Miguel Padial-Molina

Miguel Padial-Molina
University of Granada | UGR · Faculty of Odontology

DDS, PhD

About

69
Publications
15,355
Reads
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1,545
Citations
Additional affiliations
June 2010 - December 2014
University of Michigan
Position
  • Research Associate
October 2006 - February 2010
Universidad de Granada
Education
September 2006 - February 2010
University of Granada
Field of study
  • Dentistry
October 2000 - July 2005
University of Granada
Field of study
  • Dentistry

Publications

Publications (69)
Article
Purpose: The aim of this study was to establish an objective criterion in terms of marginal bone level (MBL) to know the prognosis of an implant. Materials and methods: A group of 176 patients in whom 590 implants were placed were included in this retrospective study. Patients older than 18 years, presenting either Kennedy class I or II edentulo...
Article
Full-text available
Objective To investigate if there is epidemiological evidence of an association between edentulism and cognitive decline beside that currently available from limited sample-sized case series and cross-sectional studies considering limited co-variables. Materials and methods Data from two USA national health surveys [NHIS 2014–2017 and NHANES 2005–...
Article
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Aim: To compare the effectiveness of two xenografts for maxillary sinus floor augmentation in terms of clinical, radiographical, histological and molecular outcomes. Materials and methods: A split-mouth randomized clinical trial was conducted at the University of Granada. Ten consecutive patients in need of bilateral two staged maxillary sinus f...
Article
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Titanium particles embedded on peri-implant tissues are associated with a variety of detrimental effects. Given that the characteristics of these detached fragments (size, concentration, etc.) dictate the potential cytotoxicity and biological repercussions exerted, it is of paramount importance to investigate the properties of these debris. This st...
Article
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The aim of this study was to analyze the differences in terms of the marginal bone level (MBL) around implants with either an internal conical or an internal hexagonal implant–prosthesis connection. A randomized clinical trial included patients in need of a single implant-supported restoration. The implant–prosthesis connection was either internal...
Article
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Musashi-1 (MSI1) is an RNA-binding protein that regulates progenitor cells in adult and developing organisms to maintain self-renewal capacities. The role of musashi-1 in the bone healing environment and its relation with other osteogenic factors is unknown. In the current study, we analyze the expression of MSI1 in an experimental model of rat fem...
Article
Objectives To compare the marginal bone level around implants with a thin multi‐phosphonate coated surface after either an early or conventional loading protocol. Material and methods A randomized pilot clinical trial was conducted. Dental impressions were obtained after either 4 (test) or 8 weeks (control) and single crowns screwed‐in 2 weeks lat...
Article
Introduction Ageing leads to physiological cognitive decline that it is worsened in people with neurodegenerative diseases such as Alzheimer's disease. Despite the ongoing search for a solution to this cognitive decline, no effective remedies have been established. It has been determined that modifiable external factors, such as oral health and occ...
Article
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Background: Pain has been associated with structural changes of the brain. However, evidence regarding white matter changes in response to acute pain protocols is still scarce. In the present study, we assess the existence of differences in brain white matter related to pain intensity reported by patients undergoing surgical removal of a mandibular...
Article
Background: The objective of this cross-sectional clinical study was to analyze the differences in the microbiome in gingival sulci of adult patients in the presence or absence of chronic periodontitis. Material and methods: Patients with or without periodontal disease were included in this cross-sectional study. Subgingival biofilm samples were...
Article
Objectives: To analyze a modified biphasic phycogenic biomaterial in comparison with anorganic bovine bone in maxillary sinus floor elevation in humans. Material and methods: Eight male patients in need of bilateral two-stage sinus floor elevation were consecutively recruited for this randomized split-mouth study. A combination of autogenous cor...
Article
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Objectives:: To evaluate the reported literature on the use of stem cells or growth factors for post extraction treatment of the alveolar bone. Material and Methods: A NCBI PubMed and PubMed Central databases search was conducted between September 2010 and August 2018, to identify animal or clinical studies reporting the clinical, radiographical a...
Article
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Introduction: The task of Group II was to review and update the existing data concerning extraction socket preservation with or without membranes and soft tissue influence on post-extraction alveolar ridge preservation; extraction socket preservation using different biomaterials as bone grafts, growth factors, and stem cells. Special interest was p...
Article
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Nanoparticles (NPs) based on the polymer poly (lactide-co-glycolide) acid (PLGA) have been widely studied in developing delivery systems for drugs and therapeutic biomolecules, due to the biocompatible and biodegradable properties of the PLGA. In this work, a synthesis method for bone morphogenetic protein (BMP-2)-loaded PLGA NPs was developed and...
