Mihaly Koltai

Mihaly Koltai
London School of Hygiene and Tropical Medicine | LSHTM · Centre for the Mathematical Modelling of Infectious Diseases

PhD

About

14
Publications
1,610
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245
Citations
Introduction
Mihaly Koltai currently works at the Centre for Mathematical Modelling of Infectious Diseases at the London School of Hygiene & Tropical Medicine. Mihaly does research in mathematical biology, infectious disease modelling, molecular systems biology and bioinformatics.
Additional affiliations
September 2016 - July 2020
Institut Curie
Position
  • PostDoc Position
Description
  • mathematical modelling for cancer research
June 2014 - May 2016
Max Planck Institute for Terrestrial Microbiology
Position
  • PhD Student
Description
  • mathematical modelling of microbial signalling and motility
March 2012 - May 2016
Universität Heidelberg
Position
  • Research Associate
Description
  • mathematical modelling of microbial signalling and motility
Education
April 2012 - May 2016
Universität Heidelberg
Field of study
  • Computational Biology

Publications

Publications (14)
Article
Full-text available
Background: Solutions to stochastic Boolean models are usually estimated by Monte Carlo simulations, but as the state space of these models can be enormous, there is an inherent uncertainty about the accuracy of Monte Carlo estimates and whether simulations have reached all attractors. Moreover, these models have timescale parameters (transition r...
Article
Full-text available
Animals are known to adjust their sexual behaviour depending on mate competition. Here we report similar regulation for mating behaviour in a sexual unicellular eukaryote, the budding yeast Saccharomyces cerevisiae. We demonstrate that pheromone-based communication between the two mating types, coupled to input attenuation by recipient cells, enabl...
Article
Full-text available
As numerous bacterial species, Shewanella putrefaciens CN-32 possesses a complete secondary flagellar system. A significant subpopulation of CN-32 cells induces expression of the secondary system under planktonic conditions, resulting in formation of one, sometimes two, filaments at lateral positions in addition to the primary polar flagellum. Muta...
Article
Full-text available
Introduction COVID-19 related non-pharmaceutical interventions (NPIs) led to a suppression of RSV circulation in winter 2020/21 in the UK and an off-season resurgence in Summer 2021. We explore how the parameters of RSV epidemiology shape the size and dynamics of post-suppression resurgence and what we can learn about them from the resurgence patte...
Preprint
Background: Respiratory syncytial virus (RSV) is a leading cause of respiratory tract infections and bronchiolitis in young children. The seasonal pattern of RSV is shaped by short-lived immunity, seasonally varying contact rates and pathogen viability. The magnitude of each of these parameters is not fully clear. The disruption of the regular seas...
Article
Background: In countries with weak surveillance systems, confirmed coronavirus disease 2019 (COVID-19) deaths are likely to underestimate the pandemic’s death toll. Many countries also have incomplete vital registration systems, hampering excess mortality estimation. Here, we fitted a dynamic transmission model to satellite imagery data of cemeteri...
Preprint
Full-text available
Introduction COVID-19 related non-pharmaceutical interventions (NPIs) led to a suppression of RSV circulation in winter 2020/21 throughout Europe and an off-season resurgence in Summer 2021 in several European countries. We explore how such temporary interruption may shape future RSV epidemiology and what factors drive the associated uncertainty. M...
Article
Full-text available
Signaling networks represent the molecular mechanisms controlling a cell's response to various internal or external stimuli. Most currently available signaling databases contain only a part of the complex network of intertwining pathways, leaving out key interactions or processes. Hence, we have developed SignaLink3 (http://signalink.org/), a value...
Article
Full-text available
Background: In countries with weak surveillance systems, confirmed coronavirus disease 2019 (COVID-19) deaths are likely to underestimate the pandemic’s death toll. Many countries also have incomplete vital registration systems, hampering excess mortality estimation. Here, we fitted a dynamic transmission model to satellite imagery data of cemeteri...
Preprint
Full-text available
Introduction In countries with weak surveillance systems confirmed COVID-19 deaths are likely to underestimate the death toll of the pandemic. Many countries also have incomplete vital registration systems, hampering excess mortality estimation. Here, we fitted a dynamic transmission model to satellite imagery data on burial patterns in Mogadishu,...
Preprint
Full-text available
Motivation Solutions to stochastic Boolean models are usually estimated by Monte Carlo simulations, but as the state space of these models can be enormous, there is an inherent uncertainty about the accuracy of Monte Carlo estimates and whether simulations have reached all asymptotic solutions. Moreover, these models have timescale parameters (tran...
Data
Supplementary Figures 1-9, Supplementary Table 1, Supplementary Methods and Supplementary References
Thesis
Full-text available
Microbes need to extract relevant information from their environment and use this information to produce adequate behavioral responses that ensure their survival. Quantitative, mathematical analysis of microbial sensory systems (such as various signaling pathways) and their effectors (such as bacterial motors) forms the basis of the field of system...
Article
Full-text available
Background Signaling networks in eukaryotes are made up of upstream and downstream subnetworks. The upstream subnetwork contains the intertwined network of signaling pathways, while the downstream regulatory part contains transcription factors and their binding sites on the DNA as well as microRNAs and their mRNA targets. Currently, most signaling...

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Projects

Project (1)
Archived project