Michele Carugno

Michele Carugno
University of Milan | UNIMI · Department of Clinical Sciences and Community Health

MD, Occupational Health Physician

About

123
Publications
11,611
Reads
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2,279
Citations
Additional affiliations
January 2014 - January 2016
University of Milan
Position
  • Medical Doctor, PhD Student
June 2009 - June 2014
University of Milan
Position
  • Occupational Health Resident
September 2007 - present
University of Milan

Publications

Publications (123)
Article
A few studies suggest that particulate matter (PM) exposure might play a role in bronchiolitis. However, available data are mostly focused on the risk of hospitalization and come from retrospective studies that provided conflicting results. This prospective study investigated the association between PM (PM2.5 and PM10) exposure and the severity of...
Article
Full-text available
The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) causes the coronavirus disease 2019 (COVID-19), ranging from asymptomatic conditions to severe/fatal lung injury and multi-organ failure. Growing evidence shows that the nasopharyngeal microbiota composition may predict the severity of respiratory infections and may play a role in the...
Technical Report
The guidance notes provide information and criteria to be considered in the diagnosis and prevention of the diseases included in the ILO List of Occupational Diseases (revised 2010). It is intended for the use of competent authorities, social security institutions, workers’ compensation funds, occupational safety and health professionals, physician...
Article
Background: In Italy, healthcare workers (HCWs) were among the first to receive COVID-19 vaccination. Aim of the present study is to evaluate frequency and severity of adverse events (AEs) following the second dose of BNT162b2 vaccine among HCWs of a large university hospital in Milan, Italy. Methods: One month after having received the second d...
Article
Full-text available
Disruption of age-related processes seems to play a relevant role in health effects related to night shift (NS) work. We aim to verify whether NS work can influence biological age (BA), estimated through Zbieć-Piekarska’s epigenetic signature, based on methylation of five CpG sites in ELOVL2, C1orf132/MIR29B2C, TRIM59, KLF14, and FHL2. Forty-six fe...
Article
We provide a comprehensive and updated systematic review and meta-analysis of the association between air pollution exposure and depression, searching PubMed, Embase, and Web of Sciences for relevant articles published up to May 2021, and eventually including 39 studies. Meta-analyses were performed separately according to pollutant type [particula...
Article
Full-text available
Reduced telomere length (TL) has been associated with increased risk of age-related diseases, most likely through oxidative stress and inflammation, which have also been claimed as mechanisms underlying health effects of air pollution exposure. We aimed to verify whether exposure to particulate matter with diameter ≤10 µm (PM10) affects TL. We recr...
Article
During the last month of 2019, a new Coronavirus from China started to spread all around the world causing a pandemic emergency still ongoing. The outbreak made imperative the need for diagnostic and screening tests that could identify the current and past infection state of an individual. Occupational medicine is facing a very demanding challenge,...
Article
Full-text available
Objectives To assess the seroprevalence of anti-SARS-CoV-2 IgG among health careworkers (HCWs) in our university hospital and verify the risk of acquiring the infection according to work area. Design Cross-sectional study. Setting Monocentric, Italian, third-level university hospital. Participants All the employees of the hospital on a voluntary...
Article
Bipolar Disorder (BD) alternates depressive, manic or hypomanic phases. A manic episode (ME) is the main psychopathological condition of BD and it often requires hospitalization. Air pollution is thought to play a role in onset and exacerbation of several psychiatric disorders. We aimed to verify the association between exposure to particulate matt...
Article
Full-text available
SARS-CoV-2 symptoms are non-specific and can range from asymptomatic presentation to severe pneumonia. Asymptomatic subjects carrying SARS-CoV-2 often remain undiagnosed and it is still debated whether they develop immunoglobulins (Ig) and how long they persist. The aim of this study was to investigate the development and persistence of antibodies...
Article
Full-text available
Objectives The management of healthcare workers (HCWs) exposed to confirmed cases of COVID-19 is still a matter of debate. We aimed to assess in this group the attack rate of asymptomatic carriers and the symptoms most frequently associated with the infection. Methods Occupational and clinical characteristics of HCWs who performed a nasopharyngeal...
Preprint
Full-text available
