Michitaka Honda

Michitaka Honda
Fukushima Medical University · Disaster and Comprehensive medicine

MD, PhD

About

72
Publications
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1,219
Citations

Publications

Publications (72)
Article
Purpose: The purpose of this study was to clarify the clinical features and outcomes of patients with recurrence after esophagectomy following neoadjuvant chemotherapy (NAC) related to the timing of recurrence. Methods: We reviewed 240 consecutive patients who underwent NAC followed by esophagectomy for clinical stage II/III esophageal squamous...
Article
Full-text available
Background: The optimal standard reconstruction procedure after distal gastrectomy is controversial. No large-scale persuasive clinical studies from long-term perspectives on this topic have yet been conducted. Study design: This retrospective multicenter study analyzed a database of 2510 consecutive patients with clinical stage I gastric cancer...
Article
Background: The paraaortic lymph-node (PALN) is a relatively uncommon metastasis as a first site of recurrence following colorectal cancer (CRC) surgery. Localized and resectable PALN recurrence has the potential of long-term survival by curative resection. We evaluated the risk factors for the recurrence of PALN following curative surgery in patie...
Article
Background The reintroduction of oxaliplatin as a third-or-later-line regimen has been a promising option for patients with metastatic colorectal cancer (mCRC) who previously received chemotherapy including oxaliplatin. In this single-arm phase II study, we evaluated the efficacy of biweekly SOX, which is the combination of oxaliplatin reintroducti...
Article
Background Laparoscopic gastrectomy (LG) might have greater clinical benefits for elderly patients as less invasive surgery; however, there is still little evidence to support its benefit. We evaluated the surgical outcomes of elderly patients in a nationwide prospective cohort study. Methods One hundred and sixty-nine participating institutions w...
Article
Purpose Neoadjuvant chemotherapy (NAC) followed by esophagectomy has become a standard treatment for esophageal squamous cancer (ESCC) in Japan. We used propensity-matching analysis to clarify the safety and efficacy of NAC in daily clinical practice. Methods We reviewed the medical records of 335 patients with clinical Stage II/III ESCC diagnosed...
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Background: The aim of this single-arm phase II clinical trial was to evaluate whether the alternate-day administration of S-1 plus irinotecan would reduce the incidence of severe diarrhea in comparison to consecutive-day S-1 administration (standard IRIS regimen) in second-line treatment for patients with metastatic colorectal cancer. Methods:...
Article
Background: Although colorectal cancer comprises several histological subtypes, the influences of histological subtypes on disease progression and treatment responses remain controversial. Objective: We sought to evaluate the prognostic relevance of mucinous and poorly differentiated histological subtypes of colorectal cancer by the propensity s...
Article
Objective: A large-scale multicenter historical cohort study was conducted to investigate the efficacy of laparoscopic gastrectomy (LG) in comparison to open gastrectomy (OG) for locally advanced gastric cancer. Background: LG is now practiced widely, but its applicability for advanced gastric cancer is still controversial. As oncologic outcomes...
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Background: Most previous reports to analyze risk factors for peritoneal recurrence in patients with colon cancer have been observational studies of a population-based cohort. Objective: This study aimed to determine the risk factors for peritoneal recurrence in patients with stage II to III colon cancer who underwent curative resection. Design...
Article
Background Early identification of patients at risk of postoperative pancreatic fistula (POPF) allows appropriate management after gastrectomy. Although some reports have suggested a correlation between POPF and the concentration of amylase in drained abdominal fluid (D-AMY), this has not been proven to impact sufficiently on clinical decision-maki...
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This study aimed to determine whether nerve regeneration by means of an artificial nerve conduit is promoted by ethanol-induced cervical sympathetic ganglion block (CSGB) in a canine model. This study involved two experiments—in part I, the authors examined the effect of CSGB by ethanol injection on long-term blood flow to the orofacial region; par...
Data
ARRIVE guidelines checklist. (PDF)
Article
Background: Preserving the hepatic and pyloric branches of the vagal nerve in laparoscopic pylorus-preserving gastrectomy (LPPG) is considered necessary to maintain the function of the pyloric cuff. However, the clinical benefits of preservation of the celiac branch of the vagal nerve (CBVN) remain unclear. Methods: Of 391 patients who underwent...
