Mieczyslaw Pokorski

Mieczyslaw Pokorski
Opole University · Health Sciences

Professor

About

278
Publications
15,624
Reads
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2,197
Citations
Citations since 2016
81 Research Items
948 Citations
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150
2016201720182019202020212022050100150

Publications

Publications (278)
Article
Full-text available
The history of medical records is thousand-year-long, with earlier roots in ancient civilizations. Until the 19th century, medical records mainly served educational purposes, later assuming other roles such as in insurance or legal procedures. This article comprehensively describes and reviews the development of medical records from ancient to mode...
Article
Full-text available
Microglia modulate cardiorespiratory activities during chronic hypoxia. It has not been clarified whether microglia are involved in the cardiorespiratory responses to acute hypoxia. Here we investigated this issue by comparing cardiorespiratory responses to two levels of acute hypoxia (13% O2 for 4 min and 7% O2 for 5 min) in conscious unrestrained...
Article
Chronic intermittent hypoxia (CIH) has been used as a model to mimic nocturnal apnea, which is associated with hypertension. One of the mechanisms for hypertension in patients with nocturnal apnea is an enhancement of the plasma membrane response to acute hypoxia in carotid body glomus cells. Hypoxia is known to induce depolarization via inhibiting...
Article
Suvorexant (Belsomra(R)), a dual orexin receptor antagonist widely used in the treatment of insomnia, inhibits the arousal system in the brain. However, the drug’s ventilatory effects have not been fully explored. This study aims to investigate the expression of orexin receptors in respiratory neurons and the effects of suvorexant on ventilation. I...
Article
Full-text available
A stabilization method of pertrochanteric femur fractures is a contentious issue. Here, we assess the feasibility of rapid in silico 2D finite element modeling (FEM) to predict the distribution of stresses arising during the two most often used stabilization methods: gamma nail fixation (GNF) and dynamic hip screw (DHS). The modeling was based on s...
Chapter
Extremely low-frequency electromagnetic field (ELF-MF) therapy is a promising treatment for chronic pain, given its ability to interact with body homeostasis using water-mediated transmission mechanisms typical of quantum medicine. The present study aims to assess the effects of ELF-MF therapy on chronic pain in 49 patients suffering from various m...
Chapter
Bariatric surgery is the treatment of choice for effective weight reduction in patients with morbid obesity. The influence of the surgery, mostly consisting of laparoscopic sleeve gastrectomy, on mental health is less clear. This study aims to define the influence of bariatric surgery on the perception of well-being and the general quality of life...
Article
Full-text available
Pedobarographic examination is a non-invasive method that enables the quantitative and qualitative evaluation of plantar pressure distribution, notably the plantar pressure distribution, referring to the function of the entire musculoskeletal system. This is a scoping review that aims to update knowledge on the practical use of pedobarography in fo...
Chapter
WHO has recommended the implementation of the Surgery Safety Checklist (SSC) to reign in often simple logistic errors that lead to numerous complications, some of them being fatal, in the perioperative period. This study aims to discuss doubts presented in the medical literature concerning the effectiveness of SSC in the currently existing form. Th...
Article
Full-text available
Acute hypoxia increases ventilation. After cessation of hypoxia loading, ventilation decreases but remains above the pre-exposure baseline level for a time. However, the mechanism of this post-hypoxic persistent respiratory augmentation (PHRA), which is a short-term potentiation of breathing, has not been elucidated. We aimed to test the hypothesis...
Article
Full-text available
In the history of diagnostics, breath analysis was one of the first method used until the breakthrough of biochemical testing technology. Today, breath analysis has made a comeback with the development of gas analyzers and e‐noses, demonstrating its power in its applicability for diagnosing a wide range of diseases. The physical basis of multiple c...
Chapter
This article aims to present how the advanced solutions of artificial intelligence and precision medicine work together to refine medical management. Multi-omics seems the most suitable approach for biological analysis of data on precision medicine and artificial intelligence. We searched PubMed and Google Scholar databases to collect pertinent art...
