Miguel Germán Borda

Stavanger University Hospital · Division of Psychiatry

Introduction: Understanding the natural course of neuropsychiatric symptoms (NPS) in dementia is important for planning patient care and trial design, but few studies have described the long-term course of NPS in individuals. Method: Primary inclusion of 223 patients with suspected mild dementia from general practice were followed by annual asse...

BACKGROUND/OBJECTIVES Functional status is one of the most important markers of well‐being in older adults, but the drivers of functional decline in dementia are not well known. The aim of our work was to study the association of neuropsychiatric symptoms (NPSs) with functional decline over 5 years in newly diagnosed people with Alzheimer´s disease...

Background: In dementia, functional status depends on multiple factors in addition to cognition. Nutritional status is a potentially modifiable factor related to homeostasis and proper functioning of body systems and may contribute to cognitive and functional decline. Objective: This paper aims to analyze the association of malnutrition with the...

Malnutrition is highly prevalent in older persons with dementia. Therefore, strong predictors of malnutrition in this population are crucial to initiating early interventions. This study evaluates the association between the probability of having malnutrition with the muscle volume and intramuscular fat (iMAT) of the masseter and the tongue in magn...

Background : Age-related neurodegeneration, sarcopenia, and ectopic fat accumulation are conditions with shared pathways that remain poorly understood. We have measured muscle volume and fat accumulation in masseter and tongue muscle, and aim to explore their association with the total grey matter volume using MRI in older adults recently diagnosed...

Background The relationship between oral health and specific health conditions, such as cardiovascular disease or cognitive impairment, has been extensively studied. However, the effect of oral health status on self-rated health has not been assessed. This could be relevant in older people considering that poor self-rated health status and oral dis...

Background Neuropsychiatric symptoms (NPS) are often overlooked and under-identified symptoms associated with dementia, despite their significant impact on the prognosis of individuals living with the disease. The specific role of certain NPS in functional prognosis remains unclear. Aims To determine the association of different NPS with functiona...

Background Cardiometabolic disorders (CMD) and Mild Cognitive Impairment (MCI) have been associated with an increased risk of developing dementia. However, brain glucose metabolism has not been compared between patients with CMD and MCI, and little is known about its associations with global cognitive performance. Here we examined regional brain ¹⁸...

Background Frailty has been recognized as a growing issue in older adults, with recent evidence showing that this condition heralds several health-related problems, including cognitive decline. The objective of this work is to determine if frailty is associated with cognitive decline among older adults from different countries. Methods We analyzed...

Abnormalities in the Tri-Carboxylic-Acid (TCA) cycle have been documented in dementia. Through network analysis, TCA cycle metabolites could indirectly reflect known dementia-related abnormalities in biochemical pathways, and key metabolites might be associated with prognosis. This study analyzed TCA cycle metabolites as predictors of cognitive dec...

Objective: This study aims 1) To analyse differences in resting-state electroencephalogram (rs-EEG) spectral features of Parkinson's Disease (PD) and healthy subjects (non-PD) using Functional Data Analysis (FDA) and 2) To explore, in four independent cohorts, the external validity and reproducibility of the findings using both epoch-to-epoch FDA...

Background: Malnutrition - comprising both undernutrition and overweight - has to be addressed in the medical follow-up of older adults due to the negative consequences for the functional state and general health. Still, little is known about the nutritional state of nursing home (NH) residents, especially with respect to weight gain or weight los...

Background The relationship between oral health and specific health conditions has been studied. However, data about the relationship with self-rated health is not clear. The aim of this study is to determine the association between different parameters of oral health and the self-rated health status (SRHS) in Colombian community-dwelling older adu...

Background and aims: In older adults with dementia, low body mass index (BMI) is associated with higher mortality and other adverse health outcomes. BMI or nutritional status trajectories from diagnosis have not yet been well described in dementia, especially in people with Lewy body dementia (LBD); a group that has a poorer prognosis. With this s...

Introduction Frailty is recognized as a clinical condition associated with increased vulnerability for developing negative health outcomes but has been little studied in patients with Parkinson's disease (PD). Here, we investigated the risk of frailty in de novo PD patients and its association with subsequent development of dementia. Methods We co...

