Michiyasu Suzuki

Michiyasu Suzuki
Yamaguchi University · Department of Advanced ThermoNeuroBiology

MD, PhD

About

1,423
Publications
51,283
Reads
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29,299
Citations
Introduction
Neurosurgery, Neurobiology, Thermal neuromodulation, Brain cooling, monitoring / sensing of brain function neuro intensive care, Stroke, Neurotrauma
Additional affiliations
April 2000 - present
Yamaguchi University
Position
  • Professor
April 2000 - July 2015
University Hospital Medical Information Network
Position
  • CEO
April 2020 - February 2021
Yamaguchi University
Position
  • Professor

Publications

Publications (1,423)
Article
Spreading depolarization (SD) develops after stroke and traumatic brain injury and may contribute to secondary brain damage. These diseases are often accompanied by intracranial hypertension, but little is known about the effects of intracranial pressure (ICP) on SD. Here, we study the effect of increased ICP on hemodynamic and metabolic response t...
Article
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The incidence of subarachnoid hemorrhages (SAHs) in Japan has recently decreased. However, trends in the annual rates of unruptured cerebral aneurysms (UCAs) are unclear because calculations based on follow-up periods are limited to patients with ruptured cerebral aneurysms. We aimed to clarify current trends in the estimated annual rupture rates o...
Article
This study aimed to investigate the effects of focal brain cooling (FBC) on spreading depolarization (SD), which is associated with several neurological disorders. Although it has been studied from various aspects, no medication has been developed that can effectively control SD. As FBC can reduce neuronal damage and promote functional recovery in...
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Idarucizumab, a monoclonal antibody fragment that rapidly reverses the anticoagulant effects of dabigatran, was approved in Japan in September 2016, at which time an all-case, postmarketing surveillance (PMS) study was initiated to collect data on idarucizumab in Japanese patients. Interim results were published previously, and the final results ar...
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Background: Febrile seizures (FSs) are the most frequent type of seizures in infancy and childhood. Epileptiform discharges (EDs) on electroencephalogram at the time of first FS recurrence can increase the risk of epilepsy development. Therefore, inhibition of EDs is important. Recently, WS-3, a transient receptor potential melastatin 8 (TRPM8) ago...
Article
Objective: Cerebral infarction due to cerebral vasospasm (IVS) after aneurysmal subarachnoid hemorrhage (aSAH) is associated with poor outcomes and symptomatic cerebral vasospasm (SVS). However, the difference of risk factors between SVS and IVS was unclear to date. In this study, we aimed to elucidate the risk factors for SVS and IVS based on the...
Article
Objective In elderly populations, the enlargement of the perivascular space is related to small vessel disease and the glymphatic system. Enlarged perivascular spaces (EPVS) in the basal ganglia (EPVS–BG) and EPVS in the centrum semiovale (EPVS–CSO) are associated with different pathophysiological processes. However, the prevalence of EPVS and the...
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Background Quality indicators (QIs) are an accepted tool for measuring a hospital’s performance in routine care. We examined national trends in adherence to the QIs developed by the Close The Gap-Stroke program by combining data from the health insurance claims database and electronic medical records, and the association between adherence to these...
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BACKGROUND Electrocorticography (EcoG) plays an essential role in the preoperative evaluation of epilepsy, despite its high invasiveness. Brain temperature and cerebral hemodynamics also reflect brain activity. This study examined whether a multimodal multichannel probe that simultaneously records EcoG, cortical temperature, and cerebral hemodynami...
Article
Objective As the global population ages, the incidence of traumatic brain injury (TBI) increases. While mild TBI can impair the cognitive function of older adults, the cause and background of mild TBI-induced cognitive impairment remains unclear, and the evaluation of risk factors for cognitive impairment after mild TBI remain open for consideratio...
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To determine whether increasing thrombectomy-capable hospitals with moderate comprehensive stroke center (CSC) capabilities is a valid alternative to centralization of those with high CSC capabilities. This retrospective, nationwide, observational study used data from the J-ASPECT database linked to national emergency medical service (EMS) records,...
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Neurological improvement occurs from the subacute to chronic phases in severe traumatic brain injury. We analyzed factors associated with improved neurological findings in the subacute phase, using data from the Japan Neurotrauma Data Bank (JNTDB). The subjects were 1345 patients registered in the JNTDB (Project 2015). Clinical improvement was eval...
