Miguel Ángel Rubio

Miguel Ángel Rubio
Universidad de Ciencias Aplicadas y Ambientales | UDCA · Facultad de Ciencias de la Salud

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121
Publications
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Publications

Publications (121)
Article
Background: Epicardial adipose tissue (EAT) contributes to coronary artery disease (CAD). EAT presents a specific lipidomic signature, showing increased ceramides and other proinflammatory lipids content. Besides, LPL (lipoprotein lipase) activity in EAT would contribute to its expansion, supplying fatty acids to the tissue. Our aim was to evaluat...
Article
Background: Myopathies are neuromuscular disorders of the skeletal muscles, in which the main symptom is muscle weakness due to muscle fiber dysfunction. Myopathies may be classified into two main categories: inherited and acquired. Hereditary myopathies are a heterogeneous group of diseases that include congenital myopathies, mitochondrial myopat...
Article
Full-text available
A pre-gestational thyroid reserve of iodine is crucial to guarantee the increased demand for thyroid hormone production of early pregnancy. An iodine intake ≥150 µg/day is currently recommended. The objective of this study was to assess average pre-gestational food-based iodine consumption in pregnant women at their first prenatal visit (<12 gestat...
Article
Resumen La hipoglucemia hiperinsulinémica posprandial es una complicación frecuente de la cirugía bariátrica. Aunque en general tiene una evolución leve y autolimitada, puede cursar con neuroglucopenia y comprometer la seguridad y la calidad de vida del paciente. El objetivo de este documento es ofrecer unas recomendaciones para facilitar la atenci...
Article
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The optimal maternal levels of thyroid hormones (TH) during the first trimester of gestation have not been established, nor has the ideal moment to initiate levothyroxine treatment (LT) to improve the evolution of gestation and fetal development. Cut-off points for Thyroid-stimulating hormone (TSH) <2.5 µIU/mL and free thyroxine (FT4)>7.5 pg/mL hav...
Article
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PurposeWeight regain (WR) compromises the effectiveness of bariatric surgery. The objective of this study was to determine differences in long-term WR prevalence using different definitions and analyze possible preoperative predictors involved.Methods Single-center retrospective cohort study including 445 adults who underwent 3 modalities of bariat...
Conference Paper
In adults with overweight or obesity, continued treatment with OW s.c. semaglutide 2.4 mg led to clinically relevant weight loss, while switching to placebo led to significant weight regain; these data underscore the chronicity and relapsing nature of obesity, and the need for continued treatment. Publication History Publication Date: 24 September...
Article
[Figure not available: see fulltext.] © 2021, The Author(s), under exclusive licence to Springer Science+Business Media, LLC, part of Springer Nature.
Article
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Obesity affects large numbers of patients with type 1 diabetes (T1D) across their lifetime, with rates ranging between 2.8% and 37.1%. Patients with T1D and obesity are characterized by the presence of insulin resistance, of high insulin requirements, have a greater cardiometabolic risk and an enhanced risk of developing chronic complications when...
Article
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Background: In people with overweight or obesity, long-term maintenance of weight loss is challenging. Subcutaneous (s.c.) semaglutide, a glucagon-like peptide-1 analogue, has shown clinically-relevant weight loss in a phase 2 trial in people with obesity. STEP 4 investigated the impact of continued semaglutide 2.4 mg treatment, vs switching to pla...
Article
Objective: To assess the value of measuring diplopia before and after pyridostigmine intake to differentiate myasthenia gravis from sagging eye syndrome. To establish a threshold for a positive response to pyridostigmine in the diagnosis of myasthenia gravis. Methods: 15 patients with myasthenia gravis and 15 with sagging eye syndrome diplopia were...
Article
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Importance The effect of continuing vs withdrawing treatment with semaglutide, a glucagon-like peptide 1 receptor agonist, on weight loss maintenance in people with overweight or obesity is unknown. Objective To compare continued once-weekly treatment with subcutaneous semaglutide, 2.4 mg, with switch to placebo for weight maintenance (both with l...
Article
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Cognitive impairment and behavioral changes in amyotrophic lateral sclerosis (ALS) are now recognized as part of the disease. Whether it is solely related to the extent of TDP-43 pathology is currently unclear. We aim to evaluate the influence of age, genetics, neuropathological features, and concomitant pathologies on cognitive impairment in ALS p...
Article
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Introducción: En relación con la cirugía coronaria, existen discrepancias respecto del pronóstico y tratamiento de la enfermedad cardiovascular en la mujer entre distintos estudios internacionales. Objetivo: Analizar los resultados de mortalidad y complicaciones hospitalarias y a 60 días luego de la cirugía de revascularización miocárdica aislada...