Psychiatric-onset dementia with Lewy bodies (DLB) might include symptoms of depression, hallucinations, anxiety, and apathy. Here, we report a patient with DLB with recurrent panic attacks as her first symptom 5 years before a biological-based diagnosis of probable DLB. We provide an extended description of the clinical presentation and course from...

Background Motoric Cognitive Risk Syndrome (MCR) is a predementia stage where slow gait speed and subjective memory complaints are present. The purpose of this study was to estimate the prevalence of MCR and assess its relationship with sociodemographic factors and chronic conditions. Methods This is a secondary analysis of the SABE Colombia study...

Objectives : To explore how individual depressive symptoms might contribute to different patterns of alcohol consumption in Colombian older adults living in the community. Methods : A Secondary analysis from a nationally representative cross-sectional study of more than 23,000 older adults, with data from 19,004 participants. Drinking frequency, a...

Introduction: Early markers of neurodegeneration provide an opportunity to detect, monitor, and initiate interventions in individuals who have an increased risk of developing dementia. Here, we investigated whether the Timed Up and Go (TUG) test is associated with early brain neurodegeneration and whether the TUG test could be a marker of cognitiv...

INTRODUCCIÓN: la demencia por cuerpos de Lewy (DCL) es una enfermedad neurodegenerativa con alta prevalencia y a menudo subdiagnosticada. En las demencias pueden presentarse alteraciones en la marcha que potencialmente permitan identificar su subtipo y dar una orientación clínica, diagnóstica y terapéutica temprana. Esta revisión narrativa de la li...

Objective Determine the association between different parameters of oral health and the self-rated health (SRH) in Colombian community-dwelling older adults. Methods This is a secondary analysis of the SABE-Colombia study performed in 2015. The dependent variable was defined as the SRH status assessed by the question “Compared with other people yo...

Background: Ending December 2019, the world had to face to COVID-19. Latin America and the Caribbean suffered the effects where the contiguous and the number of deaths has been significant. Studies indicate that older adults with some degree of cognitive impairment are at greater risk of worsening their cognitive status and mental health, for this...

Summary Background: Motoric Cognitive Risk Syndrome (MCR) is a predementia stage where slow gait speed and subjective memory complaints are present. The purpose of this study was to estimate the prevalence of MCR and assess its rela- tionship with sociodemographic factors and chronic conditions. Methods: This is a secondary analysis of the SABE C...

Background: We aim to study the effects of the number of medications consumed over a five-year period after diagnosis on functional decline trajectories in older adults living with AD (Alzheimer's disease) and LBD (Lewy body dementia). Methods: This is a longitudinal analysis of a Norwegian cohort study entitled "The Dementia Study of Western No...

Background The potential role of the amygdala for neuropsychiatric symptoms (NPS) in dementia is not well known, especially in dementia with Lewy bodies (DLB). Cross‐sectional studies have proposed the associations between amygdala volume and NPS in Alzheimer’s Disease (AD). However, less is known about the association between amygdala volume and l...

Background: Dementia has become a healthcare priority. As no disease-modifying treatment is available, treatment is aimed to act through prevention. Frailty have been defined as a geriatric multidimensional syndrome. Being a treatable condition, interest has raised to describe the relationship between Dementia and Frailty. This study describes fra...

Purpose: To determine the incidence of geriatric syndromes (GS) in community dwelling older adults with subclinical hypothyroidism. Methods: This is an analysis from the Mexican Health and Aging Study, of a subsample of 2089 subjects with TSH determination. From this last subsample, we included 1628 individuals with TSH levels in the subclinical r...

Dementia with Lewy bodies (DLB) research has seen a significant growth in international collaboration over the last three decades. However, researchers face a challenge in identifying large and diverse samples capable of powering longitudinal studies and clinical trials. The DLB research community has begun to focus efforts on supporting the develo...

Introduction: Mild Cognitive Impairment (MCI) is common in Parkinson's Disease (PD). Few studies have compared the Health-Related Quality of Life (HRQoL) in patients with and without MCI due to PD (PD-MCI), and its correlation to patients' subjective cognitive and communicative difficulties has not been explored. Objective: We aimed to compare H...