Article
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Background: Musashi-1 (MSI1) is a negative regulator of mesenchymal stromal cell (MSC) differentiation which in turn favors cell proliferation. However, little is known about its expression by MSC from the oral cavity and in the context of osteogenic differentiation. Aim: The aim of this study was to analyze the expression of MSI1 in the context of...
Article
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Background/Objective:To study pain-brain morphometry associations as a function of post-surgery stages (anesthesia, pain and analgesia) in an acute pain model. Method:Impacted mandible third molar were extracted. Before surgery, an anatomical T1 scan was obtained. Regional brain volumen and subcortical nuclei shapes were obtained. Statistical analy...
Article
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Aim: The aim of this study was to examine the clinical and histological differences of using a combination of alloplastic beta triphasic calcium phosphate (β-TCP) and a cross-linked collagen membrane versus autologous platelet-rich fibrin (PRF-L) in ridge preservation after dental extraction. Material and methods: Fifty-one patients were included i...
Article
Background: PLGA is widely used for the development of delivery systems for drugs and therapeutic biomolecules in tissue engineering applications. Particles of biphasic calcium phosphate can be covered by PLGA to change their manipulating characteritics. Purpose: Aim of this study was to investigate the radiological and histomorphometric results o...
Article
Objectives The aim of this study was to evaluate and compare the morphometric components and the histological properties of pristine bone and bone grafted with a biphasic ß‐tricalcium phosphate in humans using the maxillary sinus model. Reparative mesenchymal stem cells in the pristine bone and graft were also evaluated. Material/methods For this...
Article
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This study aimed to analyze the expression of Musashi-1 (MSI1) in maxillary native bone and grafted bone after maxillary sinus floor elevation. To do so, fifty-seven bone biopsies from 45 participants were studied. Eighteen samples were collected from native bone while 39 were obtained 6 months after maxillary sinus grafting procedures. Musashi-1 w...
Article
Objective: To compare the clinical and histologic outcomes of two different grafting materials (allograft and xenograft) when combined with autogenous bone and covered with a collagen membrane for sinus augmentation. Material and methods: A parallel case series of fourteen patients in need of a unilateral sinus augmentation was evaluated in this...
Article
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Objectives: Injury of the inferior alveolar nerve (IAN) is a serious intraoperative complication that may occur during routine surgical procedures, such as dental implant placement or extraction of impacted teeth. Thus, the purpose of this study was to analyze the trajectory of the mandibular canal (MC), the location of the mental foramen (MF) and...
Article
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Objective: This study was initiated to evaluate the 5-year implant survival rate and marginal bone levels around a 3.0-mm implant when replacing a single tooth in the anterior region. Materials and methods: The study was designed as a prospective, single-arm, multicenter clinical study. Patients missing 12, 22, 32, 31, 41 or 42 teeth were includ...
Article
Objective: To investigate the correlation between patient-dependent variables and dimensional variations of the maxillary sinus. Methods: In this cross-sectional study, a total of 394 individual cone-beam computed tomography scans were evaluated by one calibrated examiner to measure the total volume of the maxillary sinus, the distance between t...
Article
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Objectives To describe the microbial profiles of peri-implant diseases and the main detection methods. Material and Methods A literature search was performed in MEDLINE via PubMed database to identify studies on microbial composition of peri-implant surfaces in humans published in the last 5 years. Studies had to have clear implant status definiti...
Article
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Introduction The task of Group 2 was to review and update the existing data concerning clinical and genetic methods of diagnostics of peri-implantitis. Special interest was paid to the peri-implant crevicular fluid (PICF) overview including analysis of enzymes and biomarkers and microbial profiles from implants. Material and Methods The main areas...
Article
Background: The posterior superior alveolar (PSA) artery is frequently encountered in the area where the lateral osteotomy is performed during direct sinus augmentation procedures. Objective: To investigate the correlation between patient-dependent variables and measurements related to PSA using cone beam computed tomography (CBCT) data. Method...
Article
B a c k g r o u n d Melatonin, a hormone produced primarily in the pineal gland, possesses a series of biological properties that appear to have an influence on bone homeostasis. Currently, little is known about how melatonin influences bone metabolism in periodontology and implantology. O b j e c t i v e s The objectives of this study are (1) to r...
Poster
Full-text available
trabajo en colaboracion con la Universida de Granada presentado en el congreso de la sociedad de Protesis L16
Article
Objective: To investigate how the distance between narrow implants and adjacent teeth influences the marginal bone levels (MBL) up to 3 years after placement. Material and methods: A prospective, single-arm, multicenter clinical study was designed to include patients missing 12, 22, 32, 31, 41 or 42 teeth. Implants of 3.0 mm diameter and differe...
Article
Passive fit between prosthesis and implants or abutments is a significant factor in preventing mechanical and biologic failures of implant-supported prostheses. Therefore, impression techniques must transfer the 3D implant position as accurately as possible for a correct superstructure fabrication. A novel impression protocol that uses an individua...
