Michelle H ChenRutgers, The State University of New Jersey | Rutgers · Institute for Health, Health Care Policy and Aging Research
Michelle H Chen
Doctor of Philosophy
About
31
Publications
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Introduction
Michelle Chen is currently Assistant Professor of Neurology at Rutgers-Robert Wood Johnson Medical School and Rutgers- Institute for Health, Healthcare Policy and Aging Research.
Publications
Publications (31)
Compared with other health disciplines, there is a stagnation in technological innovation in the field of clinical neuropsychology. Traditional paper-and-pencil tests have a number of shortcomings, such as low-frequency data collection and limitations in ecological validity. While computerized cognitive assessment may help overcome some of these is...
Objective
Social support is an emerging protective factor against cognitive decline. However, the relationship between social support and cognitive functioning in the multiple sclerosis (MS) population is not well understood. The present study aimed to investigate the associations between different aspects of social support and cognitive performanc...
Objective
The current study aimed to examine real-time associations between non-cognitive symptoms and cognitive dysfunction (latter measured both objectively and subjectively in real-time) using ecological momentary assessment (EMA).
Participants and Methods
Forty-five persons with MS completed EMA four times per day for three weeks. For each EMA...
Importance: This study provides information to clinicians about how persons with MS coped in both positive and negative ways during a potentially traumatic experience (the coronavirus disease 2019 [COVID-19] pandemic), which will help clinicians to provide better services to this population in the face of stressful events.
Objective: To describe bo...
Date Presented 04/22/2023
This poster will present study findings related to demographic and psychosocial factors affecting an individual’s use of coping strategies and the impacts of coping strategies on health-related quality of life and psychological distress during the COVID-19 pandemic in people with and without acquired brain injury (ABI). Im...
Background:
Social support is a protective factor against cognitive decline in the general population. However, the relationship between social support and cognitive functioning among persons with multiple sclerosis (MS) is not well understood.
Objective:
The present study aimed to investigate the associations between different aspects of social...
Introduction
Multiple sclerosis (MS) is characterized by a wide range of disabling symptoms, including cognitive dysfunction, fatigue, depression, anxiety, pain, and sleep difficulties. The current study aimed to examine real-time associations between non-cognitive and cognitive symptoms (latter measured both objectively and subjectively in real-ti...
Multiple sclerosis (MS) is an autoimmune, demyelinating, neurodegenerative disease of the central nervous system (CNS) and is the leading cause of disability among young and middle-aged adults. To be diagnosed with clinically definite MS, one must have at least two clinical relapses reflecting involvement of the CNS with objective clinical evidence...
Objective
Examine the associations between smartphone keystroke dynamics and cognitive functioning among persons with multiple sclerosis (MS).
Methods
Sixteen persons with MS with no self-reported upper extremity or typing difficulties and 10 healthy controls (HCs) completed six weeks of remote monitoring of their keystroke dynamics (i.e., how the...
Research Objectives
To understand the relationship between use of coping skills and resilience in adults with an acquired brain injury (ABI) during the beginning of the Coronavirus Disease of 2019 (COVID-19) pandemic.
Design
Survey data was collected via online platform, Research Electronic Data Capture (REDCap).
Setting
The general community.
P...
This study examined preliminary evidence of construct validity in a stand-alone memory concerns scale constructed from the Patient-Reported Outcomes Measurement Information System (PROMIS®) Cognitive Function item bank. A sample of 396 individuals, ages 18-75 (M = 33.7, SD = 12.7), from Spain and Latin America completed an online survey regarding l...
Primary objectives:
This study examined (a) the impact of coronavirus disease-2019 (COVID-19) pandemic on engagement in activity participation in persons with acquired brain injury (ABI); and (b) whether changes in activity participation during the pandemic were associated participants' health-related quality of life (HRQoL).
Research design:
Ex...
Background: Many persons with multiple sclerosis (MS) have difficulties engaging in traditional land-based physical activity due to heat sensitivity and physical disability. Aquatic exercise may be a suitable alternative for these individuals, preventing overheating and enabling a range of movements that were otherwise difficult on land. The object...
Objective
The current study examined healthcare disruptions and use of telehealth services among persons with multiple sclerosis (pwMS) during the coronavirus disease 2019 (COVID-19) pandemic.
Design
Cross-sectional survey.
Setting
General community.
Participants
Seventy pwMS and 93 healthy controls (HCs). The majority of respondents were from t...