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Purpose: Reliable risk estimates of recurrence are necessary to establish optimal postoperative surveillance strategies. The purpose of the present study was to clarify changes in the hazard rate (HR) for tumor recurrence over time in Japanese patients with colon cancer. Methods: Data for 3984 patients from three clinical trials evaluating the bene...
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The aim of the present study was to determine whether or not the overall survival (OS) and disease-free survival (DFS) were affected by the tumor location in patients who underwent curative resection for colon cancer in a pooled analysis of three large phase III studies performed in Japan. In total, 4029 patients were included in the present study....
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This study assessed the impact of postoperative complications on the colorectal cancer survival and recurrence after curative surgery using pooled individual patients' data from three large phase III randomized trials. In total, 5530 patients were included in this study. The patients were classified as those with postoperative complications (C grou...
Data
Figure S1. The overall survival curves of the C group (those with surgical complications) and NC group (those without surgical complications) according to the type of treatment after surgery.
Data
Figure S2. The overall survival curves of the C group (those with surgical complications) and NC group (those without surgical complications) according to the primary tumor location.
Article
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Purpose: Laparoscopic pylorus-preserving gastrectomy (LPPG) is performed to preserve function in treating early gastric cancer. However, gastric stasis is a potential complication of LPPG that could decrease postoperative quality of life, possibly due to gastric edema of the pyloric cuff caused by venous stasis. We introduced an infrapyloric vein...
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Background: The feasibility and efficacy of adjuvant hepatic arterial infusion (HAI) in preventing the development of liver metastases in patients with advanced colon carcinoma have not been validated. The aim of this randomized controlled study was to compare the feasibility of HAI and the protective effect against liver metastasis after curative...
Article
Background: For patients with low-lying rectal cancer, the feasibility of anus-preserving surgery in combination with neoadjuvant chemoradiotherapy (NACRT) has been not well established from the perspective of patient-centered outcomes. Methods: We investigated 278 patients with low-lying rectal adenocarcinoma from 2005 to 2012. We compared thei...
Article
Objective: This study aimed to clarify the oncological safety of pylorus-preserving gastrectomy (PPG) compared with conventional distal gastrectomy (DG). Methods: From three institutions specializing in cancer, the medical records for a cohort of 2898 consecutive patients who had undergone DG (n = 2208) or PPG (n = 690) for clinical stage I gast...
Article
The prognostic relevance of the mucinous subtype of colorectal cancer is still controversially discussed. We designed a large-scale cohort study with a propensity score matching to evaluate the impact of mucinous subtype on postoperative survival, recurrent patterns and chemo-sensitivity in patients with colorectal cancer using the integrated datab...
Article
Estimation of the risk for tumor recurrence after curative resection of colorectal cancer is essential for establishment of a treatment plan and surveillance schedule. Several studies have identified the risk factors for the tumor recurrence occurring within a specific period of time, but the knowledge concerning the transition of the hazard rate o...
Chapter
From the era of Coley?s toxin back in the beginning of the twentieth century, it was well known that certain acute bacterial infection might lead to the regression of malignant tumors in some cases. Many types of bacteria either in its crude form or with special preparation have been reported to possess immunotherapeutic activity against cancers. T...
Article
85 Background: Total gastrectomy for gastric cancer significantly reduces body weight, especially lean body mass (LBM), through surgical stress and decrease of the calorie intake. Eicosapentaenoic acid (EPA)-enriched enteral nutrition (EPA-EN) could modulate immune function and limits catabolism. In our phase III study to compare perioperative stan...
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Full-text available
Background: Clinical trials comparing laparoscopic gastrectomy (LG) versus traditional open gastrectomy (OG) have been planned, their surgical outcomes reported but their oncologic outcomes are still pending. Consequently, we have conducted this large-scale historical cohort study to provide relevant information rapidly to guide our current practic...
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Purpose: The aim of this phase II clinical trial was to evaluate the preventive effect of dexamethasone mixing injection for venous pain in patients with colorectal cancer during chemotherapy. Materials and methods: Patients were randomized to receive a 2-h intravenous infusion of oxaliplatin 130 mg/m(2) on day 1 followed by capecitabine 1000 mg...