Chapter
The medical treatment process, particularly surgery, is inescapably bound to potential complications or undesirable adverse events. This narrative review aims to present the causes and effects of the introduction of the WHO Surgery Safety Checklist (SSC), the use of which is expected to reduce the number of perioperative errors, complications, and...
Chapter
This chapter aims to present insights into the influence of artificial intelligence (AI) on medicine, public health, and the economy. PubMed and Google Scholar databases were used for the identification and collection of articles with search commands of “artificial intelligence” AND “public health” and “artificial intelligence” AND “medicine”. A to...
Chapter
Chronic nonspecific low back pain is a frequent clinical condition affecting the general population and influencing disability level and quality of life. We performed a single-blinded, randomized, and controlled study to compare the effectiveness of manual pressure release (MPR) and electrical neuromodulation (ENM) treatments in the management of c...
Book
This book integrates topics in basic research and clinical medicine as well as molecular and cell biology. It presents innovative advances in the field of immunodeficiency syndromes and viral/bacterial respiratory infections, including a novel hyperbaric oxygen treatment for COVID-19. A comprehensive insight is offered into the unresolved molecular...
Book
This volume is dedicated to multidisciplinary research at the interface between basic biomedicine and clinical practice. This book guides best practice in the diagnosis and therapy while dealing with difficult-to-treat disorders of yet unclear etiology. Chapters address such disorders as granulomatosis with polyangiitis causing autoimmune-related...
Book
This book aims to disseminate and review the latest interdisciplinary medical knowledge to provide information on best clinical practice for difficult-to-treat conditions. The chapters address various aspects and approaches to the management of medical conditions that are not fully understood. This is exemplified by complex immune and inflammatory...
Chapter
Total ankle arthroplasty (TAR) is a procedure alternative to arthrodesis which enables the biomechanical stabilization of the ankle joint. The procedure is associated with a high risk of complications, including fractures of the medial malleolus. In this study, the finite element method (FEM), based on CT examinations, was used to model the ankle f...
Article
Dyspnea is defined as a subjective experience of breathing discomfort that consists of qualitatively distinct sensations that vary in intensity. It is a common symptom among patients with respiratory diseases that reduces daily activities, induces deconditioning, and is self-perpetuating. Although clinical interventions are needed to reduce dyspnea...
Article
Full-text available
The presentation wants to introduce a new kind of Integrated Rehabilitation Approach dedicated to Osteoporosis. Osteoporosis is a multifactorial disorder associated with degeneration of bone structure and decreased bone mass. In the general population it affects more than 1/3 women and 1/5 men aged over 50 years old, casuing many problems for those...
Article
Full-text available
It takes me great pleasure to confirm the materialization of the efforts to organize a joint research seminar on medical rehabilitation under the aegis of the Japan Society for the Promotion of Science (JSPS) and the Polish Academy of Sciences (PAN). Due to the spiking second wave of COVI-19 infections, the event will be held on the Tokyo-based ZOO...
Article
This review addresses the theories concerning the development and functioning of medical bureaucracy creating an excess of the patient records. An ever-growing number of medical files comply with the typical development of the bureaucratic management of an entrepreneurial organization, an essential feature of which is the life cycle of documentatio...
Article
TWIK-related acid-sensitive K+ (TASK) homomeric channels, TASK1 and TASK3, are present in PC12 cells. The channels do not heteromerize due plausibly to a lack of p11 protein. Single-channel recording reveals that most of the rat carotid body (CB) glomus cells express heteromeric TASK1-TASK3 channels, but the presence of p11 in glomus cells has not...
Article
Full-text available
Atopic dermatitis (AD) is characterized by chronic, relapsing, pruritic skin inflammation and does not have a well-understood pathogenesis. In this study, we addressed the contribution of adipokines to AD eczema based on the assessment of blood levels of adiponectin, resistin, leptin, lipocalin-2, and vaspin in adult non-obese patients suffering fr...
