Mihaela Badea

Mihaela Badea
Universitatea Transilvania din Brasov

PhD in chemistry; PhD in medicine; Habil Medicine

About

105
Publications
22,647
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1,146
Citations
Citations since 2016
55 Research Items
943 Citations
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2016201720182019202020212022050100150200
2016201720182019202020212022050100150200
2016201720182019202020212022050100150200

Publications

Publications (105)
Article
Full-text available
The popularity of botanical products is on the rise in Europe, with consumers using them to complement their diets or to maintain health, and products are taken in many different forms (e.g. teas, juices, herbal medicinal products, plant food supplements (PFS)). However there is a scarcity of data on the usage of such products at European level. To...
Article
Full-text available
Multiple antibiotic resistance has now become a major obstacle to the treatment of infectious diseases. In this context, the application of nanotechnology in medicine is a promising alternative for the prevention of infections with multidrug-resistant germs. The use of silver as a powerful antibacterial agent has attracted much interest. TiO2 and S...
Article
In this study, the inhibitory potential of four pyrethroid compounds on glutathione S-transferase (GST) by using molecular docking and in vitro assays was evaluated. Docking simulations of the pyrethroid ligands (bifenthrin, deltamethrin, lambda-cyhalothrin and tetramethrin) on the active site of GST were performed using Molegro Virtual Docker-MVD,...
Article
Full-text available
An original kinetic spectrophotometric procedure was developed for the determination of hydrogen cyanide (HCN) in the whole blood of fire victims. Cyanide poisoning by smoke inhalation is common in forensic medicine, but the blood HCN of fire victims has not been studied in detail so far. In this research project, we developed a simple, fast, sensi...
Article
Introduction: Diabetes is a group of metabolic disorders characterized by high blood sugar levels. The etiology is represented by a complex interaction between genetic and environmental factors. Metabolic disorders contribute to the pathogenesis of insulin resistance and of diabetes mellitus development. The insulin`s action in adipocytes is associ...
Article
Introduction: Diagnosis of diabetes mainly involves laboratory tests, which implies a high accuracy in accordance with good laboratory practices. There is a wide range of tests that shows valuable information about the patient’s glycemic curve, nutrition, insulin resistance, metabolic products, but also about the lipid status of patients. Objective...
Article
Full-text available
The increasing occurrence of infections caused by pathogens found on objects of everyday use requires a variety of solutions for active disinfection. Using active materials that do not require daily maintenance has a potential advantage for their acceptance. In this contribution, transparent films, with silver as the main antimicrobial agent and a...
Article
Introduction: Non-porous surfaces with antibacterial properties have begun to gain notoriety because strategies are being sought to prevent infections by methods that are as safe as possible for the human body. Objectives: Test methods can be variates, such as ISO 22196 standardized testing, inoculation testing with a sterile swab, bacteriological...
Article
Nanotechnology is defined as the branch that deals with the development of nanoparticles with physical and chemical properties with applicability in various industrial and medical fields. Due to their properties, nanoparticles can also be used in medical practice in the development of new types of testing and diagnosis both in vivo and in vitro. Fo...
Article
Mobile phones have become an essential "accessory" in modern society. Their use in hospitals can increase the quality of the medical act by allowing prompt communication between departments or the rapid search for data. Several studies demonstrate the possibility of microbial contamination of phones, mostly in the medical field, especially with spe...
Article
Full-text available
Antioxidants are synthetic or natural compounds capable of preventing or delaying oxidative damage caused by chemical species that can oxidize cell biomolecules, such as proteins, membranes, and DNA, leading to the development of various pathologies, such as cancer, atherosclerosis, Parkinson, Alzheimer, and other diseases serious. In this study, a...
Article
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Despite barrier measures and physical distancing tailored by the populations worldwide, coronavirus continues to spread causing severe health and social-economic problems. Therefore, researchers are focusing on developing efficient detection and therapeutic platforms for SARS-CoV2. In this context, various biotechnologies, based on novel molecules...
Article
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With the increasing prevalence of growing population, aging and chronic diseases continuously rising healthcare costs, the healthcare system is undergoing a vital transformation from the traditional hospital-centered system to an individual-centered system. Since the 20th century, wearable sensors are becoming widespread in healthcare and biomedica...
Article
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INHIBITORY ACTIVITY OF PYRETHROID PESTICIDES ON GLUTATHIONE S-TRANSFERASE. Glutathione S-transferase (GST) is one of the enzymes used to evaluate the effects caused by environmental contaminants. The aim of this work was to study the effects of four pyrethroid compounds (allethrin, cypermethrin, deltamethrin and fenpropathrin) on the catalytic acti...
