Miguel Tolentino- MS & PhD in Biomedical Sciences
- University of Wisconsin–Milwaukee
Miguel Tolentino
- MS & PhD in Biomedical Sciences
- University of Wisconsin–Milwaukee
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9
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Introduction
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Publications
Publications (9)
Background: Multiple sclerosis (MS) is a neurodegenerative condition characterized by high concentration of nitric oxide leading to the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS), a condition known as nitrosative stress. ROS and RNS produce the inhibition of the mitochondrial electron transport chain leading to...
Background: Photobiomodulation (PBM) therapy was previously shown to reduce the clinical severity of disease and modulated pro- and anti-inflammatory cytokines in an animal model of multiple sclerosis (MS). Objective: Previous observations were extended to determine the effect of PBM therapy on peripheral blood mononuclear cells and CD4+ T cells is...
Multiple sclerosis (MS) is an autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. High production of nitric oxide (NO) by iNOS contributes to the generation of reactive nitrogen species, leading to increased nitrosative stress and mitochondrial dysfunction linked to MS progression. Current therap...
Multiple sclerosis (MS) is a CD4+ Th1/Th17 mediated autoimmune disease characterized by myelin destruction, neurodegeneration and mitochondrial dysfunction. Current therapies suppress inflammation during early stages but are not effective in chronic stages characterized by oxidative damage. New therapies to slow progression, offer neuroprotection,...
