
Michelle BiscegliaUniversity of Pittsburgh | Pitt · Department of Pathology
Michelle Bisceglia
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Publications (8)
The molecular mechanisms underlying acute exacerbations of idiopathic pulmonary fibrosis (IPF) are poorly understood. We studied the global gene expression signature of acute exacerbations of IPF.
To understand the gene expression patterns of acute exacerbations of IPF.
RNA was extracted from 23 stable IPF lungs, 8 IPF lungs with acute exacerbation...
Background:
Honest broker services are essential for tissue- and data-based research. The honest broker provides a firewall between clinical and research activities. Clinical information is stripped of Health Insurance Portability and Accountability Act-denoted personal health identifiers. Research material may have linkage codes, precluding the i...
Comparison of median expression values of all samples from each metastatic patient with primary tumor expression values. After SAM analysis of the 25 metastatic and 64 primary tumors, genes whose median expression values differ at two in each metastatic patient compared to the median value of primary tumor samples were selected.
Genes identified as regulated in metastatic prostate cancer from both Codelink and Affymetrix platforms
Prostate cancer is characterized by heterogeneity in the clinical course that often does not correlate with morphologic features of the tumor. Metastasis reflects the most adverse outcome of prostate cancer, and to date there are no reliable morphologic features or serum biomarkers that can reliably predict which patients are at higher risk of deve...
Prostate cancer is the second leading cause of cancer-related deaths in the United States. However, the underlying molecular events for prostate cancer development are not clear. In this study, we applied the recently developed technology known as differential subtraction chain (DSC) to identify a novel gene whose expression is inactivated in high...
Cadherins are a family of transmembrane proteins that play a crucial role in cell differentiation, cell migration, and intercellular
adhesion. Cadherins are associated with catenins through their highly conserved cytoplasmic domain. Down-regulation of E-cadherin
protein has been shown in various human cancers. This study examined the expression of...