Mikel L. Sáez de Asteasu

• Postdoctoral researcher
• PhD at Navarrabiomed, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona (Spain)

Background Hospitalisation often results in adverse effects in older adults, particularly an increased risk of functional and cognitive decline. Although in-hospital exercise interventions have shown benefits, their impact on intrinsic capacity (IC) remains unknown. Objective To assess the effects of multicomponent exercise training on IC in acute...

Background Inpatient hospitalisation is associated with adverse outcomes in older adults, including hospital-associated deconditioning. The hospital-at-home (HaH) model may promote physical activity. This systematic review and meta-analysis compares functional outcomes between inpatient and HaH settings and evaluates the efficacy of exercise inter...

Aging, a universal and inevitable process, is characterized by a progressive accumulation of physiological alterations and functional decline over time, leading to increased vulnerability to diseases and ultimately mortality as age advances. Lifestyle factors, notably physical activity (PA) and exercise, significantly modulate aging phenotypes. Phy...

Background Hospitalization exacerbates sarcopenia and physical dysfunction in older adults. Whether tailored inpatient exercise prevents acute sarcopenia is unknown. This study aimed to examine the effect of a multicomponent exercise programme on muscle and physical function in hospitalized older adults. We hypothesized that participation in a brie...

Background This study aimed to determine the threshold of muscle power and strength enhancements that lead to functional gains after exercise intervention in an acute care unit. Methods A total of 302 older patients (intervention: 169, control: 133) from two randomized clinical trials were included (mean age 86.7 years). We measured maximal streng...

INTRODUCTION: Physical function characteristics of cognitively-unimpaired (CU) older adults at high risk of dementia are not comprehensively described. Sex may have a role in the effect of physical performance on cognition. This study aims to describe the sociodemographic and clinical characteristics of CU older adults at risk of dementia, and to...

Introduction Recent studies have suggested that sustained multidomain interventions, including physical exercise, may be beneficial in preventing cognitive decline. This review aims to assess the impact of prolonged physical exercise and multidomain strategies on overall cognitive faculties and dementia risk among community-dwelling older adults wi...

BACKGROUND: Accumulating evidence supports the notion that dementia is a multifactorial condition with various risk factors and causes. The Finnish Geriatric Intervention Study to Prevent Cognitive Impairment and Disability (FINGER) demonstrated that lifestyle interventions could confer cognitive benefits. Inspired by this, the GOIZ-ZAINDU (GZ) fea...

Background Regular exercise reduces chronic disease risk and extends a healthy lifespan, but the underlying molecular mechanisms remain unclear. DNA methylation is implicated in this process, potentially altering gene expression without changing DNA sequence. However, previous findings appear partly contradictory. Objective This review aimed to el...

Background and Objectives Exercise may reverse functional decline in hospitalized older adults, but the optimal duration is unclear. This study examined the potential relationship between in-hospital multicomponent exercise program duration and changes in physical function, cognition, and muscle function to maximize exercise-related health benefits...

Background Physical function profiles of older adults (≥ 60years) cognitively unimpaired but at high risk of dementia (CAIDE dementia risk score ≥6) have not been well described. The CAIDE index evaluates both modifiable, cardiovascular (CVRF), and non‐modifiable risk factors such as age, sex and educational level. The association of these factors...

Background The FINGER study demonstrated the efficacy of a non‐pharmacological multidomain intervention to prevent cognitive decline in at‐risk older adults. After a successful pilot feasibility study, in Q3 2021 we launched the CITA GO‐ON study, inspired by FINGER methodology to demonstrate the efficacy of a risk factor and lifestyles multimodal i...

Background Bed rest during hospitalization can negatively impact functional independence and clinical status of older individuals. Strategies focused on maintaining and improving muscle function may help reverse these losses. This study investigated the effects of a short‐term multicomponent exercise intervention on maximal strength and muscle powe...

Objetivos La actividad física (AF) y la función física (FF) podrían tener un efecto modulador de la patogenia de la enfermedad de Alzheimer (EA). El objetivo es explorar la relación entre AF o FF y biomarcadores de LCR en estadios precoces de la enfermedad. Material y métodos Estudio transversal con reclutamiento desde una cohorte de base poblaci...

