Miguel Marín Gabriel

Hospital Universitario Puerta de Hierro-Majadahonda · Departamento de Pediatría y Neonatología

Background: Respiratory syncytial virus (RSV) is a common cause of lower respiratory tract infections in infants. This phase 1/2, observer-blind, randomized, controlled study (ClinicalTrials.gov/NCT03636906) assessed the safety and immunogenicity of an investigational chimpanzee-derived adenoviral vector RSV vaccine (ChAd155-RSV, expressing RSV F,...

Background There are very few studies assessing the association between a COVID-19 infection and the rates of exclusive breastfeeding (EBF) upon discharge following the first waves of the pandemic and after the initiation of vaccination. The primary objective of this study is to compare the rates of EBF upon discharge in mothers diagnosed with a CO...

Introduction: In neonatal resuscitation, it is important to know whether the use of a combination of quality assessment tools has an impact on the preparation of the resuscitation bed and equipment, the correct performance of the procedure and the clinical outcomes of the most vulnerable neonates. Material and methods: Multicentre, prospective,...

Resumen Introducción Es importante conocer si en la reanimación neonatal el uso de diversas herramientas de calidad tiene impacto en la preparación del puesto de estabilización, correcto desarrollo del procedimiento y evolución clínica de aquellos neonatos más vulnerables. Material y métodos Estudio de intervención cuasiexperimental, prospectivo...

Objective: The aim of this prospective study was to describe demographic and clinical characteristics of neonates born to mothers with active or past Graves disease and to assess compliance since implementation of a new protocol in our center. Methods: We prospectively followed up neonates born to mothers with active or past Graves disease in a...

Background Adherence to the Ten Steps of the Baby-Friendly Hospital Initiative has been shown to have a protective role for the initiation and maintenance of breastfeeding. Research Aims (1) To determine the breastfeeding rate during the first 6 months of life in children of mothers diagnosed with COVID-19 infection at the time of birth; and (2) t...

The Saethre-Chotzen syndrome is a craniofacial malformation syndrome characterized by synostosis of coronal sutures and limb anomalies. The estimated prevalence of this syndrome is 1 in 25 000-50 000 live births. We present a case report of a neonate, without relevant family history, who presented craniofacial alterations at birth. Given the phenot...

To qualify and quantify clinical practices related to pain assessment and non-pharmacologic analgesia (NPA) in newborns in Spanish public maternity hospitals We surveyed providers online regarding their use of pain assessment scales, NPA interventions in neonates undergoing procedures, as well parents’ presence or absence during interventions. The...

Background: Our aim was to describe the clinical features of mothers with coronavirus disease 2019 (COVID-19) infection during gestation or delivery, and the potential vertical transmission. We also wish to evaluate the possible horizontal transmission after hospital discharge, by means of a follow-up of all the newborns included at 1 month of age...

Objective This study aimed to use real-time safety audits to establish whether preparation of the equipment required for the stabilization and resuscitation of newborns in the delivery room areas is adequate. Study Design This was a descriptive, multicenter study performed at five-level III-A neonatal units in Madrid, Spain. For 1 year, one researc...

Aim: The objective of our study was to determine whether the SARS-CoV-2-positive mothers transmit the virus to their hand-expressed colostrum. Methods: This is an observational prospective study that included pregnant women who tested positive for SARS-CoV-2 by PCR test on a nasopharyngeal swab at the moment of childbirth and who wanted to breastf...

Aim Our aim was to describe the clinical features of mothers infected with COVID‐19 and examine any potential vertical mother to newborn transmission. We also assessed how effective the discharge recommendations were in preventing transmission during the first month of life. Methods This multicentre descriptive study involved 16 Spanish hospitals....

Aim To evaluate the immediate clinical impact of donor human milk availability in a NICU about nutritional, clinical and biometric parameters. Methods This retrospective‐cohort study included 28‐32 weeks gestational age born at our hospital in a three‐year period before and after the donor human milk implementation. Data about starting, advance an...

Enoxaparin is a low molecular weight heparin used in the neonatal period. It requires less monitoring than standard or unfractionated heparin, although current knowledge about its dose and therapeutic levels in neonates is scarce. In addition, there is very limited information about the management of overdose in this age group. We present the first...

Background: Some studies have suggested an association between synthetic oxytocin administration and type of birth with the initiation and consolidation of breastfeeding. Aim: This study aimed to test whether oxytocin administration and type of birth are associated with cessation of exclusive breastfeeding at different periods. A second objectiv...

Lithium therapy is currently a cornerstone of treatment for mothers who suffer bipolar disorders. Those who wish to breastfeed their children are often told they have to decide whether modifying the treatment for their disorder or even avoiding lactation. Lithium administration during breastfeeding has been described to produce certain side effects...

