Michelle Maden

• PhD
• PostDoc Position at University of Liverpool

Exposure to unhealthy food, beverage, and alcohol marketing can contribute to inadequate diet and excess alcohol consumption, both risk factors for diet‐related non‐communicable diseases including obesity and cancer. By not featuring specific products, brand‐only marketing strategies circumvent restrictions that assess healthiness at the product le...

Background People with severe mental illness who experience co-occurring substance use experience poor outcome including suicide, violence, relapses and use of crisis services. They struggle to access care and treatment due to a lack of an integrated and co-ordinated approach which means that some people can fall between services. Despite these con...

Background Renal cell carcinoma is the most common type of kidney cancer, comprising approximately 85% of all renal malignancies. Patients with advanced renal cell carcinoma are the focus of this National Institute for Health and Care Excellence multiple technology appraisal. A patient’s risk of disease progression depends on a number of prognostic...

Objectives Around 10–15% of children do not achieve adequate asthma control when using low-dose inhaled corticosteroids (ICS). When asthma exacerbations occur, treatment involves add-on preventer therapies, although there is uncertainty concerning their clinical and cost-effectiveness. We previously determined that treatment escalation beyond low-d...

Objectives Different types of spinal cord stimulation (SCS) have now been evaluated for the management of chronic non-surgical refractory back pain (NSRBP). A direct comparison between the different types of SCS or between closed-loop SCS with conventional medical management (CMM) for patients with NSRBP has not been previously conducted, and there...

Introduction There is uncertainty about the best treatment option for children/adolescents with uncontrolled asthma despite inhaled corticosteroids, and international guidelines make different recommendations. Objectives We evaluated the pharmacological treatments to reduce asthma exacerbations and symptoms in uncontrolled patients <18 years on in...

Food marketing impacts the food behaviors of children and adults, but the underpinning neural mechanisms are poorly understood. This systematic review and meta‐analysis pooled evidence from neuroimaging studies of exposure to food marketing stimuli (vs. control) on brain activations in children and adults to clarify regions associated with respondi...

Background/importance Concerns have been raised that effects observed in studies of spinal cord stimulation (SCS) funded by industry have not been replicated in non-industry-funded studies and that findings may differ based on geographical location where the study was conducted. Objective To investigate the impact of industry funding and geographi...

Videogame livestreaming platforms are an emerging form of digital media, popular with young people, where users watch gaming influencers play videogames. Food and non-alcoholic beverage (hereafter: food) brands have a substantial presence on these platforms, yet no studies have examined the impact of this food marketing on young people. This system...

Background Magnetic resonance imaging-based technologies are non-invasive diagnostic tests that can be used to assess non-alcoholic fatty liver disease. Objectives The study objectives were to assess the diagnostic test accuracy, clinical impact and cost-effectiveness of two magnetic resonance imaging-based technologies (LiverMultiScan and magneti...

Approximately 30-50% of people with serious mental illness have co-existing drug or alcohol problems (COSMHAD), associated with adverse health and social care outcomes. UK guidelines advocate both co-occurring needs being met within mental health services, but uncertainty remains about how to operationalise this to improve outcomes. Various unevalu...

Frailty status in elderly people represents a stage of life when homeostatic reserves become exhausted leading to vulnerability to endogenous and exogenous stressors. Whilst elevated blood pressure is a major risk factor for poor health in the general population, this may be different in very old people whose health has deteriorated to the stage of...

Background Contact heat is commonly used in experimental research to evoke brain activity, most frequently acquired with electroencephalography (EEG). Although magnetoencephalography (MEG) improves spatial resolution, using some contact heat stimulators with MEG can present methodological challenges. This systematic review assesses studies that uti...

Background For children and young people with eye and vision conditions, research is essential to advancing evidence-based recommendations in diagnosis, prevention, treatments and cures. Patient ‘experience’ reflects a key measure of quality in health care (Department of Health. High Quality Care for All: NHS Next Stage Review Final Report: The Sta...

Background Exposure to household air pollution results in a substantial global health burden. The World Health Organization (WHO) Guidelines for Indoor Air Quality: Household Fuel Combustion stipulate emission rates for household energy devices should meet air quality guidelines and protect health. Liquefied petroleum gas (LPG), biogas, natural gas...

