Mihai Craiu

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Verified

Mihai verified their affiliation via an institutional email.

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• MD PhD
• Head of Department at Carol Davila University of Medicine and Pharmacy

Introduction: Repeated COVID-19 booster vaccination was recommended in healthcare workers (HCWs) to maintain protection. We measured the relative vaccine effectiveness (rVE) of the second booster dose of COVID-19 vaccine compared to the first booster, against laboratory-confirmed SARS-CoV-2 infection in HCWs. Methods: In a prospective cohort study...

Background: European countries have included healthcare workers (HCWs) among priority groups for COVID-19 vaccination. We established a multi-country hospital network to measure the SARS-CoV-2 incidence and effectiveness of COVID-19 vaccines among HCWs against laboratory-confirmed SARS-CoV-2 infection. Methods: HCWs from 19 hospitals in 10 countrie...

Background: Acute viral respiratory tract infections constitute a significant challenge in pediatric healthcare globally, with rhinovirus representing one of the primary etiological agents. In this context, we conducted a study with the objective of identifying the clinical characteristics and outcomes of rhinovirus infection in comparison with oth...

In the field of medical imaging, techniques like computed tomography (CT), magnetic resonance imaging (MRI), and X-rays are essential for diagnosing and monitoring diseases, particularly in pulmonary pathology. A significant development in this area is the application of automated segmentation and machine learning, enhancing the accuracy in diagnos...

Primary ciliary dyskinesia (PCD) is a congenital disorder with genetic determinism, characterized by chronic infections of the upper and lower respiratory tract. The triad of situs inversus, chronic sinusitis and bronchiectasis is called Kartagener Syndrome. PCD is a predominantly autosomal recessive disease, involving more than 40 mutations of gen...

Background: Our study aimed to explore the way artificial intelligence (AI) utilization is perceived in pediatric medicine, examining its acceptance among patients (in this case represented by their adult parents), and identify the challenges it presents in order to understand the factors influencing its adoption in clinical settings. Methods: A st...

Infants are a unique pediatric group due to their high hospitalization rates and unfavorable outcomes from acute infectious diseases. Understanding the clinical differences and aftereffects of SARS-CoV-2 in comparison to other prevalent viruses in this age group, like RSV, is crucial for effective management. We conducted a retrospective case–contr...

Background and Objectives: Childhood obesity has been increasing at a worrisome pace and emerging as a non-infectious pandemic in the pediatric population in recent years. Raising awareness on this problem is of utmost importance, in order to take action to control body weight from an early age. Materials and Methods: We performed a retrospective s...

Human adenovirus causes infections with a very heterogeneous clinical picture, and children are often the most frequently affected group. Interest in adenovirus has increased with the 2022 outbreak of severe acute hepatitis of unknown etiology as human adenovirus was considered as one of the possible etiological agents. We conducted a retrospective...

This review presents current updates of pancreatic enzyme replacement therapy in children with cystic fibrosis based on literature published in the last decade and some special considerations regarding pancreatic enzyme replacement therapy in the era of new therapies, such as cystic fibrosis transmembrane conductance regulator modulator therapies....

In a fast-paced medical reality, biosciences and bioengineering have become essential components in medical research and development. The aim of this paper is to characterize the recent progresses made in fighting antimicrobial resistance, particularly in relation to WHO’s priority pathogens, by providing an in-depth review of novel antimicrobials,...

Introduction: Tuberous sclerosis complex (TSC) is a rare autosomal dominant condition characterized by cutaneous, cerebral, and other multiorgan involvement. Aneurysms due to TSC pathogenic mechanism are rarely present, mainly aortic, renal, or intracranial and very few associated with peripheral circulation. A TSC patient, aged 31 years, who deve...

The COVID-19 pandemic, through the restrictions and the non-pharmaceutical interventions implemented, has importantly impacted the circulation and epidemiology of respiratory viruses. Specifically, the 2020/21 season was entirely dominated by SARS-CoV-2, while influenza activity reached an all-time low, despite initial warnings that a double concur...