Article
Background: The outcome and treatment of cardiovascular disease in women differ among international studies. Objective: The aim of this study was to compare in-hospital and 60-day mortality and complications following isolated or combined coronary artery bypass graft surgery between women and men. Methods: The outcomes during hospitalization and at...
Article
Background Coronary artery disease (CAD) is the leading cause of morbidity and mortality worldwide. Recently, triglyceride rich lipoproteins are proposed to contribute to CAD risk; its concentrations would be partly determined by lipoprotein lipase (LPL) and endothelial lipase (EL). Epicardial adipose tissue (EAT), a visceral AT surrounding myocard...
Article
Full-text available
Objective: Epicardial adipose tissue (EAT) is an active endocrine organ that could contribute to the pathophysiology of coronary artery disease (CAD) through the paracrine release of proatherogenic mediators. Numerous works have analyzed the inflammatory signature of EAT, but scarce informations on its lipidome are available. Our objective was fir...
Article
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Objective: To validate prospectively in multiple centers, the accuracy and clinical utility of the European System for Cardiac Operative Risk Evaluation (EuroSCORE II) to predict the operative mortality of cardiac surgery in Argentina. Methods: Between January 2012 and February 2018, 2,000 consecutive adult patients who underwent cardiac surgery...
Technical Report
Full-text available
Cardiac hydatidosis Muy interesante el artículo sobre recidiva de una hidatidosis cardíaca 25 años después del tratamiento quirúrgico inicial 1. Es evidente que con los nuevos estudios imagenológicos se pueden detectar estas recidivas o localizaciones infrecuentes de la hidati-dosis en el corazón. Igualmente fue presentado en el año 2008 en la Revi...
Article
Background and aims: Epicardial adipose tissue (EAT) is a visceral AT, surrounding myocardium and coronary arteries. Its volume is higher in Type 2 diabetic (DM2) patients, associated with cardiovascular disease risk. Lipoprotein lipase (LPL) hydrolyses triglycerides (TG) from circulating lipoproteins, supplying fatty acids to AT, contributing to...
Article
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Background: The aim of this study was to analyze the current in-hospital outcomes of aortic valve replacement (AVR) surgery in order to serve as a benchmark for comparing the local results of transcatheter aortic valve implantation (TAVI). Methods: We retrospectively analyzed the in-hospital outcomes of 422 patients undergoing isolated AVR between...
Article
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Objective: To present the current in-hospital outcomes and mid-term survival of acute type A aortic dissection (AAAD) surgery performed by a group of dedicated high-volume thoracic aortic surgeons in a University Hospital in Argentina. Methods: A retrospective analysis of prospectively collected data over a 6-year period (2011-2016) was performe...
Article
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The outcome of allogeneic hematopoietic stem cell transplant (HCT) in patients with myeloid malignancies is better in those without minimal residual disease (MRD) than in those with MRD+ as assessed by multiparametric flow cytometry (MPFC). WT1 quantitation has also been used to assess the probability of relapse in acute myeloid leukemia treated wi...
Article
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Objectives: The aim was to estimate the risk of dialysis postoperative de novo dialysis in patients undergoing elective cardiac surgery, according to varying degrees of pre-existing renal dysfunction, and to compare the outcomes with the expected prevalence of dialysis based on several risk scores. Methods: A retrospective analysis was performed...
Article
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The objective of this study was to evaluate the efficacy of age, creatinine and ejection fraction (ACEF) score and the modified ACEFCG model, incorporating creatinine clearance, to predict immediate operative mortality risk of patients undergoing elective cardiac surgery. A retrospective analysis was performed of prospectively collected data betwee...
Article
Background: Epicardial adipose tissue (EAT) is a visceral adipose tissue (AT) surrounding and infiltrating myocardium and coronary arteries. Increased EAT may represent a chronic inflammatory injury and represent a link with coronary artery disease (CAD). Metalloproteinases (MMPs) are involved in expansion of AT. Objective: to evaluate MMP-2 and...
Article
A systematic tool to assess the Carbon Footprint (CF) and Water Footprint (WF) of pork production companies was developed and applied to representative Catalan companies. To do so, a cradle-to-gate environmental assessment was carried out by means of the LCA methodology, taking into account all the stages involved in the pork chain, from feed produ...
Article
An 85-year-old man presented with dyspnea New York Heart Association functional class IV 4 years after implantation of a 26-mm CoreValve transcatheter aortic valve (TAV) (Medtronic, Minneapolis, Minnesota). Angiography revealed severe aortic regurgitation due to the deep position of the prosthesis
Article
Full-text available
Transcatheter Aortic Valve Replacement (TAVR) is performed in patients who are poor surgical candidates. Many patients have inadequate femoral access, and alternative access sites have been used such as the transapical approach discussed in this paper. We present an elderly and fragile patient not suitable for surgery for unacceptable high risk, in...
