Michel Laguerre

Michel Laguerre
Institut Européen De Chimie Et Biologie · Molecular Modeling

PhD, DsC

About

259
Publications
25,787
Reads
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4,738
Citations
Introduction
Skills and Expertise
Additional affiliations
January 1998 - present
Institut Européen De Chimie Et Biologie
Position
  • Project Manager
September 1974 - present
University of Bordeaux
Position
  • DR CNRS
September 1974 - present
French National Centre for Scientific Research
Position
  • DR2

Publications

Publications (259)
Article
The genus Balbura Walker, 1854 is entirely reviewed. Two more species are transferred to this genus: Antona diffinis (Walker, 1854) and Ardonea judaphila Schaus, 1905. All species and their male genitalia are illustrated. A distance tree of 102 COI gene sequences is presented and discussed.
Article
A replacement name for the genus Melinda Pinas, 2000 (Lepidoptera, Erebidae, Arctiinae). Nilmeda nom. nov. is proposed for the genus Melinda Pinas, 2000, after highlighting its homonymy with the genus Melinda Robineau-Desvoidy, 1830 (Diptera, Calliphoridae).
Article
Two new Ctenuchina species are described from Latin America. Pseudaethria chryseides Laguerre sp. nov. is described from two specimens collected in Boyaca, Colombia, and Marecidia oedemeriformis Laguerre sp. nov. from a series collected in the bolivian and Peruvian Yungas. Illustrations, male and female genitalia and distance tree are provided and...
Article
The genus Lepidokirbyia Travassos, 1943, is entirely reviewed. Following an identification error made by Travassos in his original study, Lepidokirbyia venigera Toulgoët, 1983, is put into synonymy with Lepidokirbyia vittipes (Walker, 1855), syn. nov. The species from s. e. brazil is described as new under the name Lepidokirbyia lauroi Laguerre sp....
Article
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Understanding the causes and consequences of insect declines has become an important goal in ecology, particularly in the tropics, where most terrestrial diversity exists. Over the past 12 years, the ForestGEO Arthropod Initiative has systematically monitored multiple insect groups on Barro Colorado Island (BCI), Panama, providing baseline data for...
Article
In preparation for a general account of the Trinidad and Tobago Arctiini, the following taxonomic changes are made and justification provided. A lectotype is designated for Castrica sordidior Rothschild, 1909. Castrica oweni Schaus, 1896, stat rev. is returned to species rank. The following new synonyms are established: Castrica sordidior Rothschil...
Article
Following a large survey of the neotropical arctiinae using the so-called “barcoding” technique (Coi gene sequencing), the genus Haemaphlebiella Collins, 1962, was found to be in fact a complex of several species. The three already known species are redescribed and four more species are described as new. pictures, male genitalia, distance tree and...
Article
The genus Robinsonia Grote, 1866 is partially reviewed following a large DNA barcode campaign. In the Robinsonia praphoea Dognin, 1906 group three new species are described: R. simulans sp. n. from French Guiana, up to now confused with R. praphoea itself and then R. decaensi sp. n. and R. maranhensis sp. n. both from the lower Amazon. R. drechseli...
Article
After a male genitalia and COi barcode sequences study, it appears that Phaio coeruleonigra Schaus, 1905, is congeneric with Scena potentia (Druce, 1894). Nevertheless the generotype, Scena propylea Druce, 1894, has very different genitalia and it was necessary to create a new genus, Contortivalva, to accommodate the former species. Three new speci...
Article
Two Lophocampa species previously known only by females are paired with morphologically highly different male specimens. This pairing was initiated after the discovery of a mosaic gynandromorph specimen and then confirmed using the mitochondrial COI gene (the so-called DNA barcode). Following the discovery of a labeling error by Rothschild during t...
Article
The authors offer a list of 56 species belonging to the tribe of Arctiini (Lepidoptera, Erebidae, Arctiinae), known from the Dominican Republic, based on several entomological missions, the examination of the material present in the collections of the museums, the consultation of the bibliography as well as the description of three new species belo...
Article
A series of different-looking tiger moths was collected at pyrrolizidine alkaloid baits in the daytime in Peru. They proved to be variants of a new genus, Vanewrightia gen. nov., and a new species, Vanewrightia kiesela sp. nov., both described here. This species presents a striking example of extensive intraspecific variation within a population. I...
