Milen Hristov

Milen Hristov
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Milen verified their affiliation via an institutional email.
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Milen verified their affiliation via an institutional email.
Medical University of Sofia · Department of Pharmacology and Toxicology

Doctor of Medicine

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20
Publications
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45
Citations

Publications

Publications (20)
Article
Full-text available
Diabetic neuropathy (DN) is a common complication of long-lasting type 1 and type 2 diabetes, with no curative treatment available. Here, we tested the effect of the incretin mimetic liraglutide in DN in mice with early-stage type 1 diabetes bred in a standard laboratory or enriched environment. With a single i.p. injection of streptozotocin 150 mg...
Article
Full-text available
PURPOSE: This study aimed to investigate the effect of combining Nω-Nitro-L-arginine methyl ester (L-NAME) and leptin on food intake and body mass gain in fasted rats, as both have been shown to suppress food consumption. Additionally, the study evaluated the impact of L-NAME on fever induced by leptin. METHODS: L-NAME and recombinant rat leptin we...
Article
Full-text available
Various studies have emphasized the intricate relationship between hydrogen sulfide (H2S) and nitric oxide (NO) in regulating diverse physiological processes. In this investigation, we aimed to elucidate the effects of simultaneous inhibition of the H2S-producing enzyme cystathionine γ-lyase and the NO-producing enzyme nitric oxide synthase on food...
Article
Full-text available
Previous studies have explored the antinociceptive effects of riboflavin (vitamin B2) across various experimental models. However, there remains a gap in the literature regarding its potential to alleviate neuropathic pain in diabetes. This study aims to investigate the effects of riboflavin on hyperalgesia and serum glutamine-to-glutamate ratio in...
Article
The adipocyte-derived hormone, leptin, plays a key role in the maintenance of energy homeostasis. Leptin binds to the long form of its receptor, which is predominantly expressed in various hypothalamic regions, including the lateral hypothalamic area (LH) and supraoptic nucleus (SO). Several studies have suggested that leptin directly activates neu...
Article
Full-text available
Both peripheral neuropathy and depression can be viewed as neurodegeneration's consequences of diabetes, at least in part coexisting with or resulting from sodium-calcium dysbalance. This study aims to assess the therapeutic potential of the orally applied reverse-mode inhibitor of the sodium-calcium exchanger (NCX) KB-R7943 in the streptozotocin (...
Article
Full-text available
Diabetes mellitus is one of the most common chronic diseases in the world. Metabolomic studies have demonstrated altered blood levels of glutamate and glutamine during type 1 diabetes and type 2 diabetes. Riboflavin is a precursor of flavin adenine dinucleotide and flavin mononucleotide, which are coenzymes necessary for the function of enzymes inv...
Article
Apelin, a peptide known for its crucial role in energy balance regulation and contributions to cardiovascular, gastrointestinal, neuroendocrine, and immune functions, has been associated with conflicting outcomes in studies exploring its role in body temperature regulation. Hydrogen sulfide, recognized as a pivotal gasotransmitter, plays a crucial...
Article
Full-text available
Diabetes mellitus (DM) is a chronic disease characterized by elevated blood glucose levels caused by a lack of insulin production (type 1 diabetes) or insulin resistance (type 2 diabetes). It is well known that DM is associated with cognitive deficits and metabolic and neurophysiological changes in the brain. Glutamate is the main excitatory neurot...
Article
Leptin is an adipokine that regulates energy balance and immune function. Peripheral leptin administration elicits prostaglandin E₂-dependent fever in rats. The gasotransmitters nitric oxide (NO) and hydrogen sulfide (H₂S) are also involved in lipopolysaccharide (LPS)-induced fever response. However, there is no data in the literature indicating if...
Article
Leptin is an adipokine that plays an important role in the regulation of energy homeostasis. The failure of endogenous and exogenous leptin to mediate its effects (for example, at suppressing appetite and decreasing body weight) has been termed leptin resistance. Hyperleptinemia and leptin resistance can be well demonstrated in animals in which obe...
Article
Full-text available
Leptin is a peptide hormone regulating food intake and body weight. The effects of leptin are mediated via leptin receptors present in the central nervous system (including hippocampal regions and gyrus dentatus). It is known that leptin induces phosphorylation of the neuronal isoform of nitric oxide synthase (nNOS) in defined hypothalamic regions....
Article
Full-text available
Leptin is an adipokine that regulates body weight by decreasing appetite and increasing energy expenditure. Besides the effects on food intake, leptin can regulate energy expenditure at least in part by modulating thermogenesis. Many of the effects of leptin are attributable to action in the central nervous system, particularly in the hypothalamus....
Article
Leptin, a hormone mainly produced by adipocytes in proportion to fat mass, is a key component in the regulation of energy homeostasis and reproductive, neuroendocrine, immune, and metabolic functions. Leptin binds to the leptin receptor, which is expressed throughout the central nervous system but particularly in neurons of several nuclei of the hy...
Article
Full-text available
GABAB receptors are G-protein-coupled receptors, playing a very important role in the regulation of many physiological processes. The GABAB signaling pathway could modulate neurotransmission processes at the level of the preoptic area in the anterior hypothalamus, which is thought to function as the thermoregulatory center. The present study was pe...
Article
Full-text available
The adipose tissue-derived hormone leptin acts via its long receptor isoform in the brain to regulate energy balance and neuroendocrine function. The goal of this study is to investigate the effects of leptin on firing rate of neurons from preoptic area of the anterior hypothalamus (PO/AH) of rats with normal weight and experimental model of obesit...
Article
Full-text available
Leptin inhibits feeding, reduces body weight and increases thermogenesis. Experimental data suggest involvement of GABAergic mechanisms in the regulation of feeding behavior and energy balance. The present study was set to determine the effect of combinations from leptin, GABAB-agonist baclofen and GABAB-antagonist CGP35348 on thermoregulation of m...
Article
Leptin as well as gamma-aminobutyric acid (GABA) are involved in the regulation of feeding behavior and energy balance. Recent experimental data suggest involvement of GABAergic mechanisms in the regulation of body temperature. The present study determined the effect of leptin on the core body temperature in rats at ambient temperature of 22±1°C. I...

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