Mike Delaney

Mike Delaney
Massachusetts Water Resources Authority, retired · Lab Services

PhD

About

49
Publications
12,033
Reads
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773
Citations
Additional affiliations
September 1980 - May 1987
Boston University
Position
  • Professor (Assistant)
January 1980 - January 1986
U.S. Food and Drug Administration
Position
  • Science Advisor
September 1978 - August 1980
Tufts University
Position
  • Professor (Assistant)

Publications

Publications (49)
Article
Full-text available
Easily detectable amounts of free cyanide (FCN) were formed when deionized water was treated like drinking water and preserved and tested for FCN. This occurred when either ascorbic acid or thiosulfate were used to dechlorinate, though higher FCN concentrations were observed with ascorbic acid. The amount of FCN observed was up to 50 – 60 ug/L, but...
Article
Full-text available
Easily detectable amounts of free cyanide (FCN) were formed when deionized water was treated like drinking water and preserved and tested for FCN. This occurred when either ascorbic acid or thiosulfate were used to dechlorinate, though higher FCN concentrations were observed with ascorbic acid. The amount of FCN observed was up to 50 – 60 ug/L, but...
Article
Full-text available
Reliable determination of cyanide in water samples is important for both wastewater and drinking water treatment plant operators and regulatory agencies. However, as a result of cyanide's diverse chemistry, obtaining reliable results has been challenging because several chemical mechanisms can form or destroy cyanide and some of these can occur wit...
Article
Full-text available
Reliable determination of cyanide in water samples is important for both wastewater and 9 drinking water treatment plant operators and regulatory agencies. However, due to cyanide's 10 diverse chemistry obtaining reliable results has been challenging because a variety of chemical 11 mechanisms can form or destroy cyanide and some of these can occur...
Article
Full-text available
Obtaining accurate and precise results for total cyanide concentrations in wastewater samples is fraught with positive and negative interferences. Even the United States Environmental Protection Agency has acknowledged that it may be difficult or impossible to adequately mitigate all interferences. We demonstrated that a field spike of complex cyan...
Article
Full-text available
Carefully controlled bench-scale and on-site experiments demonstrated that cyanide can form in the treated drinking water sample container during preservation and storage. In the bench-scale experiment, treated tap water samples were collected on 20 days over six months. The tap water samples were split and some of the splits were spiked with forma...
Article
Full-text available
Total cyanide analysis by distillation is used most commonly to assess cyanide content of water samples. This manual method is robust but slow and provides no information about cyanide speciation, a significant limitation in that cyanide species have substantially different toxicity characteristics. Seven alternative methods for the analysis of cya...
Article
Full-text available
This study compared and evaluated seven methods for the analysis of cyanide in reagent water and different contaminated water matrices. The methods compared were weak acid dissociable cyanide (APHA, 1995, 4500-CN-I), free cyanide by microdiffusion (ASTM D4282-95), available cyanide [Federal Register: December 30, 1999 (Volume 64, Number 250)], meta...
Article
Full-text available
A multivariate approach is developed for estimating detection limits for selected ion monitoring gas chromatography—mass spectrometry. This technique is directly based on the Hubaux—Vos technique which regresses instrument response onto concentration. The statistics of this regression are used to estimate the detection limit as the lowest true conc...
Article
Full-text available
Cluster analysis and principal components analysis have been used to classify nine octadecyl (C18) high-performance liquid chromatography (HPLC) columns into three general groups displaying similar chromatographic behaviour. Principal components analysis was also able to identify the key test compounds on which the classification was most highly de...
Article
Four alternatives for the selection of representative wavelength sets from a collection of 101 ultraviolet-visible (UV-vis) spectra are compared, with a view toward applications in liquid chromatography with multichannel UV-vis detection. The cumulative information content, corrected for correlations between selections, is used to evaluate the set...
Article
Several procedures are applied to a data set consisting of ultraviolet-visible spectra for nine cephalosporin solutes, for the purpose of selecting wavelengths to be used in the monitoring of absorbance ratiograms during liquid chromatographic separations. Because the solute spectra are shown to be insensitive to variations in the organic component...
Article
The sensitivity of the gas chromatography-Fourler transform infrared (GC-FTIR) spectrometry combination has been the subject of many studies. Considerable improvements have been made in both the instrumentation and information processing aspects of FTIR. Since the noise that is observed in an FTIR spectrum is a complex composite which cannot be ful...
Article
79. Experience with and student generated results using the RS/1 electric laboratory notebook software. Keywords (Audience): Second-Year Undergraduate
Article
A study if presented that is designed to perform an objective evaluation of chromatographic data systems and integrators. Topics evaluated include: repeatability, accuracy, and ruggedness. Particular attention is given to validation of software.
Article
A recently proposed method for extending the mathematical technique of self-modeling curve resolution using a library of reference spectra has been modified to take advantage of the relative simplicity of simplex optimization techniques in higher dimensions when searching for minima and maxima in a response function. Surface contouring of the libra...
Article
The recently proposed linear programming algorithm for estimating component spectra by using self-modeling curve resolution is shown to be inadequate in cases for which some of the components have similar, nondescript spectra and when the data are noisy. The extension of this technique reported is based on the use of a library of representative ref...
