Michihiro Sugano

Michihiro Sugano
Kyushu University | Kyudai · Department of Nutrition

Ph. D. in Agriculture

About

531
Publications
14,981
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14,096
Citations
Citations since 2017
7 Research Items
1806 Citations
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
2017201820192020202120222023050100150200250300
Introduction
lipid nutrition

Publications

Publications (531)
Article
Full-text available
Egg protein is a remarkably abundant source of protein, with an amino acid score of 100 and the highest net protein utilization rate. However, there have been relatively fewer studies investigating the health benefits of egg protein. In this review, we have summarized the available information regarding the health benefits of egg proteins based on...
Article
Full-text available
Dietary β-conglycinin has been shown to increase plasma adiponectin concentration and decrease visceral adipose tissue weight in rats. Since adiponectin is one of the factors regulating blood pressure, as well as modulating lipid metabolism, we examined whether dietary β-conglycinin affects blood pressure in spontaneously hypertensive rats. The exp...
Article
Full-text available
Although most current epidemiologic studies indicate no significant association between consuming one egg daily and blood cholesterol levels and cardiovascular risk, arguments still persist with a positive association. Since the diet is one of the most influential factors for this association, we illustrate characteristic features in Japanese peopl...
Article
Full-text available
The physiological effects of dietary β-conglycinin (β-CON), one of the major components of soy protein (SOY), were examined in an obese animal model. Prior studies show that β-CON intake decreases plasma triglycerides and visceral adipose tissue weight, and increases plasma adiponectin in rodents. Since plasma adiponectin is known to affect both li...
Article
Background and objectives: The excessive intake of trans fatty acids increases serum low-density lipoproteincholesterol and reduces high-density lipoprotein-cholesterol. We studied the effects of 1% energy trans fatty acid supplementation on serum lipid concentrations in healthy adult Japanese with different obesity-related gene polymorphisms. Me...
Article
Full-text available
Trans fatty acid (TFA) from partially hydrogenated oil is regarded as the worst dietary fatty acid per gram due to its role in coronary heart disease. TFA consumption is decreasing worldwide, but some but not all observational studies indicate that TFA intake has little relevance to serum cholesterol levels in populations with low TFA intake (<1% E...
Article
Recently, Hibino has reviewed bioactivity of choline in the February issue of this journal¹⁾. This review helps serve collective comprehension of the related filed of choline bioactivity, but the information regarding the trimethylamine-N-oxide (TMAO), a well-known metabolite of choline with the plausible atherogenic potential, is not introduced. T...
Article
Full-text available
Background Mayonnaise is used widely in contemporary human diet with widespread use as a salad dressing or spread on breads. Vegetable oils used in its formulation may be a rich source of ω-6 PUFAs and the higher-PUFA content of mayonnaise may be beneficial in mediating a hypocholesterolemic effect. This study, therefore, evaluated the functionalit...
Article
The effects of Aster scaber seed oil (ASO) on lipid profiles were studied in rats and hamsters. ASO contained considerable amounts of Δ3t-16:1 (11.4%), Δ3t, 9c-18:2 (4.6%), and Δ3t, 9c, 12c-18:3 (11.3%). Young rats and hamsters were fed diets containing ASO, soybean oil (SBO), or olive oil (OLO) as fat sources for 4 weeks in separate experiments wi...
Article
The World Health Organization (WHO) has recommended that trans fatty acid (TFA) intake should be less than 1% of total energy intake, but few data are available as to the influence of energy TFA intake of as low as 1% on blood cholesterol levels. A randomized, double-blind, parallel trial was conducted to assess the effects of 1% TFA dietary supple...
Article
The present study was carried out to examine if the positional distribution of medium-chain fatty acid (MCF) in dietary synthetic fat influences lymphatic transport of dietary fat and the chemical composition of chylomicrons in rats with permanent cannulation of thoracic duct. Four types of synthetic triacylglycerol were prepared: (i) sn-1(3) MCF-s...
