Mikhail G Dozmorov

Mikhail G Dozmorov
Virginia Commonwealth University | VCU · Department of Biostatistics

41.42
 · 
PhD

About

203
Publications
12,488
Reads
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2,431
Citations
Research Experience
July 2012 - present
Oklahoma Medical Research Foundation
Position
  • Research Assistant Member
Description
  • Conducted two pilot projects; Designed and implemented novel algorithms for the epigenome data analysis (GenomeRunner); Supported dozens of diverse projects in all branches of Life Sciences requiring expertise in NGS data analysis;
May 2010 - July 2012
Oklahoma Medical Research Foundation
Position
  • Senior Research Scientist
Description
  • Implemented algorithms for functional prediction of unknown or poorly annotated gene; Conducted inter-disciplinary research in cancer, aging, autoimmunity, cell biology; Supervised and trained undergraduate students in genomics and programming.
June 2005 - May 2010
University of Oklahoma Health Sciences Center
Position
  • Postdoctoral fellow
Description
  • Investigating the role of extracellular matrix driving malignant or dormant cancer phenotypes; Microarray data analysis of signaling involved in tumor cells – extracellular matrix interactions.
Education
June 1999 - March 2005
University of Gothenburg
Field of study
  • Medical Biophysics
September 1995 - June 1997
Moscow Institute of Electronic Technology
Field of study
  • Physics and Chemistry
September 1990 - June 1995
Moscow Institute of Electronic Technology
Field of study
  • Microelectronics

Publications

Publications (203)
Article
Full-text available
Background: Breast cancer metastasis is driven by a profound remodeling of the cytoskeleton that enables efficient cell migration and invasion. Anillin is a unique scaffolding protein regulating major cytoskeletal structures, such as actin filaments, microtubules, and septin polymers. It is markedly overexpressed in breast cancer, and high anillin...
Article
Full-text available
Background: The three-dimensional (3D) structure of the genome plays a crucial role in gene expression regulation. Chromatin conformation capture technologies (Hi-C) have revealed that the genome is organized in a hierarchy of topologically associated domains (TADs), sub-TADs, and chromatin loops. Identifying such hierarchical structures is a crit...
Article
Full-text available
Bacillus anthracis, the causative agent of inhalation anthrax, is a serious concern as a bioterrorism weapon. The vegetative form produces two exotoxins: Lethal toxin (LT) and edema toxin (ET). We recently characterized and compared six human airway and alveolar-resident phagocyte (AARP) subsets at the transcriptional and functional levels. In this...
Article
Full-text available
To assess the types of salivary gland (SG) T cells contributing to Sjögren’s syndrome (SS), we evaluated SG T cell subtypes for association with disease features and compared the SG CD4+ memory T cell transcriptomes of subjects with either primary SS (pSS) or non-SS sicca (nSS). SG biopsies were evaluated for proportions and absolute numbers of CD4...
Article
Full-text available
Insulin-like growth factor binding protein-3 (IGFBP-3) is a p53 tumor suppressor-regulated protein and a major carrier for IGFs in circulation. Among six high-affinity IGFBPs, which are IGFBP-1 through 6, IGFBP-3 is the most extensively investigated IGFBP species with respect to its IGF/IGF-I receptor (IGF-IR)-independent biological actions beyond...
Article
e23561 Background: While Synovial Sarcoma (SS) only accounts for about 10% of soft tissue sarcomas (STS), or ~10,000 cases/year, ~4,000 of these will be fatal. Little benefit has been seen with newer combination chemotherapies and immune checkpoint inhibitors. SS is a transcription factor-driven cancer characterized by an t(X;18) chromosomal transl...
Article
Aging is associated with reduced liver function that may increase the risk for adverse drug reactions in older adults. We hypothesized that age-related changes to epigenetic regulation of genes involved in drug metabolism may contribute to this effect. We reviewed published epigenome-wide studies of human blood and identified the cytochrome P450 2E...
Article
Full-text available
Recent research using chromatin conformation capture technologies, such as Hi-C, has demonstrated the importance of topologically associated domains (TADs) and smaller chromatin loops, collectively referred hereafter as “interacting domains.” Many such domains change during development or disease, and exhibit cell- and condition-specific difference...
Article
Full-text available
Previous studies demonstrate an association between activation of the maternal immune system during pregnancy and increased risk of neurodevelopmental psychiatric conditions, such as schizophrenia and autism, in the offspring. Relatively recent findings also suggest that the gut microbiota plays an important role in shaping brain development and be...
Conference Paper
Triple negative breast cancer (TNBC) confers the poorest prognosis of the major subtypes of breast cancers, and often inflicts young, African-American and Hispanic women. Steadily improving survival in other subsets of breast cancers are attributed to the implementation of effective targeted therapies, which are non-chemotherapy drugs that target a...