Chapter
Full-text available
This article addresses the disparity in the transduction pathways for hypoxic and hypercapnic stimuli in carotid body glomus cells. We investigated and reviewed the experimental evidence showing that the response to hypoxia, but not to hypercapnia, is mediated by 1,4,5-inositol triphosphate receptors (IP3R/s) regulating the intracellular calcium co...
Article
Full-text available
Psychological stress activates the hypothalamus, augments the sympathetic nervous output, and elevates blood pressure via excitation of the ventral medullary cardiovascular regions. However, anatomical and functional connectivity from the hypothalamus to the ventral medullary cardiovascular regions has not been fully elucidated. We investigated thi...
Article
This study addresses respiratory and motor impairments in an experimental reserpine-induced model of parkinsonism in rats. The role of chronic hypoxia due to diminished ventilation in the development and course of neurodegeneration is addressed. An attempt was made to distinguish between central and peripheral dopamine pathways in the mechanisms of...
Chapter
Atopic dermatitis (AD) is classified as a most common inflammatory skin disease. The condition is characterized by recurrent eczematous lesions and intense pruritus or itch, a hallmark of AD. The aim of this study was to identify the provoking factors of itch in severe AD adult patients. There were 34 adult patients suffering from AD of the median...
Chapter
The aim of this study was to investigate the soundness of in silico finite element model (FEM) in the assessment of strain in the femur and in the components fixing the periprosthetic fracture in elderly patients after hip arthroplasty. From a group of 55 patients, aged 27–95, treated due to fractures after hip replacement in 2012–2018, 18 patients...
Article
At the date (May 29th, 2020): article peer-reviewed and accepted; in press. The "Endless Diving Project-Step 36" took place in the harbor waters of the town of Maratea in Italy in September 2014. The goal of the project was an attempt by an experienced male diver, equipped with a wet 7-mm suit and a normal gas tank, to set the world record-breakin...
Article
Nebulization with saline solution, although commonly used to alleviate respiratory symptoms, particularly in children, is often questioned concerning its effectiveness. In this study, we investigated the effects of isotonic saline nebulization on lung function in 40 children (mean age of 14±1 years) suffering from different types of airway disorder...
Chapter
Atopic dermatitis (AD) is a chronic skin disease with the etiology not yet conclusively established. Recent reports demonstrate the role of serotonin (5-hydroxytryptamine; 5-HT) in the pathogenesis of AD. The aim of this study was to investigate the relationship between the serum content of serotonin and depression in adult patients suffering from...
Book
This book addresses hot issues in the research and management of difficult-to-treat medical disorders that are commonly encountered, but for which the underlying mechanisms are often unknown. These include the adverse effects of hemodialysis and its biocompatibility in chronic kidney insufficiency, particularly related to malnutrition and inflammat...
Book
This book shares the experimental findings and views in current multidisciplinary medical science combining both basic and applied research aimed at resolving problematic health issues. The key topics address contagious diseases, in particular the epidemiology, clinical presentation, and management of influenza and influenza-like infections as wel...
Book
This book offers a reliable source of information on the latest advances and current trends in the medical and clinical sciences. The focus is on certain fields that are of consistently high practical interest due to widespread disease morbidity, and on pathomechanisms that are not yet fully understood and their treatment. The topics covered inclu...
Chapter
Atopic dermatitis (AD) is characterized by exacerbations and remissions of eczematous skin, underlain by impaired skin barrier and aberrant Th2-type and Th-22 cytokine production. A number of allergens, in particular contact with fur animals, may aggravate the disease. This study seeks to define the influence of having a regular contact with a pet...
Article
Seizures are induced when subjects are exposed to severe hypoxia. It is followed by ventilatory fall-off and eventual respiratory arrest, which may underlie the pathophysiology of death in patients with epilepsy and severe respiratory disorders. However, the mechanisms of hypoxia-induced seizures have not been fully understood. Because astrocytes a...
