potential. The ultimate goal of functional
mapping for pediatric...
Accurate localization of brain regions responsible for language and cognitive functions in Epilepsy patients should be carefully determined prior to surgery. Electrocorticography (ECoG)-based Real Time Functional Mapping (RTFM) has been shown to be a safer alternative to electrical cortical stimulation mapping (ESM), which is currently the clinical...
RATIONALE: Electrocorticography-based functional language mapping (ECoG-FLM) utilizes an ECoG signal paired with simultaneous language task presentation to create functional maps of the eloquent language cortex in patients selected for resective epilepsy or tumor surgery. At present, the concordance of functional maps derived by ECoG-FLM and electr...
The success of surgical resection in epilepsy patients depends on preserving functionally critical brain regions, while removing pathological tissues. Being the gold standard, electro-cortical stimulation mapping (ESM) helps surgeons in localizing the function of eloquent cortex through electrical stimulation of electrodes placed directly on the co...
A common magnitude system for the processing of time and numerosity, supported by areas in the posterior parietal cortex, has been proposed by some authors. The present study aims to investigate possible intersections between the neural processing of non-numerical (time) and numerical magnitudes in the posterior parietal lobe. Using Magnetoencephal...
The first chapter of this book readers introduced BCIs, the BCI Award Foundation and 2022 jury, the procedures and criteria of the awards, and the 12 nominees in 2022. Most chapters described projects that were nominated for a BCI Research Award. This is the last chapter of the book. Here, we provide more information about the awards ceremony and t...
With brain-computer interfaces (BCIs), people can send information directly from their brains to computers. People can use BCIs to send messages or commands without moving. In 2010, we launched the Annual BCI Research Awards. People submit their projects to a jury that scores each project on many criteria and then selects the best projects from tha...
Stroke is a major cause of disability resulting in multiple system impairments. Limited extended care resulted in prioritizing high level repetitions of task-specific activities to improve function. One such modality is BCI to drive motor rehabilitation. While several systematic reviews and meta-analyses highlight the benefits of utilizing BCIs to...
Dreams are often forgotten despite their impact on our emotions and memory. In our pursuit of developing an objective dream-content recording methodology (reaDream), we focused on the motor imagery (MI)-related dream component, which is reported to be present in dreams along with other sensory, perceptual, and cognitive phenomena. It has been shown...
Description In this review article, we aimed to create a summary of the effects of internal variables on the performance of sensorimotor rhythm-based brain computer interfaces (SMR-BCIs). SMR-BCIs can be potentially used for interfacing between the brain and devices, bypassing usual central nervous system output, such as muscle activity. The carefu...
Description Sensorimotor rhythm-based brain-computer interfaces (SMR-BCIs) are used for the acquisition and translation of motor imagery-related brain signals into machine control commands, bypassing the usual central nervous system output. The selection of optimal external variable configuration can maximize SMR-BCI performance in both healthy and...
In this chapter, the authors reflect on the uses of MEG to better characterize different cortical zones within the epileptic network. First, they review the role of MEG in the presurgical workout under the classical model of epileptic zones. Under this model, MEG had been incorporated as a noninvasive tool to define the irritative zones based on re...
Stroke is the fifth leading cause of death and disability in the United States with approximately 6.8 million people living with residual deficits and approximately $34 billion spent on treatment annually [1, 2]. Simultaneously, dramatic healthcare shifts have limited extended care accessibility, with many individuals discharged from restorative th...
A common magnitude system for the processing of time and numerosity, supported by areas in the posterior parietal cortex, has been proposed by some authors. The present study aims to investigate possible intersections between the neural processing of non-numerical (time) and numerical magnitudes in the posterior parietal lobe. Using Magnetoencephal...
Successful surgical resection in epilepsy patients depends on preserving functionally critical brain regions while removing pathological tissues. Being the gold standard, Electro-cortical Stimulation Mapping (ESM) helps surgeons localize the function of eloquent cortex through electrical stimulation of the electrodes placed directly on the cortical...
Auditory steady-state response (ASSR) at 40Hz has been proposed as a potential biomarker for schizophrenia. The ASSR studies in patients have used click stimulation or amplitude-modulated tones. However, the sensitivity of 40Hz ASSRs to different stimulation types in the same group of patients has not been previously evaluated. Two stimulation type...