BACKGROUND Cognitive impairment and dementia are some of the most important health challenges we face today. Almost 60% of people with dementia live in low-and middle-income countries, such as Colombia. OBJECTIVE The aim of this study was to evaluate the association between access, capacity to use and frequency of using with cognitive impairment a...

Introduction: The amygdala is implicated in psychiatric illness. Even as the amygdala undergoes significant atrophy in mild dementia, amygdala volume is underexplored as a risk factor for neuropsychiatric symptoms (NPS). Objective: To analyze the association between baseline amygdala volume and the longitudinal trajectories of NPS and cognitive dec...

Background: In dementia, a number of factors may influence functional decline in addition to cognition. In this study, we aimed to study the potential association of the number of prescribed medications with functional decline trajectories over a five-year follow-up in people diagnosed with mild Alzheimer's disease (AD) or Lewy Body dementia (LBD)...

Background With this study, we aim to determine the associations of the different categories of the body mass index (BMI) with activities of daily living (ADL) and cognitive performance in two different populations living in the community; Colombian and South Korean older adults. Methods We performed a cross-sectional analysis of two surveys separ...

The proportion of the world’s older adults and of its dementia cases is increasing in low and middle-income countries. This is particularly true in Colombia. There, the number of individ- uals with dementia may increase five-fold by 2050. Yet research is lacking on dementia in such settings. This work estimates the prevalence ofdementia in a commun...

Objectives We aim to study the effects of the prescription of benzodiazepines and antidepressants on cognitive and functional decline in older adults living with AD (Alzheimer’s disease) and LBD (Lewy body dementia) over a five‐year follow‐up. Methods This is a longitudinal analysis of a Norwegian cohort study entitled “The Dementia Study of Weste...

Objective: To determine possible associations of hemispheric-regional alpha/theta ratio (α/θ) with neuropsychological test performance in Parkinson’s Disease (PD) non-demented patients. Methods: 36 PD were matched to 36 Healthy Controls (HC). The α/θ in eight hemispheric regions was computed from the relative power spectral density of the resting-...

Hospitalizaciones frecuentes en Epoc

Background Clinicopathological overlap between neurodegenerative diseases contributes to challenging differentiation between dementia types. Improving differential diagnosis is important to provide optimal patient care and better predict future needs. Deep learning techniques such as convolutional neural networks have in recent years gained much at...

Introduction Functionality is one of the most important markers of wellbeing in older adults. People with dementia lose functionality mainly because of cognitive impairment. However, little has been outlined regarding the independent association of Neuropsychiatric symptoms (NPS) on functional decline in this population, especially in those diagnos...

Background: With this study, we aim to describe the associations of the different categories of the Body mass index (BMI) with ADL and cognitive performance in Colombian and South Korean older adults living in the community. Methods: A cross-sectional analysis of two surveys were analyzed; Survey on Health, Well-Being, and Aging in Colombia (SABE)...

Introduction: Gait speed (GS) is a predictor of negative outcomes in older adults and in those in risk to develop cognitive impairment; as such, it has been associated with dementia. Studies in Latin-American older adults showing this association are scarce. This study aimed to evaluate the relationship between GS and dementia in a representative...

Background: Hippocampal atrophy is presented in Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). Cognition, dual-tasks, muscular function, goal-related behaviors and neuropsychiatric symptoms are linked to hippocampal volumes and may lead to functional decline in activities of daily living. We examined the association between baseline...

Objective: To assess depressive symptoms as a mediator in the association between polyvictimization and recurrent falling. Methods: Using data from the Salud, Bienestar y Envejecimiento (Health, Well-being, and Aging) Ecuador Study, we analyzed community-dwelling adults 60 years and older (n = 5227). Recurrent falling was determined as ≥2 falls dur...

Introduction: Functional status decline is related to many negative outcomes. Objective: To explore the relation between sociodemographic, medical and psychological factors with the incidence of functional status decline in Mexican older adults. Materials and methods: Data from the 2012 and 2015 waves of the Mexican Health and Aging Study (MHAS) su...

