Michal S. Karbownik- MPharm DipClinPharm PGDipStat PhD
- Associate Professor at Medical University of Lodz
Michal S. Karbownik
- MPharm DipClinPharm PGDipStat PhD
- Associate Professor at Medical University of Lodz
Łódź Voivodeship Consultant in the field of Clinical Pharmacy
About
75
Publications
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Introduction
I am a pharmacist with community pharmacy background and more than ten years of academic experience in pharmacology. I have got national certificate in clinical pharmacy and now serve as voivodeship consultant in this field. Neuroscience of probiotics and psychopharmacology are my predominant scientific interests, but I explore other disciplines as well. Thanks to my postgraduate education and broad scientific scope, I also work as a research methodology advisor and a statistics consultant.
Current institution
Publications
Publications (75)
In recent years, bacterial probiotic dietary supplementation has emerged as a promising way to improve cognition and to alleviate stress and anxiety; however, yeast probiotics have not been tested. The aim of the present study was to determine whether 30-day supplementation with Saccharomyces boulardii enhances academic performance under stress and...
Background
Bacterial probiotics are thought to exert a serotonergic effect relevant to their potential antidepressant and pro-cognitive action, but yeast probiotics have not been tested. The aim of the present study was to determine whether 30-day supplementation with Saccharomyces boulardii affects the level of salivary serotonin under psychologic...
Background
Gut microbiota-based therapeutic strategies, such as probiotic and prebiotic preparations, may benefit mental health. However, commonly consumed fermented and prebiotic-containing foods have not been well-tested. The aim of the present study was to determine whether consumption of fermented food and food-derived prebiotics is associated...
Butyrate and indole-3-propionic acid represent the CNS-available gut microbiota metabolites exhibiting potentially beneficial effects on human brain function and being tested as antidepressants. Astrocytes represent one of the putative targets for the gut metabolites; however, the mechanism of action of butyrate and indole-3-propionic acid is not w...
The intake of psychobiotic bacteria appears to be a promising adjunct to neuropsychiatric treatment, and their consumption may even be beneficial for healthy people in terms of mental functioning. The psychobiotics’ mechanism of action is largely outlined by the gut-brain axis; however, it is not fully understood. Based on very recent studies, we p...
Clozapine and olanzapine, popular second-generation antipsychotics used for various psychiatric disorders, cause significant side effects such as metabolic syndrome, but the exact mechanism remains unclear. The present study aimed to assess clozapine and olanzapine effects on the expression of mRNA insulin pathway genes (IRS-1, PTEN, PIK3CG and PIK...
Introduction
Chronic obstructive lung diseases, such as asthma and COPD, appear to have a more extensive impact on overall functioning than previously believed. The latest data from clinical trials suggests a potential link between cognitive deterioration and chronic obstructive inflammatory lung disease. This raises the question of whether these d...
Despite the significant changes that unfold during the subacute phase of stroke, few studies have examined recovery abilities during this critical period. As neuroinflammation subsides and tissue degradation diminishes, the processes of neuroplasticity and angiogenesis intensify. An important factor in brain physiology and pathology, particularly n...
Epidemiological studies show that cardiovascular events related to platelet hyperactivity remain the leading
causes of death among multiple sclerosis (MS) patients. Quantitative or structural changes of platelet cytoskel-
eton alter their morphology and function. Here, we demonstrated, for the first time, the structural changes in MS
platelets that...
Aim. The study aimed to create a Polish version of the Gender-Sensitive Depression Screening (GSDS-26) by AM Möller-Leimkühler and to assess its validity and reliability. The tool measures the overall level of depression and the following factors: depressiveness, stress perception, aggressiveness, emotional control, alcohol consumption, and risky b...
Background
A key player in the fibrotic process is the transforming growth factor β (TGF‐β) which enhances extracellular matrix production by increasing the transcription of matrix proteins. The cytokine TGF‐β first binds to the TGFβRII receptor (dimer), resulting in the recruitment of the TGFβRI receptor (dimer). The complex thus formed leads to t...
Background
It is believed that personality traits have an impact on the propensity to change and maintain favorable lifestyle habits. This issue has been raised by multiple studies, however, none of them appeared to focus on population under severe psychological stress. The aim of the present study was to investigate the link between personality tr...
The key period in post-stroke recovery is the first three months due to the high activity of spontaneous and therapeutic-induced processes related to neuroplasticity, angiogenesis and reperfusion. Therefore, the present study examines the expression of VEGF, IGF-1 and MMP-9 proteins and their genes to identify biomarkers that can prognose brain rep...