Article
A randomized crossover study in healthy young Japanese showed no significant effects of a 0.6% energy trans fatty acid (TFA) intake on the serum cholesterol concentrations and parameters of glucose metabolism. The results indicate that TFAs at this dietary level may have no adverse metabolic effects on healthy young Japanese.
Article
Dietary cholesterol oxidation products (COPs) modulate various metabolic processes, particularly lipid metabolism. In this study, we observed that dietary COPs perturbed hepatic function, linoleic acid desaturation, and cholesterol catabolism in rats that were fed with diets containing 0.5% COPs for a short duration (7 days). The rats (age, 8 weeks...
Article
Because trans fatty acids (TFAs) are a potent risk factor for coronary heart disease, it is important to know the amount of TFA consumed. We estimated TFA intakes of Japanese university students by direct measurement. Subjects included 118 students (57 males and 61 females) in two regions of Japan: Kanto (Tokyo area) and Okinawa. A dietary survey w...
Article
We examined the minimal effective dose on serum cholesterol concentration and the safety of dressing containing plant sterol in humans. EXP.1: Sixty-eight healthy Japanese males (total cholesterol (TC) > or = 170 mg/dL) were randomly divided into four groups, and were given 0, 400, 800 or 1200 mg/day of plant sterol in 15 g dressing for 4 weeks fol...
Article
In a placebo-controlled double-blind study, we examined the effects of dressing containing plant sterol (PS) on blood lipids and the safety in Japanese borderline or mildly hypercholesterolemic subjects. Fifty-nine subjects [total cholesterol (TC) concentration > or = 200 mg/dL] were randomly divided into two groups and were given daily 15 g of dre...
Article
Full-text available
Soybean protein isolate (SPI) was digested with protease to produce a peptides containing the low-molecular fraction (LD3) or a mixture of high- and low-molecular fractions (HD1). Rats were fed a diets containing SPI, LD3, or HD1 at a protein level equivalent to the 20% casein diet for 4 weeks. The serum triglyceride concentration was lower in rats...
Article
Current studies on physiological functions of certain plant seed oils containing conjugated trienoic acids as a major fatty acid component are indicative of the possible usefulness of these oils as a new type of functional oils. Here, we describe the potential health benefits of conjugated trienoic acids.
Article
Punicic acid, one of the conjugated linolenic acid (CLN) isomers, exerts a body-fat reducing effect. Although punicic acid is found in pomegranate and Tricosanthes kirilowii seeds, the amount of this fatty acid is very low in nature. The goal of this study was to produce a transgenic oil containing punicic acid. A cDNA encoding conjugase that conve...
Article
Exogenous and endogenous cholesterol oxidation products (COPs) perturb various metabolic processes, and thereby they may induce various homeostasis-related disorders. Here, we observed that procyanidin-rich dietary apple polyphenol (APP) from unripe apples alleviates the perturbation of lipid metabolism by decreasing the exogenous COP levels in rat...
Article
The combined effect of conjugated linoleic acid (CLA) with different proteins on lipid metabolism was examined in rats. Male rats were fed diets containing 1% CLA or linoleic acid (LA) in combination with different proteins (casein (CAS), soy protein isolate (SPI) or β-conglycinin (CON)) for 4 weeks. Dietary CLA, as compared with LA, reduced the we...
Article
The present study was designed to evaluate the physiological effect of trans fatty acid in the diabetic condition. After feeding the mixture of oleic (cis) or elaidic (trans) acids with safflower oil (3 : 7, wt/wt) at the dietary level of 10% for 2 weeks, rats were treated with streptozotocin and reared on the same diets for an additional week. The...
Article
Lymphatic transport of a mixture of medium-chain TAG (MCT) and long-chain TAG (LCT) was studied in lymph-cannulated rats. Animals were administered a test emulsion containing either triolein, tricaprylin, or a 1:1 mixture of triolein and tricaprylin, and the lymph was collected for 24 h. The lymphatic recovery rate of medium-chain FA (MCFA) was sig...