Background
The identification of eloquent cortex, surrounding the seizure onset zone, is important for predictable surgical outcome in epilepsy patients. The symptoms during electrical cortical stimulation (ECS) lead to a functional map that includes motor, sensory, and other functions. In this study we test whether a prevenient high-gamma mapping...
To minimize functional morbidity associated with brain surgery, new preventive approaches (also referred to as "prehabilitation") by using motor-imagery-based computer interfaces (MI-BCIs) can be utilized. To achieve successful MI-BCI performance for prehabilitation purposes, the characteristics of an electrocorticographic (ECoG) signal that is ass...
Electrical cortical stimulation (ECS) is often used in presurgical evaluation procedures for patients suffering from pharmacoresistant epilepsy. Real-time functional mapping (RTFM) is an alternative brain mapping methodology that can accompany traditional functional mapping approaches like ECS. In this paper, we present a combined RTFM/ECS system t...
Brain-Computer Interfaces (BCIs) are powerful tools for enabling communication between people and the surrounding world by directly utilizing brain activity and avoiding motor pathways. Before moving into invasive implantation of BCIs, a key issue must be resolved—localization of the areas for implantation, which might vary depending on the chosen...
Brain-Computer Interfaces (BCIs) are powerful tools for enabling communication between people and the surrounding world by directly utilizing brain activity and avoiding motor pathways. Before moving into invasive implantation of BCIs, a key issue must be resolved – localization of the areas for implantation, which might vary depending on the chose...
Employing a lexical decision task (LDT), participants determined whether or not two visually presented letter strings were words. Our novel approach used LDT trials to examine influences upon subsequent recognition of thematically-related items. LDT trials involving words semantically related to DRM lists robustly primed false recognition of critic...
Simultaneous bilateral onset and bi-synchrony epileptiform discharges in electroencephalogram (EEG) remain hallmarks for generalized seizures. However, the possibility of an epileptogenic focus triggering rapidly generalized epileptiform discharges has been documented in several studies. Previously, a new multi-stage surgical procedure using bilate...
In one form of the lexical decision task (LDT), participants determine on each trial whether or not two visually presented letter strings are words. Our approach involved using LDT trials to influence subsequent recognition performance on thematically-related DRM lists. Specifically, LDT trials that involve words semantically related to DRM lists p...
Although a number of studies have demonstrated state-related dependence of auditory steady-state responses (ASSRs), the investigations assessing trait-related ASSR changes are limited. Five consistently identified major trait dimensions, also referred to as "big five" (Neuroticism, Extraversion, Openness, Agreeableness and Conscientiousness), are c...
Introduction: There is evidence to suggest that surgically-implanted intracranial BCIs might be more efficient than scalp-based BCIs, especially for severely disabled patients. However, before moving into invasive implantation of BCIs, the important question must be addressed – localization of the areas for implantation, which might vary dependent...
Increasing evidence indicates that the brain generates signals in a wide-frequency range, including high-frequency brain signals. High-frequency brain signals are also called high-frequency oscillations (HFOs), ripples, or fast ripples. There are no established terms for describing HFOs in a variety of frequency ranges. HFOs are clinically importan...
Objective evaluation of language function is critical for children with intractable epilepsy under consideration for epilepsy surgery. The purpose of this preliminary study was to evaluate word recognition in children with intractable epilepsy by using magnetoencephalography (MEG). Ten children with intractable epilepsy (M/F 6/4, mean +/- SD 13.4 +...
The abnormality of intrinsic brain activity in autism spectrum disorders (ASDs) is still inconclusive. Contradictory results have been found pointing towards hyper-activity or hypo-activity in various brain regions. The present research aims to investigate the spatial and spectral signatures of aberrant brain activity in an unprecedented frequency...
To evaluate the use of the cortiQ-based mapping system (g.tec medication engineering GmbH, Austria) for real-time functional mapping (RTFM) and to compare it to results from electrical cortical stimulation mapping (ESM) and functional magnetic resonance imaging (fMRI).
Electrocorticographic activity was recorded in 3 male patients with intractable...