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Background: The aim of this multicenter, open-label, randomized phase II trial was to evaluate the efficacy of a dose-dense capecitabine and oxaliplatin (XELOX) regimen in patients with metastatic colorectal cancer (mCRC) for whom reintroduction of oxaliplatin had been planned as a third- or later-line regimen. Methods: The patients with mCRC wh...
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Background The objectives of this study were to evaluate the incidence of and the risk factors for readmission after gastrectomy. Our hypothesis was that early discharge may be related to an increase in the incidence of readmission. Methods This was a retrospective, single-center, observational study of 1442 patients who underwent gastrectomy for s...
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Background Few prediction models have so far been developed and assessed for the prognosis of patients who undergo curative resection for colorectal cancer (CRC). Materials and Methods We prepared a clinical dataset including 5,530 patients who participated in three major randomized controlled trials as a training dataset and 2,263 consecutive pat...
Article
Full-text available
Patients who have undergone esophagectomy or gastrectomy have certain dietary limitations because of changes to the alimentary tract. This study attempted to develop a psychometric scale, named "Esophago-Gastric surgery and Quality of Dietary life (EGQ-D)," for assessment of impact of upper gastrointestinal surgery on diet-targeted quality of life....
Article
The Maastricht, Asia-Pacific consensus guidelines strongly recommend eradication of Helicobacter pylori in patients who have a history of gastric cancer. This open-label, single-center, randomized controlled trial was conducted to investigate the appropriate timing of eradication for patients undergoing gastrectomy. One hundred and fifty patients s...
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The feasibility of gastrectomy with standard lymphadenectomy for patients over 85 years of age is not known. This study investigated short- and long-term outcomes and the tolerability of gastrectomy with standard lymphadenectomy for patients over 85 years with gastric cancer. Altogether, 77 patients aged over 85 years underwent gastrectomy with lym...
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Early-onset gastric cancer is relatively rare. To evaluate the clinicopathological features and surgical outcome of young patients with gastric cancer, this retrospective comparative study was conducted. From 2000 to 2010, 4882 patients underwent surgery for gastric adenocarcinoma in our institution. A total of 136 patients under 40 years old were...
Article
Objective Cancer-related fatigue (CRF) is a common and one of the most important issues in palliative medicine, and it has been demonstrated to have a significant impact on patient quality of life (QoL). The present pilot randomized controlled study evaluated the efficacy and toxicity of methylprednisolone (MP) for CRF in advanced cancer patients....
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TO THE EDITOR: An article by Kim et al 1 was recently published comparingthesurgicalandoncologicoutcomesbetweenlaparoscopic andopengastrectomyforgastriccancer.Theauthorsusedpropensity scorematchingtominimizetheselectionbiasinaretrospectivecohort of patients from multiple centers. Kim et al tried to adjust for confounding factors by using propensity...
Article
Background Post-gastrectomy or esophagectomy symptoms can be a significant burden for patients. However, no standard scale for evaluating these symptoms has been established. We recently developed a postoperative symptom-specific scale. Study Design After a draft scale was prepared based on a pilot study, psychometric methods were used to assess i...
Article
Ramelteon is the first selective melatonin receptor agonist and currently is approved in the United States and Japan for the treatment of insomnia. Our meta-analysis assessed the efficacy and safety of ramelteon for the treatment of insomnia in adults. We included both published and unpublished data from randomized placebo-controlled trials evaluat...
Article
Gastrointestinal stromal tumors (GISTs) are the most common mesenchymal neoplasms of the gastrointestinal tract. Surgical resection with a free margin is the gold standard treatment for these lesions. The aim of this study was to evaluate the feasibility of performing laparoscopic resection for gastric GIST from the viewpoint of operative and long-...
Article
Laparoscopy-assisted total gastrectomy (LATG) is commonly performed for early gastric cancer (EGC) in the upper stomach; however, the incidence of anastomotic complications remains high, and postoperative nutritional status is not satisfactory. This study aimed to evaluate the feasibility and nutritional impact of a novel surgical procedure, laparo...
Article
OBJECTIVE: To evaluate the risks and benefits of using a circular stapler (CS) compared with the hand-sewn (HS) method for the esophagogastric anastomosis after esophageal resection. BACKGROUND DATA: Previous randomized controlled trials (RCTs) indicated that the use of a CS might prevent anastomotic leakage, whereas it was more likely to lead to a...
