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Mikel L. Sáez de Asteasu

Mikel L. Sáez de Asteasu
Navarrabiomed, Universidad Pública de Navarra (UPNA), IdiSNA, Pamplona (Spain)

Postdoctoral researcher

About

93
Publications
15,473
Reads
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1,117
Citations
Citations since 2017
83 Research Items
1114 Citations
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2017201820192020202120222023050100150200250300350
2017201820192020202120222023050100150200250300350
Additional affiliations
April 2016 - present
Universidad Pública de Navarra
Position
  • PhD Student

Publications

Publications (93)
Article
Full-text available
Background Different multimorbidity patterns present with different prognoses, but it is unknown to what extent they may influence the effectiveness of an individualized multicomponent exercise program offered to hospitalized older adults. Methods This study is a secondary analysis of a randomized controlled trial conducted in the Department of Ge...
Article
Full-text available
Delirium is an important cause of morbidity and mortality in older adults admitted to hospital. Multicomponent interventions targeting delirium risk factors, including physical exercise and mobilization, have been shown to reduce delirium incidence by 30–40% in acute care settings. However, little is known about its role in the evolution of deliriu...
Article
Full-text available
Delirium is a transient neurocognitive disorder. Nonpharmacological measures can be efficient in reducing the incidence and intensity of delirium, but there is a paucity of evidence when using a physical exercise program exclusively. This was a secondary analysis of a randomised clinical trial that provided evidence on the functional and cognitive...
Article
This study aimed to investigate the interindividual responses following two different concurrent training (CT) regimens in neuromuscular, cardiorespiratory and functional outcomes of older men. Thirty-five older men (65.8 ± 3.9 years) were randomly allocated into one of two CT groups: power training (PT) + high-intensity interval training (HIIT) (n...
Article
It is known that muscle strength is associated with adverse health outcomes associated with cancer-related symptoms. The purpose of this study was to investigate the association between handgrip strength and cancer in frail oldest old. In this prospective cohort study, 81 nonagenarians and centenarians were included [mean age (SD): 94.2 (3.8) years...
Article
Background: Acute care hospitalization increases the likelihood of developing cognitive impairment and delirium in older adults. Objective: To summarize evidence about the effectiveness of exercise and physical rehabilitation interventions on the incidence of delirium and cognitive impairment in acutely hospitalized older patients. Methods: Re...
Article
Full-text available
Background: Physical exercise is an effective strategy for preserving functional capacity and improving the symptoms of frailty in older adults. In addition to functional gains, exercise is considered to be a cornerstone for enhancing cognitive function in frail older adults with cognitive impairment and dementia. We assessed the effects of the Vi...
Article
Background: Hospitalisation-associated disability due to reduced physical activity levels and prolonged bedrest episodes are highly prevalent in older adults. Objective: To assess the effect of gamified interventions on functional capacity in hospitalised older adults. Methods: A three-armed non-randomised controlled trial with two experimental int...
Article
This randomized clinical trial examines the effectiveness and generalizability of implementing a multicomponent exercise program for treating functional decline associated with acute hospitalization in very old patients.
Article
Full-text available
Identifying serum biomarkers that can predict physical frailty in older adults would have tremendous clinical value for primary care, as this condition is inherently related to poor quality of life and premature mortality. We compared the serum lipid profile of physically frail and robust older adults to identify specific lipid biomarkers that coul...
Poster
This study framed within the APTITUDE project presents the results of the baseline evaluations prior to a multicomponent intervention in community patients. The objective is to promote skills related to five different domains (physical exercise, nutrition, psychosocial problems, prevention of cognitive impairment and medication review). The study i...
Article
Full-text available
Introduction: The inverse association between cardiorespiratory fitness and all-cause mortality in apparently healthy populations has been previously reported; however, the existence of this association among adults diagnosed with cancer is unclear. Aim: To determine the association between cardiorespiratory fitness and all-cause mortality in ad...
