Milan B. Arambasic

• Magister of Science
• Retired at Galenika a.d. Beograd

Comparative results obtained with the Finney and Miller-Tainter methods for the calculation of LD of a compound are presented, using the example of the assessment of LD of thymoquinone following 50 50 its intraperitoneal administration to rats. The obtained results are very similar showing no statistically significant difference (P > 0.05) in morta...

The effect of exposure to increased NaCl concentrations (17.11-171.11 mmol/l) in the external medium on the viability of fertilized egg cells, 8-day-old embryos and adult animals of the pond snail Lymnaea stagnalis L. was tested. The survival time and survival rate of embryos and adults were assessed from the placement into any of the 10 hyperosmot...

Paper presents the interactive computer program "POTENCY" written in BASIC program language, based on the algorithm for classifying biological assays using the assays: "2 + 2" doses, "3 + 3" doses, twin cross-over assay and probit analysis ("2 + 2" doses) described in Yugoslav Pharmacopeia (Ph. Jug. IV). The program execution is presented by assay...

The paper presents the interactive computer program "LD50-MORTALITY", written in the program language BASIC and used for the assessment of the acute toxicity (calculation of LD50 and other LD values) based on the algorithm of the Finney's probit analysis method. The correctness of the program execution has been shown on the test-example of assessme...

The paper presents a routine biological and chemical quality control of nonoxynol-9 raw material and pharmaceutical formulation containing nonoxynol-9 (ABF contraceptive film). The biological control performed based on the determination and comparison of the spermicidal activities different dilutions of the standard raw materials solution and assay...

Abstract: The results show that it is possible to maintain marsh snail Lymnaea stagnalis L through the generations, under laboratory conditions, but with the first generation of animals bred in the laboratory from egg masses from the nature, is not infected with parasites. In conditions when egg masses are kept in Petri dishes in 50 ml of tap water...

Bakterijski endotoksini su po hemijskoj prirodi lipopolisaharidi koji se nalaze u Gram-negativnim bakterijama. Tokom života ljudi su izloženi minimalnim koli-činama endotoksina, koji se oslobađaju posle uginuća bakterija (uglavnom Escheri-chia coli Bergey) u gastrointestinalnom traktu. Ova mala količina endotoksina izazi-va u telu stvaranje umereni...

This paper presents the application of the regression analysis program and the program for comparing linear regressions (modified method for one-way, analysis of variance), writtens in BASIC program language, for instance, determination of content of Diclofenac-Sodium (active ingredient in DIKLOFEN injections, ampules á 75 mg/3 ml). Stability testi...

The dependence of the content and microbiological activity of Chloramphenicol (active substance) at dissolution time and on pH, as well as of the co9ntent and microbiological activity of Chloramphenicol (250 mg capsules)at release, on time, in in-vitro conditions, was determined using linear and non-linear regression.

The investigations of the effects of various heavy metal: Cu (as CuSO4), Pb (as Pb(NO3)2) and Zn (as ZnSO4), phenol and Na (as Na2SO4 and NaCl) concentrations on root length of onion bulbs (Allium cepa L.) and garden cress (Lepidium sativum L.), as well as on the survival rate of great water flea (Daphnia magna St.) showed varied sensitivity of the...

The parathyroid hormone (PTH) is important for the calcium balance in humans. It apparently participates in the development of osteoporosis, especially in the senile type (Type II). This study investigates the parathyroid hormone inhibitory bioactivity of the human fetal and neonatal thymus. The PTH inhibiting bioactivity was determined in the huma...

The experimental data of the linear embryonal and postembryonal growth of pond snail Lymnaea stagnalis L. have been estimated using logistic, polynomial, Gompertz's and Bertalanffy's functions of growth. The obtained results have shown that, based on the square error value, Gompertz function is, among all growth functions used, the most adequate fo...