Article
The title parameter was measured by the AgNO3-TLC / GC method and the results were compared with those for margarines produced in France and the United Kingdom (UK). 1) Trans fatty acid content in domestic margarines were expressed as the following percentages of total fatty acids, print type, 2.9-22.4% (average 13.4%); soft type 1.1-17.0% (average...
Article
The interaction of dietary protein type and fat level on the body fat-reducing activity of conjugated linoleic acid (CLA) was studied in male rats fed diets containing casein (CAS) or soy protein (SOY) as a protein source with low fat (LF, 6.0% soybean oil) or high fat (HF, 13.0% soybean oil) combinations for 4 weeks. CLA was added at the 1.0% leve...
Article
A feeding study in rats investigated the principal active component for the hypocholesterolemic effect of soy protein isolate (SPI) by comparing the effect before and after ethanol washing. Five-week-old male Sprague-Dawley rats were fed cholesterol-enriched AIN-93G diets containing 20% casein (CAS), 20% SPI, 20% ethanol-washed SPI (EWS), 18.4% EWS...
Article
The interaction of sesamin, one of the most abundant lignans in sesame seed, and types of dietary fats affecting hepatic fatty acid oxidation was examined in rats. Rats were fed purified experimental diets supplemented with 0% or 0.2% sesamin (1:1 mixture of sesamin and episesamin), and containing 8% of either palm, safflower or fish oil for 15 day...
Article
The effect of the interaction of CLA and type of dietary protein on lipid metabolism was studied in male rats by feeding diets containing casein (CAS) or soy protein (SOY) as dietary protein and either linoleic acid (LA, a control FA) or graded levels of CLA at 0, 0.1, 0.5, and 1.0% for 28 d. CLA reduced the weight of perirenal adipose tissue in a...
Article
To gain further information on physiological functions of citrus auraptene (Aur), either dried powder of the peel from amanatsu (Kawano natsudaidai, Citrus natudaidai) abundant in Aur or the Aur concentrate prepared from the rind were fed to rats in separate feeding trials. The serum components and the hepatic fatty acid compositions were analyzed....
Article
To know the effect of individual conjugated linoleic acid (CLA) isomers on lipid metabolism, male rats were fed diets containing either linoleic acid (LA, a control fatty acid), CLA containing mainly 9c,11t-isomer, 10t,12c-isomer (at the 0.8% level) or an equivalent mixture of these isomers (at the 0.4% level) for 26 days. Although there were no di...
Article
Objective: The ester of plant stanols significantly reduces plasma levels of total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C) in Western people. Effects of plant stanol ester-containing spread on plasma levels of TC, LDL-C, and apolipoprotein B (apoB) were studied in a randomized, placebo-controlled trial in Japanese subjects...
Article
Dietary soy protein, in comparison with casein, generally lowers the serum cholesterol concentration in rats fed on a cholesterol-enriched diet, while mixed results were observed in rats fed on a diet free of cholesterol. Soy protein also suppresses the conversion of linoleic acid to arachidonic acid in the rat liver. The present study examines whe...
Article
Full-text available
The effects of a combination of dietary conjugated linoleic acid (CLA) supplemented with sesamin on hepatic ketogenesis and triacylglycerol secretion were compared using the livers of rats fed diets containing 1% CLA or linoleic acid (LA) in combination with 0.2% sesamin for 14 d, respectively. The feeding of CLA, as compared to LA, caused a signif...
Article
We examined clearance rates in serum of lymph lipids collected from rats fed a diet containing one of four types of structured triglycerides containing linoleic and medium-chain fatty acids, 1) sn-1 (3) medium-chain fatty acids-sn-2 linoleic acid (MLM), 2) interesterified MLM (iMLM), 3) sn-2 medium-chain fatty acids-sn-1 (3) linoleic acid (LML), an...