Article
I am privileged to invite you to the annual IBRC conference, which will take place in Okayama on June 14. This will be the 16th annual meeting of the International Biophilia Rehabilitation Academy; an organization that has been undertaking undaunting efforts for more than two decades to reshape the rehabilitation paradigm in the super-aging society...
Article
Full-text available
The diaphragm is driven by phrenic motoneurons that are located in the cervical spinal cord. Although the anatomical location of the phrenic nucleus and the function of phrenic motoneurons at a single cellular level have been extensively analyzed, the spatiotemporal dynamics of phrenic motoneuron group activity have not been fully elucidated. In th...
Book
This book focuses on recent advances regarding clinical conditions and ailments whose mechanisms remain unclear, limiting our ability to treat them. The respective chapters address a range of multidisciplinary topics related to timely or emergent research areas, such as osteoporosis in postmenopausal women, the optimal surgical procedures for verte...
Book
This book addresses several burning issues concerning diseases involving the lungs and respiratory tract. It discusses the epidemiology, mechanisms, prevention, and diagnosis of chest conditions such as chronic obstructive pulmonary disease, sleep apnea and respiratory infections. Further, it examines the intertwined connection between oxidative st...
Book
This book tackles the role of interrelated conditions in the manifestation and course of pulmonary ailments. The articles run the gamut from basic to clinical science on such topics as airway allergy challenges, pulmonary dysfunction due to exposure to environmental pollution, molecular and functional aspects of smoking in lung carcinogenesis and i...
Book
This book focuses on issues in clinical practice and research that are of general interest. The articles primarily focus on understanding the pathogenic mechanisms of diseases, their prevention, and therapy. The topics addressed include cardiovascular regulation with regard to blood pressure and heart rate variability, and to coupling blood pressur...
Article
Aging is usually defined as the progressive loss of function accompanied by increasing morbidity with advancing age. The process of aging is multifactorial and depends on intrinsic (genetic) and extrinsic (environmental) factors. Aging concerns both physical and cognitive spheres of an individual. Detriments in functional reserve predominate in the...
Article
Inflammation, tissue hypoxia, and impaired hypoxic ventilatory response (HVR) are the intricately entwined features of diabetes which perpetuate the disease and its sequelae. Hyperglycemia, notably, is an oxygen consuming process due to enhanced cellular metabolism. Oxidative stress underlies diabetic pathogenesis and also is a crucial modulator of...
Article
Lipid derivatives of dopamine are a novel class of compounds raising a research interest due to the potential of their being a vehicle for dopamine delivery to the brain. The aim of the present paper is to review the main features of the two most prominent bioactive members of this family, namely, N-oleoyl-dopamine (OLDA) and 3'-O-methyl-N-oleoyl-d...
Chapter
This review is an attempt to provide a comprehensive view of post-traumatic-stress disorder (PTSD) and its therapy, focusing on the use of meditation interventions. PTSD is a multimodal psycho-physiological-behavioral disorder, which calls for the potential usefulness of spiritual therapy. Recent times witness a substantial scientific interest in a...
Chapter
This review updates the knowledge on the use of bioprogressive philosophy in current rehabilitation paradigms, focusing on age-related ailments and antiaging strategies. It is a holistic approach that combines aspects of biology and function into the realm of rehabilitation therapy. The bioprogressive philosophy, with assistance of modern technolog...
Book
The aim of this book is to present articles that are stimulating to read and inform readers with the most up-to-date clinical research. The articles incorporate the latest developments on a variety of topics in pulmonary medicine, therapy, and related mutlisystem disorders with varied manifestations. Emphasis is given to air quality and lung health...