Background There has been a debate about the use of Hall Technique (HT), whether it can be considered as a standard technique for the management of carious primary molars. Aim To summarise the evidence on HT for managing dentine caries in primary teeth. Design MEDLINE, Embase, CENTRAL and Epistemonikos databases were searched for clinical studies...

Purpose: The European Academy of Paediatric Dentistry (EAPD) has developed this best clinical practice guidance to help clinicians manage deep carious lesions in primary teeth. Methods: Three expert groups conducted systematic reviews of the relevant literature. The topics were: (1) conventional techniques (2) Minimal Intervention Dentistry (MID...

Background Exposure to household air pollution results in a substantial global health burden. The World Health Organization (WHO) Guidelines for Indoor Air Quality: Household Fuel Combustion stipulate emission rates for household energy devices should meet air quality guidelines and protect health. Liquefied petroleum gas (LPG), biogas, natural gas...

BACKGROUND Different waveforms of spinal cord stimulation (SCS) have now been evaluated for the management of painful diabetic neuropathy (PDN). However, no direct or indirect comparison between SCS waveforms has been performed to date. PURPOSE To conduct a systematic review and network meta-analysis to evaluate the effectiveness of SCS for PDN....

Children attending hospital for radiological procedures can experience uncertainty, anxiety and distress; this can result in sub-optimal experiences for children, poor scan quality and the need for radiological procedures to be rescheduled or sedation to be used. The preparation and education of children before clinical procedures has been shown to...

Background Tackling problematic polypharmacy requires tailoring the use of medicines to individual circumstances and may involve the process of deprescribing. Deprescribing can cause anxiety and concern for clinicians and patients. Tailoring medication decisions often entails beyond protocol decision-making, a complex process involving emotional an...

Background There is convincing evidence that unhealthy food marketing is extensive on television and in digital media, uses powerful persuasive techniques, and impacts dietary choices and consumption, particularly in children. It is less clear whether this is also the case for outdoor food marketing. This review (i) identifies common criteria used...

Music therapy (MT) has been used to support people with a variety of eating disorders (EDs), but it is unclear whether there is sufficient and robust evidence from controlled experimental studies. In this article, we report the results of a systematic review that summarises the evidence from published controlled studies where MT has been used to tr...

Background Tackling problematic polypharmacy requires tailoring the use of medicines to individual needs and circumstances. This may involve stopping medicines (deprescribing) but patients and clinicians report uncertainty on how best to do this. The TAILOR medication synthesis sought to help understand how best to support deprescribing in older pe...

Importance: There is widespread interest in the effect of food marketing on children; however, the comprehensive global evidence reviews are now dated. Objective: To quantify the association of food and nonalcoholic beverage marketing with behavioral and health outcomes in children and adolescents to inform updated World Health Organization guid...

This systematic review examined the effectiveness of policies restricting the marketing of foods and/or non‐alcoholic beverages to children to inform updated World Health Organization (WHO) guidelines. Databases were searched to March 2020. Inclusion criteria were primary studies of any design assessing implemented policies to restrict food marketi...

Objectives Intrathecal drug delivery systems (IDDS) and spinal cord stimulation (SCS) have been proposed and assessed for the management of cancer pain; however, such treatments remain underused. We conducted a systematic review to evaluate the effectiveness and safety of IDDS and SCS for cancer pain. Materials and Methods Electronic databases MED...

Objectives: Success rates of spinal surgeries to treat chronic back pain are highly variable and useable prognostic indicators are lacking. We aimed to identify and evaluate preoperative predictors of pain and disability after spinal surgery for chronic low back/leg pain. Methods: Electronic database (01/1984-03/2021) and reference searches iden...

The evidence for the functional outcome of endo- prosthetic replacement (EPR) after tumour resection has been from few cohort studies. A scoping search revealed no systematic review on patient reported outcome measures after EPR around the knee. The purpose of this study was to evaluate the functional outcome of distal femoral and proximal tibial E...

Spinal surgeries to treat chronic low back pain (CLBP) have variable success rates, and despite the significant personal and socioeconomic implications, we lack consensus for prognostic factors. This systematic review and meta-analysis evaluated the evidence for preoperative predictors of return to work (RTW) after spinal surgery for CLBP. We searc...