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Each year, the Japan Neurosurgical Society (JNS) reports up-to-date statistics from the Japan Neurosurgical Database regarding case volume, patient demographics, and in-hospital outcomes of the overall cohort and neurosurgical subgroup according to the major classifications of main diagnosis. We hereby report patient demographics, in-hospital morta...
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Epilepsy is a relatively common condition, but more than 30% of patients have refractory epilepsy that is inadequately controlled by or is resistant to multiple drug treatments. Thus, new antiepileptic drugs based on newly identified mechanisms are required. A previous report revealed the suppressive effects of transient receptor potential melastat...
Article
Background Delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (SAH) remains an important problem with a complex pathophysiology. We used data from a single-center randomized trial to assess the effect of a phosphodiesterase inhibitor, cilostazol, in patients with aneurysmal SAH to explore the relationships of DCI with vasospas...
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BACKGROUND Functional mapping in awake craniotomy has the potential risk of electrical stimulation-related seizure. The authors have developed a novel mapping technique using a brain-cooling device. The cooling probe is cylindrical in shape with a thermoelectric cooling plate (10 × 10 mm) at the bottom. A proportional integration and differentiatio...
Article
Spreading depolarizations are highly prevalent and spatiotemporally punctuated events worsening the outcome of brain injury. Trigger factors are poorly understood but may be linked to sudden worsening in supply–demand mismatch in compromised tissue. Sustained or transient elevations in intracranial pressure are also prevalent in the injured brain....
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This study aimed to determine the prevalence and risk factors for brain white matter changes in normal young and middle-aged participants who underwent Brain Dock (brain screening). We analyzed 5,000 consecutive healthy participants from the Brain Dock registry between August to December 2018. Age, sex, body mass index (BMI), medical history, deep...
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Burr hole surgery in the emergency room can be lifesaving for patients with acute subdural hematoma (ASDH). In the first part of this study, a strategy of combined burr hole surgery, a period of intracranial pressure (ICP) monitoring, and then craniotomy was examined for safe and effective treatment of ASDH. Since 2012, 16 patients with severe ASDH...
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Mass gatherings are events characterized by “the concentration of people at a specific location for a specific purpose over a set period of time that have the potential to strain the planning and response resources of the host country or community.” Previous reports showed that, as a result of the concentration of people in the limited area, injury...
Article
In each patient with traumatic brain injury, the pathology is different, and cerebral blood flow and metabolism changes over time. In such a situation, attention is being paid to neurocritical care, which provides appropriate treatment under monitoring. The emphasis of neurocritical care is (1) cerebral perfusion pressure/intracranial pressure mana...
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Focal brain cooling (FBC) is a treatment for refractory epilepsy to suppress epileptic discharges from an epileptic focus. Our wearable FBC system under development consists of a recirculating coolant apparatus and a battery located extracorporeally, and a cooling device made of titanium with water channels inside which is embedded in the skull. An...
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PurposeFluid-attenuated inversion recovery hyperintense vessels (FHVs) are linked to sluggish or disordered blood flow. The purpose of this study is to compare FHVs with digital subtraction angiography (DSA) findings and cerebral hemodynamic changes on acetazolamide challenge SPECT and to determine the clinical and imaging metrics associated with F...
Article
Background: As the aging rate in the traumatic brain injury population increases, the number of patients taking antithrombotic drugs is also expected to increase among the population with traumatic brain injury; however, the utility or risk of reversal of such drugs is unclear. Therefore, we performed a retrospective cohort study of the effect of...
Article
In traumatic brain injury (TBI), abnormal neurological changes may occur with time, despite absence of obvious symptoms/findings in the early period. Therefore, it is important to consider the probability of such changes during initial medical care. Recently, screening of brain damage or prediction of disease progression using blood biomarkers such...
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IntroductionIn patients with nonvalvular atrial fibrillation (NVAF) receiving oral anticoagulants (OACs), reversal of coagulopathy can be achieved with specific reversal drugs such as idarucizumab, which is indicated for use in patients treated with dabigatran for cases of life-threatening or uncontrolled bleeding or during emergency procedures tha...
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The Japan Neurosurgical Database (JND) is a prospective observational study registry established in 2017 by the Japan Neurosurgical Society (JNS) to visualize real-world clinical practice, promote science, and improve the quality of care and neurosurgery board certification in Japan. We summarize JND’s aims and methods, and describes the 2018 surve...