Book
The purpose of this book is to disseminate and deliberate on the latest knowledge concerning immunity and its role in protection and fight against microorganism invasion. The articles tackle both humoral and cellular immunity, and their interconnectivity. The former involves B cells that recognize invading pathogens and create the antibody-mediate...
Book
The focus of this book lies on novel aspects of rehabilitation medicine used as a treatment tool in both physical and mental spheres. The articles cover a diverse spectrum, such as rehabilitation in orthopedic pathologies, the exemplary of which is knee joint degeneration, in perioperative metastatic cancer diseases, or in neural degeneration requ...
Book
This book describes various aspects of current scientific interest in clinical developments and management of pulmonary pathologies. Non-communicable and communicable disorders are tackled. Chronic disorders of an inflammatory background, such as COPD and asthma, often overlapping, diagnostically and therapeutically misguided and always difficult t...
Book
This book is a compendium of articles providing insights into a range of contemporary ideas concerning the core yet unsettled clinical issues. Important aspects of pulmonary disorders are tackled such as occupational respiratory health hazards, asthma, or the role of vitamin D in obstructive airway diseases. Genotyping offers a clear promise in the...
Book
This book presents the current trends and state of the art solutions addressing various issues related to pulmonary disorders. Diagnostic and therapeutic challenges are tackled, starting with the noncommunicable diseases of sarcoidosis and granulomatosis with polyangiitis. Pulmonary involvement, practically unavoidable, runs an insidious course, an...
Book
Clinical investigation plays an essential role in the differential diagnosis, biomarker development, and therapy and cure of diseases. The book presents a bench-to-bed approach, with broad empirical coverage by experienced practitioners. The articles include topics like cytokine receptors in lung cancer, conduciveness of oxidative stress to carcino...
Book
Change is an inherent feature of all aspects of clinical practice and patient management. This book seeks to contribute to presenting novel knowledge in various fields of clinical work. The articles tackle transdisciplinary topics and focus on the underlying mechanisms of clinical disorders, their prevention and management. The themes addressed inc...
Article
Full-text available
Oxygen belongs to therapeutic pharmacological tools. It is a life-safer in a host of clinical conditions, notably in emergency treatment when it is supplemented on the acute basis, and in chronic hypoxic lung pathologies when it is often used in home-based self-treatment. Emergency supplementation of oxygen is often shunned due to the possibility o...
Chapter
Ventilatory inhibition is considered an undesirable pharmacological side effect of pharmacotherapy in neurodegenerative conditions underlain by brain dopamine deficiency. In this context, oleic derivatives of dopamine or N-acyl-dopamines are novel substances that may be of high therapeutic interest as having the ability to cross the blood-brain bar...
Article
Meditation is an increasingly popular psychobehavioral therapy. Various meditation techniques in use make it hard to objectively scrutinize the psychological benefits. Therefore, in this study we set out to examine the effects of two fundamentally different meditative techniques, Zazen, 'seated meditation', in which the body and mind are calmed, an...
Book
This book examines a range of contemporary ideas and arguments concerning the core yet unsettled clinical issues. Important aspects of pulmonary disorders are tackled such as occupational and environmental respiratory health hazards, the role of vitamin D supplementation in airway allergy, or nutritional aspects of care for lung cancer patients. Me...
Book
The goal of this book is to further insight into the challenges related to respiratory health. Medical experts present their lines of scientific investigations on how to contain the disease, care for patients, and use preventive measures, with a focus on pulmonary-related disorders. Progress in the diagnostics and treatment of major infectious dise...
Book
The book endeavors to provide a stimulating and thought provoking scientific content to share and exchange new clinical studies and advancements in dealing with pulmonary diseases. The topics vary from clinical to translational research in respiratory diseases such as lung cancer, obstructive sleep apnea, chronic obstructive pulmonary disease, bact...
Article
Full-text available
Background Modafinil is a wake-promoting drug and has been widely used for daytime sleepiness in patients with narcolepsy and other sleep disorders. A recent case series reported that daily oral modafinil alleviated hypercapnic respiratory failure in patients with COPD. However, the precise action of modafinil on respiration such as hypercapnic and...
