Michał Świrski

University of Warsaw | UW · Institute of Genetics and Biotechnology

Many new biotechnology applications make use of non-traditional yeast species that possess characteristics and traits that are advantageous in specific settings. To a large extent, this is possible because of advances in molecular and genomic technologies that provide opportunities to study and manipulate the genomes of diverse yeasts. There remain...

Background With the rapid growth in the use of high-throughput methods for characterizing translation and the continued expansion of multi-omics, there is a need for back-end functions and streamlined tools for processing, analyzing, and characterizing data produced by these assays. Results Here, we introduce ORFik, a user-friendly R/Bioconductor...

Background: With the rapid growth in the use of high-throughput methods for characterizing translation and the continued expansion of multi-omics, there is a need for back-end functions and streamlined tools for processing, analyzing, and characterizing data produced by these assays. Results: Here, we introduce ORFik, a user-friendly R/Bioconductor...

Utilization of non-AUG alternative translation start sites is most common in bacteria and viruses, but it has been also reported in other organisms. This phenomenon increases proteome complexity by allowing expression of multiple protein isoforms from a single gene. In Saccharomyces cerevisiae, a few described cases concern proteins that are transl...