Article
Full-text available
The aim of this study was to determine whether handgrip strength attenuates the negative relationship between age and olfactory function in a representative US population sample 40years old and over. A cross‑sectional study was performed with 2861 adults from the US National Health and Nutrition Examination Survey NHANES (2013–2014). An 8‑item odor...
Article
There is emerging evidence that emphasizes RDW as an optimal prognostic biomarker for cardiovascular diseases. However, there is hardly any evidence of interventions that are capable of modifying RDW. Our aim was to investigate the association of RDW levels and the response to an individualized exercise program in hospitalized older adults. To our...
Technical Report
https://blogs.bmj.com/bjsm/2021/03/06/vivifrail-a-multi-component-physical-training-program-to-prevent-weakness-and-falls-in-people-over-70-years/
Article
Concurrent training (CT) is an efficient strategy to improve neuromuscular function and cardiorespiratory fitness in older adults, which are factors of pivotal importance for the maintenance of functional capacity with aging. However, there is a lack of evidence about the effectiveness of power training (PT) as an alternative to traditional strengt...
Article
The early identification of seniors at high risk of geriatric syndromes is fundamental for targeting interventions to those who most need them. To date, the predictive value of the Short Physical Performance Battery (SPPB) for multifactorial clinical conditions has not been clearly established. Thus, the aim of the present study was to determine wh...
Article
Background: During the period of hospitalization patients can develop functional decline. The main aim of our study was to assess the natural trajectory of each Activity of Daily Living (ADL) and to assess how in-hospital exercise could influence short-term trajectory of ADLs. Methods: Acutely hospitalized patients (n=297, 56.5% women) were random...
Article
Acute medical illness and subsequent hospitalization are associated with several negative health consequences in older adults, even when the acute disease that caused the hospital admission is successfully treated. Loss of function in activities of daily living following hospitalization increases the risk of new disabilities, hospital readmissions,...
Article
Full-text available
The purpose of this systematic review and meta-analysis was to appraise the acute effects of exercise training on inflammatory parameters in hospitalized older adults. We conducted a systematic review using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. Web of Science, Medline and PubMed were searched for studies...
Article
Background: Lung cancer is the second most prevalent common cancer in the world and predominantly affects older adults. This study aimed to examine the impact of an exercise programme in the use of health resources in older adults and to assess their changes in frailty status. Design: This is a secondary analysis of a quasi-experimental study wi...
Article
Introduction: Clinically viable screening tools for detecting individuals at heightened risk for mobility limitations is warranted. However, it remains unclear in acutely hospitalized patients (> 75 years) whether handgrip strength might be a good predictor for "proxy" muscle strength. Objective: To examine the reliability and validity of handgrip...
Article
Background: Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective: The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and a...
Article
Background Physical function is an independent predictor of numerous chronic diseases, but its association with all-cause mortality in older adults diagnosed with cancer has received little attention. Objective The aim of this study was to conduct a systematic review and meta-analysis on the prospective association between physical function and al...
Presentation
Valoración Funcional para el programa multicomponente VIVIFRAIL https://www.youtube.com/watch?v=pHa3c49NbgI&feature=youtu.be
Presentation
Programa multicomponente VIVIFRAIL para personas con Limitación grave (No pueden levantarse de la silla https://www.youtube.com/watch?v=hYSzR-FJ0zc&feature=youtu.be
Presentation
Entrenamiento para realizar en la calle Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras https://www.youtube.com/watch?v=9-JSxU264Wo&feature=youtu.be
Presentation
Programa multicomponente VIVIFRAIL para personas con limitación leve (dificultad para levantarse 5 veces de la silla) [Vídeo] https://www.youtube.com/watch?v=MJG3NVJw_PA&feature=youtu.be
Presentation
Programa multicomponente VIVIFRAIL para personas Robustas https://www.youtube.com/watch?v=G-xXnK99nJM&feature=youtu.be
Presentation
Programa multicomponente VIVIFRAIL para personas mayores de 70 años que puedan caminar y subir escaleras [Vídeo] https://www.youtube.com/watch?v=MOciUVK8N8c&feature=youtu.be
Presentation
Entrenamiento para realizar en casa Programa multicomponente VIVIFRAIL para personas con Limitaciones para caminar y levantarse de la silla https://www.youtube.com/watch?v=I_tWOFY8sJ0&feature=youtu.be
Article
OBJECTIVE To analyze the effects of a tailored exercise intervention in acutely hospitalized oldest old diabetic patients. RESEARCH DESIGN AND METHODS This is an ancillary analysis of a randomized controlled trial. 103 acutely hospitalized older adults (mean age ~87 years) with type II diabetes were randomized to an intervention (exercise, n=54) or...