Article
the twelve species belonging to the genus Phaio have not been studied for more than a century. the analysis of the genitalia, the barcoding and the study of additional material lead to reassessment of the genus Mydropastea, to create a new one, Chrysochloe n. gen., and to describe two new species. the generic status of the three remaining species (...
Article
six new Lithosiini species are described for Neotropical fauna: Boenasa benedicti n. sp. from sierra Baoruco in dominican Republic, two Agylla species from Peru (Agylla alboapicalis n. sp.) and from eastern ecuador (Agylla atra n. sp.), two Agkonia species (Akgonia lichyi and Agkonia maracayensis n. sp.) from the cordillera de la costa in Venezuela...
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A new genus, Oodoptera laguerre n. gen., is created to accommodate a new species collected in French Guiana: Oodoptera guianensis laguerre n. sp. A new species from the lower Amazon is described within the genus Phaeomolis: Phaeomolis acailandia laguerre n. sp., and two new species from S.-E. brazil are described within the genus Hypercompe: Hyperc...
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Gloora gen. nov. is established for Eucereon alba (Druce, 1894), Hyaleucerea mundula (Berg, 1882), Agaraea sericeum (Zerny, 1931), and Gloora canae sp. nov. These species are (re‑)described considering male genitalia in particular and, in case, barcodes. Further species which might fit into Gloora gen. nov. are discussed.
Article
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Due to large differences in habitus and male genitalia, the group of the “red” Rhipha is transferred to a new genus: Rhodorhipha Laguerre gen. nov. All the species now included in this new genus are reviewed and displayed and the male genitalia of the majority of species are illustrated. In this article, five new species are described: R. gurupi La...
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Description d’une nouvelle espèce de Lithosiini de Martinique (Lepidoptera Erebidae Arctiinae Lithosiini)
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A new species and subspecies of the genus Halysidota are described from Mexico and Guadeloupe respectively: Halysidota witti sp. nov. and Halysidota leda guadulpensis ssp. nov. Details of the new species and subspecies descriptions are based upon morphological and molecular characters as well as distributional data.
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Following a large survey of the Neotropical Arctiinae using the DNA barcodes technique (COI gene sequencing), Echeta trinotata Reich, 1933 was found to be in fact a complex of three cryptic highly genetically divergent species. The two new species are described as Echeta apatela sp. nov. from the foothills of the Andean Cordillera and Echeta rhodop...
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Exocytosis depends on cytosolic domains of SNARE proteins but the function of the transmembrane domains (TMDs) in membrane fusion remains controversial. The TMD of the SNARE protein synaptobrevin2/VAMP2 contains two highly conserved small amino acids, G100 and C103, in its central portion. Substituting G100 and/or C103 with the β-branched amino aci...
Article
Two new species of Trichromia Hübner, 1815, from French Guiana are described: Trichromia supracoccinea n. sp. and T. sinefascia n. sp. The habitus and genitalia are illustrated. A comparison with the closely related species, Trichromia coccinea (Schaus, 1905), is proposed based on both morphological characters and DNA barcodes.
Article
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Polyphenols such as Epigallocatechin-3 gallate (EGCG) are currently bearer of hope to prevent or at least to slow down the deleterious effect of Tauopathies such as Alzheimer disease. One of the main effects of these neurodegenerative pathologies is the hyperphosphorylation and consequent aggregation of the Tau protein that leads to the irremediabl...
Article
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We describe a new genus, Leocephaluncus Espinoza & Laguerre n. gen., with three new species of Arctiinae (Erebidae), Leocephaluncus elianahenrichae Espinoza n. sp., Leocephaluncus rafaelangelespinozai Espinoza n. sp. and Leocephaluncus boliviensis Laguerre n. sp., from Central and South America, and clarify their identification with respect to Pseu...
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Full-text available
Following a general survey of the Neotropical Arctiinae using the so-called "barcoding" technique, three highly dimorphic females were identified and associated with their corresponding males. Idalus larissa Druce, 1890 comb. rev. is the male of Idalus albescens (Rothschild, 1909) syn. nov. Euplesia sphingidea (Perty, [1833]) is the male of Delphyr...
Article
Gaining insight into intermolecular interactions between multiple species is possible at an atomic level by looking at different parameters using different NMR techniques. In the specific case of the astringency sensation, in which at least three molecular species are involved, different NMR techniques combined with dynamic light scattering and mol...