The COVID-19 pandemic has had a significant impact on the pediatric population, particularly on their access to health services. We conducted a retrospective study to assess the influence that the pandemic, and its related containment and mitigation public health measures, had on pediatric emergencies and hospitalizations in a major tertiary pediat...

Vaccination is one of the most useful medical interventions for controlling certain infectious diseases. The aim of current research is to identify some of the drivers of vaccine hesitancy or acceptance in a rather skeptical European population by addressing parental perception on optional vaccination (OV) perception. Novel tools, delivered by soci...

Patients with chronic lung conditions, including cystic fibrosis, may be prone to severe COVID-19. Therefore, therapeutic intervention should be prompt and tailored to all associated comorbidities. We report the case of a 17-year-old male adolescent with cystic fibrosis and multiple chronic conditions (bronchiectasis, exocrine pancreatic insufficie...

Background Children with moderate-to-severe asthma continue to have disease complications despite the receipt of standard-of-care therapy. The monoclonal antibody dupilumab has been approved for the treatment of adults and adolescents with asthma as well as with other type 2 inflammatory diseases. Methods Download a PDF of the Research Summary. In...

Introduction: Urinary tract infections (UTIs) are among the most common bacterial diseases of childhood with an increased frequency in infants and young children. Methods: We conducted a retrospective study of children diagnosed with UTI in the Alessandrescu-Rusescu National Institute for Mother and Child Health, Bucharest, Romania between Janua...

Introduction: The most common clinical manifestation of mango allergy is contact dermatitis, which can be localized or systemic. The sensitising substances that have long been suspected are alk(en)yl catechols and/or alk(en)yl resorcinols. Methods: We reviewed the original articles published on Pubmed, Embase and Cochrane Library before 15 Septembe...

“Red throat” or acute pharyngitis – challenges in real life clinical practice Abstract: An interesting article by Oksana Boyarchuk et al. has just been published in the current issue of Germs – "Diagnosis and management of pharyngitis in children: a survey study in Ukraine”. This study evaluated "the knowledge of pediatricians in diagnosis and man...

Introduction: Excess body weight in children has become a public health issue in most countries. The aim of our study was to determine the prevalence of overweight and obesity in children over two years of age who presented at the Emergency Department of a tertiary pediatric hospital in Bucharest, Romania. Methods: Between July and August 2018, we...

One of the affected organs in cystic fibrosis (CF) is the pancreas, mainly translated into exocrine pancreatic insufficiency. Although rare, acute pancreatitis (AP) has been described, mostly in pancreatic sufficient patients. Objectives. Estimating AP prevalence in CF pediatric population of the I.N.S.M.C. „AlessandrescuRusescu” CF centre. Materia...

Introduction Severe asthma is a rare disease in children, for which three biologicals –anti-IgE, anti-IL-5 and anti-IL-4RA antibodies– are available in European countries. While global guidelines exist on who should receive biologicals, knowledge is lacking on how those guidelines are implemented in real life and which unmet needs exist in the fiel...

Malnutrition continues to be a major issue concerning pediatric cystic fibrosis patients’ medical care. Supplementary diagnostic association with food allergy in a cystic fibrosis patient leads to worse nutritional status decline. This particular association determines low quality of life and life expectance impairment. Low caloric intake, recurren...

Background and Aim-Regarding health issues, in our country, 75% of parents go to Social Media (SM) tools before they ask a physician. We are aiming to describe parental perception regarding nebulized medication and to describe a new educational tool delivered by SM.

Role of Social Media in exploring parental expectations regarding usage and providing education on nebulized medication in children European Respiratory Journal September 2019/Volume 54/Supplement 63;95

In the difficult landscape of a constant and slow decrease of vaccine coverage in Romania, medical education on vaccine-preventable diseases could reach parents by means of new tools, like Social Media. This paper is presenting a retrospective analysis of educational activities regarding such diseases (with a special focus on Pertussis) in a large...

