Milad Abolhasani

Milad Abolhasani
North Carolina State University | NCSU · Department of Chemical and Biomolecular Engineering

PhD

About

95
Publications
8,781
Reads
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1,436
Citations
Introduction
I am currently an Associate Professor and a University Faculty Scholar in the Department of Chemical and Biomolecular Engineering at North Carolina State University. I lead a diverse research group that studies flow chemistry strategies tailored towards accelerated development and manufacturing of advanced functional materials and molecules using autonomous robotic experimentation.
Additional affiliations
October 2014 - present
Massachusetts Institute of Technology
Position
  • PostDoc Position
September 2010 - September 2014
University of Toronto
Position
  • Research Assistant
June 2010 - present
University of Toronto
Position
  • Microfluidic Format for the Automated Exploration of Solubility and Reaction Landscapes for CO2-Liquid Mixtures
Description
  • During my PhD I made contributions in different aspects of microfluidics (MFs) and MEMS research fields and applied them to a wide range of applications related to CO2 sequestration.
Education
September 2010 - September 2014
University of Toronto
Field of study
  • Mechanical Engineering
September 2008 - June 2010
University of British Columbia - Vancouver
Field of study
  • Mechanical Engineering
September 2004 - June 2008
Sharif University of Technology
Field of study
  • Mechanical Engineering

Publications

Publications (95)
Article
Colloidal organic/inorganic metal-halide perovskite nanocrystals have recently emerged as a potential low-cost replacement for the semiconductor materials in commercial photovoltaics and light emitting diodes. However, unlike III-V and IV-VI semiconductor...
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Full-text available
In an effort to produce the materials of next‐generation photoelectronic devices, postsynthesis halide exchange reactions of perovskite quantum dots are explored to achieve enhanced bandgap tunability. However, comprehensive understanding of the multifaceted halide exchange reactions is inhibited by their vast relevant parameter space and complex r...
Article
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The optimal synthesis of advanced nanomaterials with numerous reaction parameters, stages, and routes, poses one of the most complex challenges of modern colloidal science, and current strategies often fail to meet the demands of these combinatorially large systems. In response, an Artificial Chemist is presented: the integration of machine‐learnin...
Article
Full-text available
Autonomous robotic experimentation strategies are rapidly rising in use because, without the need for user intervention, they can efficiently and precisely converge onto optimal intrinsic and extrinsic synthesis conditions for a wide range of emerging materials. However, as the material syntheses become more complex, the meta-decisions of artificia...
Article
Full-text available
Continuous Manufacturing In article number 2000245, Milad Abolhasani and co‐workers present the second generation of “Artificial Chemist”, that is, a modular robo‐fluidic material synthesizer operated by artificial intelligence for data‐driven discovery, formulation optimization, and scalable nanomanufacturing of printable photonic materials with m...
Article
Microfluidic devices and systems have entered many areas of chemical engineering, and the rate of their adoption is only increasing. As we approach and adapt to the critical global challenges we face in the near future, it is important to consider the capabilities of flow chemistry and its applications in next-generation technologies for sustainabi...
Article
Recent advances in machine learning (ML) and artificial intelligence have provided an exciting opportunity to computerize the fundamental and applied studies of complex reaction systems via self-driving laboratories. Autonomous robotic experimentation can enable time-, material-, and resource-efficient exploration and/or optimization of high-dimens...
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Synthesis of hindered amines using the atom-efficient hydroaminomethylation (HAM) route remains a challenge. Here, we report a general and accelerated HAM in segmented flow, achieved via a cooperative effect between rhodium (Rh)/N-Xantphos and a co-catalyst (2-Fluoro-4-methylbenzoic acid) to increase the reactivity by 70 fold when compared to Rh/Xa...
Article
A generalizable and versatile microfluidic approach for facile synthesis of a wide range of metal oxide microparticles using atypical metal‐organic precursors is reported. Microparticles of three single oxide materials, zinc(II) oxide, tin(IV) oxide, and cerium(IV) oxide, as well as a binary rare earth mixed oxide, lanthanum(III) praseodymium(III)...
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Self‐Driving Fluidic Micro‐Processors In article number 2200017, Milad Abolhasani and co‐workers present a self‐driving lab using artificial intelligence‐guided fluidic blocks for accelerated fundamental and applied studies of emerging clean energy materials. Autonomous doping of metal halide perovskite quantum dots is demonstrated as a material te...
