Mikhail A Kiselev

Mikhail A Kiselev
Joint Institute for Nuclear Research | jinr ОИЯИ

doctor of science

About

24
Publications
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1,104
Citations

Publications

Publications (24)
Article
Full-text available
Liposomes are nano-sized spherical vesicles composed of an aqueous core surrounded by one (or more) phospholipid bilayer shells. Owing to their high biocompatibility, chemical composition variability, and ease of preparation, as well as their large variety of structural properties, liposomes have been employed in a large variety of nanomedicine and...
Article
Full-text available
The investigation of the structural features in biological membranes represents a central topic in many aspects of biological science. It involves the study of the collective behavior of a great number of interacting macromolecules, while the study of the structure-function relationship require the observation and calculation of a large number of k...
Article
Full-text available
Scattering techniques represent non-invasive experimental approaches and powerful tools for the investigation of structure and conformation of biomaterial systems in a wide range of distances, ranging from the nanometric to micrometric scale. More specifically, small-angle X-rays and neutron scattering and light scattering techniques represent well...
Article
Full-text available
The study of nanostructured drug delivery systems allows the development of novel platforms for the efficient transport and controlled release of drug molecules in the harsh microenvironment of diseased tissues of living systems, thus offering a wide range of functional nanoplatforms for smart application in biotechnology and nanomedicine. This art...
Article
Hydration of oriented multilamellar membrane based on ceramide [AP] in the DMSO, urea and ethanol aqueous solutions at various solute concentrations was investigated by neutron diffraction. Neither urea nor DMSO influence the repeat distance of the membrane and internal structure of bilayer at their mole concentration of up to 0.15 and 0.10, respec...
Conference Paper
The parallel Asynchronous Differential Evolution (ADE) method with adaptive correlation matrix (ACM) is utilized for numerical solution of the global minimization problem within the Separated Form Factors model (SFF) for analysis of structure of the drug-delivering phospholipid transport nanosystem (PTNS). In this framework, parameters of the SFF m...
Article
Interactions of charged nanoparticles with model bio-membranes provide important insights about the soft interaction involved and the physico-chemical parameters that influence lipid bilayers stability, thus providing key features of their cytotoxicity effects onto cellular membranes. With this aim, the self-assembly processes between polyamidoamin...
Article
Full-text available
Sodium cholate is a bile acid salt, which is applied as a biological detergent. The mixed systems of phospholipid/sodium cholate are used to study the self-assembly of micelles and formation of micellar systems. The micelles consisting of a phospholipid/sodium cholate mixture are used for drug delivery through the skin. An important part of the inv...
Article
Full-text available
Parameters of the phospholipid vesicular systems are determined by means of minimization of the discrepancy between experimental data on the small angle scattering intensity and the numerical results within the frame of the separated form factors method. Effectiveness of parallel implementation is tested at the cluster HybriLIT. Results of numerica...
Article
Full-text available
The development of smart nanocarriers for the delivery of therapeutic drugs has experienced considerable expansion in recent decades, with the development of new medicines devoted to cancer treatment. In this respect a wide range of strategies can be developed by employing liposome nanocarriers with desired physico-chemical properties that, by expl...
Article
The structure of a polydispersed population of unilamellar dimyristoylphosphatidylcholine (DMPC) vesicles in sucrose solutions has been investigated by small-angle neutron scattering (SANS) and small-angle X-ray scattering (SAXS). Calculations within the model of separated form factors (SFF) show that the structure of the vesicle system depends str...
Article
Full-text available
Amphiphiles are synthetic or natural molecules with the ability to self-assemble into a wide variety of structures including micelles, vesicles, nanotubes, nanofibers, and lamellae. Self-assembly processes of amphiphiles have been widely used to mimic biological systems, such as assembly of lipids and proteins, while their integrated actions allow...
Article
Small angle neutron scattering (SANS) and dynamic light scattering (DLS) were used to study different aggregation states in sodium deoxycholate (NaDC)-phosphatidylcholine systems at T = 60 degrees C. Size and shape of the aggregates investigated as a function of the NaDC bile salt concentration (at the constant DPPC concentration of 6 mM) indicate...
Article
Full-text available
We present a study which illustrates the modeling of the Particle Scattering Structure Factor from Small Angle X-ray Scattering (SAXS) data. The studied sample was a poly(amidoamine) Pamam dendrimers in water solution. The intra-particle form factor P(q) has been analyzed employing an inverse Fourier transformation which allows to obtain the partic...
Article
Small-angle neutron and X-ray scattering, dynamic light scattering, X-ray diffraction coupled with differential scanning calorimetry, and Raman spectroscopy were applied to investigate unilamellar (ULVs) and multilamellar (MLVs) dimyristoylphosphatidylcholine (DMPC) vesicles in aqueous sucrose solutions with sucrose concentrations from 0 to 60% w/w...
Article
Full-text available
Stable oil/water (o/w) microemulsions are very effective vehicle systems for dermal administration of drugs having no or low skin penetration. These systems, consisting of oils, a blend of a high and a low HLB surfactant, and a hydrophilic phase (propylene glycol/water), were developed using pharmaceutically acceptable components. In this paper, th...
Article
Full-text available
A novel method of evaluating SANS curves is presented which for the first time allows the simultaneous determination of the internal geometry and hydration of single bilayers in unilamellar vesicles at high water excess. A multistrip model unambiguously defines the water-free hydrophobic core of the membrane as a region where the neutron scattering...
Article
The IR absorption spectroscopy of binary dimethyl sulfoxide (DMSO)/water and ternary phospholipid/DMSO/water systems was applied to the study of DMSO–water and DMSO–phospholipid hydrogen bonds. It was established that DMSO create hydrogen bonds with water above DMSO molar fraction 0.1. The interaction between DMSO and water molecules is stronger co...

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