Michela Calvi

Michela Calvi
University of Milan | UNIMI · Department of Medical Biotechnology and Translational Medicine

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10
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89
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Publications

Publications (10)
Article
Full-text available
Innate lymphoid cells (ILCs) were firstly described by different independent laboratories in 2008 as tissue-resident innate lymphocytes mirroring the phenotype and function of T helper cells. ILCs have been subdivided into three distinct subgroups, ILC1, ILC2 and ILC3, according to their cytokine and transcriptional profiles. Subsequently, also Nat...
Article
Full-text available
Even with high-dose post-transplant cyclophosphamide (PT-Cy) which was initially introduced for graft-versus-host disease (GvHD) prevention in the setting of HLA-haploidentical transplantation, both acute and chronic GvHDs remain a major clinical challenge. Despite improvements in the understanding of the pathogenesis of both acute and chronic GvHD...
Article
Full-text available
Haploidentical hematopoietic stem cell transplantation (h-HSCT) represents an efficient curative approach for patients affected by hematologic malignancies in which the reduced intensity conditioning induces a state of immunologic tolerance between donor and recipient. However, opportunistic viral infections greatly affect h-HSCT clinical outcomes....
Article
Background : Allogeneic stem cell transplantation from haploidentical donor using post-transplantation cyclophosphamide has been employed to cure hematological diseases. Due to slow immunological reconstitution, there is an increased incidence of viral infection. Objective : The aim of our study was to prospectively evaluate the efficacy and the f...
Article
Full-text available
In the context of allogeneic transplant platforms, human leukocyte antigen (HLA)-haploidentical hematopoietic stem cell transplantation (haplo-HSCT) represents one of the latest and most promising curative strategies for patients affected by high-risk hematologic malignancies. Indeed, this platform ensures a suitable stem cell source immediately av...
Article
INTRODUCTION: Acute Graft-versus-Host-Disease (aGVHD) is a frequent complication where the endothelium may play a pivotal role. We recently investigated the potential role of extracellular vesicles (EVs) as novel biomarkers of aGVHD (Lia G. et al. Leukemia 2018). In this study we further investigated the correlation of plasma EVs and their content...
Article
Natural Killer (NK) cells are innate immune cells with a primary role in the immune surveillance against non‐self‐cells. NK cell recognition of “self” relies on the surface expression on autologous cells of MHC class I (MHC‐I) molecules. Either the absence or the down‐modulation of MHC‐I on target cells “license” NK cells to kill threatening tumor‐...
Article
Full-text available
Natural Killer cells are the first lymphocyte population to reconstitute early after non myelo-ablative and T cell-replete haploidentical hematopoietic stem cell transplantation with post-transplant infusion of cyclophosphamide. The present study characterizes the transient and predominant expansion starting from the 2nd week after haploidentical h...

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