Brain-Computer Interfaces (BCIs) are expected to become a game-changing
modality for the communication and control of both devices and virtual environments in
humans whose direct neuromotor response needs to be augmented, bypassed, or
replaced. Recent developments in the area of BCI research suggest that subdural
electrocorticography (ECoG)-based B...
Purpose
To evaluate the value of a new multi-stage surgical procedure using bilateral intracranial electroencephalogram (iEEG) prior and post complete corpus callostomy (CC) for epileptogenic focus localization.
Methods
Thirty patients with drug-resistant epilepsy underwent bilateral iEEG monitoring to localize epileptogenic focus for surgical tre...
Accurate language localization expands surgical treatment options for epilepsy patients and reduces the risk of postsurgery language deficits. Electrical cortical stimulation mapping (ESM) is considered to be the clinical gold standard for language localization. While ESM affords clinically valuable results, it can be poorly tolerated by children,...
The auditory steady-state response (ASSR) is observed when stimuli are presented periodically resulting in electroencephalographic entrainment (Picton et al. 2003), i.e. the frequency of the ASSR is close to the frequency of stimulation and the greatest magnitude is observed when stimuli are presented at 40 Hz (Galambos et al. 1981). Since its disc...
uditory steady-state responses (ASSRs) are widely applied to test brain's ability to follow external stimulation in neuropsychiatric disorders. It is known that ASSRs are related to GABAergic transmission. Female sex steroid homones - both estrogens and progesterone - affect functioning of GABAergic system. However, it is not known how these hormon...
Childhood epileptic encephalopathies (CEE) are often characterized by abnormal brain development in which epileptic electrical discharges may contribute to cognitive deficits, behavioral disturbances, or psychomotor dysfunction. Electroencephalography (EEG) is the primary diagnostic imaging tool used by care providers in order to observe the aggres...
Epilepsy surgery is a potentially curative option for children with intractable epilepsy. In order to avoid postsurgical deficits in language and cognitive functioning, the mapping of these brain functions must be performed. Neurophysiological techniques, such as Electroencephalography (EEG) and Magnetoencephalography (MEG) are non-invasive procedu...
SIGFRIED (SIGnal modeling For Real-time Identification and Event Detection) software provides real-time functional mapping (RTFM) of eloquent cortex for epilepsy patients preparing to undergo resective surgery. This study presents the first application of paradigms used in functional magnetic resonance (fMRI) and electrical cortical stimulation map...
Planning for epilepsy surgery depends substantially on the localization of brain cortical areas responsible for sensory, motor, or cognitive functions, clinically also known as eloquent cortex. In this paper, we present the novel software package 'cortiQ' that allows clinicians to localize eloquent cortex, thus providing a safe margin for surgical...
Planning for epilepsy surgery depends substantially on the localization of brain cortical areas responsible for sensory, motor, or cognitive functions, clinically also known as eloquent cortex. In this paper, we present the novel software package 'cortiQ' that allows clinicians to localize eloquent cortex, thus providing a safe margin for surgical...
To quantitatively assess cortical dysfunction in pediatric migraine, 31 adolescents with acute migraine and age- and gender-matched controls were studied using a magnetoencephalography (MEG) system at a sampling rate of 6,000 Hz. Neuromagnetic brain activation was elicited by a finger-tapping task. The spectral and spatial signatures of magnetoence...
Patients with obsessive-compulsive disorder (OCD) often report sensory intolerances which may lead to significant functional impairment. This study used auditory evoked fields (AEFs) to address the question of whether neural correlates of sensory auditory information processing differ in youth with OCD compared with healthy comparison subjects (HCS...
Acute migraine could be associated with neurophysiological and cognitive changes. This study evaluates the neurophysiological changes in auditory information processing in adolescents with acute migraine by means of magnetoencephalography. The multifeature sound mismatch negativity (MMN) paradigm was used to study nine adolescents with an acute mig...
We aimed to determine the changes in neural correlates of auditory information processing such as auditory detection, encoding, and sensory discrimination in pediatric patients with intractable epilepsy.
In this magnetoencephalography (MEG) study, 10 patients and 10 age- and gender-matched healthy controls were investigated with the multi-feature m...
To investigate the functional abnormalities of the motor cortices in children with migraine using magnetoencephalography (MEG) and a finger-tapping task.