Article
To elicit the effect of dietary fat structure on mammary tumorigenesis, young female rats were given dimethylbenz(a)anthracene (DMBA) followed by diets containing triacylglycerol (TAG) or diacylglycerol (DAG). Two types of DAG prepared from fatty acids from rapeseed and palm oils in addition to these vegetable oils (TAG as respective control oils)...
Article
Determination was made of trans fatty acid content in margarines marketed in Austria, Belgium, Czech Republic, Denmark, Finland, Hungary, Japan, Norway, Poland, Sweden and the United States by gas-liquid and silver-ion thin-layer chromatography carried out in conjunction. As wt% of total fatty acid, it was found that, in print margarines, trans fat...
Article
Dietary restriction elongates life span by suppressing age-related diseases in experimental animals. It has received a great deal of attention in connection with the relationship between aging, nutrition, and oxidative stress because oxidative injury in several tissues is a prominent feature in the aging process. Although the oxidative stress theor...
Article
Total and food component-specific saliva IgAs of six donors was determined to obtain information on the secretion of salivary IgA. Saliva was collected from each donor for three consecutive days. There was no time-dependency shown on the time of collection or food intake during the three days. Saliva of five other donors showed different concentrat...
Article
植物ステロールはコレステロールに類似した構造をもち, 植物の脂溶性画分に豊富に存在する。植物ステロールはこれまで多くの臨床試験において血漿中の総コレステロール濃度および低密度リポタンパク質 (LDL)-コレステロール濃度を低下することが示されており, その効果は小腸におけるコレステロール吸収阻害作用によるものである。植物ステロールはステロール骨格内に二重結合を含み, これが飽和化されたものを植物スタノールと呼ぶ。これまで報告されたいくつかの試験では, 植物スタノールは植物ステロールに比べコレステロール低下効果が高いことが報告されている。しかし一方で, スタノールとステロールで効果に違いがみられないとの報告もある。これらのさまざまな臨床試験を検証した結果, 植物ステロールとスタノールの効果はほ...
Article
Sesamin is one of the most abundant lignans in sesame seed. Episesamin, a geometrical isomer of sesamin, is not a naturally occurring compound and is formed during the refining process of non-roasted sesame seed oil. We compared the physiological activities of these compounds in affecting hepatic fatty acid metabolism in rat liver. Rats were fed ei...
Article
In order to discover the effect of CLA on the body fat size and serum cytokine levels, four groups of male mice were fed diets containing either 1% linoleic acid (LA) or conjugated linoleic acid (CLA) with or without 0.2% sesamin for 8 weeks. The weight gain and feed efficiency were significantly lower in the CLA groups. CLA significantly reduced r...
Article
The present study compared the effect of dietary conjugated linolenic acid (CLNA) on body fat and serum and liver lipid levels with that of CLA in rats. FFA rich in linoleic acid, a-linolenic acid, CLA, or CLNA were used as experimental fats. Male Sprague-Dawley rats (4 wk old) were fed purified diets containing 1% of one of these experimental fats...
Article
The present study was carried out to clarify the dietary effect of pectin on immunoglobulin (Ig) and cytokine production of rat lymphocytes. Rats were fed a diet containing 0 (cellulose) and 1, 2 or 5% levels of pectin for 2 weeks. Dietary pectin, as compared with cellulose, enhanced production of IgA, IgG and IgM by mesenteric lymph node lymphocyt...
Chapter
We established the assay system for immunoregulatory factors using whole cell culture of mouse splenocytes to screen immunoregulatory factors and to clarify the mechanisms by which they regulate immunoglobulin (Ig) production. Adhesive cells such as macrophages and antigen-presenting cells enhanced Ig production of B lymphocytes in the presence of...
Chapter
We have previously reported that Rose Bengal (RB) can dance IgE production in rat spleen lymphocytes without increasing the production of IgG and IgM. To examine the effect of RB in human B cell lines, U-266 (IgE producer), H\My-2 (IgG producer) and NAT-30 (IgM producer) cells were cultured with RB, and the medium immunoglobulin (Ig) level was meas...