Article
Tuning aldehyde regioselectivity via homogeneous hydroformylation of olefins using the same catalyst system remains a challenge. Here, we present flexible rhodium (Rh)-catalyzed hydroformylation of 1-octene and propylene with a bulky cyclic monofluorophosphite ligand L. Hydroformylation of 1-octene with Rh/L catalyst achieves, for the first time, t...
Article
Despite the potential of hydrogen (H2) storage in liquid organic carriers to achieve carbon neutrality, the energy required for H 2 release and the cost of catalyst recycling have hindered its large‐scale adoption. In response, we report a photo flow reactor packed with rhodium (Rh)/titania (TiO2) photocatalyst for the continuous and selective acce...
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Lead halide perovskite (LHP) nanocrystals (NCs) are considered an emerging class of advanced functional materials with numerous outstanding optoelectronic characteristics. Despite their success in the field, their precision synthesis and fundamental mechanistic studies remain a challenge. The vast colloidal synthesis and processing parameters of LH...
Article
Full-text available
Despite the groundbreaking advancements in the synthesis of inorganic lead halide perovskite (LHP) nanocrystals (NCs), stimulated from their intriguing size‐, composition‐, and morphology‐dependent optical and optoelectronic properties, their formation mechanism through the hot‐injection (HI) synthetic route is not well‐understood. In this work, fo...
Article
Full-text available
CsPbI3 Nanocrystals In article number 2108687, Milad Abolhasani and co‐workers feature a modular flow chemistry strategy for synthesis science studies of CsPbI3 nanocrystals (NCs). The reconfigurable flow reactors enable on‐demand selection of the NC synthetic route and provide in‐situ access to the optical properties of the in‐flow synthesized NCs...
Article
The Cover Feature illustrates a Spin Transfer Automated Reactor (STAR), which produces a continuous stream of nuclear spin hyperpolarization. In the STAR, parahydrogen diffuses through a semi‐permeable membrane to hyperpolarize small molecules in solution, including the antibiotic drug metronidazole and the metabolite pyruvate. The STAR also produc...
Article
Autonomous experimentation and chemical discovery strategies are rapidly rising across multiple fields of science. However, closed-loop material development approaches have not been widely employed in colloidal nanoscience mainly due to the challenges in synthesis space size, sensitivity to reaction conditions, and the complexity of monitoring mult...
Article
We present an integrated flow chemistry strategy using two membrane-based flow reactors to enhance the extraction and recovery rates of switchable hydrophilicity solvents (SHSs) by five times compared to batch...
Article
We introduce a Spin Transfer Automated Reactor (STAR) that produces continuous parahydrogen induced polarization (PHIP), which is stable for hours to days. We use the PHIP variant called signal amplification by reversible exchange (SABRE), which is particularly well suited to produce continuous hyperpolarization. The STAR is operated in conjunction...
Article
Self-driving laboratories are quickly growing in capability, making research in the exploration of advanced functional materials and molecules on the edge of a new era of productivity. As researchers near the widespread adoption of these powerful tools, we must assess their trajectory and the impact of their future developments.
Article
Autonomous flow reactors offer access to unique chemical synthesis conditions and characterizations with extremely low reagent consumption, tunable/reproducible heat- and mass-transfer rates, and high sampling rates, without the need for user intervention. Broader implementation of these self-guided, robo-fluidic technologies will accelerate the pa...
Article
Among all-inorganic metal halide perovskite quantum dots (PQDs), cesium lead chloride (CsPbCl3) with its large band-gap energy is an excellent candidate for enhancement of PQD radiative pathways through incorporation of additional internal energy transfer within its exciton band gap. In this study, we introduce a post-synthetic chemistry for ultraf...
Article
Green solvent utilization and recovery enabled by switchable hydrophilicity solvents (SHSs), using carbon dioxide as the switching trigger, offer intriguing advantages in sustainable chemistry. To further elevate SHSs, an intensified...
Article
Recently, slug-flow crystallizers (SFCs) have been proposed for continuous manufacturing of colloidal quantum dots (QDs). Despite the intriguing advantages of SFCs for controlled manufacturing of QDs, it has been difficult to account for the wide crystal size distribution (CSD) caused by slug-to-slug (S2S) variation, and the absence of a modeling a...