Article
A controlled study was conducted to evaluate the feasibility of robotic automation of routine regulatory drug dissolution measurements. A commercially available laboratory robot system automated a number of dissolution analyses while concurrent manually acquired samples were analyzed by the same analytical method. The results were subjected to a st...
Article
Full-text available
Separations can be applied to the analysis of soft drinks, artificial sweeteners, fruit juices, and coffee. Keywords (Audience): Second-Year Undergraduate
Article
Compound identification by library searching of experimental spectra using instruments based on small computer systems is becoming increasingly common. For successful searching performance, large libraries are needed. Compressed spectra are typically used to increase both the number of spectra that can be stored on a small computer and the search s...
Article
Full-text available
A quantitative high-performance liquid chromatographic method using an octadecylsilane column and a methanol-water mobile phase was employed for the determination of chlordiazepoxide, chlordiazepoxide X HCl and related impurities in capsule and tablet preparations. Each component is well separated and directly detected by 254 nm absorption. For chl...
Article
Full-text available
Article
The applicability or using the gas chromatograph-microwave plasma emission detector (GC-MED) in combination with chemical derivatization based on unique elements for enhanced detectability of selected compounds in complex samples is discussed. A number of potential derivatization schemes are surveyed and results for two specific approaches are pres...
Article
A procedure is described for the quantitative evaluation of the performance of a library searching system employed for molecular structure elucidation. The technique allows the evaluation of any form of spectral representation or any spectral comparison metric. The approach is applicable to any type of spectrometry used for library searching (LS) o...
Article
A method is presented for the representation of vapor phase infrared spectra in a binary format which preserves both width and position information about each peak. Preselection of an optimally width-enhanced library of binary spectra, in advance of any actual library searching, is approached through the application of information theory and Grotch...
Article
A CdTe detector was found to be suitable for use as a ..gamma..-ray detector for high-performance liquid chromatograph (HPLC) of radiopharmaceuticals. The detector was evaluated for background count rate, photopeak energy resolution, and photopeak counting efficiency by using spectra accumulated with a Nuclear Data 4420 multichannel analyzer system...
Article
This study reports for the first time, the successful indirect ultraviolet visualization of a polycyclic polyamine, methenamine, a urinary antibacterial agent. The ability to detect a non-UV active compound quantitatively using a UV monitor is demonstrated and the optimized experimental conditions are discussed. The calibration curve obtained was l...
Article
Full-text available
The detection of 3-(3,4,6-trihydroxyphenyl)alanine and 3-methoxytyrosine in levodopa and methyldopa and 3-O-methylcarbidopa in carbidopa by high-performance liquid chromatography (HPLC) with electrochemical detection is described. An octyl-bonded reversed-phase column is employed with a buffered aqueous methanol mobile phase containing an “ion-pair...
Article
A method for the determination of metronidazole in pharmaceutical tablets is presented. Differential pulse polarography at a static mercury drop electrode is used to observe the reduction of the imidazole. The method is demonstrated to be simple, rapid, linear, reproducible and accurate.
Article
The systematic errors inherent in four methods of manual graphical chromatographic peak-area measurement are examined. Skewed peaks are simulated based on the exponentially modified gaussian equation. The errors in the peak-area measurements are calculated as a function of peak asymmetry. The Condal-Bosch trapezoidal method is seen to be largely un...
Article
The hydroxyl stretching region of over 400 vapor-phase infrared spectra is examined. Correlations between peak wavelength and functionality are observed for primary, secondary, and tertiary alcohols, phenols, carboxylic acids, and oximes. Peak shifts due to steric crowding and intramolecular hydrogen bonding are seen. The use of the tabulated resul...
Article
Computerized interpretation of vapor phase infrared spectra as an identification tool for gas chromatography is discussed. Approaches based on library searching, pattern recognition, and artificial intelligence are compared. It is seen that a combination of these techniques and the incorporation of additional information, such as selective detector...
Article
An atmospheric pressure helium microwave emission detection system (MED) for gas chromatography has been evaluated for the analysis of trihalomethanes in drinking water. Using a purge and trap technique with 10-mL samples, the detection limits for the trihalomethanes and other purgable organohalides are below 1 part per billion. The detector monito...
Article
The ability to predict the effectiveness of spectral file searching procedures for the identification of unknown compounds is demonstrated for vapor phase infrared spectrometry (VPIR) based on statistical considerations of the reference library. Matching criteria based on the Exclusive OR (XOR) function for binary spectra and least-squares for mult...
Article
The ability to distinguish functional group and the presence of specific elements in vapor phase infrared spectra is demonstrated using pattern recognition techniques. Kth nearest neighbors analysis was found to be superior to hyperplane separations. Weight-sign feature selection was used to elucidate the significant wavelengths which exhibited agr...
Article
Techniques for signal to noise ratio enhancement (filtering) of noisy experimental data are compared by comprehensive computer simulation using synthetic data. The four important descriptors: signal to noise ratio enhancement, peak width increase, peak maximum displacement, and computation time on a laboratory minicomputer are determined for each f...

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