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IntroductionIdarucizumab, a monoclonal antibody fragment, was developed to reverse the anticoagulant effect of dabigatran, and it was approved in Japan in September 2016. An all-case post-marketing surveillance is ongoing to collect data in Japanese patients treated with idarucizumab who had serious bleeding (Group A) or required an urgent procedur...
Article
OBJECTIVE Japan has been reported to have the highest (and increasing) incidence of subarachnoid hemorrhage (SAH) in the world. However, there has never been a report on the nationwide incidence rate and recent trends for SAH in Japan. In this register-based study, the authors aimed to clarify the estimated nationwide SAH incidence rate and the rec...
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The fence-post method has been used for removal of intra-axial tumors. Preoperative detailed planning with only navigation work system is sometimes difficult to identify actual brain surface, small feeding artery and passing artery. Recently, 3-dementional imaging is well developed to integrate various anatomical findings. The purpose of this study...
Article
Objective: The harmful effects of hyperoxemia have been reported in critically ill patients with various disorders, including those with brain injuries. However, the effect of hyperoxemia on aneurysmal subarachnoid hemorrhage (aSAH) patients is unclear. In this study the authors aimed to determine whether hyperoxemia during the hyperacute or acute...
Article
Background and Purpose— Symptomatic vasospasm is an important factor that affects the outcomes of aneurysmal subarachnoid hemorrhage. Subarachnoid blood volume can predict symptomatic vasospasm, and we postulated that the blood clot density would also be an important factor involved in such events. The present study aimed to determine the relations...
Article
An increase in the number of a person of advanced age in Japan, corresponding to the super-aging society world-wide, has become an urgent medical issue in Japan. According to the Japan Neurotrauma Data Bank (JNTDB) project 2015, the percentage of patients older than 65 years with severe traumatic brain injury (TBI) is 51.7%. Just more than half of...
Article
Background Limited national-level information on temporal trends in comprehensive stroke center capabilities and their effects on acute ischemic stroke patients exists. Aims To examine trends in in-hospital outcomes of acute ischemic stroke patients and the prognostic influence of temporal changes in comprehensive stroke center capabilities in Jap...
Article
Physiological brain temperature is an important determinant of brain function, and it is well established that changes in brain temperature dynamically influence hippocampal neuronal activity. We previously demonstrated that the thermosensor TRPV4 is activated at physiological brain temperature in hippocampal neurons thereby controlling neuronal ex...
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International Headache Society published the International Classification of Headache Disorders 2nd Edition (ICHD‐II) in 2004. In response to this development, the “Clinical Practice Guideline for Chronic Headache” was compiled in Japan by the Study Group for Chronic Headache Clinical Practice Guideline Development. In 2006, the book entitled “The...
Article
Background: Stroke is a major factor of morbidity in the patients with Takayasu arteritis (TA). Restenosis is more common with endovascular intervention than after bypass surgery, but vascular anastomosis is difficult due to calcification involving the whole thickness of the arterial wall in the burned-out stage of TA. We report a case of advanced...
Article
Introduction: Elevated intracranial pressure(ICP)can cause secondary brain injury after severe traumatic brain injury(TBI), and ICP is the key factor that determines the outcome. Therefore, prediction of elevation of ICP during the course of the injury would allow for more effective care of patients with severe TBI. In this study, we investigated...
Article
Objective: There are few reports on the relationship between carotid artery stenting (CAS) and frailty. In this study, medium-term outcome after CAS in patients with asymptomatic carotid artery stenosis was examined to see the effect of frailty itself. Methods: A retrospective study was performed in 71 consecutive patients who were treated with...
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More than 30% of patients with epilepsy are refractory and have inadequate seizure control. Focal cortical cooling (FCC) suppresses epileptiform discharges (EDs) in patients with refractory focal cortical epilepsy. However, little is known about the mechanism by which FCC inhibits seizures at 15°C, and FCC treatment is highly invasive. Therefore, n...
Article
Background: The epidemiology of patients with traumatic brain injury (TBI) has changed dramatically over recent decades as a result of rapid advances in aging societies. We assessed the influence of age on outcomes of patients with TBI and sought to identify prognostic factors for in-hospital mortality of TBI among elderly patients. Methods: Usi...
Article
Objective: Developed countries have rapidly aging populations and the use of antithrombotic drugs is increasing. We investigated the effects of antithrombotic drugs and reversal of these drugs in patients with geriatric traumatic brain injury (TBI). Methods: Age, sex, mechanism of injury, Glasgow Coma Scale on admission, head computed tomography...