Astmul reprezintă cea mai frecventă boală cronică diagnosticată la vârsta copilăriei. Si in România astmul are o prevalență în creștere, de la 3,3% în 1995 la 5,5% în 2001 [1]. Din acest motiv este necesară adaptarea strategiilor de abordare a părintelui copilului astmatic sau al adolescentului astmatic, in aceasta epoca de semnificative transformă...

Astmul sever la copil, deși reprezintă o minoritate de pacienți astmatici (în jur de 4% dintr-o cohortă de copii astmatici [1]) încă generează o adevărată provocare atât pentru pacient și familia acestuia, cât și pentru medic. În pofida unei complianțe mulțumitoare și a prezentării regulate la medic, copilul cu astm sever are un control mediocru al...

Community acquired pneumonia is a common disease that accounts for 16% of all deaths in children aged 5 years or younger. The purpose of the study was to identify potential modifiable factors in relation with parental perception of pneumonia management in children. Outlining such factors would allow development of approaches in order to reduce pneu...

Introduction. Community acquired pneumonia is a common disease that accounts for 16% of all deaths in children aged 5 years or younger. The purpose of the study was to identify potential modifiable factors in relation with parental perception of pneumonia management in children. Outlining such factors would allow development of approaches in order...

Introducere. Pneumonia comunitară este foarte frecventă şi este responsabilă de 16% dintre decesele la copiii cu vârstă de pană la 5 ani. Scopul prezentului studiu a fost să identifice potenţiali factori modificabili/influenţabili în legătură cu percepţia parentală privind managementul pneumoniei la copil. Conturarea unor astfel de factori ar permi...

Background and aim. In the last decade a significant increase of nebulized medication usage has been documented in Romania. Authors are aiming to describe parental and physician’s change of perspective regarding nebulized medication in the new era of online communication and education. Material and methods. Two different questionnaires were posted...

Background and aims Current recommendation in managing CF patients regarding Vitamin D status ( 2005 European Consensus) are annually Vitamin D, Calcium and electrolytes identifications with prompt therapeutic intervention. Methods 1 year retrospective Study with 68 children included (29 girls and 39 boys ) in which annual determination of Vitamin...

Background in cystic fibrosis (CF), the number of pulmonary exacerbations and their severity determine the lung function decline. Prevention of pulmonary exacerbations and thier early diagnosis slows down the progression of pulmonary disease and of lung function decline, improving both quality of life and life expectancy in CF paediatric patients....

Backgroud and Aim Antibiotics have produced an estimated increase of life-expectancy of 2 to 10 years. Due to irrational use of antibiotics, bacteria gained multi-resistance. 23.000 patients die each year in US due to infections with resistant bacteria. The aim of our paper is to describe controllable mechanisms of antibiotic excessive prescription...

Background and aims Cystic Fibrosis represents the most frequent monogenic autosomal recessive disease in Caucasians. Among multiple systemic determination, the pancreatic function is affected, with primordial exocrine dysfunction and second endocrine disorder. Acute pancreatitis is a rare complication in CF, rapid diagnosis allowing selection of p...

Background Cystic fibrosis (CF) is a complex disorder with multisystem involvement. Although we used to believe that an association between CF and food allergies is rare and more frequently a false diagnostic, in the late years, as food allergies’ prevalence is rising, the association between these two disorders is becoming more common. Aim the ai...

Background and aim Inner-city paediatric asthma patients experience a significant increase of unscheduled and emergency department visits if they are not included in a continuous monitoring and educational program. Parental education represents a corner-stone of complex approach in these patients. The aim of our study was to document outcome of a s...

Video Recordings are very useful in the clinical practice. Most times physicians should diagnose their patients based on descriptions coming from parents or other family members that are emotionally involved. It is very difficult to differentiate some entities in this circumstances. This is why many times there are patients who receive unnecessary...