Cortical hyperexcitability has been reported in adults with migraine using MEG. Many children with migraine report difficulty with motor functioning. There is no report on motor-evoked magnetic ac...
Objective evaluation of receptive language function is critical for children with intractable epilepsy, because deficient language function can be associated with poor surgery outcomes in these patients. The purpose of the present study was to evaluate the receptive language function in children with intractable epilepsy by means of magnetoencephal...
Objective evaluation of receptive language function is critical for children with intractable epilepsy, because deficient
language function can be associated with poor surgery outcomes in these patients. The purpose of the present study was to
evaluate the receptive language function in children with intractable epilepsy by means of magnetoencephal...
Abnormalities in attention, memory and information processing are considered to be the primary deficits in schizophrenia. Event-related potential (ERP) P300 could reflect deficits in auditory information processing related to active attention in schizophrenia patients. Atypical antipsychotics tend to ameliorate cognitive deficits, however their eff...
Cognitive dysfunction is considered to be a core feature in schizophrenia. It is believed that antipsychotic drugs, especially atypical ones, could improve cognitive functions in schizophrenia patients. Auditory event-related potentials (ERPs) such as mismatch negativity (MMN) and P300 response are potential candidates for objective investigation o...
The psychomotor stimulant methylphenidate (MPH) has been shown to improve attentional processes, reflected in behavioural measures such as vigilance, reaction time and visual attention tasks. The neural mechanisms of MPH action on sensory information processing, however, remain poorly understood. To the authors' knowledge, this present study is the...
Mismatch negativity (MMN) and its magnetic counterpart (MMNm) have been shown to be altered in patients with various psychiatric and neurological disorders, e.g. Alzheimer's disease and schizophrenia, indicating deficits in involuntary attention. N-Methyl-D-aspartate (NMDA) receptor-mediated glutamate dysfunction is suggested to underlie these defi...
Early effects of risperidone (2.5 +/- 1 mg/day) on auditory information processing were investigated in 9 neuroleptic naive patients with schizophrenia spectrum disorders and 9 healthy controls by using event-related potentials (ERPs). ERPs were elicited during active auditory "oddball" paradigm and were recorded before and after two weeks of treat...
The aim of the present study was to evaluate the new P300 parameters on patients with schizophrenia spectrum disorders and to compare their reliability with the commonly used P300 latency and amplitude. 56 healthy human subjects and 22 patients with schizophrenia spectrum disorders were studied. The following new parameters were considered. Some of...
We investigated effects of olanzapine (5-10 mg/day) on passive and active attention in 11 patients with schizophrenia spectrum disorders and 15 healthy controls by using auditory evoked potentials (AEPs) mismatch negativity (MMN) and P300. AEPs were elicited during active and passive auditory "oddball" paradigms before, after 2 weeks and 4 weeks of...
Visual evoked potentials (VEPs) provide an objective technique for monitoring the integrity of visual pathways and have been used to monitor the activity of post-receptoral chromatic mechanisms. The temporal properties of visual processing may now be characterized in terms of VEP integration time, defined as the stimulus duration during which respo...
ERPs could be helpful in the objectification of many psychological measures. In the last few decades one of the most commonly used ERPs has been the mismatch negativity (MMN) potential. It may be used to detect cognitive dysfunction in patients suffering from schizophrenia, dementia, depression, and can also be successfully applied in treatment mon...
ERPs could be helpful in the objectification of many psychological measures. One of the most commonly used ERPs in the last decades is P300 potential. It may be used in differentiation of cognitive dysfunction in patients suffering from schizophrenia, dementia, depression, and also could be successfully applied in treatment monitoring. Nevertheless...
Visual evoked potentials (VEPs) have been successfully employed in monitoring parvocellular and magnocellular activity in primates and hu-mans. The aim of this study was to compare the temporal characteris-tics of red/green (R/G) and S-cone-system processing by examining in-tegration times of VEPs elicited by the onset-offset of selective chroma-ti...
Cognitive impairments of attention, memory and executive functions are a fundamental feature of the pathophysiology of schizophrenia. The neurophysiological and neurochemical changes in the auditory cortex are shown to underlie cognitive impairmentsin schizophrenia patients. Functional state of the neural substrate of auditory information processin...