Background Power training (PT) has been shown to be an effective method for improving muscle function, including maximal strength, measured by one-repetition maximum (1RM), and power output in older adults. However, it is not clear how PT intensity, expressed as a percentage of 1RM, affects the magnitude of these changes. The aim of this systematic...

Cancer mostly affects older adults, causing a wide variety of diagnostic and therapeutic dilemmas. One of the most important moments in cancer patients is the hospitalization period, in which older patients usually remain bedridden for many hours and this may lead to the appearance of sarcopenia and disability. We present the research protocol for...

Delirium is a neuropsychiatric syndrome associated with increased morbidity and mortality in older patients. The aim of this study was to review predictive biomarkers of delirium in older patients to gain insights into the pathophysiology of this syndrome and provide guidance for future studies. Two authors independently and systematically searched...

The aim of the present study was to investigate the association between handgrip strength and mortality in Brazilian frail nonagenarians and centenarians. Eighty-one oldest old were included (mean age [SD]: 94.2 [3.8] years). Data on strength was assessed by handgrip strength. Mortality rate of the participants was evaluated at 1-year follow-up aft...

Background Different multimorbidity patterns present with different prognoses, but it is unknown to what extent they may influence the effectiveness of an individualized multicomponent exercise program offered to hospitalized older adults. Methods This study is a secondary analysis of a randomized controlled trial conducted in the Department of Ge...

Delirium is an important cause of morbidity and mortality in older adults admitted to hospital. Multicomponent interventions targeting delirium risk factors, including physical exercise and mobilization, have been shown to reduce delirium incidence by 30–40% in acute care settings. However, little is known about its role in the evolution of deliriu...

Delirium is a transient neurocognitive disorder. Nonpharmacological measures can be efficient in reducing the incidence and intensity of delirium, but there is a paucity of evidence when using a physical exercise program exclusively. This was a secondary analysis of a randomised clinical trial that provided evidence on the functional and cognitive...

This study aimed to investigate the interindividual responses following two different concurrent training (CT) regimens in neuromuscular, cardiorespiratory and functional outcomes of older men. Thirty-five older men (65.8 ± 3.9 years) were randomly allocated into one of two CT groups: power training (PT) + high-intensity interval training (HIIT) (n...

It is known that muscle strength is associated with adverse health outcomes associated with cancer-related symptoms. The purpose of this study was to investigate the association between handgrip strength and cancer in frail oldest old. In this prospective cohort study, 81 nonagenarians and centenarians were included [mean age (SD): 94.2 (3.8) years...

Background Acute care hospitalization increases the likelihood of developing cognitive impairment and delirium in older adults. Objective To summarize evidence about the effectiveness of exercise and physical rehabilitation interventions on the incidence of delirium and cognitive impairment in acutely hospitalized older patients. Methods Relevant...

Background Physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vivi...

Background: Hospitalisation-associated disability due to reduced physical activity levels and prolonged bedrest episodes are highly prevalent in older adults. Objective: To assess the effect of gamified interventions on functional capacity in hospitalised older adults. Methods: A three-armed non-randomised controlled trial with two experimental int...

This randomized clinical trial examines the effectiveness and generalizability of implementing a multicomponent exercise program for treating functional decline associated with acute hospitalization in very old patients.

Identifying serum biomarkers that can predict physical frailty in older adults would have tremendous clinical value for primary care, as this condition is inherently related to poor quality of life and premature mortality. We compared the serum lipid profile of physically frail and robust older adults to identify specific lipid biomarkers that coul...

This study framed within the APTITUDE project presents the results of the baseline evaluations prior to a multicomponent intervention in community patients. The objective is to promote skills related to five different domains (physical exercise, nutrition, psychosocial problems, prevention of cognitive impairment and medication review). The study i...

The aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40years old and over. A cross‑sectional study was performed with 2861 adults from the US National Health and Nutrition Examination Survey NHANES (2013–2014). An 8‑item odor...

Background: Lung cancer is the second most prevalent common cancer in the world and predominantly affects older adults. This study aimed to examine the impact of an exercise programme in the use of health resources in older adults and to assess their changes in frailty status. Design: This is a secondary analysis of a quasi-experimental study wi...