Conference Paper
Full-text available
Olfactory function in healthy and pathological condition is of increasing interest because decreasing within aging and its impairment is anticipatory of neurodegenerative diseases e.g. Alzheimer and Parkinson. These studies suggest a correlation with pathological hypoxia. Recently, we have demonstrated that olfactory threshold is temporary affected...
Article
This review tackles the unresolved issue of the existence of oxygen sensor in the body. The sensor that would respond to changes in tissue oxygen content, possibly along the hypoxia-normoxia-hyperoxia spectrum, rather than to a given level of oxygen, and would translate the response into lung ventilation changes, the major adaptive process. Studies...
Article
Aging is usually defined as the progressive loss of function accompanied by increasing morbidity with advancing age. The process of aging is multifactorial and depends on intrinsic (genetic) and extrinsic (environmental) factors. Aging concerns both physical and cognitive spheres of an individual. Detriments in functional reserve predominate in suc...
Article
The International Biophilia Rehabilitation Academy (IBRA) is an independent scientific organization devoted to creating and nurturing novel ideas on medical rehabilitation, in particluar focusing attention on innovative methods of rehabilitation in the elderly. IBRA, since its inception, delivers supports and services to education and research in a...
Article
Dimethyl sulfoxide (DMSO) is commonly used as a solvent for hydrophobic substances, but the compound’s innate bioactivity is an area of limited understanding. In this investigation we seek to determine the analgesic potential of DMSO. We addressed the issue by assessing the perception of thermal pain stimulus, using a 55 °C hotplate design, in cons...
Article
Most chemically mediated sexual communication in humans remains uncharacterized. Yet the study of sexual communication is decisive for understanding sexual behavior and evolutive mechanisms in our species. Here we provide the evidence to consider 4,16-androstadien-3-one (AND) as a man's sexual pheromone. Our experiment provides support for the phys...
Article
Full-text available
Dimethyl sulfoxide (DMSO) is one of the most commonly used solvents for hydrophobic substances in biological experiments. In addition, the compound exhibits a plethora of bioactivities, which makes it of potential pharmacological use of its own. The influence on respiration, and thus on arterial blood oxygenation, of DMSO is unclear, contentious, a...
Article
The carotid body is a highly specialized chemoreceptive organ of neural crest origin whose role is to detect changes in arterial oxygen content. The sensory units are the chemoreceptor cells, which are neuronal-like cells, surrounded by sustentacular or glial-like cells. It is suggested that the carotid body contains self-renewing multipotent stem...
Article
Parkinsonism is underlain by dopamine (DA) deficiency in the mid-brain, a neurotransmitter innately involved with respiratory regulation. However, the state of respiration in parkinsonism is an unsettled issue. In this study we seek to determine ventilation and its responses to hypoxia in a reserpine - alpha-methyl-tyrosine model of parkinsonism in...
Article
The real-time exhaled volatile organic compounds (VOCs) have been suggested as a new biomarker to detect and monitor physiological processes in the respiratory system. The VOCs profile in exhaled breath reflects the biochemical alterations related to metabolic changes, organ failure, and neuronal activity, which are, at least in part, transmitted v...
Article
Diabetes, apart from generalized neuropathy and microangiopathy, involves tissue hypoxia, which may drive chronic proinflammatory state. However, studies on the ventilatory control in diabetes are sparse and conflicting. In this study we examined the function and morphology of diabetic carotid bodies (CBs). Diabetes was evoked in Wistar rats with s...
Article
The carotid body is a neural-crest-derived organ devoted to respiratory homeostasis through sensing changes in blood oxygen levels. The sensory units are the glomeruli composed of clusters of neuronal-like (type I) cells surrounded by glial-like (type II) cells. During chronic hypoxia, the carotid body shows growth, with increasing neuronal-like ce...