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Local brain cooling of an epileptic focus at 15°C reduces the number of spikes on an electrocorticogram (ECoG), terminates seizures, and maintains neurological functions. In this study, we attempted to suppress generalized motor seizures (GMSs) by cooling a unilateral sensorimotor area. GMSs were induced in rats by intraperitoneal injection of bicu...
Article
Objective: The purpose of this research paper is to demonstrate how the integration of the multi-channel measurement capabilities of near-infrared spectroscopy (NIRS), electrocorticography (ECoG), and negative temperature coefficient (NTC) thermistor sensors into a single device compact enough for subdural implantation can provide beneficial infor...
Article
Authors evaluated the present state of neurotrauma research in Japan retroactively to the past and searched corridors to the future. The Japan Neurotrauma Data Bank had first clarified an increased risk of talk and deterioration in elderly patients owing to the increased incidence of tumble/falls, instead of traffic accidents, and the frequent use...
Article
Objective: The purpose of this study is to propose a palm-sized cryoprobe system with a built-in thermocouple (TC) for highly accurate and sensitive temperature measurements and to verify the effectiveness of the system. Methods: Conventional cryoprobe systems based on the boiling effect of a refrigerant have triple coaxial tubes. In the propose...
Article
Background: The association between physician volume and the death rate for patients who are hospitalized for ischemic and hemorrhagic stroke remains unclear. It is unknown whether a volume threshold for such an association exists. We aimed to analyze the correlation between in-hospital stroke mortality and physician volume considering board certif...
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d-dimer is a potential biomarker for the detection of traumatic brain injury (TBI). However, the mechanisms that trigger elevation of d-dimer in TBI remain unclear. The purpose of this study was to evaluate the reliability of d-dimer in blood as a biomarker for TBI and to determine the mechanisms involved in regulating its blood levels. Nine patien...
Article
Background: Delayed cerebral ischemia (DCI) is among the most dreaded complications following aneurysmal subarachnoid hemorrhage (SAH). Despite advances in neurocritical care, DCI remains a significant cause of morbidity and mortality, prolonged intensive care unit and hospital stay, and high healthcare costs. Large artery vasospasm has classicall...
Article
A focal brain cooling system for treatment of refractory epilepsy that is implantable and wearable may permit patients with this condition to lead normal daily lives. We have developed such a system for cooling of the epileptic focus by delivery of cold saline to a cooling device that is implanted cranially. The outflow is pumped for circulation an...
Article
Increases in flow velocity are observed with duplex ultrasonography when carotid artery is highly stenotic. It is very common that NASCET of 70% stenosis often shows peak systolic velocity (PSV) of over 200cm/s. The higher the stenosis, the more PSV increases. However, if the artery is occluded, the velocity cannot be detected. Therefor there shoul...
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Background: Cerebral infarction associated with a malignant tumor is widely recognized as Trousseau syndrome. In contrast, few cases of cerebral infarction associated with benign tumors have been reported. We present two cases of embolic stroke that seemed to be caused by mucin-producing adenomyosis. Case presentation: The patients were women ag...
Article
Objective Traditionally, angiographic vasospasm (aVS) has been thought to cause delayed cerebral ischemia (DCI) after aneurysmal subarachnoid hemorrhage (aSAH). However, successful treatment of aVS alone does not result in improved neurological outcome. Therefore, there may be other potential causes of poor neurological outcome including spreading...
Article
This study aimed to understand the mechanism by which brain cooling terminates epileptic discharge. Cortical slices were prepared from rat brains (n = 19) and samples from patients with intractable epilepsy that had undergone temporal lobectomy (n = 7). We performed whole cell current clamp recordings at approximately physiological brain temperatur...
Article
Background: The aim of this study was to assess the risk and the threshold of hemorrhagic transformation (HT) after treatment with recombinant tissue plasminogen activator (rtPA) under the novel oral anticoagulant, rivaroxaban. Methods: Fifty-three spontaneous hypertensive rats were used in this study. We performed transient middle cerebral arte...
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Background: Idiopathic basal ganglia calcification (IBGC) is a rare neurodegenerative disorder characterized by symmetric intracranial calcium deposition. We report a patient with IBGC associated with cerebral infarction due to impairment of cerebrovascular reactivity based on single-photon emission computed tomography (SPECT) with acetazolamide c...
Article
Objectives: Cryosurgery is an alternative technique for minimally invasive treatment of lesions. We have recently examined cryosurgery for epilepsy in animal models, and found that penicillin G (PG)-induced epileptiform discharges (EDs) mostly vanished after freezing. However, EDs were provoked again after insufficient freezing. Inadequate freezin...