Introduction: The inverse association between cardiorespiratory fitness and all-cause mortality in apparently healthy populations has been previously reported; however, the existence of this association among adults diagnosed with cancer is unclear. Aim: To determine the association between cardiorespiratory fitness and all-cause mortality in ad...

There is emerging evidence that emphasizes RDW as an optimal prognostic biomarker for cardiovascular diseases. However, there is hardly any evidence of interventions that are capable of modifying RDW. Our aim was to investigate the association of RDW levels and the response to an individualized exercise program in hospitalized older adults. To our...

https://blogs.bmj.com/bjsm/2021/03/06/vivifrail-a-multi-component-physical-training-program-to-prevent-weakness-and-falls-in-people-over-70-years/

Concurrent training (CT) is an efficient strategy to improve neuromuscular function and cardiorespiratory fitness in older adults, which are factors of pivotal importance for the maintenance of functional capacity with aging. However, there is a lack of evidence about the effectiveness of power training (PT) as an alternative to traditional strengt...

The early identification of seniors at high risk of geriatric syndromes is fundamental for targeting interventions to those who most need them. To date, the predictive value of the Short Physical Performance Battery (SPPB) for multifactorial clinical conditions has not been clearly established. Thus, the aim of the present study was to determine wh...

Background: During the period of hospitalization patients can develop functional decline. The main aim of our study was to assess the natural trajectory of each Activity of Daily Living (ADL) and to assess how in-hospital exercise could influence short-term trajectory of ADLs. Methods: Acutely hospitalized patients (n=297, 56.5% women) were random...

Acute medical illness and subsequent hospitalization are associated with several negative health consequences in older adults, even when the acute disease that caused the hospital admission is successfully treated. Loss of function in activities of daily living following hospitalization increases the risk of new disabilities, hospital readmissions,...

The purpose of this systematic review and meta-analysis was to appraise the acute effects of exercise training on inflammatory parameters in hospitalized older adults. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Web of Science, Medline and PubMed were searched for studies...

Introduction: Clinically viable screening tools for detecting individuals at heightened risk for mobility limitations is warranted. However, it remains unclear in acutely hospitalized patients (> 75 years) whether handgrip strength might be a good predictor for "proxy" muscle strength. Objective: To examine the reliability and validity of handgrip...

Background: Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective: The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and a...

Background Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and al...

Valoración Funcional para el programa multicomponente VIVIFRAIL https://www.youtube.com/watch?v=pHa3c49NbgI&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas con Limitación grave (No pueden levantarse de la silla https://www.youtube.com/watch?v=hYSzR-FJ0zc&feature=youtu.be

Entrenamiento para realizar en la calle Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras https://www.youtube.com/watch?v=9-JSxU264Wo&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas con limitación leve (dificultad para levantarse 5 veces de la silla) [Vídeo] https://www.youtube.com/watch?v=MJG3NVJw_PA&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas Robustas https://www.youtube.com/watch?v=G-xXnK99nJM&feature=youtu.be

Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras [Vídeo] https://www.youtube.com/watch?v=MOciUVK8N8c&feature=youtu.be

Entrenamiento para realizar en casa Programa multicomponente VIVIFRAIL para personas con Limitaciones para caminar y levantarse de la silla https://www.youtube.com/watch?v=I_tWOFY8sJ0&feature=youtu.be

OBJECTIVE To analyze the effects of a tailored exercise intervention in acutely hospitalized oldest old diabetic patients. RESEARCH DESIGN AND METHODS This is an ancillary analysis of a randomized controlled trial. 103 acutely hospitalized older adults (mean age ~87 years) with type II diabetes were randomized to an intervention (exercise, n=54) or...

The aim of this article is to present the research protocol for a study that will evaluate the feasibility of implementation of Health Arcade prototype multidomain intervention based on physical and cognitive training using gamification technologies at improving care for older people hospitalized with an acute illness. A total of 40 older people wi...

Objectives: To examine the effectiveness of game-based interventions compared with usual care on health-related outcomes for acutely hospitalized older patients. Design: Systematic review of randomized controlled trials (RCT) and nonrandomized trials. Setting and Participants: Adults aged 65 years or older admitted to an Acute Care for Elderly uni...

