Michal Šrámek

Czech University of Life Sciences Prague | CULS · Department of Agroenvironmental Chemistry and Plant Nutrition

Introduction Gold nanoparticles are promising candidates as vehicles for drug delivery systems and could be developed into effective anticancer treatments. However, concerns about their safety need to be identified, addressed, and satisfactorily answered. Although gold nanoparticles are considered biocompatible and nontoxic, most of the toxicology...

In recent years, there has been a massive increase in demand for renewable energy and biofuels. This is mainly to minimise the environmental impact of greenhouse gas emissions and to improve competitiveness by reducing dependence on oil imports. Considering their renewability and sustainability, biofuels are increasingly perceived as an environment...

Purpose Plasmonic photothermal cancer therapy by gold nanorods (GNRs) emerges as a promising tool for cancer treatment. The goal of this study was to design cationic oligoethylene glycol (OEG) compounds varying in hydrophobicity and molecular electrostatic potential as ligand shells of GNRs. Three series of ligands with different length of OEG chai...

Cationic gold nanorods stabilized by quaternary ammonium salts (QAS) are a promising tool for photothermal destruction of cancer cells. However, cytotoxicity of the alkanethiol‐QAS limits their medical applications. A novel design of cationic surfactant composed of the quaternary ammonium group and ethylene glycol chain significantly reduces the co...

The photothermal cancer therapy using cationic gold nanorods (GNRs) stabilized by quaternary ammonium salts (QAS) have a great potential to enhance conventional cancer treatment as it promises the effective eradication of cancer cells including cells resistant to radio‐ and chemo‐therapy and the stimulation of anti‐tumor immune response. However, a...

Cationic gold nanoparticles (GNPs) are attractive candidates for drug delivery, biomedical imaging and targeted anti-cancer therapy. Due to their unique physical-chemical properties, they have great potential, especially for so-called targeted photothermal cancer therapy. Nanoparticle properties such as size, shape and surface charge play a key rol...

Gold nanorods have a great potential to be used in biomedicine and its associated disciplines. Especially an ability to convert absorbed near infrared light into localized heat makes GNRs a promising tool for tumor cells elimination in so-called photothermal cancer therapy. However the material, surface charge and coating of the nanoparticle can in...

The exceptionally high cellular uptake of gold nanorods (GNRs) bearing cationic surfactants makes them a promising tool for biomedical applications. Given the known specific toxic and stress effects of some preparations of cationic nanoparticles, the purpose of this study was to evaluate, in an in vitro and in vivo in mouse, the potential harmful e...

Cationic gold nanorods (GNRs) have potential applications in medical diagnostics and therapy due to their unique optical and physical properties. Specifically their nanoscale size and positive surface charge allow them to enter the cells up to millions per cell. While scattering of light can be used for the particle imaging, the effective transform...

Cationic colloidal gold nanorods (GNRs) have a great potential as a theranostic tool for diverse medical applications. GNRs' properties such as cellular internalization and stability are determined by physico-chemical characteristics of their surface coating. GNRs modified by (16-mercaptohexadecyl)trimethylammonium bromide (MTAB), MTABGNRs, show ex...

The non-cytotoxic cationic (16-mercaptohexadecyl) trimethyl ammonium bromide-coated gold nanorods (MTAB-GNRs) with high cell penetration can be used in a wide range of scientific disciplines, such a biotechnology or medicine. To study GNRs at cellular level, the proper detection tools are needed. GNRs with the longitudinal surface plasmon band ‘tun...

Noted fossil representatives from Mesozoic age are located in the village Černčice near Louny in northwest Bohemia. Geologist Miroslav Váně reports in his book Geology Louny for the third millennium: "This place is still undescribed and unnoticed by anyone. All occasional outcrops in Malnice greenstone should be precisely designated and faunistic g...