Article
Objective: The surgical procedure for subglottic stenosis is technically challenging when the vocal cords are involved and concomitant management for glottic involvement is required. After total cricoidectomy and laryngotracheal anastomosis, T-tube placement for 3 to 6 months is recommended. Bone grafts might shorten this period. We report the his...
Article
No conservative treatments for chylothorax have yet been established, and surgical ligation of the thoracic duct is required in many cases. In the present study, we investigated the management of body fluid in a canine chylothorax model. Twelve beagle dogs were divided evenly into three groups: A, B, and C. Under general anesthesia, the thoracic du...
Article
Intralesional or systemic steroid administration is a promising strategy for the prevention of esophageal stricture after endoscopic therapy. The aim of this study was to evaluate the influence of steroid therapy on the process of healing of defects in the esophageal mucosa after endoscopic mucosal resection (EMR). Nine beagle dogs were divided int...
Article
EMR is an accepted treatment for early esophageal carcinoma. However, resection of a large mucosal area often causes postoperative esophageal stricture. To investigate the efficacy of autologous adipose tissue-derived stromal cells (ADSCs) for prevention of stricture formation after EMR in dogs. Animal study. University research center. Ten beagle...
Article
Purpose In Japan, chemoradiotherapy (CRT) is primarily indicated for T4 esophageal cancer for curative intent or when aiming for downstaging. However, CRT yields a low rate of complete response, is associated with a high incidence of complications such as fistula, and often results in the emergence of severe lymph node metastasis or distant organ m...
Article
Primary squamous cell carcinoma (SCC) and metaplastic squamous cell carcinoma (MSCC) are rare types of breast cancer with specific histological features. They are characterized by rapid progression, a tendency toward cyst formation, and negativity for hormone receptors. Many studies have concluded that SCC of the breast carries a poor prognosis, ba...
Article
“Linitis plastica” refers to a histological characterization of diffusely infiltrating, poorly differentiated adenocarcinoma. Linitis plastica-type esophageal adenocarcinoma is extremely rare: this is thought to be only the sixth case report of linitis plastica involving the esophagus. A 60-year-old man was referred to our hospital after repeated e...
Article
The chemotherapy regimen currently used for treating esophageal and gastric carcinoma has been either epirubicin, cisplatin, and fluorouracil (5-FU) or docetaxel, cisplatin, and 5-FU. Here, we report the efficacy and toxicity of doxorubicin, cisplatin, and 5-FU for only esophageal squamous cell carcinoma (ESCC). Between January 2000 and October 200...
Article
Resection of a large amount of the esophageal mucosa often causes esophageal ulcer and postoperative stricture. The aim of this study was to evaluate the process of healing of defects in the esophageal mucosa after endoscopic mucosal resection (EMR). Cap-assisted EMR was performed in the thoracic esophagus of six beagle dogs to prepare mucosal defe...
Article
Full-text available
To evaluate the efficacy of retrograde observation of the esophagus, pharynx, larynx and lingual root. With the beagle dog under anesthesia, the anterior wall of the stomach was fixed on the abdominal wall in a similar way to percutaneous endoscopic gastrostomy. The gastrointestinal scope was inserted via a 12 mm laparoscopic port for subsequent re...
Article
食道癌扁平上皮癌において,FP療法(5-FU+Cisplatin)無効例,もしくは有効再増悪例に対するsecond-lineの化学療法は確立されていない。当科では2005年1月から2008年4月までの期間にDocetaxel 60mg/m2・Nedaplatin 80mg/m2の併用療法をsecond-lineとして46例,64病変に施行,その有効性・安全性について検討した。対象は前治療としてFP療法もしくはFAP療法が施行された症例であり,術後再発,化学放射線療法(CRT)後の再燃,切除およびCRT不能,内視鏡治療後再発がそれぞれ12,18,15,1例であった。平均2.4回施行し,総合効果は13.0%(CR 1例,PR 5例,SD 26例,PD 14例),本治療開始日からの50%生存期間は...
Article
遠隔臓器転移を有する食道癌に対してFAP療法(5-FU+doxorubicin+CDDP)による初回治療を2002年から2007年に36例施行し,安全性,有効性についてretrospectiveに検討した。対象は男性33例,女性3例,年齢中央値は64歳(47~78歳),全例扁平上皮癌,転移臓器は肝23例,肺8例,骨5例,胃3例,副腎2例(重複あり)であった。平均治療回数は2.72回(1~8回),全体の奏効率(総合効果)は47.2%,部位別では食道原発巣45.7%,リンパ節32.3%,肝47.8%,肺37.5%であった。50%生存期間は335日(50~1593日)であり,1年生存率は45.1%であった。血液毒性は好中球減少が多く,Grade 3を7例,Grade 4を2例に認めた。その他の有害...
Article
A 70-year-old man with dysphagia was diagnosed as advanced esophageal cancer by a primary doctor, and he was admitted to our hospital for treatment in February, 2004. The pretreatment diagnosis was basaloid squamous carcinoma, Mt area, T4 (aorta) , N2 (No. 107) , M1 (liver), Stage IVb performed systemic chemotherapy by FAP (5-fluorouracil ( 5-FU)+d...
Article
40歳代の女性.検診の超音波検査で膵腫瘍を指摘された.腹部CTで膵体部上縁に強い造影効果を受ける2cm大の類円形腫瘤を認め,非機能性膵内分泌腫瘍を疑い開腹手術を行った.腫瘤は膵上縁に接していたが,膵組織から発生した腫瘍ではなく,容易に剥離・摘出可能であった.術中迅速病理診断を行いhyaline vascular-typeのCastleman's diseaseと診断されたため,腫瘤の摘出のみで手術を終了した.Castleman's diseaseは縦隔頸部に好発するリンパ節過形成性病変であり,腹腔内発生は稀である.またhyaline vascular-typeは血流豊富な腫瘤であり画像上強い造影効果を呈するため,自験例のように膵に接して存在した場合,同様に血流豊富な膵内分泌腫瘍との鑑別が問題...

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