Article
Full-text available
The aim of this article is to present the research protocol for a study that will evaluate the feasibility of implementation of Health Arcade prototype multidomain intervention based on physical and cognitive training using gamification technologies at improving care for older people hospitalized with an acute illness. A total of 40 older people wi...
Article
Objectives: To examine the effectiveness of game-based interventions compared with usual care on health-related outcomes for acutely hospitalized older patients. Design: Systematic review of randomized controlled trials (RCT) and nonrandomized trials. Setting and Participants: Adults aged 65 years or older admitted to an Acute Care for Elderly uni...
Article
Objectives: An individualized, multicomponent exercise program is effective to reverse the functional and cognitive decline that frequently occur during acute care hospitalization in old patients. The aim was to determine whether improvements in cognition mediate improvements in physical function in acutely hospitalized older patients. Design: A s...
Article
Background: Aging-related traits, including gradual loss of skeletal muscle mass and chronic inflammation, are linked to altered body composition and impaired physical functionality, which are important contributing factors to the disabling process. We sought to explore the potential relationship between lower-body muscle strength decline and infla...
Article
This study investigated the effects of concurrent training performed either with repetitions to failure or not to failure in muscle power, muscle quality (MQ), peak oxygen uptake (VO2peak), and visceral fat in older men. This is an ancillary analysis of a randomized controlled trial. 36 older men (mean age ± SD; 67.1 ± 5.1 years) were randomized in...
Article
Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalized patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualized exercise program on the functional capacity of acutely hospitalized o...
Article
Exercise rehabilitation programs have proven to increase exercise capacity and quality of life (QoL) in hospitalised patients with COPD. However, controversy exists as to the actual safety and effectiveness of this type of intervention We assessed the effects of an individualised exercise program on the functional capacity of acutely hospitalised o...
Article
Full-text available
Background Physical exercise is beneficial to reduce the risk of several conditions associated with advanced age, but to our knowledge, no previous study has examined the association of long-term exercise interventions (≥ 1 year) with the occurrence of dropouts due to health issues and mortality, or the effectiveness of physical exercise versus usu...
Article
Full-text available
The adverse effects of fat mass on functional dependence might be attenuated or worsened, depending on the level of muscular strength. The aim of this study was to determine (i) the detrimental effect of excess adiposity on dependence in activities of daily living (ADL), and (ii) whether relative handgrip strength (HGS) moderates the adverse effect...
Article
Full-text available
Background: A classic consequence of short-term bed rest in older adults is the significant loss in skeletal muscle mass and muscle strength that underlies the accelerated physical performance deficits. Structured exercise programmes applied during acute hospitalization can prevent muscle function deterioration. Methods: A single-blind randomize...
Article
Full-text available
Background: The short physical performance battery (SPPB) is a physical performance test of lower extremity function designed for non-disabled older adults. We aimed to establish reference values for community-dwelling Colombian adults aged 60 years or older in terms of (1) the total score; (2) the three subtest scores (walking speed, standing bala...
Poster
Introduction: The VIVIFRAIL project update is based on the idea that health in the elderly must be measured in terms of function and not as a disease that determines life expectancy, quality of life and the resources that each population needs. The objective is to maintain the level of functionality that ensures the highest degree of autonomy possi...