Aim: Oxytocin is a hormone involved in the mechanism of breastfeeding, uterine contractions, and social relationships. Atosiban (competitive oxytocin antagonist) is one of the most commonly used tocolytics for the threat of preterm labor in Europe. The aim of this study is to determinate if the administration of atosiban has any influence in the t...

Methods: This is a cohort prospective study of women giving birth by C-section. 48-72h after delivery, sociodemographic variables were collected, Mother-to-Infant Bonding Scale and newborn's response to separation test were performed. 10-12weeks after delivery Mother-to-Infant Bonding Scale and questions about baby's feeding were completed. Resul...

Aim: To analyze the association of labor and sociodemographic factors with cessation of exclusive breastfeeding (EBF) at 3 and 6 months of life. Materials and methods: A prospective cohort study (n = 529) was performed in a tertiary hospital with the Baby-Friendly Hospital Initiative (BFHI) award. Labor and sociodemographic factors were investig...

Aim: The consequences that intrapartum administration of hormones can have on breastfeeding are unclear. The aim of the study is to determine if synthetic intrapartum oxytocin, used routinely for induction/stimulation, has a relationship to initiation/duration of breastfeeding. Patients and methods: We conducted a cohort study that was carried o...

Several synthetic peptide manipulations during the time surrounding birth can alter the specific neurohormonal status in the newborn brain. This study is aimed at assessing whether intrapartum oxytocin administration has any effect on primitive neonatal reflexes and determining whether such an effect is dose-dependent. A cohort prospective study wa...

This review focuses on the neuroendocrine mechanisms in the mother and the newborn that are involved in the generation and consolidation of mother-child attachment. The role that different hormones and neurotransmitters play on the regulation of these mechanisms during parturition, the immediate postpartum period and lactation is discussed. Interfe...

To investigate the analgesic effect (measured with Neonatal Infant Pain Scale (NIPS)) of breastfeeding (BF) in addition to skin-to-skin contact (SSC) versus other methods of non-pharmacological analgesia during blood sampling through heel lance in healthy term neonates. Randomised controlled trial. Tertiary level maternity ward. One hundred thirty-...

Introduction: Synthetic oxytocin (Oxt) is the most commonly used drug to induce or augment labour contractions. The objective of the study is to evaluate the effect of Oxt used during labour on exclusive breastfeeding. Patients and methods: This job is part of an observational descriptive study which primary objective is to investigate the effect o...

Introduction: Maternal-infant separation (MIS) is a highly stressful situation for the neonate. Materials and methods: A study was conducted to observe and describe the reactions of term neonates to brief maternal separation and restoration of skin contact within the first 48 h of life, and to assess whether the mode of delivery influences neona...

To investigate the effect intrapartum oxytocin administration can have on Primitive Neonatal Reflexes. The secondary objective was to observe the influence of intrapartum oxytocin may have on breastfeeding. Twenty healthy primiparae with a single gestation at term were included. To assess Primitive Neonatal Reflexes, video film was taken during an...

The study of the neurohormonal and behavioral processes and neural mechanisms involved in the development of attachment between the infant and the mother has received increased attention over the last years. Oxytocin has been shown to play a central role in the regulation of affiliate social behavior, including sexual behavior, mother infant bondin...

The study of the neurohormonal and behavioral processes and neural mechanisms involved in the development of attachment between the infant and the mother has received increased attention over the last years. Oxytocin has been shown to play a central role in the regulation of affiliate social behavior, including sexual behavior, mother infant bondin...

Resumen Introducción La incidencia de secuelas neurológicas en los recién nacidos pretérmino (RNPT) con displasia broncopulmonar (DBP) es considerablemente mayor que la de aquellos que no la presentan. Conocer la cronología de adquisición de los hitos motores puede servir para proporcionar mejor información a los padres acerca de la posible existe...

Adverse neurological events in very low birth weight (VLBW) children with bronchopulmonary dysplasia (BPD) are more frequent than in children without. An understanding of the ages when preterm infants acquire certain motor skills will give parents more appropriate information on motor development. The objective of the present study is to estimate t...

Background and aims: The impact of exogenous OT on primitive neonatal reflex has not been thoroughly investigated. The objective of the study is to evaluate the effect of OT used during induced labour on neonatal separation reflexes and time of crying.Methods: Observational descriptive study approved by Local Ethical Committee. 22 women with their...

Background and aims: The effect of the infusion of synthetic oxytocin (OT) on newborn behaviour has received little attention although there is a growing body of evidence that suggests it can affect the behaviour of non human mammals both early and in the long term. The impact of exogenous OT on primitive neonatal reflex has not been thoroughly inv...