Article
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The growth factor heregulin (HRG) promotes breast cancer (BC) tumorigenesis and metastasis and differentially modulates BC cell responses to DNA-damaging agents via its dual extracellular and nuclear localization. Given the central role of telomere dysfunction to drive carcinogenesis and to alter the chemotherapeutic profile of transformed cells, w...
Article
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Telomere length, shape and function depend on a complex of six core telomere-associated proteins referred to as the telosome or shelterin complex. We here demonstrate that the isoform β2 of the heregulin family of growth factors (HRGβ2) is a novel interactor of the telosome/shelterin complex in human telomeres. Analysis of protein-protein interacti...
Conference Paper
We present the preliminary results of an ongoing study on using clustering techniques to automatically categorize the learning stage of students at the end of an introductory programming course. We have obtained some success in inferring some learning stages but work remains to be done to classify students at the intermediate levels.
Article
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Only a few reports have analysed low-risk patient outcomes and in every case, the risk was based on a logistic EuroSCORE ≤ 2. Since this original EuroSCORE overestimates surgical risk, we developed this study to prospectively evaluate the immediate results of cardiac surgery in patients with an expected mortality risk ≤ 2% according to the EuroSCOR...
Article
We have succeeded in the preparation of electrospun fibers of polystyrene incorporating a metallo-organic polymer of [Fe (II) (4-octadecyl-1,2,4-triazole)3(ClO4)2]n. The obtained fibers have diameters in the range 2–4 µm and show the characteristic spin-crossover transition associated with the metallo-organic polymer. The structure of both, polysty...
Article
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El reemplazo percutáneo de la válvula aórtica en pacientes con contraindicación de cirugía mostró una signifi cativa mejoría en la sobrevida comparado con el tratamien-to médico convencional y similar sobrevida en pacientes ancianos malos candidatos quirúrgicos comparando con cirugía convencional. El acceso transapical estuvo re-lacionado con mayor...
Article
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RESUMEN El reemplazo percutáneo de la válvula aórtica en pacientes con contraindicación de cirugía mostró una signifi cativa mejoría en la sobrevida comparado con el tratamien-to médico convencional y similar sobrevida en pacientes ancianos malos candidatos quirúrgicos comparando con cirugía convencional. El acceso transapical estuvo re-lacionado c...
Article
Full-text available
The European System for Cardiac Operative Risk Evaluation II (EuroSCORE II) is an updated version of the original EuroSCORE that must be extensively validated. The objective was to prospectively evaluate the efficacy of EuroSCORE II in predicting the immediate results of cardiac surgery in Argentinean centres. A prospective consecutive series of 50...
Article
Full-text available
The objective was to explore the usefulness of the logistic EuroSCORE to stratify the long-term survival curves in a sample of patients undergoing cardiac surgery. The 8-year survival of 390 patients undergoing cardiac surgery between 2003 and 2004 was analyzed, according to the basal value of the EuroSCORE, patients were classified into three risk...
Conference Paper
Full-text available
Approximate string matching (ASM) is a well-known computational problem with important applications in database searching, plagiarism detection, spelling correction, and bioinformatics. The two main issues with most ASM algorithms are (1) computational complexity, and (2) low specificity due to a large amount of false positives being reported. In t...
Article
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Background: The aim was to assess the incidence of prosthesis-patient mismatch (PPM) after mitral valve replacement (MVR) in patients receiving Biocor® porcine or mechanical valves, and to evaluate the effect of PPM on long-term survival. Methods: All patients undergoing MVR between 2009 and 2013 received either mechanical or bioprosthetic valve...
Article
Cited By (since 1996): 5, Export Date: 24 October 2012, Source: Scopus, CODEN: EUPJA, doi: 10.1016/j.eurpolymj.2010.10.029, Language of Original Document: English, Correspondence Address: López, D.; Instituto de Ciencia y Tecnología de Polímeros, CSIC, Juan de la Cierva 3, 28006 Madrid, Spain; email: daniel@ictp.csic.es, References: Bousseksou, A.,...
Article
Mucoepidermoid carcinoma represents between 10-30% of primary carcinomas of the submandibulary, parotid and minor salivary glands. Cutaneous involvement is extremely rare and more, as a primary origin of the tumor. A few cases of primary mucoepidermoid carcinoma of the skin have been described. We report an 83-year-old man presenting a primary cuta...