Poster
Full-text available
Introduction: Nosocomial disability generated during a hospitalization can have devastating consequences. Our team already developed an intervention based on physical exercise. Therefore, we have developed another strategy to encourage walking and cognitive tasks in a complementary way to the exercise program. Methods: An environmental modification...
Poster
Introduction: A recent randomized clinical trial has shown that a multicomponent physical exercise intervention is safe and effective to reverse the functional decline associated with acute hospitalization in very elderly patients [1]. Physical exercise is associated with physiological, biochemical or metabolic changes that could be translated into...
Article
Full-text available
Background: Exercise protocols applied during hospitalization can prevent functional and cognitive decline in older adults. The purpose of this study was to examine the individual response of acutely hospitalized patients to usual care and to physical exercise on functional capacity, muscle strength, and cognitive function and to assess the relatio...
Article
An individualized, multicomponent exercise training program may be an effective therapy for improving cognitive function (i.e., executive function and verbal fluency domains) in very old patients 3 60 during acute hospitalization. These findings support the need for a shift from the traditional (bed-rest based) hospitalization to one that recognize...
Article
Full-text available
Background: The benefit of physical exercise in ageing and particularly in frailty has been the aim of recent research. Moreover, physical activity in the elderly is associated with a decreased risk of mortality, of common chronic illnesses (i.e. cardiovascular disease or osteoarthritis) and of institutionalization as well as with a delay in functi...
Article
Introduction: Both frailty and mild cognitive impairment are prevalent issues among the geriatric population but have traditionally been evaluated on separate terms. Given the growing evidence that these two conditions might share a biological substrate, interventions aiming to improve physical function might as well induce benefits on cognitive fu...
Article
Frailty syndrome encompasses several physical hallmarks such as loss of muscle strength, power output and mass, which leads to poor gait ability, fatigue, falls and overall difficulty to perform activities of daily living. On the other hand, physical exercise interventions induce marked improvements in frailty physical hallmarks (e.g., gait ability...
Article
Objectives: To evaluate the effects of an exercise intervention on physical function, maximal muscle strength and muscle power in very old hospitalized patients. Design: In a randomized controlled trial, 130 hospitalized patients were allocated to an exercise intervention (n=65) or a control group (n=65). The intervention consisted of a multicompon...
Article
Full-text available
Importance Functional decline is prevalent among acutely hospitalized older patients. Exercise and early rehabilitation protocols applied during acute hospitalization can prevent functional and cognitive decline in older patients. Objective To assess the effects of an innovative multicomponent exercise intervention on the functional status of this...
Conference Paper
Full-text available
Background Frailty is a complex geriatric syndrome resulting in decreased physiological reserves in older people. It is very prevalent in nursing homes, as well as it is underprescription of recommended medications in this population. However, little is known about the relationship or interaction between these two entities. Purpose The aim of this...
Article
The impact of hospitalization on the treatment of elderly patients has not been widely studied. Previous studies examine some treatment characteristics in an isolated way and also provide mixed results and few until now have explored the modification of treatments during hospitalization with a mixed comprehensive approach. We have conducted a retro...
Article
Randomized clinical trial conducted in 193 patients admitted in a Geriatrics Acute Unit Hospitalized patients who met inclusion criteria (75 years and older, medical stable, frail or prefrail – SPPB 4–9-, previous ability to walk, able to communicate) were randomly assigned to the intervention or control group. The intervention consisted of a multi...
Article
Frail older adults have reduced functional and physiological reserves, rendering them more vulnerable to the effects of hospitalization, especially during the acute phase of hospitalization. Despite the theoretical support for the idea that exercise can improve cognition this idea has not been fully translated into clinical practice, especially dur...
Article
BACKGROUND AND OBJECTIVE: The identification of frail individuals has been recognized as a priority for the effective implementation of healthy aging strategies. Only a limited number of studies have examined frailty in nursing homes, and there is a big heterogeneity in the methods used. The primary objective of this study was to determine the prev...