Butyrate and indole-3-propionic acid represent the CNS-available gut microbiota metabolites exhibiting potentially beneficial effects on the human brain function and being tested as antidepressants. Astrocytes represent one of the putative targets for the gut metabolites, however, the mechanism of action of butyrate and indole-3-propionic acid is n...
Background:
Mental health deterioration in young adults in the aftermath of the COVID-19 pandemic is being increasingly studied. It is clear that the psychological consequences of the pandemic will be evident for many years, especially among the younger generation, who did not have time to acquire adaptive coping strategies before the outbreak of...
Cel: Zjawisko pogorszenia stanu zdrowia psychicznego młodych dorosłych w następstwie pandemii COVID-19 jest coraz szerzej badane. Podkreśla się, iż konsekwencje pandemii
w sferze psychiki będą widoczne przez wiele lat, zwłaszcza wśród młodszego pokolenia, które przed wybuchem pandemii nie zdążyło nabyć adaptacyjnych strategii radzenia sobie
Celem...
Background:
Asthma is a heterogeneous chronic inflammatory disease of the bronchi, the course of which is significantly influenced by extrinsic factors (specific and non-specific).
Methods:
The aim of this study was to evaluate the effect of these factors represented by nasal allergen challenge (specific factors) and methacholine challenge test...
Depression is the major cause of disability globally. Apart from lowered mood and accompanying symptoms, it leads to cognitive impairment that altogether predicts disadvantaged social functioning. Reduced cognitive function in depression appears a bit neglected in the field of clinical and molecular psychiatry, while it is estimated to occur in two...
Background
Serotonin plays an important role in mood regulation and depression. However, it is not clear whether the levels of serotonin in saliva are related to current mood.
Aim
To test the association of salivary serotonin concentrations with mood, as well as cardiovascular and autonomic parameters.
Materials and Methods
Saliva samples were ob...
The pathological conditions caused by blood platelet activation constitute a fundamental core in the pathogenesis of Acute Coronary Syndrome (ACS). The hyperactivity of platelets in ACS is well-documented, but there is still little research into the molecular basis of phenotypic changes in platelet functionality. To expand the knowledge of this phe...
The aim of the study was to investigate in vivo whether the application of immobilized superoxide dismutase (SOD) and catalase (CAT) could enhance DNA repairing systems and reduce level of CPD (cyclobutane pyrimidine dimers) and 6-4PP ((6–4) pyrimidine-pyrimidone photoproducts), and whether the immobilization on gold (AuNPs) and silver (AgNPs) nano...
Probiotic therapies and fermented food diets hold promise for improving mental health. Although in this regard psychiatric patients appear to benefit more than healthy individuals, no research has been performed to directly evaluate this hypothesis. The present study examined a cohort of medical students facing a stressful event, and some of the st...
Transcriptome analysis constitutes one of the major methods of elucidation of the genetic basis underlying the pathogenesis of various diseases. The post-transcriptional regulation of gene expression is mainly provided by microRNAs. Their remarkable stability in biological fluids and their high sensitivity to disease alteration indicates their pote...
Background:
A group particularly exposed to the occurrence of disorders in the sphere of the psyche are young people with a newly developing personality structure and a sense of identity. In the available literature there are few reports describing the mental health of doctoral students-a group that is affected by a particular group of stressors....
(1) Background: Bacterial probiotics are thought to exert a serotonergic effect relevant to their potential antidepressant and pro-cognitive action, but yeast probiotics have not been tested. The aim of the present study was to determine whether 30-day supplementation with Saccharomyces boulardii affects the level of salivary serotonin under psycho...
Background
Asthma is a heterogeneous chronic inflammatory disease of the bronchi, the course of which is significantly influenced by specific and non-specific extrinsic factors. The aim of this study was to evaluate the effect of these factors on changes in the mRNA expression of genes encoding the TGF-β (TGF-β1 and TGF-β3) - Smad (MPK1/3, Smad1/3/...
Farmakologia w zadaniach. Leki układu autonomicznego i krążenia przygotowana pod redakcją dr n. med. Małgorzaty Berezińskiej oraz dr hab. n. med. Anny Wiktorowskiej-Owczarek to nietypowy podręcznik, który uczy farmakologii poprzez rozwiązywanie zadań, problemów i przypadków klinicznych.
Książka została podzielona na trzy zasadnicze części, w obręb...
Perineuronal net (PNN) scaffolds are cellular components within the central nervous system. Various enzymes, including matrix metalloproteinases (MMPs), degrade the PNN affecting synapse homeostasis by promoting neuroplastic processes. MMPs constitute a ubiquitous class of protease enzymes involved in the pathophysiology of numerous diseases: cardi...