Article
Full-text available
In recent years, microfluidic technologies have emerged as a powerful approach for the advanced synthesis and rapid optimization of various solution‐processed nanomaterials, including semiconductor quantum dots and nanoplatelets, and metal plasmonic and reticular framework nanoparticles. These fluidic systems offer access to previously unattainable...
Article
A quaternary segmented flow regime for robust and flexible continuous biphasic chemical processes is introduced and characterized for stability and dynamic properties through over 1,500 automatically conducted experiments. The flow...
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Full-text available
Identifying the optimal formulation of emerging inorganic lead halide perovskite quantum dots (LHP QDs) with their vast colloidal synthesis universe and multiple synthesis/postsynthesis processing parameters is a challenging undertaking for material‐ and time‐intensive, batch synthesis strategies. Herein, a modular microfluidic synthesis strategy,...
Article
Inorganic lead halide perovskite quantum dots (QDs) have emerged as a promising semiconducting nanomaterial candidate for widespread applications, including next-generation solar cells, displays, and photocatalysts. The optoelectronic properties of colloidal QDs are majorly dictated by their bandgap energy (related to their size). Thus, it is impor...
Article
Developing luminescent materials with tunable emission colors provides exciting opportunities for application in the display, anti-counterfeiting, and optical sensors. Here, we report a convenient, versatile approach to synthesize color-tunable, up/down-conversion luminescence in an inorganic host material. The emission color can be tuned by varyin...
Article
Controlled synthesis of semiconductor nano/microparticles has attracted substantial attention for use in numerous applications from photovoltaics to photocatalysis and bioimaging due to the breadth of available physicochemical and optoelectronic properties. Microfluidic material synthesis strategies have recently been demonstrated as an effective t...
Article
Over the past 5 years, lead halide perovskite quantum dots (PQDs) have received significant attention due to their unique size-, composition-, and process-dependent optoelectronic properties, as well as their applications in energy and chemical technologies. However, the development pace of this remarkable class of semiconductor nanocrystals is hin...
Article
Colloidal quantum dots (QDs) have lately been pursued with intense vigor for optoelectronic applications such as photovoltaics (PV), flexible electronics, displays, mid-infrared photodetectors, lasers, and single photon emitters. These nanometer-sized semiconducting crystals can be suitably mass-produced and size-tuned via cost-effective solution-b...
Article
Metal-mediated chemical reactions have been a vital area of research for over a century. Recently, there has been increasing effort to improve the performance of metal-mediated catalysis by optimizing the structure and chemical environment of active catalytic species towards process intensification and sustainability. Network-supported catalysts us...
Article
Over the past decade, continuous flow reactors have emerged as a powerful tool for accelerated fundamental and applied studies of gas-liquid reactions, offering facile gas delivery and process intensification. In particular, unique features of highly gas-permeable tubular membranes in flow reactors (i.e., tube-in-tube flow reactor configuration) ha...
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Full-text available
In article number 2001626, Milad Abolhasani and co‐workers present an “Artificial Chemist”: a machine‐learning‐guided, self‐driving robot for on‐demand quantum dot synthesis. Flow chemistry is integrated with artificial‐intelligence‐driven experiment‐selection algorithms to autonomously conduct over 1400 unassisted experiments for accelerated synth...
Article
We present a reconfigurable flow chemistry strategy for facile transition between accelerated screening and continuous synthesis of linear aldehydes through homogeneous rhodium-catalyzed hydroformylation of 1-octene. The intensified mass and heat transport rates of the utilized membrane-based flow reactor enable access to safe and desirable reactio...
Article
Anhydrous microparticles, including a wide variety of organic and inorganic microspheres (e.g., silicone elastomers, metal oxides, metal organic frameworks), are attracting substantial attention for applications ranging from drug delivery to photocatalysis. Microfluidic materials synthesis techiques are an ideal approach for controlled synthesis of...
Article
Although a vital parameter in many colloidal nanomaterial syntheses, precursor mixing rates are typically inconsistent in batch processes and difficult to separate from reaction time in continuous flow systems. Here, we present a flow chemistry platform that decouples early-stage precursor mixing rates from reaction time (residence time) using sole...