Introduction As the world's population ages, the prevalence of cognitive impairment associated with age increases. This increase is particularly pronounced in Asia and South-America. The objective of this study was to investigate separately the longitudinal association of physical activity and cognitive function in; older adults in Mexico and South...

As the population ages, the incidence of chronic diseases such as dementia increases. Dementia with Lewy bodies (DLB) is one of the most common dementias after Alzheimer's disease, and it is characterized clinically by a tetrad consisting of visual hallucinations, spontaneous parkinsonism, REM sleep behavior disorders, and dementia. The diagnosis o...

Background: Frailty is a clinical state defined as an increase in an individual's vulnerability to developing adverse health-related outcomes. Objectives: We propose that healthy behaviors could lower the incidence of frailty. The aim is to describe the association between healthy behaviors (physical activity, vaccination, tobacco use, and cance...

It is estimated that the number of people living with dementia will reach 75 million by 2030. The most common type of dementia is Alzheimer's disease (AD) Although cognitive impairment is the main trigger for dementia, other factors play an important role in parallel, intensifying the progression of functional impairment for example neuropsychiatri...

Un posible mecanismo causal del desarrollo de demencia es la hipertensión arterial (HTA). Es importante identificar e intervenir factores de riesgo modificables para prevenir el desarrollo de demencia. La HTA altera la dinámica vascular cerebral, afectando los circuitos frontoestriatales. Esto se manifiesta tempranamente con síntomas depresivos (SD...

En personas con demencia, los valores de albúmina pueden reflejar a aquellos que tienen o están en mayor riesgo de sufrir desnutrición. La desnutrición es uno de los factores con mayor influencia en el aumento de la morbilidad, la mortalidad, la alteración de la calidad de vida y la alteración funcional. Adicionalmente, en varios estudios se ha est...

“This project, collecting data from across Europe and the world, will make efforts to answer an urgent unmet need regarding diagnostic and prognostic markers of a disease with poor prognosis by using innovative methods and equipment”

Background Body composition and height changes with aging which brings challenges in order to obtain accurate measures in this population, height measurement is of great importance both in nutritional and clinical assessment in the elderly, and it has been widely used for obtaining values such as body mass index, the aim of this study was to assess...

Introducción: el aumento de enfermedades crónicas ha motivado la creación de métodos de evaluación del adulto mayor que permitan estimar su estado general de salud. Entre estos, se ha propuesto la fuerza de prensión. El objetivo de este estudio fue buscar la asociación entre el número de comorbilidades y la fuerza de prensión. Materiales y métodos...

bold<>italic /italic<>/bold< The aim of the study is to describe the frequency of frailty in people with a new diagnosis of mild dementia due to Alzheimer's disease (AD) and dementia with Lewy bodies (DLB). >bold<>italic /italic<>/bold< This is a secondary analysis of the Dementia Study of Western Norway (Demvest). For this study, we analysed a sam...

Background and purpose: Age-related hearing loss is a prevalent condition among the growing elderly population, which has been associated with both cognitive decline and decreased daily functioning. Decreased functioning is linked to lower performance, predominantly regarding instrumental activities of daily living (IADLs). The present study aims t...

Purpose: High blood pressure is a relevant risk factor for vascular damage, leading to development of depressive symptoms and dementia in older adults. Moreover, subjective memory complaints are recognized as an early marker of cognitive impairment. However, it has been established that subjective memory complaints could also be a reflection of de...

AIM: Chronic obstructive pulmonary disease (COPD) is a pro-inflammatory condition leading to wasting states such as sarcopenia. We aimed to describe the effect of COPD and sarcopenia on mortality in Costa Rican older adults in the Costa Rican Longevity and Healthy Aging Study (CRELES). METHOD: This is a secondary analysis of the CRELES, a cohort st...

Objective: The objective was to describe the association between the presence of cognitive impairment and the use of proton pump inhibitors (PPI) in the older adult population in Bogotá, Colombia. Methods: We analyzed the SABE Bogotá study. This study included 2,000 people over 60 years, in a cross-sectional sample. The variable of interest was the...