Background: An accurate understanding of dietary supplements (DS) is a prerequisite for informed decisions regarding their intake. However, there is a need for studies on this understanding among the public based on validated research tools.
Objective: This study aims to assess the knowledge about DS among Polish internet users with no medical educ...
Background. The lockdown imposed to counter the coronavirus disease 2019 (COVID-19) pandemic has evoked an unprecedented phenomenon that could affect health behaviors and beliefs. Objective. To examine how medication-, dietary supplement-and health-related behaviors, beliefs and other psychological constructs changed in Polish online health service...
Background
Asthma is a heterogeneous disease of a complex etiology in which genetic, environmental and personality variables are important factors determining the development of complicated strategies related to coping with stress and temperament traits. Our thesis is that coping styles in asthmatic patients are modified by the environment (chronic...
BACKGROUND
Having true beliefs about dietary supplements is a prerequisite for informed decision regarding their intake. However, there is a need for studies of the public understanding of dietary supplements based on validated research tools.
OBJECTIVE
To assess knowledge about dietary supplements in Polish Internet users with no medical educatio...
Introduction: Patient adherence to medications is a constant concern. Some barriers to adherence are that the patient may believe that medications are overused or feel that the medications they take are not necessary for their well-being.
Materials and Methods: A written paper survey was given to general outpatient clinics, pharmacies and senior li...
Oddajemy do rąk Czytelników drugą część serii Farmakologia w zadaniach, tym razem poświęconą zagadnieniom farmakologii ogólnej i klinicznej.
Podręcznik ten jest wyjątkowy, a jego wartość polega na zdobywaniu wiedzy przez wykonywanie zadań – od najprostszych po coraz trudniejsze. Nauka farmakologii polegająca na rozwiązywaniu zadań, odzwierciedlają...
The following data presents the protocol and the results of partial validation of Metanephrine Plasma ELISA for the use with saliva samples. It is a part of a study by Karbownik et al. (2020) (accessed: https://pubmed.ncbi.nlm.nih.gov/32438624/) and should be cited as follows:
Karbownik MS, Kręczyńska J, Kwarta P, et al. Effect of Supplementation w...
Background
The Beliefs about Medicines Questionnaire (BMQ) is the leading tool intended to assess the cognitive representation of medication, however, the validated Polish version of the questionnaire is lacking.
Aims
To adapt the original BMQ tool to the Polish language (BMQ-PL) and to validate it.
Materials and methods
The BMQ was adapted to Po...
The following file presents the Beliefs about Medicines Questionnaire - Polish version. ©Rob Horne. The original Polish version layout has been preserved. Details about its lexical and psychometric characteristics have been reported in an underlying paper:
Karbownik MS, Jankowska-Polańska B, Horne R, Górski KM, Kowalczyk E, Szemraj J. Adaptation a...
Aim: Superoxide dismutase (SOD) and catalase (CAT) immobilized on gold nanoparticles (AuNP) and silver nanoparticles (AgNP) nanoparticles were used to reduce UV radiation-induced oxidative stress in rat skin. Materials & methods: The antioxidant influence of the enzymes was investigated on level of malondialdehyde, 8-hydroksy-2'deoksyguanozine, mye...
Background
Despite offering little overall benefit and emerging concerns about their safety, dietary supplements have become increasingly popular. Trust in advertising them may contribute to high confidence in dietary supplements in public opinion.
Aim
To develop and validate a screening questionnaire intended for the general public regarding know...
BACKGROUND:
Development of noninvasive biomarkers could potentially contribute to extending the 5-year overall survival rate of nonsmall cell lung cancer (NSCLC) patients. Circulating microRNAs (miRNAs), due to their high stability, have the potential to become valuable cancer biomarkers.
METHODS:
Using reverse transcription-quantitative polymeras...
Objective: The predictive accuracy of the Clinical High Risk criteria for Psychosis (CHR-P) regarding the future development of the disorder remains suboptimal. It is therefore necessary to incorporate refined risk estimation tools which can be applied at the individual subject level. The aim of the study was to develop an easy-to use, short refine...
Aim: To assess the diagnostic value of selected miRNAs from various material collected from hepatocellular carcinoma (HCC) patients.
Patients & methods: Tissue, serum, urine and fecal samples from HCC patients and healthy individuals were screened for associated miRNAs using microarray analysis; the selected miRNAs were then validated by real time-...
Objectives: The objective of this study was to evaluate the association between breastfeeding duration and child neurodevelopment based on the Polish Mother and Child Cohort Study.