Cognitive impairment is a common and debilitating symptom in multiple sclerosis (MS). There is limited evidence that disease-modifying therapies are effective in treating cognitive dysfunction. Cognitive rehabilitation is a promising approach to treat cognitive dysfunction in MS, gaining empirical support over the last 10 years. The current review...
Research Objectives
To examine how visual discomfort symptoms affect performance on the symbol digit modalities test (SDMT), a visually mediated information processing speed task which is considered a gold standard measure for cognition in multiple sclerosis (MS) research.
Design
Observational, cross-sectional study.
Setting
General community.
P...
Research Objectives
To examine the psychometric properties of a stand-alone memory concerns scale constructed from the Patient-Reported Outcomes Measurement Information System (PROMIS) Applied Cognition-General Concerns item bank among a sample of Spanish-speakers from Spain and Latin America.
Design
Cross-sectional analysis.
Setting
Web-based su...
Background: The COVID-19 pandemic provided a unique opportunity to explore the impact of the mandated lockdown and social distancing policies on engagement in daily occupations for individuals with multiple sclerosis (MS) and able bodied (i.e. healthy) adults. The study also examined whether the changes in daily occupations were associated with hea...
Background:
Deficits in self-awareness can be observed in persons with multiple sclerosis (MS). The current study aimed to investigate two types of self-awareness (intellectual and online) among persons with MS, which will inform clinical care. Intellectual awareness refers to knowledge of one's own abilities; online awareness refers to real-time...
Cognitive fatigue, or fatigue related to mental work, is a common experience. A growing body of work using functional neuroimaging has identified several regions that appear to be related to cognitive fatigue and that potentially comprise a “fatigue network”. These include the striatum of the basal ganglia, the dorsolateral prefrontal cortex (DLPFC...
Older adults with mild cognitive impairment (MCI) are at an increased risk for falls and fall-related injuries. It is unclear whether current balance rehabilitation techniques largely developed in cognitively intact populations would be successful in older adults with MCI. This mapping review examined the available balance rehabilitation research c...
Cognitive fatigue is common and debilitating among persons with multiple sclerosis (pwMS). Neural mechanisms underlying fatigue are not well understood, which results in lack of adequate treatment. The current study examined cognitive fatigue-related functional connectivity among 26 pwMS and 14 demographically matched healthy controls (HCs). Partic...
Background:
Olfactory dysfunction is a common symptom of multiple sclerosis (MS). The questions of whether and to what degree olfactory dysfunction can serve as a clinical marker of MS disability (i.e. cognitive impairments and functional limitations) are not yet answered. The current study aimed to explore associations between olfactory function (...
Neuroimaging underpinnings of state (in the moment, transient) mental fatigue in multiple sclerosis (MS) are not well understood. The current pilot study examined the effect of state mental fatigue on brain activation (measured using functional magnetic resonance imaging [fMRI]) during conditions of varying cognitive loads of rapid information proc...
Background
Slowed information processing speed is the most prevalent cognitive symptom in persons with multiple sclerosis (MS). The most commonly used instrument to measure information processing speed in MS is the Symbol Digit Modalities Test (SDMT). However, visual, oculomotor, and oralmotor deficits are frequently observed in persons with MS, an...
IntroductionCognitive impairment is prevalent and debilitating among persons with multiple sclerosis (MS). While many pharmacologic treatments have shown good efficacy in reducing clinical relapses, brain lesions, and improving certain physical symptoms, their efficacy for improving cognitive function is not well understood.Objectives
The current s...
Objective/Background: Sleep dysfunction is prevalent among patients with schizophrenia. Although sex differences have been identified in schizophrenia, sex differences in sleep patterns among patients with schizophrenia are not established. Therefore, the current study examined sex differences in subjective sleep quality patterns in people with sch...
Background
Neural trajectories of gait are not well established. We determined two distinct, clinically relevant neural trajectories, operationalized via functional-Near-Infrared-Spectroscopy (fNIRS) HbO2 measures in the prefrontal cortex (PFC), under single-task-walk (STW) and dual-task-walk (DTW) conditions. Course trajectory assessed neural acti...
Older adults are less efficient at avoiding obstacles compared to young adults, especially under attention-demanding conditions. Using functional near-infrared-spectroscopy (fNIRS), recent studies implicated the prefrontal cortex (PFC) in cognitive control of locomotion, notably under dual-task walking conditions. The neural substrates underlying O...
Background and purpose:
Traditional neuroimaging techniques restrict movement and make it difficult to study the processes that require oral, upper limb, or lower limb motor execution. Functional near-infrared spectroscopy (fNIRS) is an optical neuroimaging modality that measures brain oxygenation and permits movement during data acquisition. A ke...