Article
Full-text available
Objective: We aimed to evaluate the association of risk factors such as smoking and professional status (students vs employed) as determinants of disparities in perceived wellness among Romanian individuals. Methods: We conducted a cross-sectional study in which 145 participants were enrolled from December 2017 to February 2018, in Brasov, Brasov C...
Article
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Aseptic loosening and periprosthetic infections are the main causes of implant failure. Strategies to mitigate this drawback are therefore mandatory to avoid primary and revision replacement surgeries. A functional bioapatite–biopolymer double nanostructure fabricated by matrix-assisted pulsed laser evaporation to prevent infection of orthopedic an...
Article
Background: In patients with coronary artery disease, cardiovascular mortality and other acute events showed a clear correlation with risk factors and biomarkers including platelet activation. Study question of this research: Which was the incidence of low response to clopidogrel and its correlation with risk factors and biomarkers in coronary a...
Article
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Background: The rise in use of food supplements based on botanical ingredients (herbal supplements) is depicted as part of a trend empowering consumers to manage their day-to-day health needs, which presupposes access to clear and accurate information to make effective choices. Evidence regarding herbal supplement efficacy is extremely variable so...
Article
Biomonitoring studies are important for quantifying the body burden of pollutants and their possible effects on health. Serum concentration of 42 elements was assessed by ICP-MS in 89 children (7.2 ± 3.4 years old) from Bucharest (Romania). Levels of pollutants were compared with the clinical data obtained from routine blood tests. Clinical paramet...
Conference Paper
The study analyses the awareness of today's Romanian women on menopause, hormone replacement therapy (HRT) as well as on the usefulness/effects of some natural products that are used during this period. For this study we made a questionnaire with multiple choice answers applied to 200 women aged between 19-85 years Results showed that most women co...
Article
Full-text available
It is known that cigarette smoking is correlated with medical associated inquires. New electronic cigarettes are intensively advertised as an alternative to conventional smoking, but only a few studies demonstrate their harmful potential. A cross-sectional study was designed using 150 subjects from Brasov (Romania), divided into three groups: non-s...
Article
Full-text available
This study compares the values of the electromagnetic fields generated by three types of microwave ovens with the values available in scientific literature, guides and protocols, considering their impact on human health. Variations in electromagnetic radiation have been determined during and outside the operating time of the microwave ovens at diff...
Article
Full-text available
Iodine is a micronutrient of high importance for the health and good development of individuals. It is contained in many foods, but it is also part of the chemical component of oceans and soil. Its deficiency is still a problem of humanity, which has a serious repercussion on our health. It is therefore important to have specific, fast and cost eff...
Article
Persistent organochlorine pollutants (POPs) are highly lipophilic and resistant to degradation, hence these substances are commonly found in the environment even decades after their prohibition. The aim of the present study was to determine human serum concentrations of POPs and polycyclic aromatic hydrocarbons (PAHs) in the Romanian population, in...
Article
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Background: Low response to aspirin, aspirin resistance, and high platelet reactivity on aspirin treatment are similar names for lack of response to block arachidonic acid-induced aggregation with aspirin therapy and have an important role in the evolution of coronary artery disease (CAD) with thromboembolic events. Study question: Was to evalua...
Article
Pumpkin (Cucurbita maxima) seeds are a rich source of ingredients such as aminoacids, fatty acids, minerals, and phytochemicals exhibiting nutraceutical effects on human health. In this work, partially defatted pumpkin seeds flour, a by-product obtained during the manufacture of pumpkin seeds oil, was studied as an additive for common wheat flour....
Article
Smoking is considered an important source for inorganic elements, most of them toxic for human health. During the last years, there has been a significant increase in the use of e-cigarettes, although the role of them as source of inorganic elements has not been well established. A cross-sectional study including a total of 150 subjects from Brasov...
Article
Full-text available
Melatonin (N-acetyl-5-methoxytryptamin) is a ubiquitous molecule widely distributed in nature. It is a hormone produced by the pineal gland, which plays a role in the body's sleep cycles and it is a powerful antioxidant. It is possible to find it in several foods (fruit, rice, corn) and as food supplement. Screen-printed carbon electrode (DRP-150)...
Article
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Despite recent advances in understanding the complex pathogenesis of pancreatitis, the management of the disease remains suboptimal. The use of phytoceuticals (plant-derived pleiotropic multitarget molecules) represents a new research trend in pancreatology. The purpose of this review is to discuss the phytoceuticals with pancreatoprotective potent...
Article
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Ascorbic acid, well known as vitamin C, acts as antioxidant, helping the prevention of cell damage caused by free radicals. The paper presents fast methods for detecting ascorbic acid, using differential pulse voltammetry in different designed experiments. There were studied the possibilities of detection using buffer systems with pH 5.8, 7.0, 7.4...