Article
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The advancement of molecular mediators or biologic agents has increased tremendously during the last decade in periodontology and dental implantology. Implant site development and reconstruction of the lost periodontium represent main fields in which these molecular mediators have been employed and investigated. Different growth factors trigger dif...
Article
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Poly-lactic-co-glycolic acid (PLGA) is one of the most widely used synthetic polymers for development of delivery systems for drugs and therapeutic biomolecules and as component of tissue engineering applications. Its properties and versatility allow it to be a reference polymer in manufacturing of nano-and microparticles to encapsulate and deliver...
Article
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Material and methods: An observational case-control study was performed in 130 puerperal women: mothers of PB/LBW neonates (cases, n=65) and mothers of full-term normal-weight neonates (controls, n=65). Data were gathered from all participants on socio-demographic, gynecological, and periodontal variables and on placental immunohistochemical COX-2...
Article
Tissue repair and regeneration is assisted by the efficient coordination of cell and extracellular matrix interactions mediated by matricellular molecules such as periostin. Given its high expression around teeth, the periodontal organ represents an ideal system to capture the protein dynamics during wound healing. An observational prospective case...
Article
The regeneration of the original structure and function of bone-ligament interfaces remains a major challenge in biomedical research. A preclinical model that maintains physiologic mechanical loads and controls for other external factors, such as microbial influence, is of great value for testing novel regenerative materials, provided that studies...
Article
Computer-guided implant surgery in fresh extraction sites is an underdeveloped procedure. The presence of teeth that will be extracted makes the creation of an appropriate radiographic template for virtual simulation of the rehabilitation impossible. A modified radiographic template is presented to define a digital restorative simulation for the ma...
Article
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Bone regeneration is often needed prior to dental implant treatment due to the lack of adequate quantity and quality of the bone after infectious diseases, trauma, tumor, or congenital conditions. In these situations, cell transplantation technologies may help to overcome the limitations of autografts, xenografts, allografts, and alloplastic materi...
Article
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Background: Collagen-induced arthritis (CIA), a murine experimental disease model induced by immunization with type II collagen (CII), is used to evaluate novel therapeutic strategies for rheumatoid arthritis. Adult stem cell marker Musashi-1 (Msi1) plays an important role in regulating the maintenance and differentiation of stem/precursor cells....
Article
Dental pulp repair is a common process triggered by microbial and mechanical challenges. Matricellular modulators, such as periostin, are key for extracellular matrix stability and tissue healing. In the scope of the dental pulp, periostin expression has been reported during development and active dentinogenesis. However, the specific dental pulp c...
Article
Bone engineering of localized craniofacial osseous defects or deficiencies by stem cell therapy offers strong prospects to improve treatment predictability for patient care. The aim of this phase I/II randomized, controlled, clinical trial was to evaluate reconstruction of bone deficiencies of the maxillary sinus with transplantation of autologous...
Article
Although some risk factors of peri-implant disease are well defined, the lack of efficient and predictable approaches to treat peri-implantitis has created difficulty in the management of those complications. The aim of this review was to evaluate the reliability of the diagnosis methods and to provide a set of guidelines to treat peri-implant dise...
Article
Full-text available
Background: Dental implant placement is a widely used treatment that provides functional and esthetic resolution for patients suffering from tooth loss. However, the incidence of peri-implant diseases has been rising recently. Periodontal diseases and peri-implant diseases share many similarities. Hence, it is important to find out whether patient...
Data
Aim: The aim of this study was to study if generalized aggressive periodontitis (GAP) have similar survival rates (SR) and marginal bone loss (MBL) when compared to chronic periodontitis (CP) and/or healthy patients (HP). Methods: An electronic literature search was conducted by one reviewer (AM) in several databases from 2000 to 2013, including ME...
Article
The aims of this study were to analyze the success rate of mini-implants and miniscrews and to report the reasons behind them. An electronic literature search from PubMed databases and a hand search in implant- and orthodontic-related journals were performed until December 31, 2011. Human clinical studies in English that reported temporary anchorag...
Article
The periodontium is continually exposed to a variety of challenges. Over the past decade, preclinical and clinical research has highlighted the complex modulatory role of the periodontal ligament (PDL) as a mediator of tissue repair and homeostasis. Experiments carried out in both human and animal models have highlighted the importance of the PDL a...
Article
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Current knowledge about Periostin biology has expanded from its recognized functions in embryogenesis and bone metabolism to its roles in tissue repair and remodeling and its clinical implications in cancer. Emerging evidence suggests that Periostin plays a critical role in the mechanism of wound healing; however, the paracrine effect of Periostin...
