Michel KC Haagdorens

Michel KC Haagdorens
University of Antwerp | UA · Ophthalmology

MD PhD

About

22
Publications
5,732
Reads
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315
Citations
Citations since 2016
19 Research Items
314 Citations
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2016201720182019202020212022020406080
2016201720182019202020212022020406080
Introduction
Michel KC Haagdorens currently works at the Department of Ophthalmology, University of Antwerp (Belgium). Michel does research in Ophthalmology and Tissue Engineering. Their current project is 'Joining Forces in Corneal Regeneration Research.'
Additional affiliations
October 2014 - June 2020
University of Antwerp
Position
  • PostDoc Position
Education
September 2007 - June 2014
University of Antwerp
Field of study
  • Medicine

Publications

Publications (22)
Article
Full-text available
Objective: To review the current knowledge and implementation of preconceptional care (PCC) in the Western world, focusing both on health care workers and the general population, and to analyze pathways to disseminate the influence of preconceptional care on pregnancy outcome. A systematic literature study was performed using OvidSP and Pubmed, se...
Article
Full-text available
One key element to the health of the ocular surface encompasses the presence of gel-forming mucins in the pre-ocular tear film. Conjunctival goblet cells are specialized epithelial cells that secrete mucins necessary for tear film stability and general homeostasis. Their dysfunction can be linked to a range of ocular surface inflammation disorders...
Article
Full-text available
Purpose To determine feasibility of plant-derived recombinant human collagen type I (RHCI) for use in corneal regenerative implants Methods RHCI was crosslinked with 1-ethyl-3-(3-dimethyl aminopropyl) carbodiimide (EDC) and N-hydroxysuccinimide (NHS) to form hydrogels. Application of shear force to liquid crystalline RHCI aligned the collagen fibr...
Article
Full-text available
Pterygium is a multifaceted pathology that displays apparent conflicting characteristics: benign (e.g., self-limiting and superficial), bad (e.g., proliferative and potentially recurrent) and ugly (e.g., signs of preneoplastic transformation). The natural successive question is: why are we lacking reports showing that pterygium lesions become life-...
Article
Full-text available
The long-term survival of biomaterial implants is often hampered by surgery-induced inflammation that can lead to graft failure. Considering that most corneas receiving grafts are either pathological or inflamed before implantation, the risk of rejection is heightened. Here, we show that bioengineered, fully synthetic, and robust corneal implants c...
Article
To discuss and evaluate new technologies for a better diagnosis of corneal diseases and limbal stem cell deficiency the outcomes of a consensus process within the European Vision Institute ((EVI), and of a workshop at the University of Cologne) are outlined. Various technologies are presented and analyzed for their potential clinical use also in de...
Article
Full-text available
Transplantation with donor corneas is the mainstay for treating corneal blindness, but a severe worldwide shortage necessitates the development of other treatment options. Corneal perforation from infection or inflammation is sealed with cyanoacrylate glue. However, the resulting cytotoxicity requires transplantation. LiQD Cornea is an alternative...
Article
Full-text available
The introduction of tissue engineering has allowed scientists to push the boundaries and treat seriously damaged ocular surface epithelia. They have managed to do this through the development of biological substitutes that restore, maintain or improve tissue function. To ensure the generation of a therapeutically safe and effective graft, knowledge...
Article
Full-text available
Pterygium is a common eye disease, linked to an increased exposure to UV radiation and dry environments. The associated pathology culminates in visual impairment and, in some rare cases, blindness. However, there remains a lot of uncertainty concerning the pathogenesis of this fibrovascular lesion. As the composition of the tear film provides a ref...
Article
Full-text available
Purpose: To investigate the efficacy of recombinant human collagen type I (RHC I) and collagen-like peptide (CLP) hydrogels as alternative carrier substrates for the cultivation of limbal epithelial stem cells (LESC) under xeno-free culture conditions. Methods: Human LESC were cultivated on seven different collagen-derived hydrogels: (1) unmodif...
Data
Extracellular vesicles (gold colour) in CLP-PEG implanted cornea.
Article
Full-text available
Statement of significance: Although biomaterials comprising full-length recombinant human collagen and extracted animal collagen have been evaluated and used clinically, these macromolecules provide only a limited number of functional groups amenable to chemical modification or crosslinking and are demanding to process. Synthetic, customizable ana...
Article
Full-text available
Aims To evaluate the efficacy of Fourier domain-optical coherence tomography (FD-OCT) in imaging and quantifying the limbal palisades of Vogt and to correlate these images with histological findings. Methods The superior and inferior limbal region of both eyes of 50 healthy volunteers were imaged by FD-OCT. Images were processed and analysed using...
Article
INTRODUCTION: Limbal Epithelial Stem Cell (LESC) deficiency is an orphan disease leading to corneal blindness. Tissue engineering has become a treatment modality for this condition, as cultivated limbal epithelial transplantation (CLET) can successfully regenerate the anterior cornea [1]. In CLET, a limbal biopsy is cultivated and transplanted with...
Article
Full-text available
Olfactory neuroblastoma, frequently referred to as esthesioneuroblastoma (ENB), is a type of malignant tumour of the superior nasal cavity. It can be considered rare, as just 5% of all intranasal malignancies are classified as ENB. It was first described in 1924 by Berger et al., and is believed to originate from the basal progenitor cells of the o...
Article
Full-text available
Severe ocular surface disease can result in limbal stem cell deficiency (LSCD), a condition leading to decreased visual acuity, photophobia, and ocular pain. To restore the ocular surface in advanced stem cell deficient corneas, an autologous or allogenic limbal stem cell transplantation is performed. In recent years, the risk of secondary LSCD due...
Article
A 77 year old patient presented with new-onset visual and auditory hallucinations. After extensive anamnesis and clinical examination no other neurological or psychiatric symptoms were retained. By means of laboratory testing, an EEG and a CT-scan of the brain, the differential diagnosis could be reduced to the Charles Bonnet Plus Syndrome. This ra...

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Projects

Project (1)
Project
This COST Action combines scientific, clinical and industrial knowledge in the field of corneal regeneration. This will link researchers in the fields of biomaterial research, stem cell manipulation, tissue engineering, ophthalmology and immunology. This planned collaboration will, not only result in a unique European knowledge base to boost the development of biodegradable artificial corneas from basic research to clinical application, but will also provide the foundation to foster the development of a new generation of cornea specialists that are interested in regenerative medicine, especially in ophthalmology. In regard of the aging population of Europe, such a focus is of great importance to help our increasing population of elderly individuals with corneal disease.