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1. This study focuses on the importance in hyperdiverse regions, such as the Amazonian forest, of accelerating and optimising the census of invertebrate communities. 2. We carried out low-intensity sampling of tropical moth (Lepidoptera) assemblages in disturbed forest fragments in Brazil. 3. We combined DNA barcoding and taxonomists' expertise to...
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Two new species of the genus Neonerita are described from Guatemala and French Guiana: Neonerita bernardoespinozai sp. nov. and Neonerita martinezi sp. nov. Detailed species descriptions are based upon morphological and molecular characters as well as distribution data. These new taxa are discussed and compared to Neonerita dorsipuncta, species wit...
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The morphological species delimitations (i.e. morphospecies) have long been the best way to avoid the taxonomic impediment and compare insect taxa biodiversity in highly diverse tropical and subtropical regions. The development of DNA barcoding, however, has shown great potential to replace (or at least complement) the morphospecies approach, with...
Article
The ab initio design of synthetic molecular receptors for a specific biomolecular guest remains an elusive objective, particularly for targets such as monosaccharides, which have very close structural analogues. Here we report a powerful approach to produce receptors with very high selectivity for specific monosaccharides and, as a demonstration, w...
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Phosphoinositide-dependent kinase 1 (PDK1) is the master regulator of at least 23 other AGC kinases whose downstream signalling has often been implicated in various diseases and in particular in cancer. Therefore there has been great interest in determining how PDK1 is controlled and how it regulates its substrates spatially and temporally. The und...
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A catalogue of the subtribes Phaegopterina Kirby, 1892 (151 genera, 1720 species, 97 subspecies and 252 synonyms), Arctiina Leach, [1815] (7 genera, 89 species, 3 subspecies and 26 synonyms), Spilosomina Seitz, 1910 (23 genera, 244 species, 22 subspecies and 71 synonyms), Callimorphina Walker, [1865] (1 genus, 6 species, 1 subspecies and 12 synonym...
Article
The present study provides clues at a molecular level towards an understanding of the mechanism of action of wine polyphenols on the protein Tau, whose aberrant phosphorylations are responsible for Alzheimer disease progression. Ten different flavan-3-ols that cover their natural structural diversity were tested with regard to their aptitude to fix...
Article
A virtual screening strategy, through molecular docking, for the elaboration of an electronic library of Pontin inhibitors has resulted in the identification of two original scaffolds. The chemical synthesis of four candidates allowed extensive biological evaluations for their anticancer activity. Two compounds displayed an effect on Pontin ATPase...
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Two new species of Pericopini (Erebiidae, Arctiinae) are described from Guatemala: Gnophaela baileyi sp. nov. and Dysschema faustinoi sp. nov. Detailed species descriptions are based upon morphological and molecular characters as well as distributional data. Analyses of the CO1 locus (a 658 nucleotide sequence commonly referred to as a barcode) in...
Article
In the search of molecules that could recognize sizeable areas of protein surfaces, a series of ten helical aromatic oligoamide foldamers was synthesized on solid phase. The foldamers comprise three to five monomers carrying various proteinogenic side chains, and exist as racemic mixtures of interconverting right-handed and left-handed helices. Fun...
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A new species of Cosmosoma Hübner, [1823], Cosmosoma odilae Laguerre n. sp., is described from Dominican Republic and compared to Cosmosoma fenestrata (Drury, [1773]) from Jamaica. Following a DNA barcoding study for the COI gene, a phylogenetic tree is obtained which confirmed the classification of the new species within the Cosmosoma genus.
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Mutations in ITGA2B and ITGB3 cause Glanzmann thrombasthenia, an inherited bleeding disorder in which platelets fail to aggregate when stimulated. Whereas an absence of expression or qualitative defects of αIIbβ3 mainly affect platelets and megakaryocytes, αvβ3 has a widespread tissue distribution. Little is known of how amino acid substitutions of...
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Nomenclatural changes in neotropical Arctiinae (Insecta, Lepidoptera, Erebidae); second part.In order to update the neotropical Arctiinae catalogue, 38 synonymies, 52 genus changes, 10 species revalidations and 4 status changes are proposed. A lectotype is designated and the new genus Pseudepimolis n. gen. is described. These modifications are supp...
