Midhun Unni

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Verified

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• Doctor of Philosophy
• PostDoc Position at The University of Manchester

Mathematical description of our physical world revolves in a great deal around partial and ordinary differential equations (PDES/ODEs). May it be the case of modelling cardiovascular system or quantum electrodynamics, solving a system of PDEs/ODEs, including their coupled forms is indispensable. It is known that many of these system of DEs does not...

Developing a quantifier of the neural control of motion is extremely useful in characterizing motor disorders and personalizing the model equations using data. We approach this problem using a top-down optimal control methodology, with an aim that the quantity estimated from the collected data is representative of the underlying neural controller....

Freezing is an involuntary stopping of gait observed in late-stage Parkinson's disease (PD) patients. This is a highly debilitating symptom lacking a clear understanding of its causes. Walking in these patients is also associated with high variability, making both prediction of freezing and its understanding difficult. A neuromechanical model descr...

Freezing of gait (FoG) is typically a symptom of advanced Parkinson's disease (PD) that negatively influences the quality of life and is often resistant to pharmacological interventions. Novel treatment options that make use of auditory or sensory cues might be optimized by prediction of freezing events. These predictions might help to trigger exte...

Stress has become a household term for which ascertaining a meaning has become increasingly difficult these days. Physiologically, stress is observed to act through hypothalamus which modulates the autonomic nervous system mainly via sympathetically mediated effects. Utilizing this theory, a model based inference engine was developed for the estima...

Freezing of gait is a late-stage debilitating symptom of Parkinson’s disease (PD) characterised by a sudden involuntary stoppage of forward progression of gait. The present understanding of PD gait is limited, and there is a need to develop mathematical models explaining PD gait’s underlying mechanisms. A novel hybrid system model is proposed in th...

Detecting sympathetic activity can be thought of as a first step towards stress estimation, as stress sympathetically mediates blood pressure (BP) and heart rate. Clinical observations also suggest a relationship between myocardial infarction and increased sympathetic activity in mornings. In this study, we built a computational model combining mod...

Stress could be thought of as a catalyst, which accentuates a set of chemical reactions in our body. Evidence suggests that stress acts on the hypothalamus and results in sympathetically mediated effects. In this study we present a method for stress detection using Time Frequency Analysis of the Heart Rate Variability (HRV) signal derived from phot...

Abstract—Blood Pressure (BP) is a vital parameter for monitoring the wellness of an individual; as any extremity in its value (low or high) could be fatal, making the continuous monitoring of BP extremely important. This paper aims to develop an algorithm that estimates BP non-invasively using arterial displacement pulse. The constitutive model gov...

There exist a number of circumstances in businesses where we make comparative decisions. Whether it be a set of ideas, concepts, or people, what we essentially assume is that there exists some "potential" associated with each one of them, and we assign values to those potentials by comparing them with one another. This is a very difficult problem i...