Mikhail Kapralov

Mikhail Kapralov
Joint Institute for Nuclear Research | jinr ОИЯИ · Laboratory of Radiation Biology

Engineer physicist

About

12
Publications
3,215
Reads
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235
Citations
Citations since 2016
9 Research Items
227 Citations
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
201620172018201920202021202201020304050
Introduction
Astrobiology. Study of the formation of the first prebiotic biomolecules from the simpler compounds under the radiation condition using meteorites as a catalysts of synthesis Study of meteorites using a scanning electron microscope Study of terrestrial objects of biological origin
Skills and Expertise
Additional affiliations
January 2016 - present
Dubna International University for Nature, Society, and Man
Position
  • Senior Lecturer
Description
  • I teach a course of lectures on astrobiology
Education
September 2007 - February 2013

Publications

Publications (12)
Article
Full-text available
Di-glycosylated adenines act as glycosyl donors in the intermolecular trans-glycosylation of pyrimidine nucleobases under proton beam irradiation conditions. Formamide and chondrite meteorite NWA 1465 increased the yield and the selectivity of the reaction. The glycosyl transfer process was highly regioselective in yielding canonical N 1-pyrimidine...
Article
Full-text available
The Orgueil meteorite was studied using a TESCAN VEGA 3 scanning electron microscope. As a result, new microfossils were found, including a fragment of a pennate diatom shell, tubular structures with double porous cell walls (prasinophytes?), hollow spheres with a process (acritarchs?), and spore-like structures. The problem of the cometary origin...
Book
Full-text available
The results of thorough bacterialpaleontological study of the Orgueil meteorite are presented in this illustrated Atlas of microfossils (both prokaryotic and eukaryotic) found within freshly fractured interior surfaces of the meteorite. More than 60 images obtained with Scanning Electron Microscope are presented.
Article
Formation and structural modification of oxygenated polycyclic aromatic hydrocarbons (oxyPAHs) by UV irradiation on minerals have recently been proposed as a possible channel of PAH transformation in astrochemical and prebiotic scenarios of possible relevance for the origin of life. Herein, we demonstrate that high energy proton beam irradiation in...
Article
Full-text available
The abiotic phosphorylation of nucleosides is a major hurdle in origin‐of‐life studies. We suggest a plausible pathway for the synthesis of adenosine nucleotides from adenosine and NaH2PO4 under radiative conditions mimicking the solar wind in the presence of a meteorite of the aubrite‐type. Hydroxyapatite also performed as a mineral heterogeneous...
Article
Full-text available
The formation of nucleosides in abiotic conditions is a major hurdle in origin-of-life studies. We have determined the mechanism of a general reaction leading to the one-pot synthesis of ribo- and 2’-deoxy-ribonucleosides from sugars and purine nucleobases under proton irradiation in the presence of a chondrite meteorite. These conditions simulate...
Article
Full-text available
We report the discovery of frustules of pennate diatoms embedded in a freshly fractured interior surface of the Orgueil CI1 carbonaceous meteorite. Images and element composition by Energy Dispersive X-ray Spectroscopy were obtained with the TESCAN VEGA 3 Scanning Electron Microscope (SEM) in the Astrobiology Sector of the Laboratory of Radiation B...
Article
We report that 3',5' cyclic CMP undergoes non-enzymatic di- and trimerization at 20°C under dry conditions upon proton- or UV irradiation. The reaction involves stacking of the cyclic monomers and subsequent polymerization by serial transphosphorylations between the stacked monomers. Proton- and UV-induced oligomerization of 3',5' cyclic CMP demons...
Article
Full-text available
Formamide (NH2CHO) has been irradiated in condensed phase at 273 K by 11B-boron beams in the presence of powdered meteorites of the chondrite and stony-iron types. Relative to the controls (no radiation or no catalysis), a variegate panel of compounds was observed, including purine and pyrimidine nucleobases (uracil, cytosine, adenine, and guanine)...
Article
Full-text available
Significance Modern research on the origin of life started with Urey–Miller’s 1953 report on the spontaneous formation of amino acids upon application of electric discharge on a model of the pristine Earth atmosphere. Formamide provides a chemically sound starting material for the syntheses of prebiotic compounds; its role in prebiotics is becoming...
Article
Full-text available
The paper presents a mathematical model of the DNA mismatch repair system in Escherichia coli bacterial cells. The key pathways of this repair mechanism were simulated on the basis of modern experimental data. We have modelled in detail five main pathways of DNA misincorporation removal with different DNA exonucleases. Here we demonstrate an applic...

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