Chapter
Effect of Rose Bengal (RB) on immunoglobulin (Ig) production by mouse B lymphoma WEHI-279 cells was examined. At 100 μM, RB increased IgE concentration in the culture medium but decreased the levels of IgG and IgM. To examine whether RB affect to the secretion of IgE from WEHI-279 cells or its synthesis, intracellular and extracellular Ig levels we...
Article
To study whether the body fat-reducing potential of conjugated linoleic acid (CLA) could be increased through dietary manipulations, the effects of the combination of CLA with different proteins, fats, and sesamin were examined in rats. Male rats were fed diets containing 1% CLA or linoleic acid (LA) in combination with different proteins (20% of c...
Article
Analysis of sterol composition in serum, liver, adipose tissue, adrenals, and abdominal aorta demonstrated that the contents of plant sterols, campesterol and sitosterol, were evidently higher in WKY and stroke-prone spontaneously hypertensive (SHRSP) rats than in Wistar and WKA rats fed a diet containing a 0.5% plant sterol mixture. Lymphatic 24-h...
Article
The effect of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid synthesis was examined in rats. Rats were fed experimental diets containing varying amounts (0, 0.1 and 0.2% for Exp. 1 and 0, 0.2 and 0.4% for Exp. 2, respectively) of sesamin for 15 days. The activity and gene expression of enzymes involved in fatty acid...
Article
gamma-linolenic acid (GLA) has been reported to improve several inflammatory disorders through regulation of eicosanoid production. However, since GLA is a precursor of arachidonic acid, it may bring about increasing tissue arachidonic acid levels with subsequent pro-inflammatory events. To explore this possibility, we examined the effect of high-d...
Article
Endogenous oxidized cholesterols are potent atherogenic agents. Therefore, the antioxidative effects of green tea catechins (GTC) against cholesterol oxidation were examined in an in vitro lipoprotein oxidation system. The antioxidative potency of GTC against copper catalyzed LDL oxidation was in the decreasing order (−)-epigalocatechin gallate (EG...
Article
The interaction of dietary fats and proteins on lipid parameters of rats was studied using safflower oil (linoleic acid-rich), borage oil (gamma-linolenic acid-rich) or perilla oil (alpha-linolenic acid-rich) in combination with casein or soybean protein. The experiment was focused on the fatty acid composition of immune cells and the leukotriene B...
Article
We tried to establish an assay system for screening and assessment of immunoregulatory factors using whole cell cultures of mouse splenocytes and found that splenic adhesive cells markedly increased immunogobulin (Ig) production of splenocytes. In the absence of adhesive cells, lipopolysaccharides, pokeweed mitogen, and phytohemagglutinin stimulate...
Article
12GP2 and 14GP2, synthetic cationic amphiphiles, were examined in Sprague-Dawley rats for their adjuvant activity with ovalbumin (OVA) as antigen. Findings were compared with the activity of complete Freund's adjuvant (CFA) and aluminum hydroxide (Alum). Both amphiphiles induced OVA specific IgG comparable to the conventional adjuvants CFA or Alum,...
Article
Incorporation of exogenous cholesterol was compared in human adenocarcinoma colon cells (Caco-2) after incubation with 100 microM of either linoleic acid (LA, 18:2n-6), gamma-linolenic acid (GLA, 18:3n-6), arachidonic acid (AA, 20:4n-6) or adrenic acid (or n-6 docosatetraenoic acid, DTA, 22:4n-6). In both cells 7 days after seeding and 14 days afte...
Article
Full-text available
Sprague-Dawley rats were fed eicosapentaenoic (EPA) and docosahexaenoic acid (DHA) ethyl esters at the 2% level for 3 weeks to clarify their effects on immune functions. In the rats fed EPA or DHA, serum cholesterol, triglyceride, and phospholipid (PL) levels were significantly lower than those in the rats fed safflower oil. In PL fractions of seru...