Preprint
Full-text available
Chronic ocular inflammation is associated with many retinal degenerative diseases that result in vision loss. The immune-privileged environment and complex organization of retinal tissue allow for the retinas essential role in visual function processes, yet confound inquiries into cell-specific inflammatory effects that lead to retinal dysfunction...
Article
Full-text available
Background The seed and soil hypothesis was proposed over a century ago to describe why cancer cells (seeds) grow in certain organs (soil). Since then, the genetic properties that define the cancer cells have been heavily investigated; however, genomic mediators within the organ microenvironment that mediate successful metastatic growth are less un...
Article
Background and aims: Chronic diseases such as nonalcoholic fatty liver disease (NAFLD) and hepatocellular carcinoma (HCC) are associated with chronic inflammation. However, controversial reports as to the key cytokines involved in the process of chronic inflammation hinder development of targeted therapies for patients. This is because, chronic in...
Article
INTRODUCTION Specific genetic mutations are linked to clinical prognosis in gliomas. There has been increasing demand to understand the association between tissue biomarker expression and survival. Using patient-derived samples, WHO grade II-IV gliomas were evaluated by the protein-staining pattern of molecular markers of interest across tumor grad...
Article
Purpose Although survival rates for patients with localized breast cancer have increased, patients with metastatic breast cancer still have poor prognosis. Understanding key factors involved in promoting breast cancer metastasis is imperative for better treatments. In this study, we investigated the role of syndecan-1 (Sdc1) in breast cancer metast...
Conference Paper
Among HCC patients, there is a statistically significant increase in incidence and mortality as well as a decrease in 5-year survival rates in African-American (hereafter referred to as black) patients compared to non-Hispanic white (hereafter referred to as white) patients. Currently, there is a gap in our understanding of the molecular mechanism...
Conference Paper
Among HCC patients, there is a statistically significant increase in incidence and mortality as well as a decrease in 5-year survival rates in African-American (hereafter referred to as black) patients compared to non-Hispanic white (hereafter referred to as white) patients. Currently, there is a gap in our understanding of the molecular mechanism...
Article
It is unknown why some patients with hormone receptor–positive (HRþ) breast cancer present with more aggressive and invasive disease. Metastatic dissemination occurs early in disease and is facilitated by cross-talk between the tumor and tissue environment, suggesting that undefined host-intrinsic factors enhance early dissemination and the probabi...
Article
The three‐dimensional (3D) interactions of chromatin regulate cell‐type‐specific gene expression, recombination, X‐chromosome inactivation, and many other genomic processes. High‐throughput chromatin conformation capture (Hi‐C) technologies capture the structure of the chromatin on a global scale by measuring all‐vs.‐all interactions and can provid...
Article
As high fetal hemoglobin levels ameliorate the underlying pathophysiological defects in sickle cell anemia and beta (β)-thalassemia, understanding the mechanisms that enforce silencing of fetal hemoglobin postnatally offers the promise of effective molecular therapy. Depletion of the Nucleosome Remodeling and Deacetylase complex member MBD2 causes...
Preprint
Recently, long noncoding RNA (lncRNA) were implicated in the etiology of alcohol dependence (AD). As lncRNA provide another layer of complexity to the transcriptome, assessing their expression in the brain is the first critical step towards understanding lncRNA functions in AD. To that end, we profiled the expression of lncRNA and protein coding ge...
Preprint
Purpose: Although survival rates for patients with localized breast cancer have increased, patients with metastatic breast cancer still have poor prognosis. Understanding key factors involved in promoting breast cancer metastasis is imperative for better treatments. In this study, we investigated the role of syndecan-1 (Sdc1) in breast cancer metas...
Article
Full-text available
Human Dual-specificity tyrosine (Y) Regulated Kinase 1A (DYRK1A) is encoded by a dosage dependent gene whereby either trisomy or haploinsufficiency result in developmental abnormalities. However, the function and regulation of this important protein kinase are not fully understood. Here, we report proteomic analysis of DYRK1A in human cells that re...
Preprint
Full-text available
The three-dimensional (3D) structure of the genome plays a crucial role in regulating gene expression. Chromatin conformation capture technologies (Hi-C) have revealed that the genome is organized in a hierarchy of topologically associated domains (TADs), the fundamental building blocks of the genome. Identifying such hierarchical structures is a c...
Article
Adversity early in life is a reliable predictor of mood disorders which involve excessive innate immune signaling. However, the mechanisms by which early life adversity promotes inflammation are not yet fully understood. Using a chronic adolescent stress (CAS) model in rats, we hypothesized that a history of CAS exaggerates induction of the pro-inf...