Article
One fold to rule them all: New heterogeneous aliphatic backbone foldamers belonging to the γ-peptide superfamily and containing various combinations of urea/amide (U/A) and urea/carbamate (U/C) units are reported. Structural studies at atomic resolution reveal hydrogen-bonded helical structures akin to that formed by cognate Un homooligomers.
Article
Aliphatic N,N'-linked oligoureas are peptidomimetic foldamers that adopt a well-defined helical secondary structure stabilized by a collection of remote three centred H-bonds closing 12- and 14-membered pseudo rings. Delineating the rules that govern helix formation depending on the nature of constituent units is of practical utility if one aims to...
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Four new species of Lophocampa Harris, are described and illustrated: Lophocampa flavodorsata sp. n., Lophocampa griseidorsata sp. n., Lophocampa herbini sp. n. and Lophocampa sullivani sp. n. Lophocampa atriceps (Hampson) is redescribed, illustrated and compared to the new species.
Article
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Four new species of Lophocampa Harris, are described and illustrated: Lophocampa flavodorsata sp. n., Lophocampa griseidorsata sp. n., Lophocampa herbini sp. n. and Lophocampa sullivani sp. n. Lophocampa atriceps (Hampson) is redescribed, illustrated and compared to the new species.
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RhoGTPases are GDP/GTP molecular switches that control a wide variety of cellular processes, thereby contributing to many diseases, including cancer. As a consequence, there is great interest in the identification of small molecule inhibitors of RhoGTPases. Herein, using the property of GTP-loaded RhoGTPases to bind to their effectors, we describe...
Article
While the definition of tannins has been historically associated with its propensity to bind proteins in a non-specific way, it is now admitted that specific interaction also occurs. The case of the astringency perception is a good example to illustrate this phenomenon: astringency is commonly described as a tactile sensation induced by the precipi...
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Membrane interacting peptides are reviewed in terms of structure and mode of action on lipid membranes. Helical, β-stranded, peptides containing both helices and strands, cyclic, lipopeptides and short linear peptides are seen to considerably modulate membrane function. Among peptides that lead to membrane alteration or permeation, antimicrobial pe...
Article
Helically folded molecular capsules based on oligoamide sequences of aromatic amino acids which are capable of binding tartaric acid in organic solvents with high affinity and diastereoselectivity have been synthesized, and their structures and binding properties investigated by (1)H NMR, X-ray crystallography, circular dichroism, and molecular mod...
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Nucleolipids are currently under investigation as vectors for oligonucleotides (ON) delivery thanks to their supramolecular organization properties and their ability to develop specific interactions (i.e., stacking and potential Watson and Crick hydrogen bonds) for lipoplexes formation. To investigate the factors that govern the interaction events...
Article
We report the synthesis of a new series of Ketal Nucleoside Lipids (KNLs) featuring saturated hydrophobic double chains and either adenosine or uridine as nucleosides (KNL(A) and KNL(U), respectively). Physicochemical studies (differential scanning calorimetry, small angle X ray scattering, transmission electronic microscopy, atomic force microscop...
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Full-text available
The human protein Pontin, which belongs to the AAA+ (ATPases associated with various cellular activities) family, is overexpressed in several cancers and its silencing in vitro leads to tumour cell growth arrest and apoptosis, making it a good target for cancer therapy. In particular, high levels of expression were found in hepatic tumours for whic...
Article
Tau that belongs to the family of microtubule-associated proteins is the major constituent of intraneuronal fibrillar lesions described in Alzheimer’s Disease (AD). Its sequence homology with salivary proline-rich proteins (sPRP), known to fix tannins, combined with some epidemiological evidences that a moderate consumption of polyphenols presents...
Article
Association of procyanidins with enzymes has drawn attention over the past few years. This work aimed to bring insights on interaction of the protease trypsin with the procyanidin dimer (B3). This interaction was characterized by fluorescence quenching, saturation transfer difference (STD) NMR, molecular modeling, and through an enzymatic inhibitio...
Article
Full-text available
PTEN (phosphatase and tensin homologue deleted on chromosome ten) proteins are dual phosphatases with both protein and phosphoinositide phosphatase activity. They modulate signalling pathways controlling growth, metabolism and apoptosis in animals and are implied in several human diseases. In the present paper we describe a novel class of PTEN pro-...