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Introduction: Malignant rhabdoid tumor (MRT) is a highly aggressive childhood neoplasm and mainly presents in kidney and brain. We report the case of a patient with extrarenal extracranial MRT in the craniovertebral junction (CVJ). Case report: A 3-year-old boy presented with tetraparesis that had rapidly developed for 2 weeks. The tumor was loc...
Chapter
Epilepsy is a group of neurological disorders which is caused by excessive neuronal activities in cerebrum and characterized by recurrent seizures. A quarter of patients have intractable epilepsy and do not become seizure-free with medication. We are developing an implantable and wearable focal brain cooling system, which enables the patients to le...
Article
A questionnaire survey was conducted to build a navigational chart (current status) with an accurate compass for resident physicians designated as “specialist trainees” to establish future career directions. On February 9, 2015, we sent an email to persons in charge of training programs of the Japan Neurosurgical Society to request their assistance...
Article
With aging of the population in Japan, the incidence of aneurysmal subarachnoid hemorrhage (SAH) has been increasing among the elderly. We analyzed the outcomes of SAH in patients over 75-years-old. We retrospectively evaluated medical records and imaging studies of 124 patients treated with clipping, coiling, or conservative therapy between Januar...
Article
The authors reported the 10-year change in board certified neurosurgeons as recorded by the Japan Neurosurgical Society. The number of doctors increased, including those who acquired certification by the Japan Stroke Society, the Japanese Society of Neuroendovascular Therapy, and Neurospinal Society of Japan as well as our certification. As for sub...
Article
BACKGROUND: A recent randomized control study(the PATCH trial)found no beneficial effect of platelet concentrate(PC)transfusion on the prognosis of patients with intracerebral hemorrhage(ICH)treated with anti-platelet agents(APAs). However, the trial excluded surgical cases. In this study, we examined the effect of PC on ICH, including patients w...
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Full-text available
Experiments with drug-induced epilepsy in rat brains and epileptic human brain region reveal that focal cooling can suppress epileptic discharges without affecting the brain’s normal neurological function. Findings suggest a viable treatment for intractable epilepsy cases via an implantable cooling device. However, precise mechanisms by which cooli...
Article
Computed tomography (CT) scans are useful in patients with traumatic brain injury (TBI), but the potential risks associated with ionizing radiation are unknown. Furthermore, CT scans are not commonly available in developing countries. In this study, coagulopathy and abnormal fibrinolysis were investigated as blood biomarkers for detection of struct...
Article
Background: The drip-and-ship approach allows intravenous tissue plasminogen activator therapy and adjuvant endovascular treatment in acute ischemic stroke, even in rural areas. Here, we examined the safety and time course of the drip-and-ship approach. Methods: Fifty consecutive cases treated with the drip-and-ship approach (drip-and-ship group...
Article
Full-text available
Carmustine wafers (CW) were approved in Japan for newly diagnosed and recurrent malignant gliomas during 2013. The ventricle is often opened during surgery to achieve maximum resection. While not generally recommended in such situations, CW might be safely achieved by occluding an opened ventricle using gelform or collagen sheets. However, whether...
Article
Thrombosed giant aneurysm of the V1 segment of the vertebral artery is rare, and there is controversy regarding the optimal method of treatment in this portion. Here, we report a thrombosed giant aneurysm of the V1 segment of the vertebral artery with a good clinical course with endovascular proximal artery occlusion of the vertebral artery. A 59-y...
Conference Paper
Epilepsy is a group of diseases caused by excessive neuronal activities, and one-quarter of the patients do not become seizure-free by the existing treatments. The potential treatments include focal brain cooling, which aims to cool the region where the excessive neuronal activities begin. We are developing a focal brain cooling system. The system...
Article
BACKGROUND: Carmustine wafers (CW) were approved in Japan for newly diagnosed and recurrent malignant gliomas during 2013. The ventricle is often opened during surgery to achieve maximum resection. While not generally recommended in such situations, CW implantation might be safely achieved by occluding an opened ventricle using gelform or collagen...
Article
Focal brain cooling (FBC) is under investigation in preclinical trials of intractable epilepsy (IE), including status epilepticus (SE). This method has been studied in rodents as a possible treatment for epileptic disorders, but more evidence from large animal studies is required. To provide evidence that FBC is a safe and effective therapy for IE,...