Article
In the oral and craniofacial complex, tooth loss is the most commonly acquired disfiguring injury. Among the most formidable challenges of reconstructing tooth-supporting osseous defects in the oral cavity is the regeneration of functional multi-tissue complexes involving bone, ligament, and tooth cementum. Furthermore, periodontal multi-tissue eng...
Article
In the chronic established periodontal lesion, the proliferation and migration potential of periodontal ligament (PDL) cells are significantly compromised. Thus, the progressive loss of tissue integrity is favored and normal healing and regeneration compromised. Periostin, a known PDL marker, modulates cell-matrix interactions, cell behavior, as we...
Conference Paper
The proliferation and migration potential of the periodontal ligament (PDL) cells in the chronic established periodontitis lesion is significantly compromised. This important functional disruption favors the progressive loss of tissue integrity in the susceptible host exposed to the pathogenic biofilm. Periostin, a known PDL marker, acts as an impo...
Article
Aim: To determine the influence of different local and systemic factors on histologic, histomorphometric, and radiographic outcomes after maxillary sinus augmentation. Materials and methods: Fifty-two sinus augmentation procedures were performed. Grafting material consisted of a mixture of anorganic bovine bone (ABB) and autogenous bone. After 6...
Article
Full-text available
Periostin, a matricellular adapter protein highly expressed by periodontal ligament fibroblasts, is implicated in the maintenance of periodontal integrity, which is compromised during periodontal diseases. The aim of this study was to explore the influence of chronic periodontal inflammation on tissue periostin levels. Periodontal breakdown was ind...
Article
Background: Periostin is a matricellular protein essential for tissue integrity and maturation and is believed to have a key function as a modulator of periodontal ligament (PDL) homeostasis. Aim: To evaluate if periodontal disease-associated pathogen-related virulence factors (endotoxins / lipopolysaccharides) and pro-inflammatory cytokines alter...
Article
Full-text available
In humans, microbially induced inflammatory periodontal diseases are the primary initiators that disrupt the functional and structural integrity of the periodontium (i.e., the alveolar bone, the periodontal ligament, and the cementum). The reestablishment of its original structure, properties, and function constitutes a significant challenge in the...
Conference Paper
Periostin, a matricellular molecule highly expressed by periodontal ligament fibroblasts, is implicated in the maintenance of periodontal integrity. Objective: To explore the influence of chronic inflammation on the expression of the matricellular adapter protein Periostin over time. Methods: Periodontal breakdown was induced in male Sprague-Dawley...
Conference Paper
Periostin is a matricellular protein essential for tissue integrity and maturation and is believed to have a key function as a modulator of periodontal ligament (PDL) homeostasis. Objective: To evaluate whether periodontal pathogen-related byproducts (endotoxins/lipopolysaccharides (LPS)) and pro-inflammatory cytokines alter the expression of Perio...
Article
Regeneration of bone-ligament complexes destroyed due to disease or injury is a clinical challenge due to complex topologies and tissue integration required for functional restoration. Attempts to reconstruct soft-hard tissue interfaces have met with limited clinical success. In this investigation, we manufactured biomimetic fiber-guiding scaffolds...
Article
Migration of dental implants into the maxillary sinus is an uncommon, but increasingly reported complication. Implant migration may result from initial lack of primary stability, intrasinusal and nasal pressure changes, autoimmune reaction to the implant or incorrect distribution of occlusal forces. This retrospective study aims at analyzing the fa...
Article
Migration of oral implants through a previously consolidated graft is an extremely rare event. We reported 2 cases of migration at least 6 months postimplantation in sinus grafted in 2 stages, consequently over 6-month graft maturation period. Sinus elevations and implants placement in 2 patients were performed. Clinical and radiographic follow-up...
Article
Maxillary sinus augmentation is a predictable implant site development technique, although several local and systemic factors may influence outcomes. The aim of this study was to evaluate healing patterns and bone remodeling activity following the use of two different graft mixtures for maxillary sinus augmentation. Patients in need of maxillary si...
Article
Oral melanoacanthoma (OMA) is an uncommon, reactive, pigmented mucocutaneous lesion. It is a rapidly growing, well-circumscribed, small, brown-to-black, solitary or multifocal macule that is characterized histopathologically by proliferation of keratinocytes and pigment-laden dendritic melanocytes. At the end of a one-month healing period after den...
Article
Development of new biomaterials is a constant in regenerative medicine. A biomaterial's surface properties, such as wettability, roughness, surface energy, surface charge, chemical functionalities and composition, are determinants of cell adhesion and subsequent tissue behavior. Thus, the main aim of this study was to analyze the correlation betwee...
Article
The objectives of this study were to assess the microvessel density (MVD) of intra-sinus grafts after 6 months of wound healing and to study the relationship between revascularization processes and patient clinical variables and habits. We performed 45 maxillary sinus augmentations with different implant placements in 25 consecutive patients, obtai...