Article
Developing light‐harvesting materials with tunable emission colors is highly desirable in applications requiring a specific color on‐demand. The modulation in material composition, structures, and polymerization can provide a useful tool for producing a wide range of emission colors. However, controlling the color gamut in a ready‐made material rem...
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Full-text available
Titania microspheres have attracted substantial attention for a variety of applications, including ion scavenging, catalysis, and energy generation, though most synthetic techniques are limited to a few basic morphologies and narrow size ranges. Here, an intensified microfluidic strategy for continuous synthesis of anatase titania microspheres is p...
Article
Tube-in-tube flow reactors are emerging as a highly efficient flow chemistry strategy for performing various types of gas-liquid reactions due to their unique characteristics, such as high specific interfacial area, enhanced mass transfer and mixing, reduced material consumption, and safe handling of toxic and flammable gases. In this article we di...
Article
In most chemical industries, solvent removal and recovery processes are heavily dependent on hazardous volatile solvents and energy-intensive distillation process due to its ease of separation. An emerging promising alternative is implementing switchable solvents with on-demand and reversible switching of their physiochemical properties triggered b...
Article
Recently, focus has turned towards increasing chemical process safety and sustainability for fundamental and applied research as well as manufacturing of pharmaceuticals and specialty chemicals. Flow chemistry techniques have attracted significant interest as a way to implement and improve chemical processes in order to satisfy the growing demand f...
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Full-text available
In article number 1900712, Milad Abolhasani and co‐workers introduce a modular microfluidic platform, QDExer (Quantum Dot Exchanger), which enables high‐throughput in situ monitoring of the massive parameter space associated with anion exchange reactions of colloidal perovskite quantum dots. QDExer offers a time‐ and material‐ efficient approach fo...
Article
Opportunities for accessible microfluidic device integration have sharply grown with the rise of readily available lab-in-a-tube strategies. Herein, we present a facile, non-invasive, plug-and-play phase velocity and length measuring strategy for rapid deployment onto tube-based microfluidic systems, enabling quick and accurate residence (reaction)...
Article
A microfluidic strategy is developed for continuous synthesis of monodisperse yolk-shell titania microspheres. The continuous flow synthesis of titania microparticles is achieved by decoupling the microdroplet formation and interfacial hydrolysis reaction steps by utilizing a polar aprotic solvent as the continuous phase in the microreactor. The de...
Article
Macroporous microbeads are synthesized by microfluidic production of silica-loaded polymeric microdroplets followed by porogen removal via selective etching. Microdroplets are produced in a flow-focusing microreactor to ensure monodispersity with uniform...
Article
We present an autonomous microscale flow chemistry platform for rapid performance evaluation of continuous and discrete reaction parameters in homogeneous hydroformylation reactions. We demonstrate the versatility of the developed microfluidic...
Article
Colloidal semiconductor nanocrystals, known as quantum dots (QDs), are a rapidly growing class of materials in commercial electronics, such as light emitting diodes (LEDs) and photovoltaics (PVs). Among this material group, inorganic/organic perovskites have demonstrated significant improvement and potential towards high-efficiency, low-cost PV fab...
Article
Palladium (Pd)-loaded poly-hydromethylsiloxane (PHMS) microparticles of tunable size and elasticity are prepared in a capillary-based coaxial flow-focusing microfluidic device constructed using off-the-shelf components. Simultaneous droplet formation and chemical cross-linking processes are performed by tuning the dilution of the cross-linking cata...
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Full-text available
Flow-induced alignment of shape-anisotropic colloidal particles is of great importance in fundamental research and in the fabrication of structurally anisotropic materials, however rheo-optical studies of shear-induced particle orientation are time- and labor-intensive and require complicated experimental setups. We report a single-droplet oscillat...
Article
Oscillatory flow reactors provide a surface energy-driven approach for automatically screening reaction conditions and studying reaction mechanisms of bi-phasic nanocrystal ligand exchange reactions. Sulfide and cysteine ligand exchange reactions with as-synthesized CdSe quantum dots (QDs) are chosen as two model reactions. Different reaction varia...
Article
Oscillatory flow reactors provide a surface energy-driven approach for automatically screening reaction conditions and studying reaction mechanisms of bi-phasic nanocrystal ligand exchange reactions. Sulfide and cysteine ligand exchange reactions with as-synthesized CdSe quantum dots (QDs) are chosen as two model reactions. Different reaction varia...