Article
Grape skin is considered a valuable by-product for antioxidant and antibacterial agent preparation. The grape skin contains some active compounds, such as, dietary fiber, polyphenols, flavonols, and resveratrol; it is commonly used as a nutritional supplement. The main aim of this study was to establish the optimum dose of grape skin flour, to be u...
Article
Full-text available
The enzyme-based biosensor stability and its analytical performance depend on both the immobilization process and the matrix used for immobilization of the enzyme into a stable layer. In this paper, the development and evaluation of an optimal enzymatic layer for stable encapsulation of the acetylcholinesterase enzyme (AChE) through the sol-gel met...
Article
Full-text available
Grape skin is considered a valuable by-product for antioxidant and antibacterial agent preparation. The grape skin contains some active compounds, such as, dietary fiber, polyphenols, flavonols, and resveratrol; it is commonly used as a nutritional supplement. The main aim of this study was to establish the optimum dose of grape skin flour, to be u...
Chapter
The popularity of plant food supplements continues to increase with research indicating that approximately 20% of the population consume such products. This use may reflect disaffection with traditional models of medical care and a shift in focus to maintaining overall health and wellbeing. Consumers of plant food supplements tend, in the main, to...
Chapter
The object of this chapter is a short review of appropriate methods for the identification and authentication of plant materials and the quantification of bioactive compounds having physiological (or toxicological) relevance. The quality control of a botanical can be applied to raw material, a derivative (extract) or an ingredient of a commercial p...
Chapter
A remarkably high number of analytical methods concerning bioactive compounds, contaminants and biomarkers of exposure in Plant Food Supplements (PFS) have been developed by different scientific groups. The work present an update of classic and new developed methods for detection of several heavy metals, pesticides and mycotoxins from different sam...
Chapter
Both the application of official/published methods and the development of a novel analytical protocol need specific guidelines for their validation. Methods developed for quality controls of botanicals could be classified as: (1) phytochemical assays, and DNA-based identification; (2) methods for the identification and quantification of specific co...
Article
Based on advantages of available modern image processing techniques, thin-layer chromatography combined with image analysis becomes a promising alternative for the mycotoxins determinations in various foodstuffs. For this, the effect of digitizing channel selection and image processing parameters on aflatoxin B2 (AB2) and ochratoxin A (OTA) determi...
Article
Thin films of TiN, ZrC, and ZrN were deposited at room temperature on highly polished Ti and Si samples using the pulsed laser deposition technique. Grazing incidence X-ray diffraction investigations showed that films were nanocrystalline, with grain sizes from 5 to 12 nm and under compression. Simulations of X-ray reflectivity curves acquired from...
Article
Ayurvedic medicine is one of the oldest medical systems. It is an example of a coherent traditional system which has a time-tested and precise algorithm for medicinal plant selection, based on several ethnopharmacophore descriptors which knowledge endows the user to adequately choose the optimal plant for the treatment of certain pathology.This wor...
Article
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Epidemiological studies have suggested that a diet rich in antioxidant compounds could help in counteracting the effects of reactive oxygen species, reducing the risk factors for chronic diseases. The moderate consumption of wine, especially red wine, has been associated with the reduction in mortalities from cardiovascular diseases. One of the pos...
Article
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Diabetes is a rapidly growing disease that can be monitored at an individual level by controlling the blood glucose level, hence minimizing the negative impact of the disease. Significant research efforts have been focused on the design of novel and improved technologies to overcome the limitations of existing glucose analysis methods. In this cont...
Article
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Background Obesity is increasing worldwide and weight-control strategies, including the consumption of plant food supplements (PFS), are proliferating. This article identifies the herbal ingredients in PFS consumed for weight control and by overweight/obese dieters in six European countries, and explores the relationship between their consumption a...
Article
Full-text available
Ochratoxin A (OTA)-a toxin produced by Aspergillus carbonarius, Aspergillus ochraceus, and Penicillium verrucosum-is one of the most-abundant food-contaminating mycotoxins. To avoid the risk of OTA consumption for humans and animals, the rapid detection and quantitation of OTA level in different commodities are of great importance. In this work, an...
Article
In this work we try to address the large interest existing nowadays in the better understanding of the interaction between microbial biofilms and metallic implants. Our aimed was to identify a new preventive strategy to control drug release, biofilm formation and contamination of medical devices with microbes. The transfer and printing of novel bio...
Article
In this research work, the synthesis of Ag doped hydroxyapatite coatings for dental or orthopedic implants was performed. The main goal was to determine the influence of Ag content on the roughness and antimicrobial performance of the prepared thin films. The films were deposited on Ti6Al4V alloy by means of RF magnetron sputtering. Those coatings...
Article
Full-text available
Background: The use of food supplements containing botanicals is increasing in European markets. Although intended to maintain the health status, several cases of adverse effects to Plant Food Supplements (PFS) have been described. Objectives: To describe the self-reported adverse effects collected during the European PlantLIBRA PFS Consumer Sur...