Background The management of healthcare workers (HCWs) exposed to confirmed cases of COVID-19 is still a matter of debate. It is unclear whether these subjects should be tested in the absence of symptoms and if those can guide diagnosis. Methods Occupational and clinical characteristics of all the consecutive HCWs who performed a nasopharyngeal swa...
Article
Full-text available
Background: The shape of the exposure-response curve describing the effects of air pollution on population health has crucial regulatory implications, and it is important in assessing causal impacts of hypothetical policies of air pollution reduction. Methods: After having reformulated the problem of assessing the short-term impact of air pollut...
Article
Full-text available
Malignant pleural mesothelioma (MPM) is a rare and aggressive cancer, which originates from the mesothelial cells of the pleura and is associated with asbestos exposure. In light of its aggressive nature, late diagnosis and dismal prognosis, there is an urgent need for identification of biomarkers in easily accessible samples (such as blood) for ea...
Article
Full-text available
Exposure to airborne particulate matter (PM) has been associated with detrimental health effects. DNA methylation represents the most well-studied epigenetic factor among the possible mechanisms underlying this association. Interestingly, changes of DNA methylation in response to environmental stimuli are being considered for their role in the path...
Article
Full-text available
Increased breast cancer risk has been reported in some night shift (NS) workers but underlying biological mechanisms are still unclear. We assessed the association between NS work and DNA methylation of tumor suppressor (TP53, CDKN2A, BRCA1, BRCA2) and estrogen receptor (ESR1, ESR2) genes, methylation of repetitive elements (LINE-1, Alu), and telom...
Article
Introduction Studies on female nurses have reported a higher breast cancer risk among night shift (NS) workers, without a clear understanding of the underlying biological mechanisms. Aim To assess the association between night shiftwork and molecular alterations potentially related to a higher carcinogenic risk, in details: DNA methylation of estr...
Article
Background: Oil refinery workers are exposed to several well-established carcinogens and working in this type of industry has been classified by IARC as probable carcinogen to humans (Group 2A). Objectives: To examine the mortality experience of workers employed in four Italian oil refineries. Methods: The cohort included 5112 male workers eve...
Article
Full-text available
Objective Cohort studies in Europe, but not in North-America, showed an association between exposure to outdoor particulate matter with aerodynamic diameter ≤10 μm (PM10) and lung cancer risk. Only a case-control study on lung cancer and PM10 in South Korea has so far been performed. For the first time in Europe we analyzed quantitatively this asso...
Data
Distribution of subjects across area and categories of average PM10 in year 2000, the EAGLE study, Lombardy, Italy, 2002–2005. (DOCX)
Data
Lung cancer risk according to average PM10 exposure in year 2000 by histological type, the EAGLE study, Lombardy, Italy, 2002–2005. (DOCX)
Data
Association between lung cancer risk and average PM10 concentration levels (four categories) in year 2000, the EAGLE Study, Lombardy, Italy, 2002–2005. (TIF)
Data
Lung cancer risk according to average PM10 exposure (four categories) in year 2000, the EAGLE study, Lombardy, Italy, 2002–2005. (DOCX)
Data
Lung cancer risk according to average PM10 exposure in year 2000 by selected variables, the EAGLE study, Lombardy, Italy, 2002–2005. (DOCX)
Data
Legend for the minimal anonymized dataset (S1 File). (DOCX)
Article
Full-text available
Background: Aircraft noise may cause several non-auditory health effects, including annoyance, sleep disorders, hypertension, cardiovascular diseases, and impaired cognitive skills in children. Objectives: To perform a cross-sectional study among adult residents near the Orio al Serio International Airport (BGY), Italy to investigate the associa...
Article
Epigenetic mechanisms might be involved in Alzheimer's disease (AD). Genetic polymorphisms in several genes, including APOE (Apolipoprotein E), PSEN1 (Presenilin 1), CR1 (Complement receptor 1), and PICALM (Phosphatidylinositol binding clathrin assembly protein), have been associated to an increased AD risk. However, data regarding methylation of t...
Article
Respiratory syncytial virus (RSV) is the primary cause of acute lower respiratory infections in children, bronchiolitis in particular. Airborne particulate matter (PM) may influence the children's immune system and foster the spread of RSV infection. We aimed to verify whether PM10 exposure is associated with hospitalization due to RSV bronchioliti...
Presentation