Article
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux possible with the platform is...
Article
We present an automated microfluidic platform for in-flow studies of visible-light photoredox catalysis in liquid or gas-liquid reactions at the 15 μL scale. An oscillatory flow strategy enables flexible residence time while preserving the mixing and heat transfer advantages of flow systems. The adjustable photon flux possible with the platform is...
Article
A deterministic model based on population balance equations is developed to describe the formation of II-VI semiconductor nanocrystals. After deriving the necessary equations and reviewing the link between model predictions and experimental results, a parametric study is carried out to showcase the model's features. A comparison with literature exp...
Article
We report an automated flow chemistry platform that can efficiently perform a wide range of chemistries, including single/multi-phase and single/multi-step, with a reaction volume of just 14 uL. The breadth of compatible chemistries are demonstrated on common medicinal chemistry transformations with integrated product characterization, isolation, a...
Article
Full-text available
One of the challenges in the development of green and sustainable chemical processing is solvent removal and subsequent replacement with another solvent in various steps of multistep syntheses, extraction, or purification. A promising alternative approach is the use of “switchable” solvents that change their properties on demand. The evaluation of...
Article
Continuous multiphase flow strategies are commonly employed for high-throughput parameter screening of physical, chemical, and biological processes as well as continuous preparation of a wide range of fine chemicals and micro/nano particles with processing times up to 10 min. The inter-dependency of mixing and residence times, and their direct corr...
Article
Liquid-liquid extraction is an important separation and purification method; however, it faces a challenge in reducing the energy consumption and the environmental impact of solvent (extractant) recovery. The reversible chemical reactions of switchable solvents (nitrogenous bases) with carbon dioxide (CO2) can be implemented in reactive liquid-liqu...
Article
Taking advantage of the difference between the surface energies of aqueous and organic solvents on a Teflon substrate, a fully automated small-scale strategy is developed based on gas-driven oscillatory motion of a bi-phasic slug for high-throughput in-situ measurement and screening of partition coefficients of organic substances between aqueous an...
Article
A detailed understanding of the scaling behavior associated with the fluid flow and the transport of gas molecules from a train of elongated gas plugs into neighboring liquid segments is of great importance for a broad range of microscale applications. The indirect dependence of the parameters affecting the Capillary and Peclet numbers and thereby...
Article
An automated two-phase small scale platform based on controlled oscillatory motion of a droplet within a 12 cm long tubular Teflon reactor is designed and developed for high-throughput in situ studies of a solution-phase preparation of semiconductor nanocrystals. The unique oscillatory motion of the droplet within the heated region of the reactor e...
Article
Nanoparticle (NP) dispersions are extensively used for the producing nanocomposite materials. Optimization of formulations of NP dispersions is a time- and labor-consuming process that can benefit from high-throughput preparation of composite materials, followed by studies of their structure–property relationships. This paper describes a microfluid...
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Full-text available
We study microreactors with internal fields of posts as typical examples of structured microreactors to elucidate flow fields and their implications for mass transfer. Laser-induced fluorescence (LIF) visualization combined with image analysis is used to systematically quantify key features such as interfacial area, phase holdup and the characteris...
Article
Full-text available
A multi-phase flow strategy, based on oscillatory motion of a bi-phasic slug within a fluorinated ethylene propylene (FEP) tubular reactor, under inert atmosphere, is designed and developed to address mixing and mass transfer limitations associated with continuous slug flow chemistry platforms for studies of bi-phasic catalytic reactions. The techn...
Conference Paper
Owing to the constant increase of the worldwide energy demand due to the growth of populations and development of countries, the emissions of greenhouse gases (mostly carbon dioxide (CO2)) from fossil fuels will constantly increase. Currently, carbon capture and sequestration is one of the most efficient solutions to control and reduce the concentr...
Article
Purpose: To determine the pressure required to prime an Ahmed Glaucoma Valve (AGV) and determine whether the valve can be damaged by "over-priming pressure." Methods: Three AGVs, a syringe pump, and a manometer were used to assess priming pressure. Balanced salt solution was pumped through the AGV tube at increasing pressures until a jet of flui...