Manchester International Severe Asthma Forum #57 POSTER Tele-monitoring decreases unscheduled outpatient visits in pediatric patients with severe asthma Authors : Mihai Craiu, Iustina Violeta Stan INSMC Alessandrescu-Rusescu, Bucharest, Romania Keywords: Child, Asthma, Virtual-Media, Monitoring, Education Background and Aim: Pediatric asthma p...

Background: Little is known about the incidence and dynamics of occult bacteremia (OB) among infants/young children following the introduction of pneumococcal conjugate vaccines (PCVs) into the national immunization program in Israel in 2009-2010. The aim of this study was to characterize the epidemiologic and microbiologic picture of OB among feb...

Background and Aim: In limited-resource settings pediatric asthma patients experience a significant increase of unscheduled and emergency department visits. Parents can be involved in the complex effort of treatment and management. The aim of our study was to document outcome of a structured parental involvement in management of asthmatic children....

Data on the various aspects of brucellosis in children living in southern Israel are missing. Our aim was to study the epidemiological, microbiological, diagnostic, clinical, therapeutic and outcome features of brucellosis in children <19 years of age in southern Israel during 2005-2011. The study population included all patients hospitalized with...

Validarea unui scor clinic pentru abordarea copiilor cu exacerbare bronho-obstructivă în camera de gardă Acute bronchial obstruction in children is a common reason for presentation in the Emergency Unit, requiring immediate and effective therapeutic management. The authors aim to evaluate the effectiveness of a score based on four clinical paramete...

We report the case of a male patient with a normal development in the first three months of life, presenting for global regression, central axial hypotonic syndrome, pyramidal syndrome, focal epileptic seizures, and a particular aspect of the hair - almost absent, short, sparse, lightly colored, at age of five months, becoming coarse, twisted (kink...

75-80% dintre situaţiile ameninţătoare de viaţă, cu stop cardio-respirator neaşteptat, se petrec în afara spitalului (1). De aceea este întâlnită frecvent situaţia unei resuscitări dificile. Principala cauză de eşec este obţinerea tardivă a unei căi de acces vascular pentru administrarea fluidelor şi medicaţiei necesare în aceste situaţii (2). Abor...

75-80% of life threatening situations, with unexpected arrest, are documented out of hospital (1). This situation generates frequently a difficult resuscitation. Main cause for failure is delay in gaining vascular access for fluid and drug delivery (2). Intraosseous access (IO) is used for treatment in patients without a previously placed intraveno...

Both allergic and non-allergic rhinitis are extremely common in children, given the constant urbanizing of the population, corroborated with the increase in global pollution and the microand macro- climate changes. Despite its increased frequency in developed countries, allergic rhinitis in children is often ignored by the parents and down-staged b...

We describe the case of a 15 month old boy, investigated for repeated and prolonged infections, associated to progressive neurological impairment. Immunological work-up found low immunoglobulin levels and decreased numbers of T and B lymphocytes, with a T-B-NK+ phenotype. Imaging showed lack of thymus and cerebral cortex atrophy. The key towards th...

Background: We present clinical and molecular findings of a patient with ceroid-lipofuscinosis CLN7, with a compound heterozygous mutation of the MFSD8 gene, with Rett syndrome clinical signs onset and a later development of full picture of vLINCL. Case presentation: A 7 years-old female patient with normal development until the age 12 months, d...

Scopuri şi obiective. Astmul bronşic este cea mai frecventă boală cronică la copii. În peste 50% din cazurile pediatrice, inflamaţia căilor aeriene este eozinofilică. În monitorizarea astmului, cel mai important aspect este prevenirea exacerbărilor printr-o bună comunicare medic-pacient-familie şi o complianţă ridicată a acestora din urmă la tratam...

Purposes and objectives. Bronchial asthma is the most frequent chronic disease in children and in almost 50% of these cases, it occurs eosinophillic airway inflammation. The most important objective in monitoring asthma is preventing exacerbation by means of good communication between physician, patient and family, a good compliance of the latter a...

