Mihai Victor Curtasu

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Mihai Victor verified their affiliation via an institutional email.

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• PhD in Animal Sciences (biomedical models for metabolic diseases)
• Professor (Assistant) at Aarhus University

This study investigated faecal microbial composition and blood metabolome profile of piglets fed different levels of supplementary zinc oxide (ZnO) after weaning. A dose-response study was conducted with four experimental diets containing 153 (D153), 1022 (D1022), 1601 (D1601), and 2407 (D2407) ppm zinc (Zn) in the feed. At the end of the trial, bl...

Improving feed efficiency (FE) of grower-finisher pigs is of great importance considering its impact on production economy, nutrient excretions as well as carbon-footprint. The biological background describing variation in FE between pen mates, is difficult to establish as feed intake (FI) and FE are not estimated on an individual level. In this st...

Willow trees (Salix spp.) exhibit remarkable genetic and phenotypic diversity, yielding a broad spectrum of bioactive compounds, notably valuable phenolic compounds such as condensed tannins (phenolic polymers), flavonoids, salicylic glucosides, and phenolic compounds. These enhance the economic value of willow crops and make them suitable for circ...

The potent greenhouse gas, methane, is formed as an end-product during the fermentation of feed in the forestomach compartments of ruminants. The red seaweed Bonnemaisonia hamifera (Rhodophyta) has demonstrated in vitro anti-methanogenic effects in systems simulating rumen fermentation. Untargeted metabolomics profiling revealed that wild B. hamife...

Plant secondary metabolites (PSMs) can potentially reduce ruminal methane formation. However, related to differences in their molecular structures, it is not yet clear what causes an anti-methanogenic effect. In an in vitro system simulating rumen fermentation, we investigated the impact of eight compounds with distinct chemical characteristics (ga...

Willow (Salix spp.) is gaining an increasing interest as a fast-growing tree with high biomass yield from low agricultural inputs, which contains potentially bioactive compounds. The present work aimed to develop a high-yield extraction procedure combined with robust, sensitive and fast microLiquid Chromatography-Triple Quadrupole Mass Spectrometry...

Macroalgae have attracted significant attention in recent years as potential feeds or feed additives, since their cultivation is not associated with use of arable land suitable for human food production, and because of the ability of some species to reduce methane formation during enteric fermentation in ruminants. However, most macroalgae species...

In previous in vitro experiments simulating rumen fermentation, it has been found that two Fucus species. possess significant ability to suppress methane formation associated with rumen fermentation of feeds. In contrast to Asparagopsis species the anti-methanogenic activity of Fucus species cannot be ascribed to halomethanes. The aim of this exper...

Zinc oxide (ZnO) has been commonly added to the diet of weaned piglets at high levels (2500 – 3000 ppm) to reduce the prevalence and severity of diarrhoea potentially due to modulation of the fecal microbial commu- nity. The objective of this study was to investigate fecal microbial com- munity of pigs when received different dietary Zn levels afte...

Gastric ulceration is a common disease in pig production worldwide and is associated with economic losses as well as animal health and welfare issues. The aim of this study was to explore potential salivary biomarkers for gastric ulceration in pigs. In addition, the aim was to study the effect of hemp on the incidence of gastric ulcers. Approximate...

La supplémentation en acides aminés spécifiques améliore les performances de croissance des porcelets en post-sevrage dans un modèle d'infection naturelle La supplémentation en acides aminés spécifiques améliore les performances de croissance des porcelets en post-sevrage dans un modèle d'infection naturelle Un modèle naturel de challenge a été dév...

Consumption of fructose has been associated with a higher risk of developing obesity and metabolic syndrome (MetS). The aim of this study was to examine the long-term effects of fructose compared to starch from high-amylose maize starch (HiMaize) at ad libitum feeding in a juvenile Göttingen Minipig model with 20% of the diet provided as fructose a...

The metabolome and gut microbiota were investigated in a juvenile Göttingen minipig model. This study aimed to explore the metabolic effects of two carbohydrate sources with different degrees of risk in obesity development when associated with a high fat intake. A high-risk (HR) high-fat diet containing 20% fructose was compared to a control lower-...

Obesity-related metabolic syndrome has been linked with gut microbiome dysbiosis while dietary fibre (DF) and protein can modify the gut microbial ecosystem and metabolism. After 20-weeks of high-fat fructose-rich diet feeding for the development of obesity, forty-three 30-week old Göttingen Minipigs (31 ± 4.0 kg body weight) were allocated to one...

The effects of dietary fibre (DF) and protein on insulin response, lipidemia and inflammatory biomarkers were studied in a model experiment with juvenile obese Göttingen Minipigs. After 20 weeks feeding on a high-fat fructose-rich low-DF diet, forty-three 30-week old minipigs (31.3 ± 4.0 kg body weight) were allocated to low or high DF and protein...

Sows suffering excess weight loss during lactation may delay weaning to estrus interval (WEI) and have a detrimental effect on subsequent reproductive performance, however, the underlying mechanism is not completely clear. Therefore, the goal of this study was to investigate physiological profiles manifested in plasma originating from high (HWL) an...

Miniature pig models for human metabolic disorders such as obesity and Metabolic Syndrome are gaining popularity. However, in-depth knowledge on the phenotypic and metabolic effects of metabolic dysregulation is lacking and ad libitum feeding is not well characterized in these pig breeds. Therefore, an investigation was performed into the metabolom...

In pigs, the alpha-(1,2) fucosyltransferase (FUT1) gene has been highlighted for its properties in controlling the intestinal expression of enterotoxigenic E. coli (ETEC) F18 receptors; a pathogen causing edema disease and post-weaning diarrhoea. In this study, we hypothesized that pigs with different genotypes (ETEC F18 resistant (FUT1AA) versus s...

Relative expression of selected genes in mucosa from the stomach, ileum, caecum and mid colon of piglets 34 days of age (one-week post-weaning) belong to FUT1AG and FUT1AA groups. (DOCX)

Dry matter content (%) and pH of digesta from the gastrointestinal tract of 34 days old piglets (one-week post-weaning)1. (DOCX)

Complete list of discriminant plasma metabolites for FUT1AG and FUT1AA obtained from piglets at 7, 28 and 34 days of age by the sMLPLS-DA. (DOCX)

Background: Whole-grain intake is associated with a lower risk of chronic Western-style diseases, possibly brought about by the high concentration of phytochemicals, among them plant lignans (PLs), in the grains. Objective: We studied whether treatment of rye bran with cell wall–degrading enzymes changed the solubility and kinetics of PLs in multic...

Traditional AA dose-response studies utilize many animals for evaluation of growth performance, and it is hypothesized that a new experimental design based on modern analytical techniques can reduce the number of used animals. The objective was to evaluate a short-term approach with a low number of pigs based on plasma metabolites as a method to de...

ABSTRACT: Survival and growth of suckling piglets is highly dependent on the nutrients, growth factors, and protective components provided by sow colostrum and milk. The macrochemical composition undergoes large alterations during the lactation period, but knowledge of the composition and variation of low molecular weight metabolites is presently l...

The objective was to evaluate a short-term approach with a low number of pigs based on blood samples as a method to determine the requirement for Ile, Leu, and Val. Three independent 6x6 Latin square experiments with six diets containing incrcasing concentrations of Ile, Leu or Val fed to six 8-9 kg pigs for two d each were conducted during a perio...

Survival and growth of suckling piglets is highly dependent on the nutrients, growth factors, and protective components provided by sow colostrum and milk. The macrochemical composition undergoes large alterations during the lactation period, but knowledge of the composition and variation of low molecular weight metabolites is presently lacking. Sa...