Article
The effect on genetically obese mice of a milk whey protein isolate (WPI) and soy protein isolate (SPI) and their hydrolysates (WPI-H, SPI-H) on the rate of body fat disappearance was investigated. Male yellow KK mice were made obese by feeding with a high-fat diet containing 30% fat from 6 to 10 weeks of age. They were then fed with an energy-rest...
Article
Margarines and shortenings contain trans fatty acids formed during the hydrogenation of material oils and fats. Trans fatty acids have been shown to influence serum cholesterol and lipoprotein levels subsequent to consumption of these substances in certain amounts. For preparation of margarines for household use, free from trans fatty acids are sol...
Article
The fat intake pattern of Japanese that was estimated from the annual report of national nutrition survey was introduced as a comprehensive model for a healthy way of eating polyunsaturated fatty acids (PUFA). The n-6/n-3 ratio of 4 and the polyunsaturated/saturated (P/S) ratio of 1 in the recommended dietary allowance (RDA) of fat for Japanese tha...
Article
Trans fatty acid content in domestic and imported chocolates and chocolate confectioneries were measured by gas-liquid chromatography and silver-ion thin-layer chromatography. Mean total trans fatty acid content in domestic chocolates (3.1%, 80 brands) exceeded that in imported products (1.3%, 10 countries, 37 brands). High trans fatty acid type ha...
Article
Clinical studies on foods containing plant stanol ester repeatedly demonstrate 10-14% reduction in serum LDL-cholesterol. Since plant stanols are the agents responsible for the cholesterol-lowering activity of stanol ester, an analytical method was developed for quantitative and routine analysis of plant stanol content in spreads containing clinica...
Article
The dietary effects of conjugated linoleic acid (CLA) on Ig production of Sprague-Dawley rats were examined at various doses such as 0 (control), 0.05, 0.10, 0.25, and 0.50%. CLA increased IgG and IgM production of spleen lymphocytes in a dose-dependent manner, and these levels reached a plateau at 0.25%. IgA production was not detected in the cont...
Article
The levels of cholesterol oxidation derivatives (OxChol) in eight commercial species of meat products were examined. These products contained more than 1 mg/100 g of OxChol, and 7beta-hydroxycholesterol + 5beta-epoxycholesterol (111-1092 microg/100 g), 5alpha-epoxycholesterol (80-712 microg/100 g), cholestanetriol (0-368 microg/100 g), and 7-ketoch...
Article
Male Wistar rats were given purified diets containing safflower (SAF), perilla (PER), or palm (PAL) oils with or without 1% tea polyphenols (TP) for 3 weeks, and chemical mediator releasing activity from rat peritoneal exudate cells (PEC) was measured. Histamine releasing activity was not influenced by TP, while histamine release and intracellular...
Article
Dietary fat plays an important regulatory role in the pathogenesis of a range of immune reactions. In food allergies, especially in type I allergic reactions, dietary fat can modulate the development of clinical symptoms through influencing the production of immunoglobulins (Ig), cytokines and chemical mediators. In general, polyunsaturated fatty a...
Article
The effects of oxidized cholesterol on immune parameters were examined by using spleen lymphocytes and peritoneal exudate cells (PEC) derived from 5-week- (Young) and 9-month-old (Adult) rats. The immunoglobulin (Ig) G and IgM production was inhibited by oxidized cholesterol in the rats of both ages when lymphocytes were exposed to 30 micrograms/ml...
Article
Rice bran oil (RBO), when blended with safflower oil (SFO) at the ratio of 7 to 3, has been shown to lower serum cholesterol in humans consuming cholesterol. The mechanism as to how this oil blend exerts its effect is not yet clear. This study examined the effect of cholesterol supplementation on the cholesterol-lowering ability of different RBO/SF...