Objectives: An individualized, multicomponent exercise program is effective to reverse the functional and cognitive decline that frequently occur during acute care hospitalization in old patients. The aim was to determine whether improvements in cognition mediate improvements in physical function in acutely hospitalized older patients. Design: A s...

Background: Aging-related traits, including gradual loss of skeletal muscle mass and chronic inflammation, are linked to altered body composition and impaired physical functionality, which are important contributing factors to the disabling process. We sought to explore the potential relationship between lower-body muscle strength decline and infla...

This study investigated the effects of concurrent training performed either with repetitions to failure or not to failure in muscle power, muscle quality (MQ), peak oxygen uptake (VO2peak), and visceral fat in older men. This is an ancillary analysis of a randomized controlled trial. 36 older men (mean age ± SD; 67.1 ± 5.1 years) were randomized in...

Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalized patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualized exercise program on the functional capacity of acutely hospitalized o...

Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalised patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualised exercise program on the functional capacity of acutely hospitalised o...

Background Physical exercise is beneficial to reduce the risk of several conditions associated with advanced age, but to our knowledge, no previous study has examined the association of long-term exercise interventions (≥ 1 year) with the occurrence of dropouts due to health issues and mortality, or the effectiveness of physical exercise versus usu...

The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect...

Background A classic consequence of short‐term bed rest in older adults is the significant loss in skeletal muscle mass and muscle strength that underlies the accelerated physical performance deficits. Structured exercise programmes applied during acute hospitalization can prevent muscle function deterioration. Methods A single‐blind randomized cl...

Background: The short physical performance battery (SPPB) is a physical performance test of lower extremity function designed for non-disabled older adults. We aimed to establish reference values for community-dwelling Colombian adults aged 60 years or older in terms of (1) the total score; (2) the three subtest scores (walking speed, standing bala...

Introduction: The VIVIFRAIL project update is based on the idea that health in the elderly must be measured in terms of function and not as a disease that determines life expectancy, quality of life and the resources that each population needs. The objective is to maintain the level of functionality that ensures the highest degree of autonomy possi...

Introduction: Nosocomial disability generated during a hospitalization can have devastating consequences. Our team already developed an intervention based on physical exercise. Therefore, we have developed another strategy to encourage walking and cognitive tasks in a complementary way to the exercise program. Methods: An environmental modification...

Introduction: A recent randomized clinical trial has shown that a multicomponent physical exercise intervention is safe and effective to reverse the functional decline associated with acute hospitalization in very elderly patients [1]. Physical exercise is associated with physiological, biochemical or metabolic changes that could be translated into...

Background: Exercise protocols applied during hospitalization can prevent functional and cognitive decline in older adults. The purpose of this study was to examine the individual response of acutely hospitalized patients to usual care and to physical exercise on functional capacity, muscle strength, and cognitive function and to assess the relatio...

Background Acute illness requiring hospitalization frequently is a sentinel event leading to long-term disability in older people. Prolonged bed rest increases the risk of developing cognitive impairment and dementia in acutely hospitalized older adults. Exercise protocols applied during acute hospitalization can prevent functional decline in older...

Background: The benefit of physical exercise in ageing and particularly in frailty has been the aim of recent research. Moreover, physical activity in the elderly is associated with a decreased risk of mortality, of common chronic illnesses (i.e. cardiovascular disease or osteoarthritis) and of institutionalization as well as with a delay in functi...

Introduction: Both frailty and mild cognitive impairment are prevalent issues among the geriatric population but have traditionally been evaluated on separate terms. Given the growing evidence that these two conditions might share a biological substrate, interventions aiming to improve physical function might as well induce benefits on cognitive fu...

XVIII Congreso Zahartzaroa y XI Congreso de la Sociedad Navarra de Geriatría y Gerontología.

Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g., gait ability...

Objectives: To evaluate the effects of an exercise intervention on physical function, maximal muscle strength and muscle power in very old hospitalized patients. Design: In a randomized controlled trial, 130 hospitalized patients were allocated to an exercise intervention (n=65) or a control group (n=65). The intervention consisted of a multicompon...

Importance Functional decline is prevalent among acutely hospitalized older patients. Exercise and early rehabilitation protocols applied during acute hospitalization can prevent functional and cognitive decline in older patients. Objective To assess the effects of an innovative multicomponent exercise intervention on the functional status of this...