Article
In this study we investigated the possibility to use in implantology of a new composite made from antibiotic imbedded in polymer matrix with goal to merge the mechanical advantages of the metallic substrate with the excellent corrosion protection of the polymer and antimicrobial effect of the antibiotics. Furthermore the addition of small quantity...
Article
The main goal of the paper is to enhance the resistance to the bacteria of the hydroxyapatite deposited on Ti6Al4V alloy substrate. Hydroxyapatite coatings, enriched with SiC and Ag, were prepared and investigated for this paper. SiC was added to enhance film corrosion resistance, while by Ag addition the improvement of the antibacterial properties...
Article
A solution is proposed to surpass the inconvenience caused by the corrosion of stainless steel implants in human body fluids by protection with thin films of bioactive glasses or with composite polymer-bioactive glass nanostructures. Our option was to apply thin film deposition by matrix-assisted pulsed laser evaporation (MAPLE) which, to the diffe...
Article
TiN thin films were deposited at room temperature on polished Ti samples by PLD. GIXRD investigations showed that films were crystalline, with grain sizes around 25 run. Simulations of XRR curves indicated that the layers were dense and only slightly rougher than Ti substrates. Nanoindentation results showed that TiN films possessed a hardness of 2...
Article
Full-text available
The organophosphorus insecticides, especially those based on methyl parathion as active principle, have been used extensively in the protection of rice in the Maranhão State, in the North-East of Brazil. This paper describes the optimization of a solid phase microextraction (SPME) procedure in confined atmosphere (headspace, HS) for the determinati...
Article
A solution to get rid of the inconvenience caused by corrosion of stainless steel implants inside human body is proposed. It consists in coating the stainless steel surface with thin films of bioactive glasses or with bioactive glass - polymer composite nanostructures which may change the implants behavior when inside the physiologic corrosive envi...
Article
The immobilization of enzymes onto transducer support is a mature technology and has been successfully implemented to improve biocatalytic processes for diverse applications. However, there exists still need to design more sophisticated and specialized strategies to enhance the functional properties of the biosensors. In this work, a biosensor plat...
Conference Paper
Full-text available
Introduction Ochratoxin A (OTA) is one of the most common naturally occurring mycotoxins and is found in a variety of grain crops such as barley, corn, wheat, rye and oats. In the past OTA, was found and analyzed in different food and beverages (e.g. beer). OTA is considered a serious health hazard to humans as it possesses nephrotoxic, hepatotoxi...
Conference Paper
Introduction Ochratoxin A (OTA) is one of the most common naturally occurring mycotoxins and is found in a variety of grain crops such as barley, corn, wheat, rye and oats. In the past OTA, was found and analyzed in different food and beverages (e.g. beer). OTA is considered a serious health hazard to humans as it possesses nephrotoxic, hepatotoxic...
Article
The aim of this systematic review is to summarize the evidence for or against the efficacy of plant food supplements (PFS) for coping inflammatory conditions by considering epidemiological and human intervention studies. The review considers six botanical species commonly used as food supplements/medicinals: Urtica dioica L., Symphytum officinalis...
Article
Plant food supplements (PFS) receive great acceptance by European consumers. However, quality and efficacy of these products remain a question of concern. The aim of this systematic review is to summarize and critically evaluate the evidence for or against the efficacy of PFS for coping inflammatory conditions by considering epidemiological and hum...
Article
All living organisms are dynamic systems, functioning as a result of interdependent (bio) chemical reactions that are permanently maintained in an equilibrium state. Human exposure over a period of time to a complex mixture of pollutants at low level and consumption of polluted water and/or foods, is likely to significantly contribute to the human...
Article
The retrospective study was based on the data obtained from the laboratory of the Water Treatment Plant Tarlung-Sacele and the Air Quality Monitoring Station BV5 Brasov. We have analysed the bacteriological indicators of water correlated with the main climatological factors and different phases of the technological flow of water treatment. The stud...
Article
Nasal carriage of Staphylococcus aureus is present in 20-40% of healthy people and appears to play a key role in the epidemiology of infections. The most concerning issue regarding S. aureus species is MRSA (methicillin-resistant Staphylococcus aureus) which is often resistant to many antibiotics. The aim of our study has consisted in the determina...
Article
Congenital abnormalities have traditionally been associated with genetically inherited conditions. Even though the importance of genes as factors in causation is accepted, environmental factors seem to be implicated just as strongly. There is very good evidence that pollutant-related congenital defects are widespread both in humans and wildlife but...
Article
Full-text available
It is essential to guarantee the safety of unprocessed plants and food supplements if consumers' health is to be protected. Although botanicals and their preparations are regulated at EU level, at least in part, there is still considerable discretion at national level, and Member States may choose to classify a product either as a food supplement o...