Material and Methods: The current analysis included 501 mother–child pairs. The analysis evaluating the association between the length of breastfeeding and child neurod...
Background:
Despite the extensive research performed on prediction of psychosis from a Clinical High Risk for Psychosis state (CHR-P), the positive predictive value of the CHR-P designation remains unsatisfactory and further models including additional clinical and biological variables are required. Existing studies indicate that schizotypy assess...
Restricting smoking is one of the most important public health challenges in Poland and in the world. The implementation of the program aimed at facilitating the fight against tobacco addiction is a great interest of pharmacists from generally accessible pharmacies, which thus become an important tool limiting the harmfulness resulting from smoking...
Introduction: Nowadays special attention is paid to sociodemographic determinants for initiation and duration
of breastfeeding.
Aim of the study: The objective of this study was to evaluate the association of sociodemographic determinants
and initiation and duration of breastfeeding based on the Polish Mother and Child Cohort Study.
Material and me...
Farmakologia w zadaniach. Receptura i postacie leków” to nietypowy podręcznik do nauki farmakologii poprzez rozwiązywanie zadań i problemów, przypadków klinicznych. Książka skierowana jest przede wszystkim do studentów wszystkich kierunków medycznych, ale może też być przydatna ich absolwentom.
Pierwsza część zawiera krótkie charakterystyki różnyc...
Objective
Clinical criteria for diagnosing Clinical High Risk for psychosis are now available. However, an understanding of the factors modulating the risk of subsequent development of frank psychosis in “at risk” individuals remains elusive. The aim of the study was to identify associations between obstetric history and the development of psychoti...
Background:
Although an immense effort has been made to develop novel diagnostic methods and treatment strategies for non-small cell lung cancer (NSCLC), the survival rate of this disease has remained virtually unchanged. Small non-coding RNAs called microRNAs (miRNAs) have appeared to be very promising biomarkers of cancer including NSCLC.
Objec...
Background. Adequate undergraduate education of medical students has been recognized as one of the crucial factors in nurturing the successful development of antimicrobial stewardship (Vickers, Student BMJ, 2011). Undergraduate curricula should be enriched with interactive clinically-oriented learning methods such as educational games to ensure tha...
Background/aims
Catalytic subunit delta of phosphoinositide 3-kinase, p110δ, encoded by the PIK3CD gene, was recently proposed as a target for pharmacological treatment of schizophrenia. Current antipsychotic drugs were found to decrease the mRNA expression of PIK3CD, but the mechanism of this process is not known. The aim of the study was to eluc...
The effect of antipsychotic drugs (haloperidol, clozapine, olanzapine, quetiapine and amisulpride) on PI3Kdelta was tested with a kinase assay. The enzyme, which was used in the experiments was N-terminal His6-tagged recombinant, full-length, human p110delta associated with regulatory subunit p85alpha. The data presents luminescence of experimental...
Metabolic syndrome is a very serious health issue, not only from internal medicine's point of view. Patients suffering from overweight, arterial hypertension, lipids and carbohydrates metabolism disorders are also in the circle of interest of other areas of medicine, including psychiatry. Currently, one of key problems of pharmacotherapy is a comor...
Aim:
The aim of the study was to verify whether implantation of hip or knee endoprosthesis affect anxiety and depressive symptoms among patients with RA.
Materials and methods:
The study enrolled a group of 128 rheumatoid arthritis patients, including 64 patients before and 64 patients after the joint replacement procedure. Anxiety was assessed...
Objective:
Existing knowledge of the relationship between olfactory identification (OI) ability and clinical risk of psychosis is inconsistent. To address this inconsistency, the aim of the present study was to identify the relationship between OI ability, with regard to the hedonic attributes of odors, and the risk of transition to psychosis in i...
Wstęp: Postępowanie procesu zapalnego w przebiegu reumatoidalnego zapalenia stawów (RZS, RA) może spowodować trwałe zniszczenie stawów. Może to stanowić obciążenie psychiczne, szczególnie w przypadku dużych stawów (np. biodrowych lub kolanowych).
Celem pracy była ocena, czy implantacja endoprotezy stawu biodrowego lub kolanowego wpływała na objawy...
Background
: There is barely any evidence of antipsychotic drugs affecting the molecular clockwork in human, yet it is suggested that clock genes are associated with dopaminergic transmission, i.e. the main target of this therapeutics. We decided to verify if haloperidol and olanzapine affect expression ofCLOCK, BMAL1, PER1andCRY1in a human central...
Aim:
The aim of this study is to present sociodemographic and clinical characteristics of Polish individuals with an at-risk mental state (ARMS).