There is currently no global review of the conceptual literature on the equity of healthcare coverage (including access) for older people. It is important to understand the factors affecting access to health and social care for this group, so that policy and service actions can be taken to reduce potential inequities. A scoping review of published...

Background and Objectives A systematic review was conducted to explore the use of smartphones and tablet computers as cognitive and memory aids by older adults with and without cognitive impairment, specifically the effects of smartphone and tablet use on participants’ cognition and memory, and the barriers to facilitators to smartphone and tablet...

Purpose This umbrella review systematically appraised published systematic reviews on Minimal Intervention Dentistry interventions carried out to manage dentine carious primary teeth to determine how best to translate the available evidence into practice, and to provide recommendations for what requires further research. Method An experienced info...

Background: For children and young people with eye and vision conditions, research is essential to advancing evidence-based recommendations in diagnosis, prevention, treatments and cures. Patient ‘experience’ reflects a key measure of quality in health care (1); research participant ‘experiences’ are equally important. Therefore, in order to achiev...

Introduction: Health professionals are expected to consistently perform to a high standard during a variety of challenging clinical situations, which can provoke stress and impair their performance. There is increasing interest in applying sport psychology training using performance mental skills (PMS) immediately before and during performance. M...

Globally, approximately 3 billion primarily cook using inefficient and poorly vented combustion devices, leading to unsafe levels of household air pollution (HAP) in and around the home. Such exposures contribute to nearly 4 million deaths annually (WHO 2018a, 2018b ). Characterizing the effectiveness of interventions for reducing HAP concentration...

Recent attempts to utilise machine learning (ML) to predict pain-related outcomes from Electroencephalogram (EEG) data demonstrate promising results. The primary aim of this review was to evaluate the effectiveness of ML algorithms for predicting pain intensity, phenotypes or treatment response from EEG. Electronic databases MEDLINE, EMBASE, Web of...

Background People who experience homelessness and those vulnerably housed experience disproportionately high rates of drug use and associated harms, yet barriers to services and support are common. We undertook a systematic ‘review of reviews’ to investigate the effects of interventions for this population on substance use, housing, and related out...

Improving health outcomes for children in the social care system is a public health priority. In the UK, Canada and Australia, increasing numbers of children are being taken into out of home care (OHC), especially in disadvantaged areas (Bennett et al., 2020; O’Donnell et al., 2016). Amongst the possible explanations, rising levels of poverty and d...

Background The CLUSTER model of searching was proposed as a systematic method of searching for studies for reviews of complex interventions. The method has not been evaluated before. Aim This methodological review identified and evaluated a sample of evidence syntheses that have used CLUSTER. Methods A forward citation search on the seed CLUSTER...

Background Local authorities in England commission the NHS Health Check programme to invite everyone aged 40–74 years without pre-existing conditions for risk assessment and eventual intervention, if needed. However, the programme’s effectiveness, cost-effectiveness and equity impact remain uncertain. Aim To develop a validated open-access flexibl...

Spinal cord stimulation (SCS) has been suggested as a treatment option for patients with painful diabetic neuropathy (PDN). We conducted a systematic review and undertook a meta-analysis on individual patient data from randomised controlled trials (RCTs) to assess the effectiveness of SCS for the management of PDN. Electronic databases were searche...

Introduction Asthma affects millions of children worldwide—1.1 million children in the UK. Asthma symptoms cannot be cured but can be controlled with low-dose inhaled corticosteroids (ICSs) in the majority of individuals. Treatment with a low-dose ICS, however, fails to control asthma symptoms in around 10%–15% of children and this places the indiv...

Background The number of young adults with complex health-care needs due to life-limiting conditions/complex physical disability has risen significantly over the last 15 years, as more children now survive into adulthood. The transition from children to adult services may disrupt provision of essential respite/short break care for this vulnerable p...

Objective To systematically identify and describe studies that have evaluated the impact of gardens and gardening on health and well-being. A secondary objective was to use this evidence to build evidence-based logic models to guide health strategy decision making about gardens and gardening as a non-medical, social prescription. Design Scoping re...

Introduction There are national and international concerns about equity in basic and postgraduate medical education, especially about differential rates of access and attainment across groups of learners. Qualitative research has been increasingly used to understand the factors that influence equity but there are potential limitations to this unde...