BACKGROUND: Extracellular vesicle (EV) production is a powerful and not yet fully understood biological mechanism, probably involved in systemic responses to particulate matter (PM) exposure. As PM enters the human body through inhalation, and locally modifies the composition of the nasal microbiota (NMB), it is possible to hypothesize that NMB mod...
Conference Paper
Full-text available
Introduction In Italy about 45% of people aged ≥18 years are overweight/obese and might thus be more susceptible to the adverse health effects of air pollution exposure. Particulate matter ≤10 µm (PM10) represents a common pollutant of living and working environments and has been associated with increased risk of cardiovascular diseases (CVD) and h...
Conference Paper
Introduction IARC defined shift work as probably carcinogenic to humans (Group 2A), after investigations highlighted an increased breast cancer risk in night-shift female workers. The biological mechanisms underlying this association are still unclear. Hence, we evaluated the relationship between night-shift work and molecular alterations potential...
Conference Paper
Introduction Arsenic is an environmental carcinogen that undergoes methylation while metabolised. Subsequent intracellular methyl groups depletion can decrease global DNA methylation, facilitating carcinogenesis. On the other hand, hypermethylation in promoter regions of tumour suppressor genes related to arsenic exposure has been observed in-vivo....
Conference Paper
Introduction The association of gene expressions with exposure to ambient particulate matter (PM) concentrations is still mainly explorative. We took advantage of a study designed to evaluate the short-term association between PM exposure in working environment and biological molecular targets to assess the correlation between PM10 exposure and gen...
Article
Full-text available
Background Exposure to particulate matter (PM) is associated with increased incidence of cardiovascular disease and increased coagulation, but the molecular mechanisms underlying these associations remain unknown. Obesity may increase susceptibility to the adverse effects of PM exposure, exacerbating the effects on cardiovascular diseases. Extracel...
Article
Introduction: Exposure to particulate matter with diameter ≤10 μm (PM10) entails well documented adverse effects on human health. In the last decade, concentration of PM10 in Lombardy (10 million inhabitants), Italy, has been gradually decreasing. We evaluated how the mortality burden due to PM10 varied in that same period. Methods: We focused o...
Conference Paper
Carcinogenic agents for nasal cavity and paranasal sinuses cancers (hereafter sinonasal cancers, SNC) with sufficient evidence in humans include nickel compounds and wood and leather dusts. Still limited evidence is available for carpentry and joinery, hexavalent chromium compounds, formaldehyde, and textile manufacturing. We studied occupational r...
Article
Context: Histone modifications regulate gene expression; dysregulation has been linked with cardiovascular diseases. Associations between histone modification levels and blood pressure in humans are unclear. Objective: We examine the relationship between global histone concentrations and various markers of blood pressure. Materials and methods: Usi...
Article
Background: Extracellular vesicles (EVs) represent a plausible molecular mechanism linking particulate matter (PM) inhalation to its systemic effects. Microvesicles (MVs) are released from many cell types in response to various stimuli. Increased body mass index (BMI) could modify the response to PM exposure due to enhanced PM uptake and/or an und...
Article
Full-text available
Background The opportunity to assess short term impact of air pollution relies on the causal interpretation of the exposure-response association. However, up to now few studies explicitly faced this issue within a causal inference framework. In this paper, we reformulated the problem of assessing the short term impact of air pollution on health usi...
Article
Objectives: To quantify the contribution of each individual month to the annual mortality burden attributable to particulate matter (PM) in 2015 in Milan, Italy, after authorities and media considered December 2015 as an outlying month carrying an exceptional population exposure to PM. Study design: We used routinely available daily time series...
Chapter
An epigenomic epidemiologic study may be used to investigate relationships among exposures to environmental, lifestyle, genetic, and socioeconomic risk factors, the epigenome, and disease development or other specific outcomes.The choice of an appropriate study design has a key role in determining the success of the study. In addition, since epigen...
Article
Full-text available
Study design: Cross-sectional survey with longitudinal follow-up OBJECTIVES.: To test the hypothesis that pain which is localised to the low back differs epidemiologically from that which occurs simultaneously or close in time to pain at other anatomical sites SUMMARY OF BACKGROUND DATA.: Low back pain (LBP) often occurs in combination with other...