Article
A study was carried out to examine if the positional distribution of medium chain fatty acids (MCF) in triacylglycerol influences dietary fat absorption in rats. Two types of structure-specific fats, one predominantly composed of MCF in sn-1(3) and iinoleic acid in sn-2 [sn1(3)MCF-structured] and the others of MCF in sn-2 and linoleic acid in sn-1(...
Article
Matured human milk from healthy mothers was studied for Trans and conjugated fatty acid (CLA) and prostaglandin E2 content. Average fat content was 2.74g/100ml, somewhat less than that reported for milk in Japanese mothers. Cholesterol and phospholipids showed essentially average values. In total fatty acids, trans acid was 1.18% on the average (0....
Article
Exogenous oxidized cholesterol disturbs both lipid metabolism and immune functions. Therefore, it may perturb these modulations with ageing. Effects of the dietary protein type on oxidized cholesterol-induced modulations of age-related changes in lipid metabolism and immune function was examined using differently aged (4 weeks versus 8 months) male...
Article
The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels...
Article
105名の被験者を対象に, 無作為に植物スタノールエステルを含有しないスプレッド群 (対照群), 植物スタノール2g (植物スタノールエステルとして3.4g)/日含有スプレッド群 (2g植物スタノール群), 植物スタノール3g (植物スタノールエステルとして5.1g)/日含有スプンッド群 (3g植物スタノール群) の3群に分け, 4週間摂取させ血清脂質, アポタンパク値の変化を検討した。併せて自覚症状, 一般臨床検査を検討し, 安全性を調査した。1) 血清総コレステロール値は摂取4週目で, 対照群0.6%, 2g植物スタノール群6.3%, 3g植物スタノール群5.5%低下し, 植物スタノール群の低下率は対照群より有意に大であった。2g植物スタノール, 3g植物スタノール群で低下率に有意差は認...
Article
The amount of polyunsaturated fatty acids (PUFAs) in the food chain in Japan is reviewed on the basis of the newest nutrition survey data. The Japanese are currently consuming, on average, approximately 26% of energy as fats with ratios of polyunsaturated to saturated fats and n-6 to n-3 fatty acids of approximately 1.2:1 and 4:1, respectively. The...
Article
The dietary effect of the water-soluble dietary fibers (WSDF), guar gum, partially hydrolyzed guar gum (PHGG), glucomannan, highly methoxylated (HM) pectin, on the serum lipid level and immunoglobulin (Ig) production of Sprague-Dawley rats was compared with that of water-insoluble cellulose. Although serum total cholesterol and triglyceride levels...
Article
The immunoregulatory effects of dietary alpha-tocopherol (Toc) and tocotrienols (T-3) on humoral and cell-mediated immunity and cytokine productions were examined in Brown Norway rats. We found that the IgA and IgG productivity of spleen and mesenteric lymph node (MLN) lymphocytes was significantly enhanced in the rats fed on Toc or T-3, irrespecti...
Article
The effects of sesamin, one of the most abundant lignans in sesame seed, on hepatic fatty acid oxidation were examined in rats that were fed experimental diets containing various amounts (0%, 0.1%, 0.2%, and 0.5%) of sesamin (a 1:1 mixture of sesamin and episesamin) for 15 days. Dietary sesamin dose-dependently increased both mitochondrial and pero...
Article
Although scientific evidence is relatively limited, rice bran oil (RBO) is tenaciously believed to be a healthy vegetable oil in Asian countries. It exerts hypocholesterolemic activity in relation to more commonly used vegetable oils and is characterized by a relatively high content of non-fatty acid components, some of which are known to have bene...
Article
Full-text available
To estimate the relative significance of exogenous and endogenous fatty acid substrates in decreasing hepatic triacylglycerol secretion after sesamin feeding, livers from rats fed diets supplemented with and without sesamin (sesamin: episesamin, 1:1, w/w) were perfused in the presence and absence of an exogenous di-trans isomer of linoleic acid (li...