Cystic fibrosis ormucoviscidosis (CF) is the most frequent monogenic genetic disease with autosomal dominant transmision in caucasians. Currently, the typical approach is referring the CF patient to specialized centers with multidisciplinary teams. The inherent questions appear: which is then the role of the general practitioner (GP)? Should the GP...

BACKGROUND: The neonatal and pediatric antimicrobial point prevalence survey (PPS) of the Antibiotic Resistance and Prescribing in European Children project (http://www.arpecproject.eu/) aims to standardize a method for surveillance of antimicrobial use in children and neonates admitted to the hospital within Europe. This article describes the audi...

The neonatal and pediatric antimicrobial point prevalence survey (PPS) of the Antibiotic Resistance and Prescribing in European Children project (http://www.arpecproject.eu/) aims to standardize a method for surveillance of antimicrobial use in children and neonates admitted to the hospital within Europe. This article describes the audit criteria u...

Asthma is the most frequent chronic disease of childhood. In spite of significant improvement of treatment options and diagnostic tools, asthma remains in many patients uncontrolled. The term of "severe asthma" seems to be rather a large umbrella for a heterogeneous group of diseases. This paper is presenting our experience in two respiratory disea...

Pediatru ro TEMA EDIŢIEI Preţ: 25 RON FOTO: FOTOLIA GHID Starea de nutriţie a sugarului în România pag. 6 STADIUL ACTUAL Exacerbările pulmonare în fibroza chistică pag. 12 Imunodeficienţele primare -o permanentă provocare pag. 22 Relaţii între nutriţie și imunitate în patologia pediatrică www.pulsmedia.eu

The objective of this study was to investigate the percent of infections with adenovirus (ADV) in children who had pneumonia, acute bronchiolitis or viral respiratory infections and were admitted to two pediatrics hospitals in Bucharest (Grigore Alexandrescu Hospital and Alfred Rusescu Hospital). Subjects: 70 children aged one month - five years, a...

Life threatening events in children are frequently managed in out-of-hospital settings by emergency personnel without special pediatric background. Application of adult principles is generally sufficient to buy some time in extreme situations involving pediatric-age victims. Because very young children, and most of all infants, are not just small a...

Cough is a common presenting symptom to pediatricians and a frequent reason for consultation in primary care. Generally, an acute cough is a self-limited condition resulting from expected childhood viral illnesses. The causes of chronic cough in childhood are significantly different from those in adults and different approach to diagnosis and manag...

The Rotavirus is one of the most important etiological agents in infectious gastroenteritis in infants and small children. The authors present recently published data regarding the rotavirus gastroenteritis and clinical aspects from their practice. The article is concluding with discussion upon particular therapeutic strategies regarding the rotavi...

Abstract: Only about 1 % of the 10 million under-5 death every year occur in wealthy countries. The causes of child deaths in the industrialized world differ dramatically from those in developing countries. In the developing world, most of under-5 deaths are caused by pneumonia, diarrhea or newborn conditions. These problems rarely lead to death in...

We present the case of a female infant admitted in the Mother and Child Care Institute (IOMC) Bucharest at the age of 2 month. The main reasons for admission are: generalized hypertonia, clonic type seizures, opistotonic posture and intermittent fever. Summarizing data from the infant's medical history: severe intrauterine growth restriction (term...

The goal of this study is to present the clinical and evolutive features of Pneumocystis infection (PCP) in infants admitted in our clinic. We summarise these aspects from 17 cases (10 male and 7 female infants), admitted between 1st January 2004 and 31st May 2005. PCP infection is rare. It represents 1,5/1000 children (17 cases of 11328 total pati...

The objectives of this study were to verify comparatively clinical age reported antecedents and the morphological aspect of the intestinal mucosa in patients sensitive to gluten, hospitalised at IOMC ("Alfred Russescu" Hospital) in the last 7 years. Celiac disease is an inflammation most frequently affecting the proximal small intestine, depending...