Mikael A. Kowal

Mikael A. Kowal
Bedrocan International · Science and Regulatory Affairs

PhD

About

8
Publications
12,270
Reads
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310
Citations
Citations since 2017
3 Research Items
282 Citations
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20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
20172018201920202021202220230102030405060
Additional affiliations
September 2010 - October 2016
Leiden University
Position
  • PhD Student
Education
October 2005 - June 2010
University of Warsaw
Field of study
  • Psychology

Publications

Publications (8)
Article
Full-text available
Background: In humans, the effect of cannabis on ventilatory control is poorly studied, and consequently, the effect of Δ9-tetrahydrocannabinol (THC) remains unknown, particularly when THC is combined with an opioid. We studied the effect of THC on breathing without and with oxycodone pretreatment. We hypothesised that THC causes respiratory depre...
Article
Full-text available
In this experimental randomized placebo-controlled 4-way crossover trial, we explored the analgesic effects of inhaled pharmaceutical-grade cannabis in 20 chronic pain patients with fibromyalgia. We tested 4 different cannabis varieties with exact knowledge on their [INCREMENT]-tetrahydrocannabinol (THC) and cannabidiol (CBD) content: Bedrocan (22....
Article
Full-text available
Cannabis has been suggested to impair the capacity to recognize discrepancies between expected and executed actions. However, there is a lack of conclusive evidence regarding the acute impact of cannabis on the neural correlates of error monitoring. In order to contribute to the available knowledge, we used a randomized, double-blind, between-group...
Article
Full-text available
Rationale: Cannabis users often claim that cannabis has the potential to enhance their creativity. Research suggests that aspects of creative performance might be improved when intoxicated with cannabis; however, the evidence is not conclusive. Objective: The aim of this study was to investigate the acute effects of cannabis on creativity. Meth...
Article
Full-text available
In sum, existing research seems to undermine Schier's et al. (2012) suggestion regarding the lack of a relationship between CBD and cognition. Rather, it seems that both cognitive and affective consequences of CBD administration may be mediated by the ACC. However, the lack of clear-cut results renders the extent and nature of this modulation uncle...
Article
Full-text available
In 2010 a review by Hazekamp and Grotenhermen covered controlled clinical trials of the years 2006-2009 on cannabis-based medicines, which followed the example of the review by Ben Amar (2006). The current review reports on the more recent clinical data available from 2010-2014. A systematic search was performed in the scientific database of PubMed...
Article
Full-text available
Chronic cannabis use has been shown to block long-term depression of GABA-glutamate synapses in the striatum, which is likely to reduce the extent to which endogenous cannabinoids modulate GABA- and glutamate-related neuronal activity. The current study aimed at investigating the effect of this process on striatal dopamine levels by studying the sp...

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