Introduction There are national and international concerns about equity in basic and postgraduate medical education, especially about differential rates of access and attainment across groups of learners. Qualitative research has been increasingly used to understand the factors that influence equity but there are potential limitations to this unde...

Introduction High participation rates in screening programmes targeting non-communicable diseases are instrumental in achieving full screening benefits; however, screening programmes remain underused, especially among vulnerable populations. We conducted an umbrella review to assess the type of approaches screening programmes use to maximise uptake...

Background: We aimed to locate, appraise, and synthesize the available literature to assess the functional outcome of modular bicompartmental knee arthroplasty (BKA) compared to total knee arthroplasty (TKA) for medio-patellofemoral osteoarthritis. Methods: After an extensive literature search based on electronic databases such as MEDLINE, EMBAS...

This article describes The Evidence of Impact Model that was recently developed to support the analysis of short- to medium-term impact arising from Participatory Action Research and Developmental Evaluation approaches that were used within the Evidence for Change initiative. Evidence for Change was a team capacity building initiative that supporte...

Introduction The number of young adults with complex healthcare needs due to life-limiting conditions/complex physical disability has risen significantly as children with complex conditions survive into adulthood. Respite care and short breaks are an essential service, however, needs often go unmet after the transition to adult services, leading to...

Introduction Recent evidence suggests that growth restriction in utero may lead to neurocognitive disorders in late life, either through impaired brain development or adverse metabolic programming. Methods Systematic review of literature investigating the relationship between size at birth and cognitive abilities in late life. The search, data ext...

Introduction The expert searcher, able to deliver high-quality searches in challenging or pressured environments, is central to accessing and utilising information (Lasserre, 2012). One key example is that health care professionals require reliable, evidence-based information to inform ‘high quality decision-making, learning, research and innovatio...

Background Recent equity systematic review guidance encourages reviewers to consider whether it is likely that their findings may impact on health inequalities. Much of the guidance assumes that health inequalities have either already been identified as the focus of the review, or that reviewers are able to recognise if and how health inequalities...

Objective: To develop a theory-led framework to inform reviewers' understanding of what, how and why healthcare interventions may lead to differential effects across socio-economic groups. Study design and setting: A meta-framework approach combined two theoretical perspectives (socio-economic health inequalities and complex interventions) into...

Cambridge Core - General - Research, Evaluation and Audit - edited by Maria J. Grant

Introduction Recent equity review guidance encourages reviewers to consider whether it is likely that their findings may impact on health inequalities. Much of the guidance assumes that health inequalities have either already been identified as the focus of the review, or that reviewers are able to recognize if and how health inequalities matter. H...

Background: Systematic review guidance recommends the use of programme theory to inform considerations of if and how healthcare interventions may work differently across socio-economic status (SES) groups. This study aimed to address the lack of detail on how reviewers operationalise this in practice. Methods: A methodological systematic review...

Children and young people with long-term conditions are not always provided with opportunities to engage fully in consultations. This systematic review examined the effectiveness or worth of methods used to engage children and young people with long-term conditions in their consultations. Searches were undertaken in October 2016 in eight databases...

In an era when library budgets are being reduced, Massive Online Open Courses (MOOC's) can offer practical and viable alternatives to the delivery of costly face‐to‐face training courses. In this study, guest writers Gil Young from Health Care Libraries Unit ‐ North, Lisa McLaren from Brighton and Sussex Medical School and Liverpool University PhD...

This review assessed evidence of disparities in benefits of pharmacogenomics related to 'model performance' in subgroups of patients and studies which reported impact on health inequalities. 'Model performance' refers to the ability of algorithms including clinical, environmental and genetic information to guide treatment. A total of 4978 abstracts...

Editorial

Background Eighty per cent of care home residents in the UK are living with dementia. The prevalence of faecal incontinence (FI) in care homes is estimated to range from 30% to 50%. There is limited evidence of what is effective in the reduction and management of FI in care homes. Objective To provide a theory-driven explanation of the effectivene...

The prevalence of fecal incontinence (FI) in care homes is estimated to range from 30% to 50%. There is limited evidence of what is effective in the reduction and management of FI in care homes. Using realist synthesis, 6 potential program theories of what should work were identified. These addressed clinician-led support, assessment, and review; t...