Methods:
A group of 99 individuals meeting the ARMS criteria were assessed in terms of sociodemographic data, psychopathological symptoms, psychosocial functioning and comorbidity.
Results:
The sampl...
Background:
Although the development of novel diagnostic and treatment strategies concerning laryngeal cancer is highly intensive, the survival rate remains virtually unchanged. Small non-coding RNAs appear to be very promising biomarkers - and so remain the focus of extensive investigation in laryngeal cancer.
Objective:
We examined the express...
Background/aims:
The PIK3CD gene encodes the delta catalytic subunit of phosphoinositide 3-kinase (PI3K), an element of the neuregulin 1-downstream ErbB4-PI3K signaling pathway, which was recently identified as a molecular target for the treatment of schizophrenia. The aim of the study was to examine the effect of haloperidol (HALO), clozapine (CL...
Background:
The effectiveness of an educational board game developed to teach the pharmacology of antimicrobial drugs to medical students was compared with the lecture-based seminar as a supplemental tool to improve short- and long-term knowledge retention and the perception of the learning method by students.
Methods:
A group of 124 students wa...
Hyaluronan (HA) is an extracellular matrix (ECM) polymer that may contribute to the emergence of anti-cancer drug resistance. Attempts to reverse drug resistance using small hyaluronan oligomers (oHA) are being made. The initial reports suggest that the oHA fraction may effectively reverse anti-cancer drug resistance in glioma models. However, the...
The understanding of the role of hyaluronan in physiology and various pathological conditions has changed since the complex nature of its synthesis, degradation and interactions with diverse binding proteins was revealed. Initially perceived only as an inert component of connective tissue, it is now known to be involved in multiple signaling pathwa...
Hyaluronan (HA) is a linear high-molecular-weight polysaccharide composed of repeating units of D-glucuronic acid residues and N-acetyl-D-glucosamine. Hyaluronan belongs to the family of glycosaminoglycans (GAGs), but it differs from the other members of GAGs. It is a principal element of extracellular matrix, contributing to maintenance of appropr...
https://nazdrowie.pl/artykul/farmacja/oslona-w-antybiotykoterapii/
https://nazdrowie.pl/artykul/informacje/medycyna-personalizowana/
https://nazdrowie.pl/artykul/farmacja/produkty-pszczele-w-lecznictwie/
Questions
Questions (36)
Does an entity conducting medical experiments in Germany have to be insured against civil liability? Such a need exists in Poland and I'd like to know whether the same applies to Germany. Thanks for your help!
Hello Everyone,
I'm looking for a statistician to collaborate under a meta-analysis manuscript. Interested to join our research team? Please let me know on priv: michal.karbownik@umed.lodz.pl
Russia ruthlessly invaded Ukraine and far-reaching sanctions were imposed on Russia in many areas. Should the research community proceed in the same way by closing journals to Russian manuscripts, not accepting to review Russian manuscripts, not citing papers by Russian scientists, block cooperation with Russian colleagues, etc.?
1) Such solution could fit the model of overall sanctions; the affected scientists could pressure the government to stop the war. But:
2) Russian scientists may be overwhelmingly not involved in politics and the war itself; their work may be honest and very likely consistent with good scientific practice; as a result the sanctions could just make their research and inventions more difficult with no effect on the war.
I would like to here your opinion on this topic...
This has been already more than a half of a year that COVID-19 vaccine is available (Comirnaty). There appears robust data suggesting its safety as obtained from medical event reports from vaccinated people (https://www.ema.europa.eu/en/documents/covid-19-vaccine-safety-update/covid-19-vaccine-safety-update-comirnaty-14-july-2021_en.pdf). However, majority of data is observational and this is difficult to suggest causality. Meanwhile, the randomised controlled trial (RCT) paper, that reported the initial data on Comirnaty ( ), declared a two-year follow-up safety monitoring. And RCT would be indeed an ideal research setting to investigate causality.
Is there any report of long-term safety of Comirnaty (or other) COVID-19 vaccine that is based on RCT results?
Clarivate announced today an updated list of journals' impact factors for 2020. Many journals presented unprecedented growth of ca. 15-30%. Eg. 'NEJM' from 74.7 to 91.2, 'Nature' from 42.8 to 50.0, but also middle class journals as 'Nutrients' from 4.6 to 5.7 or 'BMC Complement Altern Med' from 2.8 to 3.7. Please share your opinion on why there is such a growth in impact factor? Is it only this year phenomenon (COVID?) or should we expect further rise (or maybe drop) in impact factors in the next year?