Article
Motivation: With the development of chromatin conformation capture technology and its high-throughput derivative Hi-C sequencing, studies of the three-dimensional (3D) interactome of the genome that involve multiple Hi-C datasets are becoming available. To account for the technology-driven biases unique to each dataset, there is a distinct need fo...
Article
Full-text available
Background: Changes in spatial chromatin interactions are now emerging as a unifying mechanism orchestrating the regulation of gene expression. Hi-C sequencing technology allows insight into chromatin interactions on a genome-wide scale. However, Hi-C data contains many DNA sequence- and technology-driven biases. These biases prevent effective com...
Article
Full-text available
Modern research is increasingly data-driven and reliant on bioinformatics software. Publication is a common way of introducing new software, but not all bioinformatics tools get published. Giving there are competing tools, it is important not merely to find the appropriate software, but have a metric for judging its usefulness. Journal's impact fac...
Article
Full-text available
Treatment of glioblastoma (GBM) remains a challenge using conventional chemotherapy, such as temozolomide (TMZ), and is often ineffective as a result of drug resistance. We have assessed a novel nitrone-based agent, OKN-007, and found it to be effective in decreasing tumor volumes and increasing survival in orthotopic GBM xenografts by decreasing c...
Data
Microarray data of genes either up- or downregulated from rat F98 glioma-bearing tumor RNA samples that were treated with OKN-007 (T) and compared to those that were untreated (U).
Data
Ingenuity Pathways Analysis (IPA) of genes and associated pathways from microarray data of genes either up- (red) or down-regulated (green) from rat F98 glioma-bearing tumor RNA samples that were treated with OKN-007 (T) and compared to those that were untreated (U).
Article
Genome wide association studies (GWAS) for behavioral traits and psychiatric disorders have inspired both confident optimism and withering criticism. Although many recent findings from well powered GWAS have been replicated in independent data sets, the genes identified have pinned down few if any underlying causal mechanisms. Therefore, a key issu...
Article
Full-text available
Retinoic acid-inducible gene I (RIG-I) is an important regulator of virus-induced antiviral interferons (IFNs) and proinflammatory cytokines. It requires interaction with an adaptor molecule, mitochondrial antiviral-signaling protein (MAVS), to activate downstream signaling pathways. To elucidate the mechanism(s) by which RIG-I-dependent recognitio...
Article
Overexpression of the oncogene MYBL2 (B-Myb) is associated with increased cell proliferation and serves as a marker of poor prognosis in cancer. However, the mechanism by which B-Myb alters the cell cycle is not fully understood. In proliferating cells, B-Myb interacts with the MuvB core complex including LIN9, LIN37, LIN52, RBBP4, and LIN54, formi...
Article
Background Compared to non-surgical weight loss (Diet), weight loss after Roux-en-Y gastric bypass (RYGB) results in greater rates of non-alcoholic steatohepatitis (NASH) resolution. Changes in bile acid physiology and farnesoid X receptor (FXR) signaling are suspected mediators of postoperative NASH improvement. Recent experimental evidence sugges...
Article
Chronic inflammation is a known hallmark of cancer and is central to the onset and progression of hepatocellular carcinoma (HCC). Hepatic macrophages play a critical role in the inflammatory process leading to HCC. The oncogene Astrocyte elevated gene-1 (AEG-1) regulates NF-kappaB activation, and germline knockout of AEG-1 in mice (AEG-1-/-) result...
Article
Full-text available
BANK1 is a susceptibility gene for several systemic autoimmune diseases in several populations. Using the genome-wide association study (GWAS) data from Europeans (EUR) and African Americans (AA), we performed an extensive fine mapping of ankyrin repeats 1 (BANK1). To increase the SNP density, we used imputation followed by univariate and condition...
Article
Antipsychotic drugs, including both typical such as haloperidol and atypical such as clozapine, remain the current standard for schizophrenia treatment. These agents are relatively effective in treating hallucinations and delusions. However, cognitive deficits are at present essentially either persistent or exacerbated following chronic antipsychot...
Article
The oncogene MYBL2 (encoding B-Myb) is a poor prognostic biomarker in many cancers. B-Myb interacts with the MuvB core of five proteins (LIN9, LIN37, LIN52, LIN53/RBBP4, and LIN54) to form the MMB (Myb-MuvB) complex and promotes expression of late cell cycle genes necessary for progression through mitosis. Both MYBL2 amplification and over-expressi...
Article
A fundamental challenge of modern biomedical research is understanding how diseases that are similar on the phenotypic level are similar on the molecular level. Integration of various genomic data sets with the traditionally used phenotypic disease similarity revealed novel genetic and molecular mechanisms and blurred the distinction between monoge...