Objective: To explore the association between educational level and the scores obtained in each of the domains of the Montreal Cognitive Assessment test. Methods: This is a secondary analysis of the SABE/2012 Bogotá survey; a cross-sectional study including 2000 subjects aged ≥60years. The MoCA test was the dependent variable and was stratified...

Descriptive studies can be the point of departure for more complex studies both in geriatrics and in gerontology. The ongoing need of information regarding new conditions highly prevalent in the older adults, begins with a thorough description of these phenomenon in addition to the magnitude of them in specific populations and its associations with...

Las vasculitis asociadas a anticuerpos contra el citoplasma del neutrófilo configuran patologías multisistémicas caracterizadas por afectar pequeños vasos. Se ha descrito compromiso de sistema nervioso central en 2-8% de los casos, rara vez al inicio del cuadro clínico. Este corresponde al caso de un hombre de 67 años de edad con vasculitis p-ANCA,...

Objetivo: Destacar los resultados de mayor impacto para la población adulta mayor en Bogotá, de ma- nera que sirvan como referencias para priorizar las decisiones y las medidas públicas en su beneficio. Materiales y métodos: Estudio de cohorte transversal, con un muestreo probabilístico por conglome- rados, polietápico, con un nivel de confiabilida...

La desnutrición es una condición frecuente en las personas mayores de 65 años. El mal estado nutricional se ha relacionado con mayores estancias hospitalarias, complicaciones, aumento en comorbilidades y mortalidad. Este estudio busca describir la relación entre el estado nutricional de adultos mayores hospitalizados y factores como red de apoyo, f...

Introducción: La desnutrición es una condición frecuente en las personas mayores de 65 años. El mal estado nutricional se ha relacionado con mayores estancias hospitalarias, complicaciones, aumento en comorbilidades y mortalidad. Este estudio busca describir la relación entre el estado nutricional de adultos mayores hospitalizados y factores como r...

Vasculitis associated with antibodies against the neutrophil cytoplasm they form multisystemic pathologies characterized by affecting small vessels. Central nervous system involvement has been described in 2 - 8% of cases, rarely at the beginning of the clinical picture. This corresponds to the case of a 67-year-old man with p-ANCA vasculitis, who...

Introducción: la desnutrición es una condición frecuente en las personas mayores de 65 años. El mal estado nutricional se ha relacionado con mayores estancias hospitalarias, complicaciones, aumento en comorbilidades y mortalidad. Este estudio busca describir la relación entre el estado nutricional de adultos mayores hospitalizados y factores como r...

El adulto mayor frágil es una persona más vulnerable a sufrir de desenlaces adversos. Esta condición se establece por un compromiso de múltiples dominios que van más allá de las manifestaciones neurológicas. Esto crea la necesidad de un manejo interdisciplinario integral. Este abordaje inte- grado requiere consideraciones especiales para la prescri...

Due to the phenomenon of demographic transition, the amount of elderly individuals is on the rise. This is an enormous success for humanity, however it does imply some challenges for modern societies. As our population ages, the prevalence and burden of chronic diseases also increase, and these pathologies raise the frequency of admission of elderl...

La población mundial de personas mayores de 60 años viene en incremento y se proyecta que para el año 2050 ésta corresponda al 21% del total de la población. Actualmente en Colombia se estima que existen cerca de 4.5 millones de adultos mayores de 60 años, representando el 10% de todos sus habitantes y para el 2020 se espera que este número supere...

Objetivo: Conocer el Auto-reporte de Diabetes en la población de adultos mayores de la ciudad de Bogotá y su asociación con variables sociodemográficas, del estado de salud y medidas antropométricas. Diseño: Estudio observacional y poblacional de corte transversal Marco de referencia: Datos del estudio SABE (Encuesta de Salud, Bienestar y Envejecim...

Edentulism is related to a number of conditions in older adults, impacting their overall health status and thus their quality of life and relationship with the environment. At the same time, self­rated health has been shown to be an accurate marker of overall health status. However there is little information on how edentulism relates to self­rated...