Background: Oxytocin is a common drug used during labour. The placenta is not an effective barrier to the passage of drugs, and the blood/brain barrier is under-developed in the fetus. Therefore, the assumption that oxytocin does not cross the placenta and the fetal blood/brain barrier have been questioned. Cortisol (a stress hormone) in umbilical...

Background and aims: The effect of the infusion of synthetic oxytocin on newborn behaviour has received little attention although there is a growing body of evidence that suggests it can affect the behaviour of non human mammals both early and in the long term. The impact of exogenous oxytocin on spontaneous breastfeeding has not been thoroughly in...

The aims of this study is to (i) determine the age of sitting unsupported and independent walking in preterm infants with birth weight under 1500 g (very low birth weight, VLBW); (ii) estimate differences between VLBW children and a reference population and (iii) estimate the association between clinical characteristics and late age at sitting and...

To estimate the influence of skin-to-skin care on the thermal regulation of the infant and the rate of breastfeeding at different points of time. We also aim to establish whether skin-to-skin contact reduces maternal pain during episiotomy repair and decreases the time to expel the placenta. A randomized control study was performed with 137 patient...

To determine whether the pain suffered during the endocrine metabolic test can be lowered by adding skin to skin care to the use of sucrose. To establish factors that may modify the feeling of pain and evaluate the parents opinion during the extraction. Controlled clinical trial. Two groups: group 1 (n= 27), skin to skin and sucrose, and group 2 (n...

Objectives To determine whether the pain suffered during the endocrine metabolic test can be lowered by adding skin to skin care to the use of sucrose. To establish factors that may modify the feeling of pain and evaluate the parents opinion during the extraction. Patients and methods Controlled clinical trial. Two groups: group 1 (n = 27),skin to...

Cytomegalovirus (CMV) is one of the most common opportunistic infections in AIDS patients. The aim of this study was to assess the influence of CMV infection in the first year of life and its the impact on survival and progression of the disease. This prospective cohort study included all children with a diagnosis of HIV infection in the first year...

To determine the rates of influenza-related hospitalization and to know the clinical manifestations and underlying diseases in children younger than 3 years who are hospitalized with influenza. Retrospective, descriptive study (1996-2003), performed in a tertiary teaching hospital in Madrid. Data of hospitalized children, younger than 3 years, with...

The New Ballard Score (NBS) is commonly used to estimate gestational age (GA) in the newborn. The aims of this study were: a) to determine the reliability of the NBS; b) to estimate the agreement between two methods of GA assessment, NBS and ultrasonography (US) or last menstrual period (LMP); c) to estimate the agreement between NBS and US/LMP in...

Background and objectives The New Ballard Score (NBS) is commonly used to estimate gestational age (GA) in the newborn. The aims of this study were: a) to determine the reliability of the NBS; b) to estimate the agreement between two methods of GA assessment, NBS and ultrasonography (US) or last menstrual period (LMP); c) to estimate the agreement...

Unlabelled: We report the outpatient management of acalculous colecistitis in an 18-y-old male with X-linked chronic granulomatous disease. The patient complained of abdominal pain and the initial ultrasound showed a gallbladder with a thickened wall. Conclusion: In chronic granulomatous disease, pain from a thickened gallbladder disappears afte...

Background/Aims: Clinical protocols based on available evidence and supported by wide staff consensus are considered an effective means to introduce potentially better practices in the diagnosis/treatment of medical conditions. In the management of neonatal shock, a wide variability has been observed. This study aims to determine the level of compl...

Background Cytomegalovirus (CMV) is the most common congenital viral infection, mainly in the infants of HIV-infected women. The aim of this study was to evaluate the prevalence of congenital CMV infection in infants born to HIV-infected women in our hospital, the possible influence of maternal antiretroviral therapy, the relationship between verti...

Cytomegalovirus (CMV) is the most common congenital viral infection, mainly in the infants of HIV-infected women. The aim of this study was to evaluate the prevalence of congenital CMV infection in infants born to HIV-infected women in our hospital, the possible influence of maternal antiretroviral therapy, the relationship between vertical HIV tra...

We describe a newborn boy with a gastric heterotopia located in the nasopharynx, which caused airway obstruction soon after delivery. Gastric heterotopia is an uncommon lesion generally found throughout the alimentary tract, but nasopharynx is an exceptional location. To our knowledge, this is the second reported case of gastric heterotopia located...

Among other diseases, Chlamydia trachomatis causes epididymitis and prostatitis in men and urethritis, cervicitis and pelvic inflammatory disease in women. In children, it most usually causes conjunctivitis and is also responsible for lower respiratory tract disease, occasionally requiring hospital admission. To draw attention to this disease, whic...

Correspondencia: Sección de Inmunodeficiencias. Departamento de Pediatría. Hospital Universitario 12 de Octubre. Avda. Córdoba, s/n. 28041 Madrid. España