Preprint
Full-text available
Human DYRK1A gene encoding Dual-specificity tyrosine (Y)- Regulated Kinase 1A (DYRK1A) is a dosage-dependent gene whereby either trisomy or haploinsufficiency result in developmental abnormalities. However, the function and regulation of this important protein kinase are not fully understood. Here we report proteomic analysis of DYRK1A in human cel...
Article
High-risk neuroblastoma is often distinguished by amplification of MYCN and loss of differentiation potential. We performed high-throughput drug screening of epigenetic-targeted therapies across a large and diverse tumor cell line panel and uncovered the hypersensitivity of neuroblastoma cells to GSK-J4, a small-molecule dual inhibitor of lysine 27...
Article
Full-text available
Purpose Basal-like breast cancers are aggressive and often metastasize to vital organs. Treatment is largely limited to chemotherapy. This study aims to characterize the efficacy of cancer therapeutics in vitro and in vivo within the primary tumor and metastatic setting, using patient-derived xenograft (PDX) models. Methods We employed two basal-l...
Article
Full-text available
Preclinical studies demonstrate that environmentally-induced alterations in inflammatory cytokines generated by the maternal and fetal immune system can significantly impact fetal brain development. Yet, the relationship between maternal cytokines during gestation and later cognitive ability and executive function remains understudied. Children (n...
Article
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HER2 (ERBB2) amplification is a driving oncogenic event in breast cancer. Clinical trials have consistently shown the benefit of HER2 inhibitors (HER2i) in treating patients with both local and advanced HER2+ breast cancer. Despite this benefit, their efficacy as single agents is limited, unlike the robust responses to other receptor tyrosine kinas...
Article
48 Background: C-terminal binding protein 2 (CtBP2) is an oncogenic transcription factor that promotes cancer stem cell (CSC) growth and self-renewal, and controls pathways for tumor initiation, progression, and response to therapy. Expression of CtBP2 is linked to aggressive behavior in ovarian cancer, while genetic or pharmacologic targeting of C...
Data
Fig. S1 Definitions of sex difference and sex divergence. Fig. S2 Bisulfite Oligonucleotide Capture Sequencing (BOCS) method. Fig. S3 Bisulfite Oligonucleotide Capture Sequencing (BOCS) metrics. Fig. S4 Sample‐sample correlations. Fig. S5 Global mean methylation with age in female and male hippocampus.
Data
Data S1 Age‐related methylation differences at CG sites and CH sites.
Data
Data S2 Autosomal lifelong sex differences in CG and CH sites.
Article
Full-text available
Purpose: Epithelial-to-mesenchymal transition (EMT) confers resistance to a number of targeted therapies and chemotherapies. However, it has been unclear why EMT promotes resistance, thereby impairing progress to overcome it. Experimental design: We have developed several models of EMT-mediated resistance to EGFR inhibitors (EGFRi) in EGFR mutan...
Article
Motivation One of the goals of functional genomics is to understand the regulatory implications of experimentally obtained genomic regions of interest (ROIs). Most sequencing technologies now generate ROIs distributed across the whole genome. The interpretation of these genome-wide ROIs represents a challenge as the majority of them lie outside of...
Article
Full-text available
Genome-wide association studies (GWAS) have discovered thousands loci associated with disease risk and quantitative traits, yet most of the variants responsible for risk remain uncharacterized. The majority of GWAS-identified loci are enriched for non-coding single-nucleotide polymorphisms (SNPs) and defining the molecular mechanism of risk is chal...
Data
A step-by-step guide to reproducing this publication’s analyses and results. In this vignette, we provide data sources for DNase-seq data, ChIP-seq data, TCGA RNA-seq data, TCGA genotype data, TCGA phenotype data, breast cancer GWAS catalog information, and PSWM databases used in our study. We provide detailed documentation of the computational ana...
Data
A bundle of all the individual executable scripts we used in this publication. This zipped file contains the full set of R, Python, and Shell scripts used in this publication. (ZIP)
Data
TF expression correlates with patient outcome in a subtype-specific manner. High expression of IRF7, BATF, and TP73 is correlated with better breast cancer patient outcome in Luminal A, HER2+, and Basal-like subtype, respectively. TF expression groups are classified as either high or low expression and with the corresponding patient number is noted...
Data
Genotypic variants of rs8103622 affect CTCF binding in many cell types. ENCODE ChIP-seq data (top) indicates that CTCF is strongly bound in HMEC at rs8103622. The risk allele C of rs8103622 is predicted to increase CTCF binding, which was identified in round 33 of our de novo motif analysis from MCF7 (middle). By analyzing ENCODE ChIP-seq count dat...