This work was undertaken to support the development of guidance on targeted drug misuse prevention interventions by the National Institute for Health and Care Excellence (NICE). We used systematic review methods to identify cost-effective interventions that prevent or delay drug use, or that prevent escalation of drug use. In line for the scope for...

Background Given that we know that interventions shown to be effective in improving the health of a population may actually widen the health inequalities gap while others reduce it, it is imperative that all systematic reviewers consider how the findings of their reviews may impact (reduce or increase) on the health inequality gap. This study revie...

Objective – Systematic reviews are becoming increasingly popular within the Library and Information Science (LIS) domain. This paper has three aims: to review approaches to quality assessment in published LIS systematic reviews in order to assess whether and how LIS reviewers report on quality assessment a priori in systematic reviews, to model the...

Purpose We aimed to investigate association between bibliometric parameters, reporting and methodological quality of vascular and endovascular surgery randomised controlled trials. Methods The most recent 75 and oldest 75 randomised controlled trials published in leading journals over a 10-year period were identified. The reporting quality was ana...

A research project funded by CILIP – The Chartered Institute of Library and Information Professionals

The role of volunteers in end-of-life care in the acute hospital setting is not widely established. This article reports on an innovative model of care using trained volunteers that was introduced at a Liverpool trust in 2012. The volunteers were to provide a listening ear, comfort and support for patients who were dying, their families and friends...

Background: Systematic reviews have found limited evidence of effectiveness and impact of clinical librarians (CLs) due to the poor quality of reporting, scale and design of previous studies. Objectives: To measure specific CL impact on organisational and patient outcomes using a robust approach that helps CLs develop research skills. Methods:...

Background: Randomised controlled trials (RCTs) are subject to bias if they lack methodological quality. Moreover, optimal and transparent reporting of RCT findings aids their critical appraisal and interpretation. Objectives: The aim of this study was to ascertain whether the methodological and reporting quality of RCTs in vascular and endovascula...

Oxygen is one of the commonest health-care interventions worldwide. This might suggest that health-care professionals (HCPs) would be knowledgeable and familiar with its uses and limitations. Yet it is apparent, through clinical audit, that oxygen is probably misunderstood by many HCPs. The aim of this critical interpretive synthesis (CIS) is to ex...

To synthesize evidence from systematic reviews on the management of urinary incontinence and promotion of continence using conservative/behavioural approaches in older people in care homes to inform clinical practice, guidelines and research. Incontinence is highly prevalent in older people in care home populations. Systematic review of systematic...

Oxygen therapy is a common intervention in health care worldwide; yet, despite universal use, it is evident through poor practice that oxygen is often prescribed and administered injudiciously. It is proposed that possibly an influencing culture presides, whereby oxygen is often poorly understood and uncertainty regarding its use exists. It is uncl...

Ormskirk, Evidence based Practice Research Centre, Faculty of Health & Social Care, Edge University & Health Education North West, Manchester. Final Report May 2014. Report submitted to Health Education North West. http://nw.hee.nhs.uk/wp-content/uploads/sites/480/2014/06/WPlitrev280514Submitted.pdf

  Previous systematic reviews have indicated limited evidence and poor quality evaluations of clinical librarian (CL) services. Rigorous evaluations should demonstrate the value of CL services, but guidance is needed before this can be achieved.   To undertake a systematic review which examines models of CL services, quality, methods and perspectiv...

  Many healthcare librarians are undertaking training in critical appraisal but a significant number are not cascading the training to their end-users.   To examine the barriers to healthcare librarian involvement in delivering critical appraisal training.   A questionnaire survey of 57 library services across 48 NHS Trust Library Services in north...

The quality of facilities available for relatives and carers of hospital patients, which is particularly important when distressing news is given, often receives little attention. This article outlines a project undertaken at a Liverpool trust to improve the environment of relatives' rooms. The project adopted an evidence-based, design-led approach...

Although healthcare librarians are undertaking training in critical appraisal skills, what is not so clear is the impact of the training on the understanding and dissemination of these skills. This study aims to examine the attitudes of healthcare librarians towards delivering critical appraisal training and their level of involvement. A questionna...